Dr. Luc Maroteaux, PhD - Sorbonne University INSERM UMR S-1270

Dr. Luc Maroteaux

PhD

Sorbonne University INSERM UMR S-1270

Paris | France

Main Specialties: Other, Pharmacology

Additional Specialties: Serotonin signaling in plasticity and disease

ORCID logohttps://orcid.org/0000-0002-9499-8603


Top Author

Dr. Luc Maroteaux, PhD - Sorbonne University INSERM UMR S-1270

Dr. Luc Maroteaux

PhD

Introduction

Our group is interested in the control of neuronal plasticity in the central nervous system and its pathological and pharmacological alterations. Functional neural circuits rely on a sophisticated balance between developing synapses and eliminating redundant or inappropriate neural connections. Schizophrenia and autism spectrum disorders are neurodevelopmental disorders characterized by disturbances in brain connectivity that cause a range of symptoms, including cognitive and social deficits. It has been hypothesized that these pathologies arise in part due to deficits in pruning the synapses, thus producing aberrant circuits. Recent studies have highlighted links between activation of microglial cells, resident macrophages of the brain, and psychiatric pathologies, in particular depression, schizophrenia or autism. However, the role of microglia in controlling behavior has not been established, and it is unclear how microglial activation is modulated in these pathologies.

Over the past few years, our research group has demonstrated an unexpected role for a serotonin receptor, 5-HT2B, in the central nervous system. We have shown that loss of function mutations in the 5-HT2B receptor gene are associated with psychiatric diseases marked by high impulsivity and suicidal behavior in humans, and that mice knocking out for this receptor also exhibit impulsive behavior. After having demonstrated that the 5-HT2B receptor was expressed by neurons in the brainstem that produce serotonin, we uncovered the need for this receptor for the antidepressant effects of the selective serotonin reuptake inhibitors (SSRIs), blockers of the serotonin transporter SERT, as well as its function positive serotonergic autoreceptor. The genetic or pharmacological inactivation of this receptor eliminates the behavioral and neurogenic effects of SSRI antidepressants, clearly implicating the presynaptic 5-HT2B receptors in serotonergic homeostasis. The 5-HT2B receptor therefore appears to be a positive modulator of serotonergic activity and its study can thus give clues to the search for new targets in the development of antidepressants.

More recently, we have discovered that microglia mainly express this serotonin receptor: the 5-HT2B receptor modulates the motility of microglial extensions as well as the expression of markers of inflammation in the brain after peripheral inflammation; the early absence of expression of this receptor specifically in microglia is associated with behavioral alterations. This discovery in our laboratory of the expression of the 5-HT2B receptor by microglia, supports the hypothesis that microglia could interact with the serotonergic system to regulate central responses to peripheral inflammation in adults, certain stages of development of the brain, and thus regulate its connectivity.

On the other hand, schizophrenia is highly hereditary, and genome-wide association studies have shown that the major histocompatibility complex has the greatest genetic association with schizophrenia. In particular, the complement C4, which is located in this locus, is associated with schizophrenia since specific mutations which cause an increased expression of C4 confer a greater risk for this pathology. We are interested in understanding the role of a key protein in the immune system, the C4 complement, in brain damage that is associated with schizophrenia. We are studying in particular the implication of C4 in glia-neuron interactions and synaptic transmission. In the longer term, these results can be used to identify new drug targets and thus develop new therapeutic strategies.

Questions raised

In recent years, we have progressed in understanding the molecular mechanisms initiated by the activation of serotonin receptors and / or microglia thanks to cell models and transgenic mice. Our work in progress is focused on:

• Role of presynaptics of 5-HT2B receptors in the upregulation of serotonin neurons: contribution to anxiety and depression? The excess inhibitory control exerted by the 5-HT1A receptors in the absence of 5-HT2B receptors may explain the lack of behavioral response to SSRIs. Our recent results, which reveal the 5-HT2B receptor as a direct positive regulator of serotonergic neurons, support the hypothesis that the 5-HT2B receptors control the excitability of these neurons counteract the negative action of the 5-HT1A/1B receptors and thus participate in the homeostasis of the serotonergic system. Our work seeks to elucidate the molecular mechanisms involved.

• Role of the 5-HT2B receptor in neuroinflammation: the microglia new targets of the serotonergic system in psychiatric disorders? We propose to test the hypothesis that inflammation, and in particular an abnormal activation of microglia by serotonin, is a factor of sensitivity to psychiatric disorders. This work should indicate how the interactions of the gene (mutation) and the environment (infection) can determine susceptibility to psychiatric disorders.

