Luc J Smink

Luc J Smink

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Luc J Smink

Luc J Smink

Publications by authors named "Luc J Smink"

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Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene.

J Immunol 2010 May 2;184(9):5075-84. Epub 2010 Apr 2.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge.

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http://dx.doi.org/10.4049/jimmunol.0903734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886967PMC
May 2010

Genome bioinformatic analysis of nonsynonymous SNPs.

BMC Bioinformatics 2007 Aug 20;8:301. Epub 2007 Aug 20.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.

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http://dx.doi.org/10.1186/1471-2105-8-301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978506PMC
August 2007

New tools for defining the 'genetic background' of inbred mouse strains.

Nat Immunol 2007 Jul;8(7):669-73

Division of Rheumatology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15218, USA.

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http://dx.doi.org/10.1038/ni0707-669DOI Listing
July 2007

Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.

J Leukoc Biol 2007 Mar 5;81(3):581-3. Epub 2007 Jan 5.

Juvenile Diabetes Research Foundation/Wellcome Trust, Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1189/jlb.0906577DOI Listing
March 2007

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Nat Genet 2007 Mar 4;39(3):329-37. Epub 2007 Feb 4.

Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology and Infectious Diseases, Institute of Inflammation, Infection and Immunity, Faculty of Medicine, The University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1038/ng1958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886969PMC
March 2007

Type 1 diabetes genes and pathways shared by humans and NOD mice.

J Autoimmun 2005 28;25 Suppl:29-33. Epub 2005 Oct 28.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1016/j.jaut.2005.09.009DOI Listing
June 2006

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.

Nat Genet 2006 Jun 14;38(6):617-9. Epub 2006 May 14.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1038/ng1800DOI Listing
June 2006

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.

BMC Genet 2006 Apr 20;7:22. Epub 2006 Apr 20.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1471-2156-7-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479364PMC
April 2006

Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse.

Novartis Found Symp 2005 ;267:57-65; discussion 65-75

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes & Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2XY, UK.

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November 2005

Population structure, differential bias and genomic control in a large-scale, case-control association study.

Nat Genet 2005 Nov 9;37(11):1243-6. Epub 2005 Oct 9.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, CB2 2XY, UK.

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http://www.nature.com/articles/ng1653
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http://dx.doi.org/10.1038/ng1653DOI Listing
November 2005

Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes.

J Autoimmun 2005 Aug;25(1):13-20

Department of Immunology, 1 King's College Circle, University of Toronto, Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.jaut.2005.04.007DOI Listing
August 2005

No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.

Biochem Biophys Res Commun 2005 Jun;331(2):435-41

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.203DOI Listing
June 2005

T1DBase, a community web-based resource for type 1 diabetes research.

Nucleic Acids Res 2005 Jan;33(Database issue):D544-9

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1093/nar/gki095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC540049PMC
January 2005

Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes.

Diabetes 2004 Sep;53(9):2479-82

JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2XY, UK.

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http://diabetes.diabetesjournals.org/content/53/9/2479.full.
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http://dx.doi.org/10.2337/diabetes.53.9.2479DOI Listing
September 2004

Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.

J Immunol 2004 Jul;173(1):164-73

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.4049/jimmunol.173.1.164DOI Listing
July 2004

Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping.

BMC Biotechnol 2004 Jul 27;4:15. Epub 2004 Jul 27.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes, Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1472-6750-4-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514612PMC
July 2004

Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.

Diabetes 2004 Feb;53(2):505-9

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, U.K.

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http://dx.doi.org/10.2337/diabetes.53.2.505DOI Listing
February 2004

Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.

Diabetes 2003 Jun;52(6):1551-6

Juvenile Diabetes Research Foundation/Wellcome Trust (JDRF/WT) Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2XY, U.K.

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http://dx.doi.org/10.2337/diabetes.52.6.1551DOI Listing
June 2003

Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

Genome Res 2003 Jan;13(1):27-36

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1101/gr.695703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC430954PMC
January 2003