Publications by authors named "Luca Busino"

28Publications

FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.

Cancer Res 2020 06 29;80(12):2498-2511. Epub 2020 Apr 29.

Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417195PMC
June 2020

Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer therapy.

Semin Cancer Biol 2020 Dec 18;67(Pt 2):53-60. Epub 2020 Mar 18.

Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Perelman School of Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2020.03.007DOI Listing
December 2020

The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin Ligases.

Adv Exp Med Biol 2020 ;1217:111-122

Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-981-15-1025-0_8DOI Listing
February 2020

Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway.

Am J Cancer Res 2019 1;9(8):1682-1694. Epub 2019 Aug 1.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania 421 Curie Blvd., Philadelphia 19014, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726985PMC
August 2019

Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma.

Metallomics 2019 08 18;11(8):1430-1440. Epub 2019 Jul 18.

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1039/c9mt00042aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693990PMC
August 2019

E3 ubiquitin ligases in B-cell malignancies.

Cell Immunol 2019 06 26;340:103905. Epub 2019 Feb 26.

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584052PMC
June 2019

KLHL6 is a tumor suppressor gene in diffuse large B-cell lymphoma.

Cell Cycle 2019 02 24;18(3):249-256. Epub 2019 Jan 24.

a Department of Cancer Biology , University of Pennsylvania , Philadelphia , PA , USA ; Perelman School of Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1080/15384101.2019.1568765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380389PMC
February 2019

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

Cell Cycle 2018 25;17(18):2243-2255. Epub 2018 Sep 25.

a Department of Cancer Biology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/15384101.2018.1522912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226225PMC
November 2019

KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis.

Genes Dev 2018 01 12;32(2):181-193. Epub 2018 Feb 12.

Penn Epigenetics Institute, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.306241.117
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http://dx.doi.org/10.1101/gad.306241.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830930PMC
January 2018

SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket.

Nature 2013 Apr 17;496(7443):64-8. Epub 2013 Mar 17.

Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/nature11964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618506PMC
April 2013

SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma.

Sci Signal 2012 Dec 4;5(253):pt14. Epub 2012 Dec 4.

NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, NY 10016, USA.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2003408
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http://dx.doi.org/10.1126/scisignal.2003408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871187PMC
December 2012

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.

Nat Cell Biol 2012 Mar 4;14(4):375-85. Epub 2012 Mar 4.

NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339029PMC
http://dx.doi.org/10.1038/ncb2463DOI Listing
March 2012

APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.

J Cell Biol 2011 Jul 18;194(2):177-86. Epub 2011 Jul 18.

Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1083/jcb.201101062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144416PMC
July 2011

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization.

Cell Cycle 2010 Mar 9;9(5):971-4. Epub 2010 Mar 9.

Department of Pathology, New York University Cancer Institute, Smilow Research Center, New York University School of Medicine, New York, NY, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.9.5.10914
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827631PMC
http://dx.doi.org/10.4161/cc.9.5.10914DOI Listing
March 2010

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

Cell 2008 Jul;134(2):256-67

Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.cell.2008.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2591934PMC
July 2008

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.

Science 2007 May 26;316(5826):900-4. Epub 2007 Apr 26.

Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA.

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http://dx.doi.org/10.1126/science.1141194DOI Listing
May 2007

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis.

Oncogene 2004 Mar;23(11):2050-6

European Institute of Oncology, 435 Via Ripamonti, Milan 20141, Italy.

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http://www.nature.com/articles/1207394
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http://dx.doi.org/10.1038/sj.onc.1207394DOI Listing
March 2004

Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation.

Cell Cycle 2004 Apr 1;3(4):469-71. Epub 2004 Apr 1.

European Institute of Oncology, Milan, Italy.

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April 2004

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

Nature 2003 Nov;426(6962):87-91

European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy.

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http://dx.doi.org/10.1038/nature02082DOI Listing
November 2003

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.

Dev Cell 2003 Jun;4(6):799-812

Department of Pathology and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/s1534-5807(03)00154-0DOI Listing
June 2003

Up-regulation of c-Jun N-terminal kinase pathway in Friedreich's ataxia cells.

Hum Mol Genet 2002 Nov;11(23):2989-96

BioGeM Consortium and Department of Molecular and Cellular Biology and Pathology and IEOS, CNR, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1093/hmg/11.23.2989DOI Listing
November 2002