Publications by authors named "Lu Zhang"

2,937 Publications

  • Page 1 of 1

Racial Disparity and Social Determinants in Receiving Timely Surgery Among Stage I-IIIA Non-small Cell Lung Cancer Patients in a U.S. Southern State.

Front Public Health 2021 2;9:662876. Epub 2021 Jun 2.

Department of Public Health Sciences, Clemson University, Clemson, SC, United States.

Delayed surgery is associated with worse lung cancer outcomes. Social determinants can influence health disparities. This study aimed to examine the potential racial disparity and the effects from social determinants on receipt of timely surgery among lung cancer patients in Louisiana, a southern state in the U.S. White and black stage I-IIIA non-small cell lung cancer patients diagnosed in Louisiana between 2004 and 2016, receiving surgical lobectomy or a more extensive surgery, were selected. Diagnosis-to-surgery interval >6 weeks were considered as delayed surgery. Social determinants included marital status, insurance, census tract level poverty, and census tract level urbanicity. Multivariable logistic regression and generalized multiple mediation analysis were conducted. A total of 3,616 white (78.9%) and black (21.1%) patients were identified. The median time interval from diagnosis to surgery was 27 days in whites and 42 days in blacks ( < 0.0001). About 28.7% of white and 48.4% of black patients received delayed surgery ( < 0.0001). Black patients had almost two-fold odds of receiving delayed surgery than white patients (adjusted odds ratio: 1.91; 95% confidence interval: 1.59-2.30). Social determinants explained about 26% of the racial disparity in receiving delayed surgery. Having social support, private insurance, and living in census tracts with lower poverty level were associated with improved access to timely surgery. The census tract level poverty level a stronger effect on delayed surgery in black patients than in white patients. Tailored interventions to improve the timely treatment in NSCLC patients, especially black patients, are needed in the future.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpubh.2021.662876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206495PMC
June 2021

STK10 knockout inhibits cell migration and promotes cell proliferation via modulating the activity of ERM and p38 MAPK in prostate cancer cells.

Exp Ther Med 2021 Aug 8;22(2):851. Epub 2021 Jun 8.

Research Center for Experimental Medicine, State Key Laboratory of Medical Genomics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.

Prostate cancer (PCa) is one of the most common types of cancer and is a serious threat to men's health due to the high rate of incidence and metastasis. However, the exact underlying pathology of this malignant disease has yet to be fully elucidated. The ezrin-radixin-moesin (ERM) family of proteins are associated with the development and metastasis of various types of cancer. Serine threonine kinase 10 (STK10) is an ERM kinase that is involved in the activation of ERM proteins and serves essential roles in the aggregation and adhesion of lymphocytes. To evaluate the functional roles of STK10 in the pathogenesis of PCa, a -knockout (KO) DU145 PCa cell line was generated using the CRISPR-Cas9 gene editing system, and the effects of STK10 deletion on tumor biological behaviors were further analyzed. The present data suggested that STK10 KO promoted PCa cell proliferation by inhibiting p38 MAPK activation and suppressed migration primarily via the inhibition of p38 MAPK signaling and ERM protein activation. To the best of our knowledge, this is the first study to provide evidence that STK10 plays important roles in the proliferation and migration of PCa cells, which will be useful for further investigation into the pathogenesis of this disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2021.10283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210223PMC
August 2021

A merged method for targeted analysis of amino acids and derivatives using parallel reaction monitoring combined with untargeted profiling by HILIC-Q-Orbitrap HRMS.

J Pharm Biomed Anal 2021 Jun 15;203:114208. Epub 2021 Jun 15.

Frontiers Science Center for Disease-related Molecular Network, Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

With continuously increased scan rate and sensitivity, high resolution mass spectrometry (HRMS) allows for both reliable targeted analysis (e.g., parallel reaction monitoring, PRM) and a global overview for discovery-based untargeted profiling (e.g., data dependent acquisition, DDA) to be performed. Based on previous study on PRM for large scale targeted metabolomics quantification, we developed an innovative method merged targeted and untargeted approaches in a single run. In our workflow, the scheduled PRM for targeted analysis of amino acids and derivatives combined with the full scan was acquired in every sample injection by hydrophilic interaction liquid chromatography tandem quadrupole-Orbitrap high resolution mass spectrometry (HILIC-Q-Orbitrap HRMS). The identification of metabolic features from full scan was further performed with DDA methodology on grouped quality control (QC) samples and matched with available database. Specifically, 20 amino acids and 40 derivatives were selected for targeted analysis with optimal chromatographic separation and PRM parameters. All isomers within the selected metabolites were totally separated in the robust HILIC condition. 36 of selected metabolites were well-detected and showed a good linearity and reproducibility in NIST SRM 1950 plasma. Moreover, the absolute quantification performance of targeted PRM method was systematically validated using 10 amino acids with the corresponding stable isotope-labeled internal standards (SIL-IS). Finally, the newly developed method was successfully applied to analysis of the plasma samples from patients of pancreatic benign tumor and pancreatic cancer. The significant reduction of circulating amino acids in patients with pancreatic malignancy was confirmed by targeted PRM method and other amino acids modifications as well as polar metabolites were identified with untargeted profiling. Therefore, we have established a workflow that combines specifically and reliably targeted PRM method as well as broad-coverage untargeted profiling, which provides an innovative strategy for basic and clinical metabolomics study.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2021.114208DOI Listing
June 2021

Racial differences in the risk of second primary bladder cancer following radiation therapy among localized prostate cancer patients.

Cancer Epidemiol 2021 Jun 16;73:101967. Epub 2021 Jun 16.

Epidemiology Program, School of Public Health Sciences, Louisiana State University Health Sciences Center, United States; Louisiana Tumor Registry, School of Public Health Sciences, Louisiana State University Health Sciences Center, United States.