• Role of the C4 complement in schizophrenia: the microglia new therapeutic targets? Previous work has shown that mice deficient in various complement proteins have a reduced size of synaptic terminations during development, supporting that C4 exerts its effects by activating the complement cascade. We propose that there is a critical development window during which the prefrontal cortical circuits are sensitive to alterations in C4 expression, thus opening up the possibility of early therapeutic intervention to modify the development trajectory of schizophrenia.

Together, these studies should make it possible to determine the link between autism/depression/psychosis, and the relevant pathways (serotonin, neuron subtypes and/or microglial cells) and thus help to define precisely the role of serotonin and microglia in the connectivity and activity of these neurons.

Primary Affiliation: Sorbonne University INSERM UMR S-1270 - Paris , France

Specialties:

Additional Specialties:

Research Interests:


View Dr. Luc Maroteaux’s Resume / CV

Education

Apr 1984
Strabourg University
PhD
Sep 1976
Ecole Normale Superieure: Paris-St Cloud, FR
Master

Publications

63Publications

1003Reads

142Profile Views

847PubMed Central Citations

Serotonin (5-HT) Shapes the Macrophage Gene Profile through the 5-HT-Dependent Activation of the Aryl Hydrocarbon Receptor.

J Immunol 2020 May 6;204(10):2808-2817. Epub 2020 Apr 6.

Laboratorio de Células Mieloides, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain;

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http://dx.doi.org/10.4049/jimmunol.1901531DOI Listing
May 2020
4.922 Impact Factor

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Nat Neurosci 2019 07 17;22(7):1053-1056. Epub 2019 Jun 17.

The Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41593-019-0421-4DOI Listing
July 2019
6 Reads
16.095 Impact Factor

Dimers of serotonin receptors: Impact on ligand affinity and signaling.

Biochimie 2019 Jun 24;161:23-33. Epub 2019 Jan 24.

INSERM UMR-S839, S1270, Paris, 75005, France; Sorbonne Université, Paris, 75005, France; Institut du Fer à Moulin, Paris, 75005, France.

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http://dx.doi.org/10.1016/j.biochi.2019.01.009DOI Listing
June 2019
2 Reads
2.963 Impact Factor

Frontiers of Serotonin Beyond the Brain.

Pharmacol Res 2019 02 22;140:1-6. Epub 2018 Oct 22.

Departments of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.10.022DOI Listing
February 2019
2 Reads
4.410 Impact Factor

Evolutionary considerations on 5-HT receptors.

Pharmacol Res 2019 02 14;140:14-20. Epub 2018 Sep 14.

INSERM UMR-S839, Paris, 75005, France; Sorbonne Université, Paris, 75005, France; Institut du Fer à Moulin, Paris, 75005, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183132
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http://dx.doi.org/10.1016/j.phrs.2018.09.014DOI Listing
February 2019
5 Reads
4.410 Impact Factor

A positive association between a polymorphism in the gene and cocaine-crack in a French Afro-Caribbean population.

World J Biol Psychiatry 2019 Jan 28:1-6. Epub 2019 Jan 28.

Department of Psychiatry and Addictive Disorders, University Sorbonne Paris-Cité (Faculty of Medicine Paris Descartes), INSERM UMR 894-Team1 Center of Psychiatry and Neuroscience, University Hospital Cochin (site Tarnier), Paris, France.

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http://dx.doi.org/10.1080/15622975.2018.1563721DOI Listing
January 2019
10 Reads
4.183 Impact Factor

Regulation of raphe serotonin neurons by serotonin 1A and 2B receptors.

Neuropsychopharmacology 2019 01;44(1):218-219

INSERM U 839, Paris, 75005, France.

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http://dx.doi.org/10.1038/s41386-018-0214-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235922PMC
January 2019
4 Reads
7.050 Impact Factor

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices.

J Vis Exp 2019 01 31(143). Epub 2019 Jan 31.

Institut National de la Santé et de la Recherche Médicale (INSERM), UMR-S 1270 Paris, France; Sorbonne Université, Paris, France; Institut du Fer à Moulin, Paris, France;

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http://dx.doi.org/10.3791/58788DOI Listing
January 2019
2 Reads

Somato-Dendritic Regulation of Raphe Serotonin Neurons; A Key to Antidepressant Action.

