Publications by authors named "Lu Liu"

2,486 Publications

  • Page 1 of 1

SPAG1 promotes the development of AML by activating the ERK/MAPK signaling pathway and affects the chemotherapy sensitivity of venetoclax.

Neoplasma 2022 Aug 12. Epub 2022 Aug 12.

Department of Hematology, The Second Hospital of Hebei Medical University, Key Laboratory of Hematology, Shijiazhuang, Hebei, China.

Sperm-associated antigen 1 (SPAG1) is considered to be associated with infertility and tumorigenesis. However, its function in acute myeloid leukemia (AML) remains unclear. In this study, we evaluated the expression level of SPAG1 and explored its clinical prognostic value in patients with AML, as well as its biological function in AML cells. SPAG1 is widely expressed in AML patients, resulting in a poor prognosis. However, its expression was not associated with Fms-related receptor tyrosine kinase 3 (FLT3) mutations. Utilizing the RNA interference knockdown tests, we found that SPAG1 could promote the proliferation and survival of AML cells and regulate the expression of structural maintenance of chromosomes protein 3 (SMC3), activating the ERK/MAPK signaling pathway. Furthermore, we discovered that inhibiting SPAG1 impacted AML cell susceptibility to venetoclax. In conclusion, SPAG1 may serve as a potential therapeutic target in AML.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4149/neo_2022_220415N416DOI Listing
August 2022

Mapping nucleosome and chromatin architectures: A survey of computational methods.

Comput Struct Biotechnol J 2022 26;20:3955-3962. Epub 2022 Jul 26.

Institute for Health and Equity, MCW Cancer Center, and Mellowes Center for Genome Science and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.

With ever-growing genomic sequencing data, the data variabilities and the underlying biases of the sequencing technologies pose significant computational challenges ranging from the need for accurately detecting the nucleosome positioning or chromatin interaction to the need for developing normalization methods to eliminate systematic biases. This review mainly surveys the computational methods for mapping the higher-resolution nucleosome and higher-order chromatin architectures. While a detailed discussion of the underlying algorithms is beyond the scope of our survey, we have discussed the methods and tools that can detect the nucleosomes in the genome, then demonstrated the computational methods for identifying 3D chromatin domains and interactions. We further illustrated computational approaches for integrating multi-omics data with Hi-C data and the advance of single-cell (sc)Hi-C data analysis. Our survey provides a comprehensive and valuable resource for biomedical scientists interested in studying nucleosome organization and chromatin structures as well as for computational scientists who are interested in improving upon them.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.csbj.2022.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340519PMC
July 2022

Does the addition of Braun anastomosis to Billroth II reconstruction on laparoscopic-assisted distal gastrectomy benefit patients?

World J Gastrointest Oncol 2022 Jun;14(6):1141-1147

Department of General Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.

Background: Operation is the primary therapeutic option for patients with distal gastrectomy. Braun anastomosis is usually performed after Billroth II reconstruction, which is wildly applied on distal gastrectomy because it is believed to benefit patients. However, studies are needed to confirm that.

Aim: To identify whether the addition of Braun anastomosis to Billroth II reconstruction on laparoscopy-assisted distal gastrectomy benefits patients.

Methods: A total of 143 patients with gastric cancer underwent laparoscopy-assisted distal gastrectomy at Centre 1 of PLA general hospital between January 2015 and December 2019. Clinical data of the patients were collected, and 93 of the 143 patients were followed up. These 93 patients were divided into two groups: Group 1 (Billroth II reconstruction, 33 patients); and Group 2 (Billroth II reconstruction combined with Braun anastomosis, 60 patients). Postoperative complication follow-up data and relevant clinical data were compared between the two groups.

Results: There were no significant differences between Group 1 and Group 2 in postoperative complications (6.1% 6.7%, = 0.679), anal exhaust time or blood loss. The follow-up prevalence of reflux gastritis indicated no significant difference between Group 1 and Group 2 (68.2% 51.7%, = 0.109). The follow-up European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 scores revealed no evident difference between Group 1 and Group 2 as well. Group 1 had a shorter operating time than Group 2 on average (234.6 min 262.0 min, = 0.017).

Conclusion: Combined with Billroth II reconstruction, Braun anastomosis has been applied due to its ability to reduce the prevalence of reflux gastritis. Whereas in this study, the prevalence of reflux gastritis showed no significant difference, leading to a conclusion that under the circumstance of Braun anastomosis costing more time and more money, simple Billroth II reconstruction should be widely applied.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4251/wjgo.v14.i6.1141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244985PMC
June 2022

Fear of cancer recurrence and hope level in patients receiving surgery for non-small cell lung cancer: a study on the mediating role of social support.

Support Care Cancer 2022 Aug 10. Epub 2022 Aug 10.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Purpose: To study the level of fear of cancer recurrence (FCR) in patients receiving surgery for non-small cell lung cancer (NSCLC) and explore related factors that can increase levels of hope in this population, enhance the confidence to defeat the disease, and thus increase the quality of life.

Methods: A total of 327 postoperative NSCLC patients from the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College were enrolled. All participants completed the General Questionnaire, Fear of Progression Questionnaire-Short Form (FoP-Q-SF), Herth Hope Index (HHI) Scale, and Social Support Rating Scale (SSRS).

Results: The mean FoP-Q-SF score was (30.3 ± 9.48) points in postoperative NSCLC patients, Among them, there were 188 patients (57.5%) who had psychological dysfunction, indicated by a score of > / = 34. Patient sex and family income were independent risk factors for FCR (both p < 0.05). Correlation analysis revealed a negative association between FCR and hope level (p < 0.05) and a positive association between hope level and social support (p < 0.05). Notably, social support mediated the association between FCR and hope in patients receiving surgery for NSCLC (contribution effect: 30.24%).

