Publications by authors named "Lu-Yang Wang"

47Publications

Synaptic competition: 'to be or not to be' the calyx of Held?

J Physiol 2020 Oct 18;598(20):4425-4426. Epub 2020 Aug 18.

Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, M5G 1X8, Canada.

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October 2020

Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors.

J Neuroinflammation 2020 Feb 7;17(1):51. Epub 2020 Feb 7.

Toronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.

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February 2020

Delayed expression of activity-dependent gating switch in synaptic AMPARs at a central synapse.

Mol Brain 2020 01 15;13(1). Epub 2020 Jan 15.

Program in Neurosciences & Mental Health, SickKids Research Institute, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada.

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January 2020

The ED and ED of oxytocin infusion rate for maintaining uterine tone during elective caesarean delivery: a dose-finding study.

BMC Pregnancy Childbirth 2019 Dec 31;20(1). Epub 2019 Dec 31.

Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.

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December 2019

Ca-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity.

Cell Death Dis 2019 10 10;10(10):774. Epub 2019 Oct 10.

Department of Otorhinolaryngology, The Sixth People's Hospital of Shanghai and Shanghai Jiao Tong University, 600 Yishan Road, 200233, Shanghai, P. R. China.

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October 2019

Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules.

Nat Commun 2019 02 18;10(1):826. Epub 2019 Feb 18.

Program in Neurosciences and Mental Health, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada.

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February 2019

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.

Proc Natl Acad Sci U S A 2019 03 14;116(10):4218-4227. Epub 2019 Feb 14.

Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;

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March 2019

Interneuron NMDA receptors change the gear of motor learning in the cerebellar machine.

J Physiol 2019 02 30;597(3):663-664. Epub 2018 Dec 30.

Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, M5G 1X8, Canada.

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February 2019

Rectification ratio based determination of disulfide bonds of β2 extracellular loop of BK channel.

Channels (Austin) 2019 12;13(1):17-32

a Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology , Huazhong University of Science and Technology , Wuhan , China.

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December 2019

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.

Neuron 2018 11 18;100(4):799-815.e7. Epub 2018 Oct 18.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address:

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November 2018

Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain.

Mol Psychiatry 2020 09 17;25(9):2017-2035. Epub 2018 Sep 17.

Program in Neurosciences & Mental Health, SickKids Research Institute, Toronto, ON, M5G 1X8, Canada.

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September 2020

Accelerated Development of the First-Order Central Auditory Neurons With Spontaneous Activity.

Front Mol Neurosci 2018 31;11:183. Epub 2018 May 31.

Department of Otorhinolaryngology, The Sixth People's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai, China.

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May 2018

Bilirubin augments Ca load of developing bushy neurons by targeting specific subtype of voltage-gated calcium channels.

Sci Rep 2017 03 27;7(1):431. Epub 2017 Mar 27.

Department of Otorhinolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, P. R. China.

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March 2017

NAD+ Attenuates Bilirubin-Induced Hyperexcitation in the Ventral Cochlear Nucleus by Inhibiting Excitatory Neurotransmission and Neuronal Excitability.

Front Cell Neurosci 2017 3;11:21. Epub 2017 Feb 3.

Department of Otorhinolaryngology, The Sixth People's Hospital, Shanghai Jiao Tong University Shanghai, China.

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February 2017

Ageing brains attend a symphony with asynchronous transmitter release.

J Physiol 2017 02;595(3):613-614

Program in Neurosciences and Mental Health, SickKids Research Institute and Department of Physiology, University of Toronto, Toronto, Ontario, M5G 1X8, Canada.

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February 2017

The glycosylation of the extracellular loop of β2 subunits diversifies functional phenotypes of BK Channels.

Channels (Austin) 2017 Mar 3;11(2):156-166. Epub 2016 Oct 3.

a Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology , Huazhong University of Science and Technology , Wuhan , Hubei , China.

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March 2017

Extrapolating microdomain Ca(2+) dynamics using BK channels as a Ca(2+) sensor.

Sci Rep 2016 Jan 18;6:17343. Epub 2016 Jan 18.

Key Laboratory of Molecular Biophysics, Huazhong University of Science and Technology, Ministry of Education, College of Life Science and Technology, Wuhan, Hubei, China.

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January 2016

The role of gamma-aminobutyric acid/glycinergic synaptic transmission in mediating bilirubin-induced hyperexcitation in developing auditory neurons.

Toxicol Lett 2016 Jan 21;240(1):1-9. Epub 2015 Oct 21.

Department of Otorhinolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai 200233, PR China. Electronic address:

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January 2016

Presynaptic nanodomains: a tale of two synapses.

Front Cell Neurosci 2014 26;8:455. Epub 2015 Jan 26.