Objectives: To investigate the race-specific second primary bladder cancer (SPBC) risk following prostatic irradiation.

Methods: Louisiana residents who were diagnosed with localized prostate cancer (PCa) in 1996-2013 and received surgery or radiation were included. Patients were followed until SPBC diagnosis, death, or Dec. 2018. The exposure variable was type of treatment (radiation only vs. surgery only). The outcome was time from PCa diagnosis to SPBC diagnosis, stratified by race. Fine and Gray's competing risk model was applied with death as a competing event and adjustment of sociodemographic and tumor characteristics. We used 5 years and 10 years as lag time in the analyses.

Results: A total of 26,277 PCa patients with a median follow-up of 10.7 years were analyzed, including 18,598 white and 7679 black patients. About 42.9 % of whites and 45.7 % of blacks received radiation. SPBC counted for 1.84 % in the radiation group and 0.90 % in the surgery group among white patients and for 0.91 % and 0.58 %, respectively, among black patients. The adjusted subdistribution hazard ratio of SPBC was 1.80 (95 % CI: 1.30-2.48) for radiation recipients compared to surgery recipients among white patients; 1.93 (95 % CI: 1.36-2.74) if restricted to external beam radiation therapy (EBRT). The SPBC risk was not significantly different between irradiated and surgically treated among blacks.

Conclusions: The SPBC risk is almost two-fold among white irradiated PCa patients compared to their counterparts treated surgically. Our findings highlight the need for enhanced surveillance for white PCa survivors receiving radiotherapy, especially those received EBRT.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canep.2021.101967DOI Listing
June 2021

Muscle pathological features and extra-muscle involvement in idiopathic inflammatory myopathies with anti-mitochondrial antibody.

Semin Arthritis Rheum 2021 Jun 6;51(4):741-748. Epub 2021 Jun 6.

Department of Rheumatology, China-Japan Friendship Hospital, 100029 Beijing, China. Electronic address:

Objective: Anti-mitochondrial antibodies (AMAs) can be detected in some idiopathic inflammatory myopathy (IIM) patients. We aimed to investigate the clinical features of IIM patients with AMAs.

Methods: We retrospectively analysed 1,167 consecutive patients with IIM for AMA-associated myositis and compared them to age- and gender-matched AMA-negative IIM patients.

Results: Twenty-nine patients (2.5%) were identified with AMA-positive myositis; eight of them had primary biliary cholangitis (PBC). There were no significant differences in skin rash, dysphagia, interstitial lung disease, and muscle strength between AMA-positive patients and AMA-negative patients. Of 23 cases, 12 (52.2%) showed immune-mediated necrotizing myopathy (IMNM)-like pathological features. amongst AMA-positive patients, 11 of 16 patients with isolated anti-AMAs were classified as IMNM which was significantly higher than that of patients with coexistent anti-AMAs and myositis-specific antibodies (p = 0.026). Moreover, subclinical cardiac involvement was significantly more common in AMA-positive patients than in AMA-negative patients (21/29 VS 33/116, p<0.001). In addition, patients without PBC had a significantly higher incidence of abnormal echocardiography findings than that of patients with PBC (p = 0.009). Patients without heart abnormalities took significantly less time to achieve disease remission and prednisone tapering to <10 mg than patients with heart abnormalities (p = 0.000 and p = 0.001, respectively).

Conclusions: IMNM was a major histopathological finding in IIM patients with isolated AMAs. AMAs were significantly associated with subclinical cardiac involvement in IIM. PBC seemed to be a protective factor for abnormal echocardiography findings in AMA-positive patients. Patients without heart involvement took less time to achieve disease remission and prednisone tapering off.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semarthrit.2021.05.019DOI Listing
June 2021

Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.

Front Oncol 2021 17;11:643416. Epub 2021 May 17.

Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The incidence of papillary thyroid carcinoma (PTC) is increasing. Lymph node metastatic status of PTC is a major factor for decision marking of surgery and surgical extend, however, no reliable tool exists for prediction of PTC nodal metastasis, for example, ultrasound cannot qualitatively diagnose and effectively detect central lymph node metastasis (CLNM). Therefore, the development of a new diagnostic biomarker is crucial for CLNM. Metabolic dysregulation is an important factor associated with malignancy and metastasis of tumors. Pyruvate carboxylase (PC) is a major anaplerotic enzyme that catalyzes the carboxylation of pyruvate to form oxaloacetate, which has been suggested to be involved in the tumorigenesis of several cancers, including PTC. This study aimed to explore the role of expression in thyroid fine-needle aspiration (FNA) wash-out fluid for predicting CLNM in PTC, and to explore how PC is involved in PTC development. The expression levels of in PTC tissues and normal thyroid tissues were first compared based on bioinformatics analysis of public databases, including the Gene Expression Profiling (GEPIA), Oncomine and Gene Expression Omnibus (GEO) databases. Then, the mRNA and protein expression levels were measured by RT-PCR and Immunohistochemistry (IHC) in surgical tissues from a total of 42 patients with surgically confirmed PTC, and compared in patients with and without CLNM. Further, to assess expression in diagnostic biopsies, a total of 71 thyroid nodule patients with ultrasound-guided FNA wash-out fluid samples and cytological diagnosis were prospectively enrolled in the study. Then, we analyzed the mechanism of PC-mediated PTC progression . This study showed that PC expression was higher in PTC tissues and thyroid FNA wash-out fluid samples from patients with CLNM than those from patients without CLNM, and that PC-induced PTC metastasis may occur through the TGF-β/Smad-regulated epithelial-mesenchymal transition (EMT) pathway.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2021.643416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202284PMC
May 2021

A step-economic and one-pot access to chiral C-tetrasubstituted α-amino acid derivatives a bicyclic imidazole-catalyzed direct enantioselective -acylation.

