Publications by authors named "Luca Tamagnone"

72Publications

Semaphorins in health and disease.

Cytokine Growth Factor Rev 2020 Sep 2. Epub 2020 Sep 2.

Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario "A. Gemelli", IRCCS, Rome, Italy. Electronic address:

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September 2020

Autocrine Signaling of NRP1 Ligand Galectin-1 Elicits Resistance to BRAF-Targeted Therapy in Melanoma Cells.

Cancers (Basel) 2020 Aug 8;12(8). Epub 2020 Aug 8.

Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

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August 2020

Plexin-Bs enhance their GAP activity with a novel activation switch loop generating a cooperative enzyme.

Cell Mol Life Sci 2020 Jun 29. Epub 2020 Jun 29.

Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

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June 2020

Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD+ AML.

Blood Adv 2019 12;3(24):4155-4160

Section of Histology & Medical Embryology, Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Sapienza University of Rome, laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.

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December 2019

Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins.

Int J Mol Sci 2019 Nov 27;20(23). Epub 2019 Nov 27.

Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

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November 2019

Targeting Semaphorin 4D in Cancer: A Look from Different Perspectives.

Cancer Res 2019 Oct;79(20):5146-5148

Cancer Cell Biology Laboratory, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy.

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October 2019

Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1.

Immunohorizons 2019 02;3(2):71-87

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;

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February 2019

Semaphorins and Their Receptors in Hematological Malignancies.

Front Oncol 2019 9;9:382. Epub 2019 May 9.

Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.

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May 2019

Neuropilins Controlling Cancer Therapy Responsiveness.

Int J Mol Sci 2019 Apr 25;20(8). Epub 2019 Apr 25.

Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, 10168 Rome, Italy.

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April 2019

Semaphorins as Regulators of Phenotypic Plasticity and Functional Reprogramming of Cancer Cells.

Trends Mol Med 2019 04 26;25(4):303-314. Epub 2019 Feb 26.

Università Cattolica del Sacro Cuore, 00168 Rome, Italy; Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168 Rome, Italy. Electronic address:

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April 2019

Semaphorin Signaling in Cancer-Associated Inflammation.

Int J Mol Sci 2019 Jan 17;20(2). Epub 2019 Jan 17.

Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, 10168 Rome, Italy.

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January 2019

Sema4C/PlexinB2 signaling controls breast cancer cell growth, hormonal dependence and tumorigenic potential.

Cell Death Differ 2018 07 19;25(7):1259-1275. Epub 2018 Mar 19.

Cancer Cell Biology Laboratory, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy.

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July 2018

Taming the Notch Transcriptional Regulator for Cancer Therapy.

Molecules 2018 Feb 15;23(2). Epub 2018 Feb 15.

Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.

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February 2018

Experimental Approaches for Studying Semaphorin Signals in Tumor Growth and Metastasis in Mouse Models.

Methods Mol Biol 2017 ;1493:467-484

Laboratory of Cancer Cell Biology, Candiolo Cancer Institute-FPO, IRCCS, Str. Prov. 142, Candiolo, TO, Italy.

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February 2018

Antibody-Feeding Assay: A Method to Track the Internalization of Neuropilin-1 and Other Cell Surface Receptors.

Methods Mol Biol 2017 ;1493:311-319

Laboratory of Cancer Cell Biology, Candiolo Cancer Institute-FPO, IRCCS, Str. Prov. 142, 10060, Candiolo, TO, Italy.

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February 2018

PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells.

PLoS One 2016 17;11(10):e0164660. Epub 2016 Oct 17.

Cancer Cell Biology Laboratory, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy.

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May 2017

Transmembrane semaphorins: Multimodal signaling cues in development and cancer.

Cell Adh Migr 2016 11 13;10(6):675-691. Epub 2016 Jun 13.

a Department of Oncology , University of Torino c/o IRCCS , Candiolo ( TO ), Italy.

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November 2016

Transmembrane semaphorins, forward and reverse signaling: have a look both ways.