Front Neurosci 2018 20;12:982. Epub 2018 Dec 20.

INSERM UMR-S 839, Institut du Fer à Moulin, Paris, France.

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http://dx.doi.org/10.3389/fnins.2018.00982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307465PMC
December 2018
5 Reads

Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression.

Transl Psychiatry 2018 08 16;8(1):159. Epub 2018 Aug 16.

Université Côte d'Azur, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275 CNRS, 660 Route des lucioles, Sophia Antipolis, 06560, Valbonne, France.

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http://dx.doi.org/10.1038/s41398-018-0210-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095913PMC
August 2018
45 Reads
4.360 Impact Factor

Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.

J Cell Physiol 2017 Dec 12;232(12):3520-3529. Epub 2017 Apr 12.

Departments of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, Arkansas.

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http://dx.doi.org/10.1002/jcp.25812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522371PMC
December 2017
22 Reads
1 Citation
3.840 Impact Factor

The role of 5-HT receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors.

Br J Pharmacol 2017 Nov 15;174(22):4123-4139. Epub 2017 Oct 15.

Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire (EA7296), Faculté de Médecine, Fédération de Médecine Translationnelle, Université et Centre Hospitalier de Strasbourg, Strasbourg, France.

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http://doi.wiley.com/10.1111/bph.13981
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http://dx.doi.org/10.1111/bph.13981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680644PMC
November 2017
82 Reads
1 Citation
4.842 Impact Factor

Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT protomers.

J Biol Chem 2017 04 3;292(15):6352-6368. Epub 2017 Mar 3.

the Institut Cochin, INSERM U1016, CNRS UMR8104, Paris 75014,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M117.779041
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http://dx.doi.org/10.1074/jbc.M117.779041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391763PMC
April 2017
8 Reads
4 Citations
4.573 Impact Factor

New therapeutic opportunities for 5-HT receptor ligands.

Pharmacol Ther 2017 02 19;170:14-36. Epub 2016 Oct 19.

Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire EA7296, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg, Université et Centre Hospitalier de Strasbourg, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.10.008DOI Listing
February 2017
8 Reads
3 Citations
9.723 Impact Factor

[Pulmonary arterial hypertension, bone marrow, endothelial cell precursors and serotonin].

Biol Aujourdhui 2016 30;210(2):79-88. Epub 2016 Sep 30.

INSERM UMR-S 839, Université Pierre et Marie Curie, 75005 Paris, France - Institut du Fer à Moulin, 17 rue du Fer à Moulin, 75005 Paris, France.

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http://dx.doi.org/10.1051/jbio/2016012DOI Listing
January 2017
14 Reads
1 Citation

Cardiovascular remodeling and the peripheral serotonergic system.

Arch Cardiovasc Dis 2017 Jan 21;110(1):51-59. Epub 2016 Dec 21.

Laboratoire de neurobiologie et pharmacologie cardiovasculaire (EA7296), faculté de médecine, fédération de médecine translationnelle, laboratoire de neurobiologie et pharmacologie cardiovasculaire (EA7296), université et centre hospitalier de Strasbourg, 67085 Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.acvd.2016.08.002DOI Listing
January 2017
8 Reads
2 Citations

Discrepancy in Insulin Regulation between Gestational Diabetes Mellitus (GDM) Platelets and Placenta.

J Biol Chem 2016 Apr 26;291(18):9657-65. Epub 2016 Feb 26.

From the Departments of Biochemistry and Molecular Biology, and

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http://dx.doi.org/10.1074/jbc.M116.713693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850303PMC
April 2016
20 Reads
3 Citations
4.573 Impact Factor

Mice lacking the serotonin 5-HT2B receptor as an animal model of resistance to selective serotonin reuptake inhibitors antidepressants.

Eur Neuropsychopharmacol 2016 Feb 11;26(2):265-279. Epub 2015 Dec 11.

INSERM UMR-S 839, F75005 Paris, France; Université Pierre et Marie Curie, F75005 Paris, France; Institut du Fer à Moulin, F75005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2015.12.012DOI Listing
February 2016
17 Reads
3 Citations
4.370 Impact Factor

Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats.

