Luca A Lotta

Luca A Lotta

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Luca A Lotta

Luca A Lotta

Publications by authors named "Luca A Lotta"

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MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition.

EBioMedicine 2019 Jun 28;44:467-475. Epub 2019 May 28.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.05.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607082PMC
June 2019

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.

Cell 2019 Apr;177(3):597-607.e9

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.03.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476272PMC
April 2019

Complications of whole-exome sequencing for causal gene discovery in primary platelet secretion defects.

Haematologica 2019 Feb 28. Epub 2019 Feb 28.

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and Università degli Studi di Milano

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http://dx.doi.org/10.3324/haematol.2018.204990DOI Listing
February 2019

Next-generation DNA sequencing to identify novel genetic risk factors for cerebral vein thrombosis.

Thromb Res 2018 09 15;169:76-81. Epub 2018 Jun 15.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2018.06.011DOI Listing
September 2018

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-04611-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997992PMC
June 2018

Genomic insights into the causes of type 2 diabetes.

Lancet 2018 06;391(10138):2463-2474

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/S0140-6736(18)31132-2DOI Listing
June 2018

Prioritising Risk Factors for Type 2 Diabetes: Causal Inference through Genetic Approaches.

Curr Diab Rep 2018 05 19;18(7):40. Epub 2018 May 19.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1007/s11892-018-1009-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960479PMC
May 2018

Genome-wide association study for risk taking propensity indicates shared pathways with body mass index.

Commun Biol 2018 3;1:36. Epub 2018 May 3.

1MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0SL UK.

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http://www.nature.com/articles/s42003-018-0042-6
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http://dx.doi.org/10.1038/s42003-018-0042-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123697PMC
May 2018

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.

EBioMedicine 2018 Jan 7;27:151-155. Epub 2017 Dec 7.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828558PMC
January 2018

PCSK9 inhibition and type 2 diabetes.

Lancet Diabetes Endocrinol 2017 12 15;5(12):926-927. Epub 2017 Sep 15.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK; Primary Care Unit, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(17)30321-2DOI Listing
December 2017

Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease.

Cell Metab 2017 Aug;26(2):281-283

Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg 41345, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.07.006DOI Listing
August 2017

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

Nat Commun 2017 07 12;8:16015. Epub 2017 Jul 12.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms16015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510175PMC
July 2017

Next-Generation Sequencing and In Vitro Expression Study of ADAMTS13 Single Nucleotide Variants in Deep Vein Thrombosis.

PLoS One 2016 1;11(11):e0165665. Epub 2016 Nov 1.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165665PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089687PMC
June 2017

Whole-exome sequencing to identify genetic risk variants underlying inhibitor development in severe hemophilia A patients.

Blood 2016 06 8;127(23):2924-33. Epub 2016 Apr 8.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; and Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda, Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2015-12-685735DOI Listing
June 2016

Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.

J Natl Cancer Inst 2015 Sep 1;107(9). Epub 2015 Jul 1.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK (KTN, SJS, AB, JRBP, LAL, CL, NJW, RAS); Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (KTN); Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (DJT, DFE, PDPP); Queensland Institute of Medical Research, Brisbane, Australia (JNP, ANECS, TO, ABS); University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, UK (DBS, RKS); Hunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia (JA, EH, RJS); Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, The University of Newcastle, Newcastle, Australia (JA, MM); Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (AMD, DFE, PDPP); Centre for Information Based Medicine, School of Medicine and Public Health, University of Newcastle, Australia (EH, RJS).

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http://dx.doi.org/10.1093/jnci/djv178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572886PMC
September 2015

Pregnancy complications in acquired thrombotic thrombocytopenic purpura: a case-control study.

Orphanet J Rare Dis 2014 Nov 28;9:193. Epub 2014 Nov 28.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Milan, Italy.

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http://dx.doi.org/10.1186/s13023-014-0193-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279798PMC
November 2014

Prevalence of disease and relationships between laboratory phenotype and bleeding severity in platelet primary secretion defects.