Conclusion: Postoperative NSCLC patients experience a moderate level of FCR, especially females and those with a low family income. Social support partially mediates the relationship between FCR and hope in this population. Therefore, an increase in the level of social support can increase hope among these patients and advancing recovery.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00520-022-07318-6DOI Listing
August 2022

High-Resolution Micro-object Separation by Rotating Magnetic Chromatography.

Anal Chem 2022 Aug 9. Epub 2022 Aug 9.

Department of Chemistry, Yanbian University, Park Road 977, Yanji City, Jilin Province 133002, China.

The development of new technologies for the separation, selection, and isolation of microparticles such as rare target cells, circulating tumor cells, cancer stem cells, and immune cells has become increasingly important in the last few years. Microparticle separation technologies are usually applied to the analysis of disease-associated cells, but these procedures often face a cell separation problem that is often insufficient for single specific cell analyses. To overcome these limitations, a highly accurate size-based microparticle separation technique, herein called "rotating magnetic chromatography", is proposed in this work. Magnetic nanoparticles, placed in a microfluidic separation channel, are forced to move in well-defined trajectories by an external magnetic field, colliding with microparticles that are in this way separated on the basis of their dimensions with high accuracy and reproducibility. The method was optimized by using fluorescein isothiocyanate-modified polystyrene particles (chosen as a reference standard) and then applied to the analysis of cancer cells like Hep-3B and SK-Hep-1, allowing their fast and high-resolution chromatographic separation as a function of their dimensions. Due to its unmatched sub-micrometer cell separation capabilities, RMC can be considered a break-through technique that can unlock new perspectives in different scientific fields, that is, in medical oncology.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.2c01385DOI Listing
August 2022

Correlation Analysis of miR-1246 Expression in Saliva of Patients with Chronic Periodontitis and Periodontal Indexes, Inflammatory Cytokines, and Protease Molecules.

Evid Based Complement Alternat Med 2022 30;2022:1949159. Epub 2022 Jul 30.

Stomatology Clinic of Cangzhou Central Hospital, Cangzhou, Hebei, China.

Objective: The study aimed to investigate the correlation of miR-1246 in saliva with periodontal indicators, inflammatory cytokines, and protease molecules in patients with chronic periodontitis.

Methods: Thirty-five patients with chronic periodontitis were included as the chronic periodontitis group, and 35 healthy individuals were selected as the healthy control group during the same period. The miR-1246 levels, inflammatory cytokine interleukin (IL)-1, IL-6, IL-17, tumor necrosis factor- (TNF-), matrix metalloproteinase (MMP-1), MMP-8, and MMP tissue inhibitor (TIMP-1) in saliva were determined, and periodontal indexes, including the plaque index (PLI), bleeding index (BI), periodontal probing depth (PD), and attachment loss (AL) were examined.

Results: The salivary levels of miR-1246, IL-1, IL-6, IL-17, TNF-, MMP-1, MMP-8, and TIMP-1 and the periodontal indexes PLI, GI, PD, and AL in the chronic periodontitis group were significantly higher than those in the healthy control ( < 0.05). Salivary levels of miR-1246 in patients with chronic periodontitis were positively correlated with the levels of IL-1, IL-6, IL-17, TNF-, MMP-1, MMP-8, TIMP-1, PLI, GI, PD, and AL ( < 0.05).

Conclusion: Abnormally elevated levels of miR-1246 in saliva of patients with chronic periodontitis correlate with levels of periodontal indices, inflammatory cytokines, and protease molecules.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2022/1949159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356776PMC
July 2022

Fire Needling Acupuncture for Adult Patients with Acute Herpes Zoster: Protocol of a Systematic Review and Meta-Analysis.

J Pain Res 2022 2;15:2161-2170. Epub 2022 Aug 2.

Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, People's Republic of China.

Background: Acute herpes zoster (HZ) is characterized as a vesicular rash with unilateral distribution produced by the reactivation of varicella zoster virus. It can induce various comorbidities that can adversely influence the quality of life of patients. The purpose of this systematic review is to assess the effect and safety of fire needling acupuncture on acute HZ.

Methods: Three English databases (PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials) and four Chinese Databases (China National Knowledge Infrastructure, Wanfang database, Chongqing VIP database, and China Biology Medicine database) will be searched from their inceptions to July 2022. Randomized controlled trials investigating fire needling acupuncture therapy for acute HZ will be included, regardless of publication status. Two reviewers will independently conduct the study screening, data extraction, and research quality assessments. The primary outcome measures are the Pain Visual Analogue Scale and the occurrence of postherpetic neuralgia. Secondary outcomes measures are the evaluation of skin lesions, time to resolution of pain, tolerance evaluation, total effective rate, adverse events and changes in inflammatory and immune suppression markers in peripheral plasma. All included studies will be assessed for methodological quality via the Cochrane Collaboration's bias risk assessment tool. Meta-analyses will be undertaken using Review Manager V.5.3 software. The findings will be reported as the risk ratio of the binary data and the mean difference (MD) or standardized MD of the continuous data. Subgroup analyses and sensitivity analyses will be conducted where appropriate. The Grading of Recommendations Assessment, Development, and Evaluation will be used to assess evidence certainty.

Results: From the study, we will ascertain the effects and safety of fire needling acupuncture on acute HZ.

Conclusion: This study will validate the effects and safety of fire needling acupuncture in the management of acute HZ, generating new evidence to guide acupuncture interventions for acute HZ in the future.

Registration Number: PROSPERO CRD42020199047.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/JPR.S370484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356735PMC
August 2022

Association between constipation and the development of asthma: a meta-analysis.

Allergy Asthma Clin Immunol 2022 Aug 8;18(1):73. Epub 2022 Aug 8.

Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, No. 256, West Youyi Road, Xi'an, Shaanxi, 710068, People's Republic of China.

Background: Constipation has been hypothesized to be associated with the increased risk of wheezing or asthma. However, the relation remains a subject of debate. We conducted this meta-analysis to assess whether constipation influences the risk of wheezing/asthma.