Chem Sci 2020 Apr 24;11(18):4801-4807. Epub 2020 Apr 24.

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University Shanghai 200240 China

C-Tetrasubstituted α-amino acids are ubiquitous and unique structural units in bioactive natural products and pharmaceutical compounds. The asymmetric synthesis of these molecules has attracted a lot of attention, but a more efficient method is still greatly desired. Here we describe the first sequential four-step acylation reaction for the efficient synthesis of chiral C-tetrasubstituted α-amino acid derivatives from simple -acylated amino acids an auto-tandem catalysis using a single nucleophilic catalyst. The synthetic efficiency is improved a direct enantioselective -acylation; the methodology affords the corresponding C-tetrasubstituted α-amino acid derivatives with excellent enantioselectivities (up to 99% ee). This step-economic, one-pot, and auto-tandem strategy provides facile access to important chiral building blocks, such as peptides, serines, and oxazolines, which are often used in medicinal and synthetic chemistry.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0sc00808gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159231PMC
April 2020

Redox deracemization of β,γ-alkynyl α-amino esters.

Chem Sci 2020 Apr 21;11(17):4444-4449. Epub 2020 Apr 21.

School of Pharmaceutical Sciences, Shandong University Jinan 250012 China

The first non-enzymatic redox deracemization method using molecular oxygen as the terminal oxidant has been described. The one-pot deracemization of β,γ-alkynyl α-amino esters consisted of a copper-catalyzed aerobic oxidation and chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation with excellent functional group compatibility. By using benzothiazoline as the reducing reagent, an exclusive chemoselectivity at the C[double bond, length as m-dash]N bond over the C[triple bond, length as m-dash]C bond was achieved, allowing for efficient deracemization of a series of α-amino esters bearing diverse α-alkynyl substituent patterns. The origins of chemo- and enantio-selectivities were elucidated by experimental and computational mechanistic investigation. The generality of the strategy is further demonstrated by efficient deracemization of β,γ-alkenyl α-amino esters.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0sc00944jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159540PMC
April 2020

Doxorubicin-loaded natural daptomycin micelles with enhanced targeting and anti-tumor effect in vivo.

Eur J Med Chem 2021 Jun 2;222:113582. Epub 2021 Jun 2.

Ocean NanoTech, LLC, San Diego, CA, 92126, USA. Electronic address:

Development of a simple method to enhance targeting and anti-tumor effect of the chemotherapeutic agents in vivo is a major problem. Amphipathic and natural daptomycin is biocompatible antibacterial polypeptide used in clinical practice. Herein, doxorubicin (DOX) was stabilized by zwitterionic daptomycin (Dap) micelles in aqueous solution to form a zwitterionic nanodrug (Dap-DOX micelles). The hydrodynamic size and zeta potential of Dap-DOX micelles were 85 nm and -10 mV, respectively. The study on the controlled release showed that more DOX molecules were released from Dap-DOX micelles at acidic condition of tumor tissue than that at neutral condition of normal tissue which was due to pH responsiveness of Dap-DOX micelles. Dap-DOX micelles exhibited good stability in fibrinogen solution. Moreover, MTT studies showed that Dap-DOX micelles had higher cytotoxicity than free DOX. Notably, the results of flow cytometry indicated that the average fluorescence intensity of Dap-DOX micelle-treated cells was higher than that of free DOX-treated cells, and acidic conditions were more favorable for Dap-DOX micelles than normal pH in cell uptake assay. More importantly, Dap-DOX micelles were biocompatible in vivo based on the changes of weight and blood indexes of mice. Dap-DOX micelles were selectively accumulated at tumor sites in vivo through EPR effect, which reduced the toxicity of free DOX and achieved excellent tumor inhibition effect. The tumor inhibition rate of Dap-DOX micelles reached 96%. Dap-DOX micelles also effectively inhibited the growth of bacterial. Taken together, Dap-based drug delivery systems are promising and effective in cancer therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2021.113582DOI Listing
June 2021

Deep-level transient spectroscopy for effective passivator selection in perovskite solar cells to attain high efficiency over 23.

ChemSusChem 2021 Jun 13. Epub 2021 Jun 13.

Shaanxi Normal University, School of Materials Science and Engineering, No. 620, West Chang'an Avenue, Chang'an District, Xi'an, Shaanxi, 710119, Xi'an, CHINA.

Most studies choose passivators essentially in a trial-and-error fashion in an attempt to attain high efficiency in perovskite solar cells (PSCs). Using deep-level transient spectroscopy (DLTS) measurements, we firstly determined the type of defects in perovskite films to guide the passivator selection for PSCs. There are three kinds of positively charged defects found in our target PSC system. Therefore, fluorinated phenylethylamine hydroiodide (FPEAI) is chosen to passivate the surface defects due to the electronegativity and hydrophobicity of fluorine. Due to the decreased surface roughness, increased hydrophobicity, lowered defect density and improved carrier dynamics as observed by ultrafast transient absorption spectroscopy (TAS), a PSC with meta-F-PEAI has the best efficiency over 23% with open-circuit voltage (V oc ) of 1.155 V and fill factor (FF) of 80.15%. In addition, the long-term stability of the PSC is significantly improved. The present work provides a new means to select the best passivator for different types of defects.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/cssc.202100980DOI Listing
June 2021

Is physical capacity correlated with health-related quality of life in patients with adolescent idiopathic scoliosis?

Ann Palliat Med 2021 Jun 4. Epub 2021 Jun 4.

Department of Physical Medicine and Rehabilitation, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: There have been no report about the association between physical capacity and healthrelated quality of life in patients with adolescent idiopathic structural scoliosis (AIS). This study aims to investigate the correlation between dynamic cardiopulmonary capacity and quality of life in AIS patients.