PLoS One 2013 2;8(4):e60396. Epub 2013 Apr 2.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Università degli Studi di Milano and Fondazione Luigi Villa, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060396PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614926PMC
September 2013

Smoking and the risk of mortality and vascular and respiratory events in patients undergoing major surgery.

JAMA Surg 2013 Aug;148(8):755-62

Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon4Angelo Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Foundation Maggiore Policlinico Hospital, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1001/jamasurg.2013.2360DOI Listing
August 2013

Preoperative hematocrit concentration and the risk of stroke in patients undergoing isolated coronary-artery bypass grafting.

Anemia 2013 30;2013:206829. Epub 2013 Apr 30.

Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Beirut 1107 2020, Lebanon ; Angelo Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, University of Milan, 20122 Milan, Italy.

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http://dx.doi.org/10.1155/2013/206829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657438PMC
June 2013

The emerging concept of residual ADAMTS13 activity in ADAMTS13-deficient thrombotic thrombocytopenic purpura.

Blood Rev 2013 Mar 14;27(2):71-6. Epub 2013 Feb 14.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, U.O.S. Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, Università Degli Studi di Milano and Fondazione Luigi Villa, Milan, Italy.

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http://dx.doi.org/10.1016/j.blre.2013.01.001DOI Listing
March 2013

Genome-wide association studies in myocardial infarction and coronary artery disease.

J Tehran Heart Cent 2010 31;5(3):116-21. Epub 2010 Aug 31.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Università degli Studi di Milano, Milan, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466835PMC
October 2012

Prothrombin mutation conveying antithrombin resistance.

N Engl J Med 2012 09;367(11):1069; author reply 1069-70

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http://dx.doi.org/10.1056/NEJMc1208510DOI Listing
September 2012

Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura.

Blood 2012 Jul 23;120(2):440-8. Epub 2012 Apr 23.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Unitá Operativa Semplice Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Università degli Studi di Milano and Luigi Villa Foundation, Via Pace 9, Milan, Italy. 5P01HL078826-06

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http://www.bloodjournal.org/content/bloodjournal/early/2012/
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-01-40
Publisher Site
http://dx.doi.org/10.1182/blood-2012-01-403113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721603PMC
July 2012

Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes.

BMC Med Genomics 2012 Feb 21;5. Epub 2012 Feb 21.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, U.O.S. Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1186/1755-8794-5-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305575PMC
February 2012

Addressing the complexity of cardiovascular disease by design.

Lancet 2011 Jan 14;377(9763):356-8. Epub 2011 Jan 14.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Luigi Villa Foundation, Ospedale Maggiore Policlinico, University of Milan, Milan 20122, Italy.

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http://dx.doi.org/10.1016/S0140-6736(10)62240-4DOI Listing
January 2011

Different clinical severity of first episodes and recurrences of thrombotic thrombocytopenic purpura.

Br J Haematol 2010 Dec 19;151(5):488-94. Epub 2010 Oct 19.

Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Luigi Villa Foundation, Department of Medicine and Medical Specialities, Università degli Studi di Milano, Milan, Italy.

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http://doi.wiley.com/10.1111/j.1365-2141.2010.08385.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2141.2010.08385.xDOI Listing
December 2010

Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.

Thromb Haemost 2010 Aug 10;104(2):231-42. Epub 2010 May 10.

Department of Medical and Surgical Critical Care, University of Florence, Viale Morgagni 85, 50134 Florence, Italy.

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http://www.thieme-connect.de/DOI/DOI?10.1160/TH09-11-0748
Publisher Site
http://dx.doi.org/10.1160/TH09-11-0748DOI Listing
August 2010

ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura.

Hum Mutat 2010 Jan;31(1):11-9

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Universitá degli Studi di Milano, Department of Medicine and Medical Specialities, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Luigi Villa Foundation, Milan, Italy.

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http://dx.doi.org/10.1002/humu.21143DOI Listing
January 2010

Inhibitors of factor VIII in hemophilia.

N Engl J Med 2009 Jul;361(3):309; author reply 310

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July 2009