Methods: PubMed, Embase, and Web of Science were systematically searched for studies published between 1955 and January 2022. Two reviewers independently extracted data and assessed the quality of each study. Results were pooled using fixed-effects models or random-effects models as appropriate.

Results: In total, 3 original articles with 178,661 participants, which met the criteria, were included in this meta-analysis. Constipation was associated with an increased risk of wheezing/asthma in later life (RR = 2.02, 95% CI = 1.24-3.29, P < 0.01).

Conclusions: The meta-analysis suggests an association between constipation and the subsequent development of wheezing/asthma. Well-designed and highly standardized prospective studies that adequately address concerns for potential confounding factors are required to validate the risk identified in our current meta-analysis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13223-022-00708-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358868PMC
August 2022

Pulmonary trunk compression due to multiple aneurysms associated with a coronary-pulmonary artery fistula.

Eur Heart J 2022 Aug 8. Epub 2022 Aug 8.

Department of Cardiovascular Surgery, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu 610041, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/eurheartj/ehac441DOI Listing
August 2022

PavGA2ox-2L inhibits the plant growth and development interacting with PavDWARF in sweet cherry (Prunus avium L.).

Plant Physiol Biochem 2022 Sep 21;186:299-309. Epub 2022 Jul 21.

Department of Plant Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Minhang, Shanghai, 200240, China. Electronic address:

Dwarf dense planting is helpful to improve the yield and quality of sweet cherry, which has enormous market demand. GA2oxs (GA oxidases) affect plant height, dormancy release, flower development, and seed germination by participating in the metabolic regulation and signal transduction of GA (Gibberellin). However, the research on GA2ox in sweet cherry is little and worthy of further investigation. Therefore, we identified the PavGA2ox-2L gene from sweet cherry, close to PynGA2ox-2 from Prunus yedoensis var. Nudiflora. The phylogenetic analysis indicated conserved functions with these evolutionarily closer GA2ox subfamily genes. Subcellular localization forecast analysis indicated that PavGA2ox-2L was localized in the nucleus or cytoplasm. The expression levels of PavGA2ox-2L were higher in winter, indicating that PavGA2ox-2L promoted maintained flower bud dormancy. The expression levels of PavGA2ox-2L were significantly increased after GA treatment while decreased after GR24 (a synthetic analog of SLs (Strigolactones)) or TIS108 (a triazole-type SL-biosynthesis inhibitor) treatments. Over-expression of PavGA2ox-2L resulted in decreased plant height, delayed flowering time, and low seed germination rate in Arabidopsis thaliana. Furthermore, the interaction between PavGA2ox-2L and PavDWARF was verified by Y2H and BiFC assays. In the current investigation, PavGA2ox-2L functions as a GA metabolic gene that promotes dwarf dense planting, delays flowering time, and inhibits seed germination. In addition, it also participates in regulating plant growth and development through the interaction with the critical negative regulator PavDWARF of Gibberellin. These results will help us better explore the molecular mechanism of GA2ox-mediated dwarf and late-maturing varieties for fruit trees.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plaphy.2022.07.019DOI Listing
September 2022

Navigations of the targeting pathway of nanomedicines towards tumor.

Expert Opin Drug Deliv 2022 Aug 5. Epub 2022 Aug 5.

Department of Minimally Invasive Interventional Radiology, the State Key Laboratory of Respiratory Disease, College of Biomedical Engineering & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, P. R. China.

Introduction: Nanomedicines (NMs) have emerged as a promising approach for revolutionizing cancer treatment outcomes, mainly due to their benefits in the tumor targeted delivery of therapeutics. The preferential accumulation of NMs in tumor has been widely verified by macroscopical technologies. Accordingly, several classic and emerging targeting mechanisms have been proposed to support the tumor-specific delivery of NMs. The targeting mechanism has been a topic of intensive interest and controversy in the field of NMs development. Especially, the mechanisms by which NMs target tumor remain elusive.

Area Covered: This topical review mainly discussed the evolution of the targeting mechanisms, crucial issues associated with each mechanism, and confused debates among the mechanisms. The targeting mechanisms of tumor-specific NMs discussed here include the enhanced permeability and retention (EPR) effect, protein corona-mediated targeting delivery, circulating cell mediated transportation, and transcytosis.

Expert Opinion: It is of great significance for ultimate clinical translation to have more comprehensive considerations on the mechanism driving the pathway of NMs toward tumors. Our thoughts in this review are expected to provide comprehensive understanding on the mechanisms and elicit thorough explorations on new mechanism to renovate the knowledge framework of NMs delivery.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/17425247.2022.2110064DOI Listing
August 2022

Short-time intensive insulin therapy upregulates 3 beta- and 17 beta-hydroxysteroid dehydrogenase levels in men with newly diagnosed T2DM.

Front Endocrinol (Lausanne) 2022 19;13:894743. Epub 2022 Jul 19.

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective: Our previous study has found that short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes mellitus (T2DM) increased serum testosterone levels, but the underlying mechanisms remain unclear.

Design And Methods: In this self-controlled study, 43 men with newly diagnosed drug naïve T2DM, aged 18-60 years, with HbA9.0% were treated with continuous subcutaneous insulin infusion (CSII) to normalize blood glucose within one week. Venous blood specimens were collected for measuring of serum total testosterone, dehydroepiandrosterone sulfate (DHEA-S), 3β- and 17β-hydroxysteroid dehydrogenase (3β- and 17β-HSD) concentrations before and after insulin therapy.

Results: Testosterone increased from 13.0 (11.3, 14.6) nmol/L to 15.7 (13.9, 17.5) nmol/L after intensive insulin therapy (<0.001), while the levels of DHEA-S decreased significantly after treatment (from 6.5 (5.7, 7.3) μmol/L to 6.0 (5.3, 6.7) μmol/L, =0.001). The ratio of testosterone/DHEA-S increased significantly (2.4 (2.0, 2.8) vs. 3.1 (2.6, 3.7) nmol/μmol, <0.001). After blood glucose normalization with the short-term CSII therapy, 3β-HSD increased from 11.0 (9.5, 12.5) pg/mL to 14.6 (13.5, 15.7) pg/mL, =0.001, and 17β-HSD increased from 20.7 (16.3, 25.2) pg/mL to 28.2 (23.8, 32.5) pg/mL, =0.009.