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore ; Institute of Molecular and Cell Biology Singapore, Singapore ; Center for Functional Connectomics, Korea Institute of Science and Technology Seoul, South Korea ; Marine Biological Laboratory Woods Hole, MA, USA.

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February 2015

Enhancing the fidelity of neurotransmission by activity-dependent facilitation of presynaptic potassium currents.

Nat Commun 2014 Jul 31;5:4564. Epub 2014 Jul 31.

1] Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada M5G 1X8 [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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July 2014

Gene delivery in mouse auditory brainstem and hindbrain using in utero electroporation.

Mol Brain 2014 Jul 26;7:51. Epub 2014 Jul 26.

The Hospital for Sick Children Research Institute & Department of Physiology, Program in Neurosciences and Mental Health, University of Toronto, 555 University Ave, Toronto M5G 1X8, ON, Canada.

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July 2014

Structural basis for calcium and magnesium regulation of a large conductance calcium-activated potassium channel with β1 subunits.

J Biol Chem 2014 Jun 24;289(24):16914-23. Epub 2014 Apr 24.

From the Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China and

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June 2014

Remodelling at the calyx of Held-MNTB synapse in mice developing with unilateral conductive hearing loss.

J Physiol 2014 Apr 27;592(7):1581-600. Epub 2014 Jan 27.

Corresponding Author L.-Y. Wang, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8.

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April 2014

Morphological and functional continuum underlying heterogeneity in the spiking fidelity at the calyx of Held synapse in vitro.

J Neurosci 2011 Sep;31(38):13386-99

Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8.

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September 2011

GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse.

J Physiol 2011 Sep 20;589(17):4209-27. Epub 2011 Jun 20.

Program in Neurosciences & Mental Health, The Hospital For Sick Children and Department of Physiology, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada.

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September 2011

Early dating influences long-term synaptic partnerships.

J Physiol 2010 Nov;588(Pt 22):4339-40

Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada.

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November 2010

A new Kv1.2 channelopathy underlying cerebellar ataxia.

J Biol Chem 2010 Oct 9;285(42):32160-73. Epub 2010 Aug 9.

Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Canada.

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October 2010

[Test-retest reliability of Mandarin monosyllable lists: a multi-center study in Chinese dialectal regions].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010 Mar;45(3):200-5

Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.

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March 2010

Action potential evoked transmitter release in central synapses: insights from the developing calyx of Held.

Mol Brain 2009 Nov 25;2:36. Epub 2009 Nov 25.

Program for Neurosciences and Mental Health, The Hospital for Sick Children and Department of Physiology, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

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November 2009

Synaptic vesicles in mature calyx of Held synapses sense higher nanodomain calcium concentrations during action potential-evoked glutamate release.

J Neurosci 2008 Dec;28(53):14450-8

The Program for Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.

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December 2008

Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission.

Mol Cell Biol 2008 Dec 22;28(23):7012-29. Epub 2008 Sep 22.

Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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December 2008

Coincident activation of metabotropic glutamate receptors and NMDA receptors (NMDARs) downregulates perisynaptic/extrasynaptic NMDARs and enhances high-fidelity neurotransmission at the developing calyx of Held synapse.

J Neurosci 2007 Sep;27(37):9989-99

The Program for Neurosciences and Mental Health and Division of Neurology, The Hospital for Sick Children, and Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5G 1X8.

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September 2007

Activity-dependent changes in temporal components of neurotransmission at the juvenile mouse calyx of Held synapse.

J Physiol 2007 Jun 8;581(Pt 2):581-602. Epub 2007 Mar 8.

Division of Neurology, The Hospital for Sick Children, Department of Physiology, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada.

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June 2007

Amplitude and kinetics of action potential-evoked Ca2+ current and its efficacy in triggering transmitter release at the developing calyx of Held synapse.

J Neurosci 2006 May;26(21):5698-708

Division of Neurology, The Hospital for Sick Children, Department of Physiology, University of Toronto, Toronto, Ontario, M5G 1X8, Canada.

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May 2006

Developmental transformation of the release modality at the calyx of Held synapse.

J Neurosci 2005 Apr;25(16):4131-40

The Program for Brain and Behavioural Research and Division of Neurology, The Hospital for Sick Children, and Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5G 1X8.

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April 2005

The role of AMPA receptor gating in the development of high-fidelity neurotransmission at the calyx of Held synapse.

J Neurosci 2004 Jan;24(1):183-96

The Program for Brain and Behavioral Research and Division of Neurology, The Hospital for Sick Children and Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5G, 1X8.

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January 2004

Properties of voltage-gated sodium channels in developing auditory neurons of the mouse in vitro.

Chin Med Sci J 2003 Jun;18(2):67-74

Department of Cardiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029.

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June 2003

Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem.

J Physiol 2002 May;540(Pt 3):861-73

The Program for Brain and Behavioral Research & Division of Neurology, The Hospital for Sick Children and Department of Physiology, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.

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May 2002