J Hypertens 2015 Nov;33(11):2310-21

aLaboratoire de Neurobiologie et Pharmacologie Cardiovasculaire EA7296, Faculté de Médecine, Fédération de Médecine Translationnelle, Université et Centre Hospitalier de Strasbourg, Strasbourg bMouse Clinical Institute, Illkirch-Graffenstaden cCNRS, UMR7213, University of Strasbourg, Illkirch-Graffenstaden dINSERM U1063, Stress oxydant et pathologies métaboliques, LUNAM Université, Angers eINSERM UMR S-839, Institut du Fer à Moulin, Université Pierre et Marie Curie, 17 rue du Fer à Moulin, Paris, France *Estelle Ayme-Dietrich and Halim Marzak contributed equally to this work.

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http://dx.doi.org/10.1097/HJH.0000000000000695DOI Listing
November 2015
31 Reads
2 Citations
4.720 Impact Factor

GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake.

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5697-705. Epub 2014 Dec 15.

Departments of Biochemistry and Molecular Biology and

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http://dx.doi.org/10.1073/pnas.1416675112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284607PMC
December 2014
21 Reads
9 Citations
9.810 Impact Factor

Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ß/δ in osteoblasts.

PLoS One 2013 17;8(9):e75783. Epub 2013 Sep 17.

INSERM UMR606, Hôpital Lariboisière, Paris, France ; Université Paris Diderot Sorbonne Paris Cité, Paris France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075783PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775737PMC
June 2014
25 Reads
3.234 Impact Factor

Role of the N-terminal region in G protein-coupled receptor functions: negative modulation revealed by 5-HT2B receptor polymorphisms.

Mol Pharmacol 2014 Jan 30;85(1):127-38. Epub 2013 Oct 30.

Institut du Fer à Moulin, Université Pierre et Marie Curie, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche S-839, Paris, France (A.B., S.D., V.S., S.M.B., I.M., K.B., L.M.); and Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina (T.K.).

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http://dx.doi.org/10.1124/mol.113.089086DOI Listing
January 2014
8 Reads
9 Citations
4.130 Impact Factor

A serotonin-induced N-glycan switch regulates platelet aggregation.

Sci Rep 2013 Sep 30;3:2795. Epub 2013 Sep 30.

Departments of Biochemistry and Molecular Biology, and Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

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http://www.nature.com/articles/srep02795
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http://dx.doi.org/10.1038/srep02795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786303PMC
September 2013
50 Reads
16 Citations
5.080 Impact Factor

5-HT(2B) receptors are required for serotonin-selective antidepressant actions.

Mol Psychiatry 2012 Feb 13;17(2):154-63. Epub 2011 Dec 13.

UMR-S839 INSERM, Paris, France.

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http://dx.doi.org/10.1038/mp.2011.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381222PMC
February 2012
10 Reads
35 Citations
14.500 Impact Factor

Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.

Nat Med 2011 Nov 27;17(12):1668-73. Epub 2011 Nov 27.

Fibrosis Laboratory, Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1038/nm.2490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428919PMC
November 2011
12 Reads
43 Citations
27.363 Impact Factor

Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin.

Pharmacol Ther 2010 Dec 7;128(3):559-67. Epub 2010 Sep 7.

Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Physiopathologie et Médecine Translationnelle EA 4438, Faculté de Médecine, 11 rue Humann, 67085 Strasbourg, France.

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http://dx.doi.org/10.1016/j.pharmthera.2010.08.004DOI Listing
December 2010
22 Reads
7 Citations
9.723 Impact Factor

Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.

Nat Med 2011 Nov 27;17(12):1668-73. Epub 2011 Nov 27.

Fibrosis Laboratory, Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1038/nm.2490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428919PMC
November 2011
12 Reads
43 Citations
27.363 Impact Factor

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.

Circ Res 2009 Jan 20;104(1):113-23. Epub 2008 Nov 20.

Institut National de Santé et de Recherche Médicale, U839, Paris, France.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.180976DOI Listing
January 2009
15 Reads
28 Citations
11.020 Impact Factor

Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice.

Hypertension 2008 Aug 30;52(2):301-7. Epub 2008 Jun 30.

INSERM U-715, Faculté de Médecine, 11 rue Humann, Strasbourg, France.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.105551DOI Listing
August 2008
45 Reads
9 Citations
6.480 Impact Factor

Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro.

J Neurosci 2008 Mar;28(11):2933-40

Inserm, U839 and Université Pierre et Marie Curie-Paris 6, Institut du Fer à Moulin, Unité Mixte de Recherche-S0839, Paris 75005, France.

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http://dx.doi.org/10.1523/JNEUROSCI.5723-07.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670669PMC
March 2008
10 Reads
25 Citations
6.344 Impact Factor

Functions of serotonin in hypoxic pulmonary vascular remodeling.