Cell Mol Life Sci 2016 Apr 21;73(8):1609-22. Epub 2016 Jan 21.

Department of Oncology, University of Torino c/o IRCCS, Str. Prov. 142, 10060, Candiolo (TO), Italy.

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April 2016

Bad vessels beware! Semaphorins will sort you out!

EMBO Mol Med 2015 Oct;7(10):1251-3

Department of Oncology, University of Torino and Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy.

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October 2015

Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.

Nat Commun 2015 Feb 27;6:6385. Epub 2015 Feb 27.

1] Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172, 59045 Lille, France [2] University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114), 59045 Lille, France.

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February 2015

Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A.

PLoS Biol 2014 Mar 11;12(3):e1001808. Epub 2014 Mar 11.

INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France; UDSL, School of Medicine, Place de Verdun, Lille, France; Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France.

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March 2014

Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.

Cancer Cell 2013 Dec;24(6):695-709

Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, 3000 Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Department of Oncology, Vesalius Research Center, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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December 2013

To die or not to die: Sema3E rules the game.

Cancer Cell 2013 Nov;24(5):564-6

Institute for Cancer Research at Candiolo (IRCC), Department of Oncology, University of Turin, 10060 Candiolo, Italy. Electronic address:

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November 2013

Semaphorins in cancer: biological mechanisms and therapeutic approaches.

Semin Cell Dev Biol 2013 Mar 23;24(3):179-89. Epub 2012 Oct 23.

Institute for Cancer Research at Candiolo (IRC@C), University of Torino-Dept. of Oncology, 10060 Candiolo, Italy.

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March 2013

Neuropilin-1-dependent regulation of EGF-receptor signaling.

Cancer Res 2012 Nov 17;72(22):5801-11. Epub 2012 Sep 17.

Institute for Cancer Research at Candiolo, IRC@C, and University of Torino Medical School, Candiolo, Italy.

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November 2012

Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer.

Authors:
Luca Tamagnone

Cancer Cell 2012 Aug;22(2):145-52

IRCC-Institute for Cancer Research at Candiolo, Candiolo, Italy.

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August 2012

Semaphorin signals tweaking the tumor microenvironment.

Adv Cancer Res 2012 ;114:59-85

University of Torino Medical School, Institute for Cancer Research (IRCC), Candiolo, Turin, Italy.

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September 2012

Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform.

EMBO Mol Med 2012 Mar 13;4(3):234-50. Epub 2012 Jan 13.

Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo, Italy.

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March 2012

Semaphorin signals on the road of endothelial tip cells.

Dev Cell 2011 Aug;21(2):189-90

Institute for Cancer Research, Laboratory of Cell Biology, University of Torino Medical School, 10060 Candiolo, Italy.

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August 2011

Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.

Differentiation 2011 Feb 30;81(2):81-91. Epub 2010 Oct 30.

Institute of Biomedicine/Medical Biochemistry and Developmental Biology, Biomedicum Helsinki, PO Box 63, FI-00014 University of Helsinki, Finland.

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February 2011

The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth.

J Biol Chem 2010 Dec 11;285(50):38756-64. Epub 2010 Oct 11.

Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, 10060 Candiolo, Torino, Italy.

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December 2010

Overexpression of GAP-43 modifies the distribution of the receptors for myelin-associated growth-inhibitory proteins in injured Purkinje axons.

Eur J Neurosci 2009 Nov 6;30(10):1837-48. Epub 2009 Nov 6.

Department of Neuroscience, Neuroscience Institute of Turin (NIT), University of Turin, Turin, Italy.

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November 2009

Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.

J Biol Chem 2009 Dec;284(51):35962-72

Departments of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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December 2009

Semaphorin signaling in cancer cells and in cells of the tumor microenvironment--two sides of a coin.

J Cell Sci 2009 Jun;122(Pt 11):1723-36

Institute for Cancer Research and Treatment (IRCC), University of Turin, S.P. 142, 10060, Candiolo (TO), Italy.

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June 2009

Tyrosine phosphorylation in semaphorin signalling: shifting into overdrive.