Conclusions: Blood glucose normalization short-term intensive insulin therapy increases plasma total testosterone levels in men with newly diagnosed type 2 diabetes, associated with a decreased level of DHEA-S, probably because of the enhanced conversion from DHEA to testosterone catalyzed by 3β-HSD and 17β-HSD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2022.894743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344891PMC
August 2022

Changes in dimensions and functions of crystalline lens in high myopia using CASIA2 optical coherence tomography.

Ophthalmic Res 2022 Aug 4. Epub 2022 Aug 4.

Introduction: Crystalline lens is the major dioptric component and varies with refractive status. In this study, we aim to evaluate the changes of dimensions and functions of crystalline lens in high myopia and its correlated variables using CASIA2 swept-source optical coherence tomography (SS-OCT).

Methods: One hundred and thirty eligible eyes of myopic patients from 18-40 years old were enrolled and divided into low-to-moderate myopia (LMM) and high myopia (HM) groups according to spherical equivalent (SE). Anterior segment features, including lens thickness (LT), anterior radius of curvature (ARC), posterior radius of curvature (PRC), anterior chamber depth (ACD) and lens tilt were obtained by CASIA2. Lens power was calculated using Bennett's formula. Sixty-seven participants were imaged at static state and accommodative state induced by -3 diopter (D) stimulus.

Results: Compared to LMM group, HM group exhibited a significantly reduction in LT, ARC and lens tilt (all P<0.01). Each parameter correlated positively with SE (all P<0.01). Lens power increased with LT and tilt (r=0.42, 0.45), but decreased with ARC and axial length (AL) (r=-0.37, -0.62) among highly myopic eyes. Multivariate regression analysis revealed that lower lens power appeared to be independently associated with axial elongation in both groups (LMM: β=-1.124, P=0.002; HM: β=-1.603, P<0.001, respectively). Decreases in ARC and ACD were accompanied by accommodative response in each group, while PRC reduced during accommodation (P=0.009) only in high myopia.

Conclusions: Young adults with high myopia presented the thinner thickness, smaller tilt, less lens power and higher accommodative response. Lens shape was closely associated with SE, however AL was a meaningful indicator of lens power.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1159/000526246DOI Listing
August 2022

Apogossypolone Inhibits Cell Proliferation and Epithelial-Mesenchymal Transition in Cervical Cancer Activating DKK3.

Front Oncol 2022 18;12:948023. Epub 2022 Jul 18.

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, China.

Apogossypolone (ApoG2), a novel derivative of gossypol lacking of two aldehyde groups, exhibits anti-tumor effects. However, the mechanisms by which ApoG2 regulates cervical cancer (CC) cells remain unclear. In this study, we treated two CC cell lines (CaSki and HeLa) with an increasing concentration of ApoG2 for 24 h. Cell Counting Kit-8 (CCK-8) assay, colony formation assay, flow cytometry and transwell invasion assay were utilized to detect cell proliferation, apoptosis and invasion . We first observed that ApoG2 inhibited cell proliferation, invasion and epithelial-to-mesenchymal transition (EMT) process in CC cells, along with upregulation of Dickkopf Wnt signaling pathway inhibitor 3 (DKK3) in a dose-dependent manner. The immunohistochemistry confirmed the downregulation of DKK3 in tumor tissues. Moreover, DKK3 was correlated with FIGO stage and lymph node metastasis. Functionally, DKK3 overexpression significantly suppressed cell viability, colony formation and invasion, but promoted apoptosis in CaSki and HeLa cells. Overexpression of DKK3 upregulated the protein levels of cleaved caspase-3 and E-cadherin, but downregulated the protein levels of Bcl-2, N-cadherin and Vimentin. Furthermore, DKK3 knockdown reversed the suppressive effects of ApoG2 on CaSki cell proliferation, invasion and EMT markers, while DKK3 overexpression enhanced these effects. In addition, ApoG2 treatment inhibited CC xenograft tumor growth and upregulated the protein levels of DKK3, cleaved caspase-3 and E-cadherin. In conclusions, these findings suggested that ApoG2 could effectively inhibit the growth and invasion of CC cells at least partly by activating DKK3.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2022.948023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341244PMC
July 2022

Enantioselective para-C(sp2)-H Functionalization of Alkyl Benzene Derivatives via Cooperative Catalysis of Gold/Chiral Brønsted Acid.

Angew Chem Int Ed Engl 2022 Aug 3. Epub 2022 Aug 3.

East China Normal University, School of Chemistry and Molecular Engineering, 500 Dongchuan Road, 200241, Shanghai, CHINA.

An asymmetric para-C(sp2)-H bond functionalization of alkyl benzene derivatives was successfully developed via cooperative catalysis of gold and chiral phosphoric acid (CPA), leading to synthetically useful chiral 1,1-diaryl motifs. Chiral phosphoric acid, ligand, and molecular sieves were found crucial for enantioselectivity control of this transformation. The salient features of this protocol include mild conditions, high efficiency, commercially available starting materials, highly chemo- and site- as well as enantioselective aromatic C-H functionalization, broad substrate scope, and extensive applications of the chiral products. The mechanistic studies suggested that two CPAs might be involved in chiral induction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202208874DOI Listing
August 2022

Involucrasin C, Anti-inflammatory 2,3-Dihydro-1H-indene Derivative from Chinese Dai ethnic medicine Shuteria involucrata.

Chem Biodivers 2022 Aug 3. Epub 2022 Aug 3.