Cell Biochem Biophys 2007 ;47(1):33-44

IGBMC, F-67400 France.

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http://dx.doi.org/10.1385/cbb:47:1:33DOI Listing
January 2008
8 Reads
15 Citations
1.680 Impact Factor

Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors.

Mol Pharmacol 2007 Jun 26;71(6):1463-74. Epub 2007 Feb 26.

Centre National de la Recherche Scientifique UMR7104, Illkirch, France.

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http://dx.doi.org/10.1124/mol.106.032656DOI Listing
June 2007
17 Reads
10 Citations
4.130 Impact Factor

Endogenous 5-HT2B receptor activation regulates neonatal respiratory activity in vitro.

J Neurobiol 2006 Aug;66(9):949-61

Center of Anatomy, University of Göttingen, 37075 Göttingen, Germany.

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http://doi.wiley.com/10.1002/neu.20253
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http://dx.doi.org/10.1002/neu.20253DOI Listing
August 2006
5 Reads
14 Citations

The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions.

Mol Pharmacol 2005 Apr 29;67(4):983-91. Epub 2004 Dec 29.

INSERM U616 Hospital Pitié-Salpetrière, Batiment Pédiatrie, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France.

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http://dx.doi.org/10.1124/mol.104.008268DOI Listing
April 2005
50 Reads
4 Citations
4.130 Impact Factor

Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts.

Circulation 2004 Aug 9;110(8):969-74. Epub 2004 Aug 9.

Laboratoire de Neurobiologie et de Pharmacologie Cardiovasculaire, INSERM E333, Faculté de médecine, Strasbourg, France.

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http://dx.doi.org/10.1161/01.CIR.0000139856.20505.57DOI Listing
August 2004
10 Reads
21 Citations
14.430 Impact Factor

[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].

J Soc Biol 2004 ;198(1):22-9

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, Université L. Pasteur de Strasbourg, BP 10142, 67404 Illkirch, France.

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July 2004
5 Reads
1 Citation

The developmental role of serotonin: news from mouse molecular genetics.

Nat Rev Neurosci 2003 Dec;4(12):1002-12

INSERM U 106, Hôpital Salpêtrière, 47, Boulevard de l'Hôpital, 75651, Paris cedex 13, France.

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http://search.proquest.com/openview/7ff973794379f399c1ae12a0
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http://dx.doi.org/10.1038/nrn1256DOI Listing
December 2003
5 Reads
248 Citations
31.430 Impact Factor

Functional consequence of serotonin/5-HT2B receptor signaling in heart: role of mitochondria in transition between hypertrophy and heart failure?

Circulation 2003 Aug;108(7):902-8

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Strasbourg, 1 Rue Laurent Freies, BP 10142-67404 Illkirch Cedex, France.

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http://dx.doi.org/10.1161/01.CIR.0000081520.25714.D9DOI Listing
August 2003
7 Reads
16 Citations
14.430 Impact Factor

Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling.

FASEB J 2003 Jul 8;17(10):1373-5. Epub 2003 May 8.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université L. Pasteur de Strasbourg, BP 10142, 67404 Illkirch Cedex, France.

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http://www.fasebj.org/doi/10.1096/fj.02-1122fje
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http://dx.doi.org/10.1096/fj.02-1122fjeDOI Listing
July 2003
18 Reads
21 Citations
5.043 Impact Factor

The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis.

J Biol Chem 2002 May 21;277(19):17170-8. Epub 2002 Feb 21.

Centre de Recherche Claude Bernard Pathologie Expérimentale et Communications Cellulaires, IFR 6, Service de Biochimie, Hôpital Lariboisière Assistance Publique-Hopitaux de Paris (AP-HP), 75475 Paris Cedex 10, France.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M200195200
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http://dx.doi.org/10.1074/jbc.M200195200DOI Listing
May 2002
21 Reads
17 Citations
4.573 Impact Factor

Developmentally regulated serotonin 5-HT2B receptors.

Int J Dev Neurosci 2001 Jul;19(4):365-72

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université L. Pasteur de Strasbourg, BP 163-67404 Cedex, Illkirch, France.

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http://dx.doi.org/10.1016/s0736-5748(01)00022-3DOI Listing
July 2001
8 Reads
6 Citations
2.580 Impact Factor

Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function.