Methods: This retrospective study involved 63 patients. Correlations between cardiopulmonary exercise test parameters and Scoliosis Research Society (SRS)-22 scores were evaluated using Spearman's correlation test.

Results: Fifty-four female patients [mean age: 14.1 (range, 10-19) years] and 9 male patients [15.9 (range, 14-19) years] with AIS (Cobb angle: 28°-86°) were included. Significant correlations were found between the peak oxygen uptake normalized by body weight and the SRS-22 scores in female patients, as reflected by the function (r=0.511, P<0.001), pain (r=0.418, P=0.002), mental health (r=0.536, P<0.001) and subtotal (r=0.618, P<0.001) scores. Significant correlations were also found between oxygen uptake at anaerobic threshold normalized by body weight and the SRS-22 scores in female patients, as reflected by the function (r=0.404, P=0.002), pain (r=0.455, P=0.001), and subtotal (r=0.501, P<0.001) scores, along with respiratory exchange ratio reflected by subtotal (r=0.464, P<0.001) score.

Conclusions: The physical capacity and capacity for the exercise intensity and endurance correlated with quality of life among patients with AIS. Exercise may better the quality of life of patients with AIS.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm-20-2624DOI Listing
June 2021

Maternal smoking during pregnancy and risks to depression and anxiety in offspring: An observational study and genome-wide gene-environment interaction analysis in UK biobank cohort.

J Psychiatr Res 2021 May 27;140:149-158. Epub 2021 May 27.

Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China. Electronic address:

Background: Maternal smoking during pregnancy (MSDP) has been reported to be associated with increased anxiety and depression behaviors in offspring. However, there is still scant evidence to support the link between MSDP and anxiety/depression.

Methods: Using the subjects from the UK Biobank cohort (n = 371,903-432,881). Logistic regression analyses were first conducted to test the correlation between MSDP and anxiety/depression in offspring. Second, genome-wide gene-environment interaction study (GWGEIS) analyses were conducted by PLINK, using MSDP as environmental factor. Genetic correlation analysis of anxiety/depression and smoking was conducted by the LDSC software using the published genome-wide association study (GWAS) summary data of four smoking traits (n = 337,334-1,232,091), anxiety (n = 31,880) and depression (n = 490,359). Finally, pathway enrichment analysis was carried out to detect the pathway involved in the development of offspring anxiety caused by the interaction of MSDP × SNPs.

Results: Observational analyses showed that anxiety and depression status in offspring were significantly associated with MSDP (all p < 0.0001). Further GWEGI analyses observed significant MSDP-gene interaction effects at UNC80 gene for anxiety (p = 9.09 × 10). LDSC did not detect significant genetic correlation between anxiety and smoking traits. Pathway analysis identified 19 significant pathways for anxiety, such as MANALO_HYPOXIA_UP (FDR = 5.50 × 10), REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS (FDR = 0.0304) and ONDER_CDH1_TARGETS_2_UP (FDR = 0.0371).

Conclusion: Our study results suggested the important impact of MDSP on the risk of anxiety in offspring, partly attributing to environment-gene interactions effects.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2021.05.067DOI Listing
May 2021

LncRNA BANCR promotes proliferation of hepatocellular carcinoma Huh-7 cells by activating Wnt/β-catenin signaling pathway.

Minerva Gastroenterol (Torino) 2021 Jun 11. Epub 2021 Jun 11.

Department of Emergency, The First hospital of Jiaxing, First Affiliated Hospital of Jiaxing University, Jiaxing, China -

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.23736/S2724-5985.21.02899-0DOI Listing
June 2021

Cellular and molecular mediators of lymphangiogenesis in inflammatory bowel disease.

J Transl Med 2021 Jun 10;19(1):254. Epub 2021 Jun 10.

Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, People's Republic of China.

Background: Recent studies reporting the intricate crosstalk between cellular and molecular mediators and the lymphatic endothelium in the development of inflammatory bowel diseases (IBD) suggest altered inflammatory cell drainage and lymphatic vasculature, implicating the lymphatic system as a player in the occurrence, development, and recurrence of intestinal diseases. This article aims to review recent data on the modulatory functions of cellular and molecular components of the IBD microenvironment on the lymphatic system, particularly lymphangiogenesis. It serves as a promising therapeutic target for IBD management and treatment. The interaction with gut microbiota is also explored.

Main Text: Evidence shows that cells of the innate and adaptive immune system and certain non-immune cells participate in the complex processes of inflammatory-induced lymphangiogenesis through the secretion of a wide spectrum of molecular factors, which vary greatly among the various cells. Lymphangiogenesis enhances lymphatic fluid drainage, hence reduced infiltration of immunomodulatory cells and associated-inflammatory cytokines. Interestingly, some of the cellular mediators, including mast cells, neutrophils, basophils, monocytes, and lymphatic endothelial cells (LECs), are a source of lymphangiogenic molecules, and a target as they express specific receptors for lymphangiogenic factors.

Conclusion: The effective target of lymphangiogenesis is expected to provide novel therapeutic interventions for intestinal inflammatory conditions, including IBD, through both immune and non-immune cells and based on cellular and molecular mechanisms of lymphangiogenesis that facilitate inflammation resolution.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12967-021-02922-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190852PMC
June 2021

[Clinical Characteristics and Prognostic Analysis of Extranodal NK/T-Cell Lymphoma Patients Treated with Pegaspargase Based Chemotherapy].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):735-740

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730,

Objective: To investigate the clinical characteristics of patients with extranodal NK/T-cell lymphoma (ENKL), and to analyze the factors that affecting the survival and prognostic of patients treated with pegaspargase based chemotherapy.

Methods: The clinical data of 61 ENKL patients treated in Peking Union Medical College Hospital from January 2015 to June 2019 were enrolled and retrospectively analyzed. The clinical characteristics, survival rate and influencing factors of prognostic in patients were investigated.