Yunnan University of Traditional Chinese Medicine, Yunnan Key Labaratory of Southern Medicine Utilization, Yuhua Road, Kunming, CHINA.

(±)-Involucrasin C (1), a pair of new 2,3-Dihydro-1H-indene enantiomers, along with an enantiomeric analogue (2) were isolated from Shuteria involucrata. Their structures were established by the basis of comprehensive spectroscopic data analysis and X-ray crystallographic diffraction. Both 1 and 2 significantly inhibited the secretion of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β, suggesting that these two natural 2,3-Dihydro-1H-indene derivatives may be active components of S. involucrata and may block inflammation in the initial stage.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbdv.202200188DOI Listing
August 2022

Genetic markers in Andean species (Bromeliaceae) with implications on plastome evolution and phylogeny.

Ecol Evol 2022 Aug 29;12(8):e9159. Epub 2022 Jul 29.

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, and Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden Chinese Academy of Sciences Guangzhou China.

The Andean plant endemic is a striking example of recent and rapid diversification from central Chile to the northern Andes, tracking mountain uplift. This study generated 12 complete plastomes representing nine species and compared them to five published plastomes for their features, genomic evolution, and phylogeny. The total size of the plastomes ranged from 159,542 to 159,839 bp with 37.3%-37.4% GC content. The plastomes were highly conserved in organization and structure with a typical quadripartite genome structure. Each of the 17 consensus plastomes harbored 133 genes, including 87 protein-coding genes, 38 tRNA (transfer RNA) genes, and eight rRNA (ribosomal RNA) genes; we found 69-78 tandem repeats, 45-60 SSRs (simple sequence repeats), and 8-22 repeat structures among 13 species. Four protein-coding genes were identified under positive site-specific selection in . The complete plastomes and hypervariable regions collectively provided pronounced species discrimination in and a practical tool for future phylogenetic studies. The reconstructed phylogeny and estimated divergence time for the lineage suggest that the diversification of is related to Andean orogeny and Pleistocene climatic oscillations. This study provides plastome resources for species delimitation and novel phylogenetic and biogeographic studies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/ece3.9159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336176PMC
August 2022

Prognostic value of combined coronary angiography-derived IMR and myocardial perfusion imaging by CZT SPECT in INOCA.

J Nucl Cardiol 2022 Aug 2. Epub 2022 Aug 2.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.

Background: A significant proportion of ischemia with non-obstructive coronary artery disease (INOCA) demonstrate coronary microvascular dysfunction (CMD), a condition associated with abnormal myocardial perfusion imaging (MPI) and adverse outcomes. Coronary angiography-derived index of microvascular resistance (caIMR) is a novel non-invasive technique to assess CMD. We aimed to investigate the prognostic value of combined caIMR and MPI by CZT SPECT in INOCA patients.

Methods: Consecutive 151 patients with chest pain and < 50% coronary stenosis who underwent coronary angiography and MPI within 3 months were enrolled. caIMR was calculated by computational pressure-flow dynamics. CMD was defined as caIMR ≥ 25. The endpoint was major adverse cardiac events (MACE: cardiovascular death, nonfatal myocardial infarction, revascularization, angina-related rehospitalization, heart failure, and stroke).

Results: Of all INOCA patients, CMD was present in 93 (61.6%) patients. The prevalence of abnormal MPI was significantly higher in CMD compared with non-CMD patients (40.9% vs 13.8%, P < .001). CMD showed a higher risk of MACE than non-CMD patients. Patients with both CMD and abnormal MPI had the worst prognosis, followed by patients with CMD and normal MPI (log-rank P < .001). Cox regression analysis identified CMD (HR 3.121, 95%CI 1.221-7.974, P = .017) and MPI (HR 2.704, 95%CI 1.030-7.099, P = .043) as predictive of MACE. The prognostic value of INOCA patients enhanced significantly by adding CMD and MPI to the model with clinical risk factors (AUC = 0.777 vs 0.686, P = .030).

Conclusion: caIMR-derived CMD is associated with increased risk of MACE among INOCA patients. Patients with abnormalities on both caIMR and MPI had the worse outcomes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-022-03038-wDOI Listing
August 2022

Effectiveness of the implementation of a perinatal bereavement care training programme on nurses and midwives: protocol for a mixed-method study.

BMJ Open 2022 08 2;12(8):e059660. Epub 2022 Aug 2.

Obstetrics Department, Zhejiang University School of Medicine Women's Hospital, Hangzhou, Zhejiang, China

Introduction: The psychological outcomes for many parents who experience perinatal loss depend on nursing staff's ability to provide effective bereavement support. However, most nurses and midwives lack the ability to provide bereavement care and suffer from heavy emotional burden. The study aims to investigate the effectiveness of the perinatal bereavement care training programme on nurses and midwives to increase their perinatal bereavement care confidence (PBCC) and to reduce secondary traumatic stress and emotional exhaustion.

Methods And Analysis: This study will follow a mixed methodology consisting of two stages. The first stage will adopt a pre/post repeated quasi-experimental design without a control group. The second stage will use a qualitative interview study. This study will be conducted in a tertiary maternity hospital in China in 2022-2023. Ethical approval was obtained from the institutional review board in January of 2020. Outcome measures will be assessed using the Chinese version of the PBCC, STS and the EE subscale of Chinese Burn-out Inventory at baseline, postintervention and at the 3-month follow-up. Participants will be interviewed to understand their perceptions of the training programme.

Ethics And Dissemination: This research protocol was approved by the Ethics Committee of the Women's Hospital School of Medicine, Zhejiang University (IRB no. 20210091). The results will be disseminated through peer-reviewed journals and academic conferences.

Trial Registration Number: ChiCTR2100049730.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2021-059660DOI Listing
August 2022

Direct observation of the Mottness and p-d orbital hybridization in the epitaxial monolayer α-RuCl.

Nanoscale 2022 Aug 2. Epub 2022 Aug 2.

State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200438, China.