EMBO Rep 2008 Sep 25;9(9):865-71. Epub 2008 Jul 25.

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino, S.P. 142, 10060 Candiolo, Torino, Italy.

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September 2008

Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts.

Blood 2008 Feb 3;111(4):2290-9. Epub 2007 Dec 3.

Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy.

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February 2008

Semaphorin signals in cell adhesion and cell migration: functional role and molecular mechanisms.

Adv Exp Med Biol 2007 ;600:90-108

University of Turin Medical School, Institute for Cancer Research and Treatment, Str. Prov. 142, I-10060 Candiolo, Torino, Italy.

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August 2007

Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis.

BMC Dev Biol 2007 May 22;7:55. Epub 2007 May 22.

Institute for Cancer Research and Treatment, University of Torino Medical School, Division of Molecular Oncology, Candiolo, Turin, Italy.

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May 2007

Semaphorin signals on the road to cancer invasion and metastasis.

Cell Adh Migr 2007 Apr-Jun;1(2):62-8. Epub 2007 Apr 13.

Institute for Cancer Research and Treatment (IRCC), Division of Molecular Oncology, University of Torino Medical School, Candiolo, Italy.

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June 2009

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors.

FASEB J 2006 Jul;20(9):1462-72

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, P.O.B. 63, FI-00014 University of Helsinki, Helsinki, Finland.

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July 2006

Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function.

Blood 2006 Apr 27;107(8):3321-9. Epub 2005 Dec 27.

Dipartimento di Patologia Molecolare, Politecnica delle Marche, Via Ranieri, 60131, Ancona, Italy.

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April 2006

p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.

J Cell Sci 2005 Oct 27;118(Pt 20):4689-700. Epub 2005 Sep 27.

Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, Candiolo, Torino 10060, Italy.

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October 2005

Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis.

Cancer Res 2005 Jul;65(14):6167-77

Institute of Cancer Biology, Department of Biostatistics and Electronic Data Processing, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.

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July 2005

Sema4D induces angiogenesis through Met recruitment by Plexin B1.

Blood 2005 Jun 4;105(11):4321-9. Epub 2005 Jan 4.

Division of Molecular Oncology, Department of Oncological Sciences, IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142 10060, Candiolo, Torino, Italy.

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June 2005

CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival.

Blood 2005 Apr 21;105(8):3042-50. Epub 2004 Dec 21.

Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy.

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April 2005

Plexin-B3 is a functional receptor for semaphorin 5A.

EMBO Rep 2004 Jul 25;5(7):710-4. Epub 2004 Jun 25.

Institute for Cancer Research and Treatment (IRCC), University of Torino--Medical School, 10060 Candiolo (TO), Italy.

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July 2004

To move or not to move? Semaphorin signalling in cell migration.

EMBO Rep 2004 Apr;5(4):356-61

Institute for Cancer Research and Treatment, University of Turin Medical School-IRCC, SP 142, 10060 Candiolo, Turin, Italy.

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April 2004

Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferation.

FASEB J 2004 Feb 4;18(2):358-60. Epub 2003 Dec 4.

Department of Molecular Pathology and Innovative Therapies, Laboratory of Experimental Pathology, Polytechnic University of Marche, Ancona, Italy.

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February 2004

Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function.

Nature 2003 Jul;424(6947):391-7

Division of Molecular Angiogenesis, IRCC, Institute for Cancer Research and Treatment, and Department of Oncological Sciences, University of Torino School of Medicine, 10060 Candiolo, TO, Italy.

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July 2003

Functional regulation of semaphorin receptors by proprotein convertases.

J Biol Chem 2003 Mar 17;278(12):10094-101. Epub 2003 Jan 17.

Institute for Cancer Research and Treatment (IRCC), University of Torino School of Medicine, 10060 Candiolo, Italy.

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March 2003

The semaphorin 4D receptor controls invasive growth by coupling with Met.

Nat Cell Biol 2002 Sep;4(9):720-4

Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.

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September 2002