Results: The male and female ratio in the whole group was 2.8∶1. The median age was 46 years old (range, 17-67 years old). 30 patients were in stage I/II, while 31 patients were in stage III/IV. The ratio of nasal and non-nasal type was 4.1∶1. The common sites of extranodal involvement were skin and subcutaneous tissue (26.2%), liver (14.8%), lung (13.1%) and gastrointestinal tract (13.1%). 9.8% of patients showed central nervous system involvement and 11.5% showed bone marrow involvement. The median follow-up time was 22 months (range, 1-53 months). The 2-year PFS and OS rates of patients in the whole group were 51.6% and 53.2%, respectively. The 2-year OS rate of patients at stage I/II was 87.5%, while that of patients at stage III/IV was only 21.2%, the difference showed statistically significant (P<0.0001). Patients with non-nasal type disease showed a higher proportion in adverse factors of prognosis, of whom the median OS was only 3 months. Multivariate analysis showed that age>60 years old and Ann Arbor stage III-IV were the independent adverse factors that affecting the prognosis of PFS and OS (HR=3.681, 95% CI 1.322-10.250; HR=4.611, 95% CI 1.118-19.009).

Conclusion: The survival of ENKL patients has been significantly improved by pegaspargase based chemotherapy. Patients with stage I/II disease have achieved a relatively good 2-year OS rate of 87.5%, but the prognosis of stage III/IV and non-nasal type patients are still poor. Age>60 years old and Ann Arbor stage III/IV are independent adverse prognostic factors for ENKL patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2021.03.014DOI Listing
June 2021

Poloxometalates-based Semi-flexible Metal-semiconductor Triboelectric Nanogenerators for Low Frequency and Small Amplitude Mechanical Energy Harvesting.

Chemistry 2021 Jun 7. Epub 2021 Jun 7.

Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Department of Chemistry, Northeast Normal University, Ren Min Street No.5268, 130024, Changchun, CHINA.

The development of high-performance and low-cost durable triboelectric nanogenerators (TENGs) is essential for converting mechanical energy into electrical energy. Many organic polymer friction materials used widely have thermal stability problems , which makes TENGs with semiconductors as friction materials stand out. Here, we report a semi-flexible TENG based on metal and TiO 2 modified by polyoxometalates (POMs) as pure inorganic friction materials. Six different POMs are firstly selected to modify the friction materials of TENGs, and the output performance of TENGs with different POMs-modified semiconductors and different metals as friction materials are tested. Compared with the unmodified TENGs, the open-circuit voltage ( V OC ) of the optimal Ag-K 6 P 2 Mo 18 O 62 (P 2 Mo 18 )/TiO 2 TENG device is increased by more than 4 times, which is mainly attributed to the strong electron-accepting and storage capabilities of POMs. This study has demonstrated that TENGs modified by POMs have potential application prospects and provided a new method for increasing the electrical output of TENGs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.202100719DOI Listing
June 2021

Longitudinal Assessment of Pulmonary Function and Bronchodilator Response in Pediatric Patients With Post-infectious Bronchiolitis Obliterans.

Front Pediatr 2021 19;9:674310. Epub 2021 May 19.

Department of Pediatrics, The First Hospital of Jilin University, Changchun, China.

Postinfectious bronchiolitis obliterans (PIBO) is a rare respiratory disease. In recent years, the disease has been recognized and diagnosed increasingly in children. Pulmonary function is important for diagnosis, identifying the severity of the PIBO and monitoring progression. But there have been only a few studies that followed the evolution of PIBO on the basis of pulmonary function tests (PFTs). The study targeted the evolution of pulmonary function and bronchodilator response in a case series of Chinese children with PIBO. Twelve children between the ages of 6-99 months with PIBO were studied retrospectively from 2009 to 2019. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV), the FEV/FVC ratio, and maximal midexpiratory flow velocity 25-75% (MMEF were collected at each PFT, and bronchodilator responses were evaluated. Spirometric parameters were monitored over time, and generalized linear mixed models were used to analyze longitudinal panel data. The median baseline PFT values for FVC, FEV, the FEV/FVC ratio, and MMEF were 41.6, 39.75, 90.7, and 22.2%, respectively. At the initial PFTs, 10 (83.3%) patients demonstrated a significant bronchodilator response. FVC and FEV increased by 8.212%/year and 5.007%/year, respectively, and the FEV/FVC ratio decreased by an average of 3.537%/year. MMEF showed improvement at an average rate of 1.583% every year. Overall, FEV and MMEF showed different degrees of improvement after the use of inhaled bronchodilators at each PFT session for 10 patients, and FEV measures demonstrated significant (>12%) β-bronchodilation in 56% of PFT sessions. Pediatric patients with PIBO showed an obstructive defect in pulmonary function. The FVC, FEV, and MMEF improved as they grew older, while the FEV/FVC ratio decreased. This may be due to the development of lung parenchyma more than airway growth. Airway obstruction in some patients improved with the use of β agonists.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2021.674310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169978PMC
May 2021

The Clinical, Radiologic, and Prognostic Differences Between Pediatric and Adult Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Encephalomyelitis.

Front Neurol 2021 20;12:679430. Epub 2021 May 20.

Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.