Circulation 2001 Jun;103(24):2973-9

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université de Strasbourg, Illkirch.

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http://dx.doi.org/10.1161/01.cir.103.24.2973DOI Listing
June 2001
5 Reads
20 Citations
14.430 Impact Factor

Serotonin 2B receptor is required for heart development.

Proc Natl Acad Sci U S A 2000 Aug;97(17):9508-13

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université L. Pasteur de Strasbourg, Illkirch, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC16895PMC
http://dx.doi.org/10.1073/pnas.97.17.9508DOI Listing
August 2000
6 Reads
53 Citations
9.810 Impact Factor

5-hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways.

Proc Natl Acad Sci U S A 2000 Mar;97(6):2591-6

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur de Strasbourg, B.P. 163, 67404 Illkirch Cedex, France.

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http://dx.doi.org/10.1073/pnas.050282397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC15973PMC
March 2000
6 Reads
25 Citations
9.810 Impact Factor

PDZ-dependent activation of nitric-oxide synthases by the serotonin 2B receptor.

J Biol Chem 2000 Mar;275(13):9324-31

Centre de Recherche Claude Bernard "Pathologie Expérimentale et Communication Cellulaires," IFR 6, Service de Biochimie, Hôpital Lariboisière AP-HP, 75010 Paris, France.

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http://dx.doi.org/10.1074/jbc.275.13.9324DOI Listing
March 2000
3 Reads
14 Citations
4.573 Impact Factor

Serotonin and the 5-HT(2B) receptor in the development of enteric neurons.

J Neurosci 2000 Jan;20(1):294-305

Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774223PMC
January 2000
4 Reads
24 Citations
6.344 Impact Factor

Maternal and zygotic control of serotonin biosynthesis are both necessary for Drosophila germband extension.

Mech Dev 1999 Sep;87(1-2):67-76

CR C. Bernard 'Pathologie expérimentale et communications cellulaires', IFR Hôpital Lariboisière, Service de Biochimie, 2 rue Ambroise Paré, 75475, Paris, France.

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http://dx.doi.org/10.1016/s0925-4773(99)00140-9DOI Listing
September 1999
8 Reads
9 Citations
2.440 Impact Factor

5-HT2B receptors are expressed by neuronal precursors in the enteric nervous system of fetal mice and promote neuronal differentiation.

Ann N Y Acad Sci 1998 Dec;861:246

Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1111/j.1749-6632.1998.tb10203.xDOI Listing
December 1998
7 Reads
1 Citation
4.313 Impact Factor

5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells.

Development 1997 May;124(9):1745-55

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université L. Pasteur de Strasbourg, CNRS, INSERM, Illkirch, France.

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May 1997
1 Read
6.462 Impact Factor

Functional serotonin-2B receptors are expressed by a teratocarcinoma-derived cell line during serotoninergic differentiation.

Mol Pharmacol 1995 Mar;47(3):458-66

Laboratoire de Différenciation Cellulaire, Institut Pasteur, Paris, France.

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March 1995
4.128 Impact Factor

Serotonin receptors and therapeutics.

Cell Mol Biol (Noisy-le-grand) 1994 May;40(3):327-36

FRA C. Bernard Neurochimie des Communications Cellulaires, Hôpital St. Louis, Paris, France.

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May 1994
1.234 Impact Factor

The mouse 5-HT2B receptor: possible involvement in trophic functions of serotonin.

Cell Mol Biol (Noisy-le-grand) 1994 May;40(3):403-11

Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U184 de Génétique, et de Biologie Moléculaire de l'INSERM, Faculté de Médecine de Strasbourg, France.

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May 1994
1.234 Impact Factor

Priming affects the transcription rate of human interferon-beta 1 gene.

J Biol Chem 1985 Nov;260(26):14242-7

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November 1985
4.573 Impact Factor

Top co-authors

Jean-Marie Launay
Jean-Marie Launay

Université Paris Descartes

12
Laurent Monassier
Laurent Monassier

Université de Strasbourg

11
Stephane Doly
Stephane Doly

Université Pierre et Marie Curie

9
Arnauld Belmer
Arnauld Belmer

University of North Carolina

6
Fabrice Jaffre
Fabrice Jaffre

Beth Israel Deaconess Medical Center

6
Fusun Kilic
Fusun Kilic

College of Medicine

6
Imane Moutkine
Imane Moutkine

Université Pierre et Marie Curie

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Emily Quentin
Emily Quentin

Sorbonne Université?

5