α-RuCl, a promising material to accomplish the Kitaev honeycomb model, has attracted enormous interest recently. Mottness and p-d bonds play vital roles in generating Kitaev interactions and underpinning the potential exotic states of quantum magnets, and the van der Waals monolayer is considered to be a better platform to approach a two-dimensional Kitaev model than the bulk. Here, we worked out the growth art of an α-RuCl monolayer on a graphite substrate and studied its electronic structure, particularly the delicate orbital occupations, through scanning tunneling microscopy and spectroscopy. An in-plane lattice expansion of 2.67 ± 0.83% is observed and the pronounced t-p and e-p hybridization are visualized. The Mott nature is unveiled by an ∼0.6 eV full gap at the Fermi level located inside the t-p manifold which is further verified by the density functional theory calculations. The monolayer phase of α-RuCl fulfills the criteria of recent theoretical predictions of tuning the relevant properties in this material and provides a novel platform to explore the Kitaev physics.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d2nr02827aDOI Listing
August 2022

Targeted inhibition of osteoclastogenesis reveals the pathogenesis and therapeutics of bone loss under sympathetic neurostress.

Int J Oral Sci 2022 Aug 1;14(1):39. Epub 2022 Aug 1.

State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss, but the mechanisms and therapeutics remain incompletely elucidated. Here, we reveal an osteoclastogenesis-centered functionally important osteopenic pathogenesis under sympatho-adrenergic activation with characterized microRNA response and efficient therapeutics. We discovered that osteoclastic miR-21 was tightly regulated by sympatho-adrenergic cues downstream the β2-adrenergic receptor (βAR) signaling, critically modulated osteoclastogenesis in vivo by inhibiting programmed cell death 4 (Pdcd4), and mediated detrimental effects of both isoproterenol (ISO) and chronic variable stress (CVS) on bone. Intriguingly, without affecting osteoblastic bone formation, bone protection against ISO and CVS was sufficiently achieved by a (D-Asp)-lipid nanoparticle-mediated targeted inhibition of osteoclastic miR-21 or by clinically relevant drugs to suppress osteoclastogenesis. Collectively, these results unravel a previously underdetermined molecular and functional paradigm that osteoclastogenesis crucially contributes to sympatho-adrenergic regulation of bone and establish multiple targeted therapeutic strategies to counteract osteopenias under stresses.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41368-022-00193-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343357PMC
August 2022

Spin-Orbital States and Strong Antiferromagnetism of Layered EuSrFeO and SrFeOCl.

Inorg Chem 2022 Aug 1. Epub 2022 Aug 1.

Laboratory for Computational Physical Sciences (MOE), State Key Laboratory of Surface Physics, and Department of Physics, Fudan University, Shanghai 200433, China.

The insulating iron compounds EuSrFeO and SrFeOCl have high-temperature antiferromagnetic (AF) order despite their different layered structures. Here, we carry out density functional calculations and Monte Carlo simulations to study their electronic structures and magnetic properties aided with analyses of the crystal field, magnetic anisotropy, and superexchange. We find that both compounds are Mott insulators and in the high-spin (HS) Fe state ( = 2) accompanied by the weakened crystal field. Although they have different local coordination and crystal fields, the Fe ions have the same level sequence and ground-state configuration (3-)(, )()(-). Then, the multiorbital superexchange produces strong AF couplings, and the (3-)/(, ) mixing via the spin-orbit coupling (SOC) yields a small in-plane orbital moment and anisotropy. Indeed, by tracing a set of different spin-orbital states, our density functional calculations confirm the strong AF couplings and the easy planar magnetization for both compounds. Moreover, using the derived magnetic parameters, our Monte Carlo simulations give the Néel temperature = 420 K (372 K) for the former (the latter), which well reproduce the experimental results. Therefore, the present study provides a unified picture for EuSrFeO and SrFeOCl concerning their electronic and magnetic properties.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.inorgchem.2c01706DOI Listing
August 2022

The global burden and associated factors of ovarian cancer in 1990-2019: findings from the Global Burden of Disease Study 2019.

BMC Public Health 2022 07 30;22(1):1455. Epub 2022 Jul 30.

Department of Preventive Medicine Laboratory, School of Public Health, Zunyi Medical University, Zunyi, China.

Background: Ovarian cancer (OC) is a major cause of cancer-related deaths among women. The aim of this study was to estimate and report data on the current burden of ovarian cancer worldwide over the past 30 years.

Method: Based on the data provided by GBD 2019, we collected and interpreted the disease data of ovarian cancer by incidence, mortality, disability-adjusted life-years (DALYs), and used corresponding age-standardized rates as indicators. Also, we categorized the data by attributed risk factors and captured deaths due to high fasting plasma glucose, occupational exposure to asbestos and high body-mass index, respectively. All outcomes in the study were reported using mean values and corresponding 95% uncertainty intervals (95% UI).

Results: Globally, there were 294422 (260649 to 329727) incident cases in 2019, and the number of deaths and DALYs were 198412 (175357 to 217665) and 5.36 million (4.69 to 5.95). The overall burden was on the rise, with a percentage change of 107.8% (76.1 to 135.7%) for new cases, 103.8% (75.7 to 126.4%) for deaths and 96.1% (65.0 to 120.5%) for DALYs. Whereas the age-standardized rates kept stable during 1990-2019. The burden of ovarian cancer increased with age. and showed a totally different trends among SDI regions. Although high SDI region had the declining rates, the burden of ovarian cancer remained stable in high-middle and low SDI regions, and the middle and low-middle SDI areas showed increasing trends. High fasting plasma glucose was estimated to be the most important attributable risk factor for ovarian cancer deaths globally, with a percentage change of deaths of 7.9% (1.6 to 18.3%), followed by occupational exposure to asbestos and high body mass index.