To evaluate the clinical differences between pediatric and adult patients with myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM). We retrospectively reviewed the clinical features of pediatric and adult patients with MOG-EM in our center between November 2015 and October 2020. Twenty-eight pediatric patients and 25 adults were admitted to our study. Bilateral optic neuritis (BON) was the most common initial phenotype in the pediatric group but less common in the adult group (28.57 vs. 0%, = 0.0119). Almost half of the adult patients presented with neuromyelitis optica spectrum disease (NMOSD), which was less prevalent among the pediatrics (48 vs. 21.43%, = 0.0414). Visual impairment was the most common symptom in both groups during the initial attack (pediatric group, 39.29%; adult group, 64%) and throughout the full course (pediatric group, 57.14%; adult group, 72%). More pediatric patients suffered from fever than adult patients at onset (pediatric group, 28.57%; adult group, 4%; = 0.0442) and throughout the full course (pediatric group, 39.29%; adult group, 12%; = 0.0245). Multiple patchy lesions in subcortical white matter (pediatric group, 40.74%; adult group, 45%), periventricular (pediatric group, 25.93%; adult group, 35%), infratentorial (pediatric group, 18.52%; adult group, 30%) and deep gray matter (pediatric group, 25.93%; adult group, 20%) were frequent in all cases, no significant difference was found between the two groups, while bilateral optic nerve involvement was more frequent in pediatric group (61.54 vs. 14.29%, = 0.0042) and unilateral optic nerve involvement was higher in adult group (64.29 vs. 15.38%, = 0.0052). At the last follow-up, adult patients had a higher average EDSS score (median 1.0, range 0-3) than pediatrics (median 0.0, range 0-3), though not significant ( = 0.0752). Patients aged 0-9 years (61.54%) and 10-18 years (70%), and patients presenting with encephalitis/meningoencephalitis (100%) and ADEM (75%) were more likely to recover fully. Visual impairment was the dominant symptom in both pediatric and adult patients, while fever was more frequent in pediatric patients. Data suggested that BON and bilateral optic nerve involvement were more common in pediatric cases whereas NMOSD and unilateral optic nerve involvement were more prevalent in adults. The younger patients and patients presenting with encephalitis/meningoencephalitis and ADEM tended to recover better.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2021.679430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173107PMC
May 2021

Sex differences in changes in BMI and blood pressure in Chinese school-aged children during the COVID-19 quarantine.

Int J Obes (Lond) 2021 Jun 5. Epub 2021 Jun 5.

Department of Preventive Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, China.

There may be sex differences in BMI and blood pressure levels in school-age children, especially in the face of lifestyle changes. This study aimed to explore sex differences in changes in BMI and blood pressure in Chinese school-aged children during the COVID-19 quarantine. The cohort study of 445 school-aged children examined the change of BMI and blood pressure during the five-month quarantine. Multivariable Cox regression models were created to identify potential predictors of overweight, obesity, and elevated blood pressure (EBP). During the COVID-19 quarantine, the proportion of boys with overweight and obesity increased (P = 0.036), and the proportion of both boys and girls with Pre-EBP and EBP increased (P = 0.004 in boys; P < 0.001 in girls). The multivariate Cox regression analysis demonstrated that the setting, eating chili, parents' perception of their child's size and family doting were associated with overweight, obesity, and EBP. The study showed that BMI was more likely to increase in boys, and blood pressure increased in both boys and girls during the COVID-19 quarantine.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41366-021-00871-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178658PMC
June 2021

An induced pluripotent stem cell line (EHTJUi004-A) generated from a neonate with c.4683_4684delCT:p.Leu1563fs mutation in the gene DSP causing Familial Arrhythmogenic Right Ventricular Dysplasia (ARVD).

Stem Cell Res 2021 May 11;53:102369. Epub 2021 May 11.

Institute for Regenerative Medicine, National Stem Cell Translational Resource Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address:

Familial Arrhythmogenic Right Ventricular Dysplasia (ARVD) is a primary cardiomyopathy characterized by the abnormality of the right ventricular muscle. ARVD may be life-threatening due to the induction of paroxysmal refractory ventricular tachycardia or supraventricular arrhythmia. A human induced pluripotent stem cell line (EHTJUi004-A) was generated from human umbilical cord blood mononuclear cells (UCBMCs) of a female neonate with heterozygous mutation of p.Leu1563fs (c.4683_4684delCT) in the DSP gene. This iPS cell line resource provides an ideal in vitro model to study the pathological mechanism of ARVD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2021.102369DOI Listing
May 2021

An induced pluripotent stem cell line (EHTJUi003-A) generated from a neonate with c.1377delC mutation in the gene MYBPC3 causing hypertrophic cardiomyopathy.

Stem Cell Res 2021 May 12;53:102328. Epub 2021 Apr 12.

Institute for Regenerative Medicine, National Stem Cell Translational Resource Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address:

Hypertrophic cardiomyopathy (HCM) is an autosomal dominant heart disease. An induced pluripotent stem cell line (EHTJUi003-A) was generated from umbilical cord blood mononuclear cells (UCBMCs) of a female neonate with heterozygous mutation of p.L460Wfs (c.1377delC) in the MYBPC3 gene. This iPSC model offers a very valuable resource to study the pathological mechanism of HCM in vitro.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2021.102328DOI Listing
May 2021

Study on ageing characteristics and evaluation methods of RTV silicone rubber in high humidity area.

PLoS One 2021 4;16(6):e0251092. Epub 2021 Jun 4.

Electric Power Research Institute, State Grid Shaanxi Electric Power Company Xi'an, Xi'an, PR China.

Due to high humidity, the ageing of room temperature vulcanized silicone rubber (RTV) has been a serious problem in Southwestern China. In order to solve the problem of RTV life prediction, the aging classification method was established by analyzing the microtopography of RTV samples in this paper. Besides, the comprehensive analysis of RTV element content, partial element content ratio, and major chemical groups of RTV samples in each aging level were conducted. It is found that as the ageing level increases, the element contents of C, Si, O, Al change accordingly and the ratio of C:Si drops from 2.39 to 1.54, and absorption peaks of the chemical groups of Si-(CH3)2, Si-O-Si, Si-CH3 and C-H in CH3 decrease. This work can enrich the investigation of RTV, and may provide useful reference for performance evaluation and replacement of RTV in substations.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0251092PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177440PMC
June 2021

Polyethylenimine-Modified Mesoporous Silica Nanoparticles Induce a Survival Mechanism in Vascular Endothelial Cells Microvesicle-Mediated Autophagosome Release.