Conclusions: Although the age-standardized rates of ovarian cancer didn't significantly change at the global level, the burden still increased, especially in areas on the lower end of the SDI range. Also, the disease burden due to different attributable risk factors showed heterogeneous, and it became more severe with age.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-022-13861-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339194PMC
July 2022

Inhibiting SRC activity attenuates kainic-acid induced mouse epilepsy via reducing NR2B phosphorylation and full-length NR2B expression.

Epilepsy Res 2022 Jul 8;185:106975. Epub 2022 Jul 8.

Department of Neurology, Zhongshan Hospital, Fudan University, Fenglin Road, Shanghai 200032, China; Department of The State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China. Electronic address:

Objective: To explore the effect of SRC activation on spontaneously recurrent seizures and to investigate the underlying mechanisms of NR2B phosphorylation.

Methods: C57BL/6 mice were injected intrahippocampally with kainic acid (KA, 0.4 μg/25 g) to induce status epilepticus (SE). Saracatinib(STB) was used as an SRC inhibitor. Spontaneously recurrent seizures were monitored from day 7 to day 14 after the KA injection. Nissl's stain and NeuN were used to detect neuron loss and Timm stain was used to evaluate mossy fibre sprouting 14 days after KA injection. We also investigated the effect of SRC on full-length expression of NR2B. MDL28170 was used to inhibit calpain activity. Western blotting and qPCR were performed to verify phosphorylation levels and expression of SRC and NR2B 24 h after KA injection.

Results: The duration of status epileptics in the SRC inhibitor group decreased significantly compared to the KA group 24 h after the injection of KA (P < 0.05). The application of the SRC inhibitor significantly reduced the degree of contralateral mossy fibre sprouting (P < 0.05) and improved the degree of neuron loss (P < 0.01) compared to the epilepsy group. Full-length NR2B levels in the ipsilateral hippocampus decreased in the epilepsy group (P < 0.01) compared to the sham group, and it further decreased in the STB inhibitor group (P < 0.01). The effect of the STB inhibitor was counteracted by simultaneous inhibition of SRC activity and calpain activation, while the level of full-length NR2B increased compared to the KA+STB group(P < 0.01). Reduction of NR2B cleavage by MDL28170 significantly increased the duration of epileptic status compared to the KA group (P < 0.05).

Significance: Our data indicated that the early application of SRC inhibitors exerted protective effects on seizure severity, loss of neurons, and sprouting of mossy fibres in KA-induced mouse epilepsy. Seizure severity attenuation due to SRC inhibition was associated with the decrease of NR2B in both the phosphorylation and full-length forms.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2022.106975DOI Listing
July 2022

The cyclometalated iridium (III) complex based on 9-Anthracenecarboxylic acid as a lysosomal-targeted anticancer agent.

J Inorg Biochem 2022 Jul 6;235:111913. Epub 2022 Jul 6.

School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. Electronic address:

9-Anthracenecarboxylic acid (9-Ac) was reported early as a chloride channel inhibitor and was found to exhibit significant anti-proliferative activity on leukemic cells, but has not been researched in solid tumor cells. Herein, a 9-anthraceneic acid derivative was introduced into the cyclometalated Iridium (III) species to construct a novel Iridium (Ir) complex Ir-9-Ac, [Ir(ppy)(9-Ac-L)]PF (ppy = 2-phenylpyridine, 9-Ac-L = N-((4'-methyl-[2,2'-bipyridin]-4-yl)methyl)anthracene-9-carboxamide), which could accumulated in lysosomes. Ir-9-Ac showed good cytotoxic activity against several tumor cell lines, notably on A549 cells. Besides Ir-9-Ac could inhibit the cell colony formation and growth of the 3D cell spheroids, demonstrating the potential to suppress tumors in vivo. This design provided a platform for the design of cyclometalated Iridium (III) anticancer complexes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2022.111913DOI Listing
July 2022

Neural Dynamics Underlying Cognitive Control Modulated by Reinforcement Learning of Irrelevant Stimulus-Response Associations.

J Cogn Neurosci 2022 Jul 22:1-17. Epub 2022 Jul 22.

South China Normal University.

Human behavioral studies have shown that reward has multifaceted (motivational, learning, and emotional) effects on cognitive control. Past studies have extensively explored the neural underpinning of the motivational effect of reward on cognitive control, but less is known on the other components. The present study investigates the learning effect of reward on cognitive control with a novel paradigm reinforcing task-irrelevant stimulus-response (S-R) associations. We manipulated the contingency of irrelevant spatial stimulus-response-reward between participants (n = 54) in an orthogonal Simon task while EEG recording. The behavioral results showed that the orthogonal Simon effect in RTs and error rates increased or reversed when performance-contingent reward always followed spatially compatible or incompatible trials. The EEG results showed that the initial incorrect activation of the lateralized readiness potential, reflecting response preparation based on irrelevant spatial S-R associations, was present in the incompatible or compatible condition when reward always followed compatible or incompatible trials. Meanwhile, the P3b amplitude also showed a similar pattern of increase or reversal depending on the contingency of irrelevant stimulus-response-reward. These findings suggest that the brain used reward-strengthened irrelevant spatially compatible or incompatible S-R associations to predict responses. Moreover, the frontocentral N2 amplitude and theta band (4-8 Hz) power showed similar reward-related increase or reversal in the conflict effect, suggesting that there was conflict when the response predicted by the reward-strengthened irrelevant S-R associations was different from the correct response. Taken together, these results suggest that reinforcement learning of irrelevant spatial S-R associations can modulate cognitive control.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1162/jocn_a_01895DOI Listing
July 2022

Neural Dynamics Underlying Cognitive Control Modulated by Reinforcement Learning of Irrelevant Stimulus-Response Associations.

J Cogn Neurosci 2022 Jul 22:1-17. Epub 2022 Jul 22.

South China Normal University.