ACS Nano 2021 Jun 3. Epub 2021 Jun 3.

College of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou 450001, China.

Surface-modified mesoporous silica nanoparticles (MSNs) have attracted more and more attention as promising materials for biomolecule delivery. However, the lack of detailed evaluation relevant to the potential cytotoxicity of these MSNs is still a major obstacle for their applications. Unlike the bare MSNs and amino- or liposome-modified MSNs, we found that polyethylenimine-modified MSNs (MSNs-PEI) had no obvious toxicity to human umbilical vein endothelial cells (HUVECs) at the concentrations up to 100 μg/mL. However, MSNs-PEI induced autophagosomes accumulation by blocking their fusion with lysosomes, an essential mechanism for the cytotoxicity of many nanoparticles (NPs). Thus, we predicted that an alternative pathway for autophagosome clearance exists in HUVECs to relieve autophagic stress induced by MSNs-PEI. We found that MSNs-PEI prevented STX17 loading onto autophagosomes instead of influencing lysosomal pH or proteolytic activity. MSNs-PEI induced the structural alternation of the cytoskeleton but did not cause endoplasmic reticulum stress. The accumulated autophagosomes were released to the extracellular space microvesicles (MVs) when the autophagic degradation was blocked by MSNs-PEI. More importantly, blockade of either autophagosome formation or release caused the accumulation of damaged mitochondria and excessive ROS production in the MSNs-PEI-treated HUVECs, which in turn led to cell death. Thus, we propose here that the MV-mediated autophagosome release, a compensation mechanism, allows the vascular endothelial cell survival when the degradation of autophagosomes is blocked by MSNs-PEI. Accordingly, promoting the release of accumulated autophagosomes may be a protective strategy against the endothelial toxicity of NPs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.1c03456DOI Listing
June 2021

Effects of Corrosion on Compressive Arch Action and Catenary Action of RC Frames to Resist Progressive Collapse Based on Numerical Analysis.

Materials (Basel) 2021 May 19;14(10). Epub 2021 May 19.

College of Civil Engineering and Architecture, Guilin University of Technology, Guilin 541004, China.

Many negative factors can influence the progressive collapse resistance of reinforced concrete (RC) frame structures. One of the most important factors is the corrosion of rebar within the structure. With increasing severity of corrosion, the duration, robustness, and mechanical performance can be greatly impaired. One specific side effect of rebar corrosion is the significant loss of protection against progressive collapse. In order to quantify the effects of rebar corrosion on load-resisting mechanisms (compressive arch action (CAA) and tensile catenary action (TCA)) of RC frames, a series of numerical investigations were carried out in this paper. The previous experimental results reported in the literature provide a benchmark for progressive collapse behavior as a sound condition and validate the proposed numerical model. Furthermore, based on the verified numerical model, the CAA and TCA with increasing corrosion and an elapsed time from 0 to 70 years are investigated. Comparing with the conventional empirical model, the proposed numerical model has shown the ability and feasibility in predicting the collapse resistance capacity in structures with corroded rebar. Therefore, this numerical modeling strategy provides comprehensive insights into the change of load-resisting mechanisms in these structures, which can be beneficial for optimizing the design.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma14102662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161380PMC
May 2021

Combination of Corn Pith Fiber and Biobased Flame Retardant: A Novel Method toward Flame Retardancy, Thermal Stability, and Mechanical Properties of Polylactide.

Polymers (Basel) 2021 May 13;13(10). Epub 2021 May 13.

IMDEA Materials Institute, C/Eric Kandel, 2, 28906 Getafe, Madrid, Spain.

Some crop by-products are considered to be promising materials for the development of novel biobased products for industrial applications. The flammability of these alternatives to conventional materials is a constraint to expanded applications. Polylactide (PLA) composites containing a combination of oxidized corn pith fiber (OCC) and a biobased flame retardant (PA-THAM) have been prepared via an in situ modification method. SEM/EDS, FTIR and TGA were performed to establish that PA-THAM was coated onto the surface of OCC. The mechanical properties, thermal stability and fire behavior of PLA-based biocomposites were investigated. The incorporation of 5 phr PA-THAM imparted biocomposite good interfacial adhesion and increased decomposition temperature at 10% mass loss by 50 °C. The flame retardant properties were also improved, as reflected by an increased LOI value, a UL-94 V-2 rating, reduction of PHRR, and increased formation of char residue. Therefore, the introduction of 5 phr PA-THAM can maintain a good balance between flame retardancy and mechanical properties of this PLA/OCC system.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/polym13101562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152498PMC
May 2021

Abiotic and Biotic Influences on the Movement of Reintroduced Chinese Giant Salamanders () in Two Montane Rivers.

Animals (Basel) 2021 May 21;11(6). Epub 2021 May 21.

Department of Wildlife, Fisheries and Aquaculture, Mississippi State University, Starkville, MS 39762, USA.