Human behavioral studies have shown that reward has multifaceted (motivational, learning, and emotional) effects on cognitive control. Past studies have extensively explored the neural underpinning of the motivational effect of reward on cognitive control, but less is known on the other components. The present study investigates the learning effect of reward on cognitive control with a novel paradigm reinforcing task-irrelevant stimulus-response (S-R) associations. We manipulated the contingency of irrelevant spatial stimulus-response-reward between participants (n = 54) in an orthogonal Simon task while EEG recording. The behavioral results showed that the orthogonal Simon effect in RTs and error rates increased or reversed when performance-contingent reward always followed spatially compatible or incompatible trials. The EEG results showed that the initial incorrect activation of the lateralized readiness potential, reflecting response preparation based on irrelevant spatial S-R associations, was present in the incompatible or compatible condition when reward always followed compatible or incompatible trials. Meanwhile, the P3b amplitude also showed a similar pattern of increase or reversal depending on the contingency of irrelevant stimulus-response-reward. These findings suggest that the brain used reward-strengthened irrelevant spatially compatible or incompatible S-R associations to predict responses. Moreover, the frontocentral N2 amplitude and theta band (4-8 Hz) power showed similar reward-related increase or reversal in the conflict effect, suggesting that there was conflict when the response predicted by the reward-strengthened irrelevant S-R associations was different from the correct response. Taken together, these results suggest that reinforcement learning of irrelevant spatial S-R associations can modulate cognitive control.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1162/jocn_a_01895DOI Listing
July 2022

downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.

Virulence 2022 12;13(1):1270-1284

Institute of Pathogenic Biology, Hengyang Medical School, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China.

Airway epithelial cells function as both a physical barrier against harmful substances and pathogenic microorganisms and as an important participant in the innate immune system. Matrix metalloproteinase-9 (MMP-9) plays a crucial role in modulating inflammatory responses during respiratory infections. However, the signalling cascade that induces MMP-9 secretion from epithelial cells infected with remains poorly understood. In this study, we investigated the mechanism of MMP-9 secretion in airway epithelial cells infected with . Our data clearly showed that induced the secretion of MMP-9 from bronchial epithelial cells and upregulated its enzymatic activity in a time- and dose-dependent manner. Using specific inhibitors and chromatin co-precipitation experiments, we confirmed that the expression of MMP-9 is reliant on the activation of the Toll-like receptor 2 (TLR2) and TLR6-dependent mitogen-activated protein kinase/nuclear factor- κB/activator protein-1 (MAPK/NF-κB/AP-1) pathways. Additionally, epigenetic modifications such as histone acetylation and the nuclear transcription factor Sp1 also regulate MMP-9 expression. infection also decreased the expression of the tumour suppressor reversion-inducing cysteine-rich protein with Kazal motifs (RECK) by inducing Sp1 phosphorylation. Overexpression of RECK significantly impaired the -triggered increase in MMP-9 enzymatic activity, although the level of MMP-9 protein remained constant. The study demonstrated that -triggered MMP-9 expression is modulated by TLR2 and 6, the MAPK/NF-κB/AP-1 signalling cascade, and histone acetylation, and downregulated the expression of RECK, thereby increasing MMP-9 activity to modulate the inflammatory response, which could play a role in airway remodelling.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/21505594.2022.2101746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336473PMC
December 2022

One-Step Synthesis of Nitrogen/Fluorine Co-Doped Carbon Dots for Use in Ferric Ions and Ascorbic Acid Detection.

Nanomaterials (Basel) 2022 Jul 12;12(14). Epub 2022 Jul 12.

Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.

Carbon dots (CDs) have caught enormous attention owing to their distinctive properties, such as their high water solubility, tunable optical properties, and easy surface modification, which can be generally used for the detection of heavy metals and organic pollutants. Herein, nitrogen and fluorine co-doped carbon dots (NFCDs) were designed via a rapid, low-cost, and one-step microwave-assisted technique using DL-malic acid and levofloxacin. The NFCDs emitted intense green fluorescence under UV lighting, and the optical emission peak at 490 nm was observed upon a 280 nm excitation, with a high quantum yield of 21.03%. Interestingly, the spectral measurements illustrated excitation-independent and concentration-independent single-color fluorescence owing to the presence of nitrogen and fluorine elements in the surface functional groups. Additionally, the NFCDs were applied for the selective detection of Fe and ascorbic acid based on the "turn-off" mode. The detection limits were determined as 1.03 and 4.22 µM, respectively. The quenching mechanisms were explored using the static quenching mechanism and the inner filter effect. Therefore, a NFCDs fluorescent probe with single color emission was successfully developed for the convenient and rapid detection of Fe and ascorbic acid in environments.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nano12142377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323265PMC
July 2022

One-Pot Synthesis of LiFePO/N-Doped C Composite Cathodes for Li-ion Batteries.

Materials (Basel) 2022 Jul 6;15(14). Epub 2022 Jul 6.

Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education, School of Energy and Power Engineering, Xi'an Jiaotong University, 28 Xianning West Road, Xi'an 710049, China.

LiFePO/N-doped C composites with core-shell structures were synthesized by a convenient solvothermal method. Cetyltrimethylammonium bromide (CTAB) and glucose were used as nitrogen and carbon sources, respectively. The growth of LiFePO nanocrystals was regulated by CTAB, resulting in an average particle size of 143 nm for the LiFePO/N-doped C. The N atoms existed in the carbon of LiFePO/N-doped C in the form of pyridinic N and graphitic N. The LiFePO/N-doped C composites delivered discharge specific capacities of 160.7 mAh·g (0.1 C), 128.4 mAh·g (5 C), and 115.8 mAh·g (10 C). Meanwhile, no capacity attenuation was found after 100 electrochemical cycles at 1 C. N-doping enhanced the capacity performance of the LiFePO/C cathode, while the core-shell structure enhanced the cycle performance of the cathode. The electrochemical test data showed a synergistic effect between N-doping and core-shell structure on the enhancement of the electrochemical performance of the LiFePO/C cathode.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma15144738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323570PMC
July 2022
-->