Understanding animal movement is a key question in ecology and biodiversity conservation, which is particularly important for the success of reintroduction projects. The movement of critically endangered Chinese giant salamander () remains poorly understood due to the rareness of wild individuals of this species. We lack movement details about the full annual cycle after reintroduction, especially the abiotic and biotic influences that affect its movement. We utilized pilot reintroduction projects as opportunities to fill in some knowledge gaps on their movement ecology. We released 31 juvenile captive-reared Chinese giant salamanders of two age groups in two rivers in the Qinling Mountains of central China and monitored their daily movements for 16 months using surgically implanted radio transmitters. We examined the impacts of individual traits (body mass, body condition) and environmental conditions (temperature, precipitation, and moon phase) on their daily movement patterns. Data were analyzed using a mixed-effects logistic regression model to understand the drivers of their movement tendency (i.e., whether they move or not) and a linear mixed-effects model was used to understand the drivers of their movement distance. We found that movement tendency of the older salamander cohort was positively affected by the moon phase, increasing near the Full Moon, whereas the younger cohort of animals were not impacted by the moon phase. For daily distance moved, we found temperature had a strong positive effect on both cohorts, whereas precipitation had moderate but opposite effects on the two cohorts Body mass and body condition did not have any significant impacts on either age classes' movement tendency or distance. This study provides insight into the abiotic factors that impact the temporal and spatial movement ecology of reintroduced giant salamander, which will in turn help with designing best practices for future releases and conservation of this iconic montane aquatic predator.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ani11061480DOI Listing
May 2021

Impact of various vegetation configurations on traffic fine particle pollutants in a street canyon for different wind regimes.

Sci Total Environ 2021 May 23;789:147960. Epub 2021 May 23.

State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment, Chinese Research Academy of Environmental Sciences, Dayang Fang 8, Chaoyang District, Beijing 100012, China; Institute of Ecological Environment, Chinese Research Academy of Environmental Sciences, Dayang Fang 8, Chaoyang District, Beijing 100012, China.

Vegetation establishment in urban areas is a potential solution to combat elevated particulate matter (PM) pollution, create cleaner environment for residents and enhance the sustainability of cities. However, vegetation effect at the points of interest in street-canyon on traffic pollutant from multiple interconnected factors (e.g., plant species, vegetation configurations, aerodynamic effect, deposition effect and complex wind regimes) is still not well studied. Therefore, taking roadside vegetation and street canyon as research objects, we evaluated vegetation effect (VE) for vegetation configurations (VCs) with several tree species on the dispersion, deposition, and distribution of traffic generated PM pollutant under different wind regimes. Results showed that (1) the transportation and distribution of traffic PM pollutant were different from wind regimes; (2) total VEs varied from -88.3% to 25.5%, depending on different VCs and wind regimes; perpendicular wind had the best VEs, while oblique wind had the worst VEs among the three wind directions; VEs of cypress were better than pine and poplar; VEs of one side planting were better than two sides planting. (3) the optimal VCs were found by each wind direction; two sides planting by shrub was suitable for parallel and oblique winds; for the perpendicular wind, the optimal VC was that two sides planting by cypress-shrub and increased canopy volume in the street center; and (4) VE were significantly correlated (P < 0.05) with vegetation parameters at lower wind speed, however, no correlations were found at higher wind speed under parallel wind; leeward wall VEs were significantly correlated with aerodynamic parameter (P < 0.001) while windward wall VEs and pedestrian-level VEs with deposition parameter (P < 0.05) under perpendicular wind; VEs were significantly decreased (P < 0.001) with aerodynamic parameter under oblique wind. The study highlights the impact of urban vegetation on air environment and provides insights for vegetation establishment from the viewpoint of improving air quality.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2021.147960DOI Listing
May 2021

Immunofluorescent Labeling of Plant Virus and Insect Vector Proteins in Hemipteran Guts.

J Vis Exp 2021 May 14(171). Epub 2021 May 14.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences;

Most plant viruses in nature are transmitted from one plant to another by hemipteran insects. A high population density of the vector insects that are highly efficient at virus transmission plays a key role in virus epidemics in fields. Studying virus-insect vector interactions can advance our understanding of virus transmission and epidemics with the aim of designing novel strategies to control plant viruses and their vector insects. Immunofluorescence labeling has been widely used to analyze interactions between pathogens and hosts and is used here in the white-backed planthopper (WBPH, Sogatella furcifera), which efficiently transmits the southern rice black streaked dwarf virus (SRBSDV, genus Fijivirus, family Reoviridae), to locate the virions and insect proteins in the midgut epithelial cells. Using laser scanning confocal microscopy, we studied the morphological characteristics of midgut epithelial cells, cellular localization of insect proteins, and the colocalization of virions and an insect protein. This protocol can be used to study virus activities in insects, functions of insect proteins, and interactions between virus and vector insect.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3791/62605DOI Listing
May 2021

40.1% Record Low-Light Solar-Cell Efficiency by Holistic Trap-Passivation using Micrometer-Thick Perovskite Film.

Adv Mater 2021 May 31:e2100770. Epub 2021 May 31.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi'an, 710119, China.

Perovskite solar cells exhibit not only high efficiency under full AM1.5 sunlight, but also have great potential for applications in low-light environments, such as indoors, cloudy conditions, early morning, late evening, etc. Unfortunately, their performance still suffers from severe trap-induced nonradiative recombination, particularly under low-light conditions. Here, a holistic passivation strategy is developed to reduce traps both on the surface and in the bulk of micrometer-thick perovskite film, leading to a record efficiency of 40.1% under 301.6 µW cm warm light-emitting diode (LED) light for low-light solar-cell applications. The involvement of guanidinium into the perovskite bulk film and 2-(4-methoxyphenyl)ethylamine hydrobromide (CH O-PEABr) passivation on the perovskite surface synergistically suppresses the trap states. The charge carrier lifetimes of the perovskite film increase by tenfold and fivefold to 981 ns and 8.02 µs at the crystal surface and in its bulk, respectively. The decreased nonradiative recombination loss translates to a high open-circuit voltage (V ) of 1.00 V, a high short-circuit current (J ) of 152.10 µA cm , and a fill factor (FF) of 79.52%. Note that this performance also stands as the highest among all photovoltaics measured under indoor light illumination. This work of trap passivation for micrometer-thick perovskite film paves a way for high-performance, self-powered IoT devices.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.202100770DOI Listing
May 2021