Publications by authors named "Lu Jiang"

563 Publications

Histone demethylase LSD1 promotes RIG-I poly-ubiquitination and anti-viral gene expression.

PLoS Pathog 2021 Sep 16;17(9):e1009918. Epub 2021 Sep 16.

Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, Hubei, China.

Under RNA virus infection, retinoic acid-inducible gene I (RIG-I) in host cells recognizes viral RNA and activates the expression of type I IFN. To investigate the roles of protein methyltransferases and demethylases in RIG-I antiviral signaling pathway, we screened all the known related enzymes with a siRNA library and identified LSD1 as a positive regulator for RIG-I signaling. Exogenous expression of LSD1 enhances RIG-I signaling activated by virus stimulation, whereas its deficiency restricts it. LSD1 interacts with RIG-I, promotes its K63-linked polyubiquitination and interaction with VISA/MAVS. Interestingly, LSD1 exerts its function in antiviral response not dependent on its demethylase activity but through enhancing the interaction between RIG-I with E3 ligases, especially TRIM25. Furthermore, we provide in vivo evidence that LSD1 increases antiviral gene expression and inhibits viral replication. Taken together, our findings demonstrate that LSD1 is a positive regulator of signaling pathway triggered by RNA-virus through mediating RIG-I polyubiquitination.
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http://dx.doi.org/10.1371/journal.ppat.1009918DOI Listing
September 2021

The Application of Skin Care Product in Melasma Treatment.

Clin Cosmet Investig Dermatol 2021 7;14:1165-1171. Epub 2021 Sep 7.

Department of Dermatology, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, 637000, People's Republic of China.

Melasma is an acquired and chronic hyperpigmentation disorder which is recognized as one of the most psychologically distressing and difficult to cure forms of skin hyperpigmentation. It is associated with substantial quality of life impairments. Treatments of melasma include local application, oral medication, physical laser therapy and program combination therapy. However, routine treatment usually leads to the damage of skin barrier function, resulting in adverse reactions such as erythema, pruritus, post-inflammatory pigmentation and even scar. Skin care products contain a variety of active ingredients, which are widely concerned by cosmetic dermatologists because of high safety, good tolerance and the effect of improving the damaged skin barrier. Using skin care products alone or in combination with routine treatment not only can improve the curative effect for melasma, reduce side effects and recurrence rate, but also improve patient satisfaction. This article mainly describes the application of skin care products in the treatment of melasma.
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http://dx.doi.org/10.2147/CCID.S323748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435474PMC
September 2021

SeekDoc: Seeking eligible doctors from electronic health record.

Math Biosci Eng 2021 Jun;18(5):5347-5363

Northeast Normal University, Changchun 130117, China.

With the development of online medical service platform, patients can find more medical information resources and obtain better medical treatment. However, it is difficult for patients to discover the most suitable doctors from the complex information resources. Therefore, the analysis and mining of Electronic Health Record(EHR) is very important for patients' timely and accurate treatment. Discovering the most suitable doctor is actually predicting the exact performance of the doctor for a specific disease. We believe that "a curative/bad treatment is likely to be caused by a good/bad doctor, and a good/bad doctor has a higher/lower evaluation by the patient(s)". In this paper, we propose a novel approach named SeekDoc, which is to seek the most effective doctor for a specific disease. Specifically, we build a doctor-disease heterogeneous information network and collect patients reviews and rating records for doctors. Then, we embed the comprehensive comment data for doctors and the constructed heterogeneous information network. Next, we use the autoencoder mechanism to learn the embedded features, which is an effective learning algorithm for constructing the latent feature representation in an unsupervised manner. After this learning, the latent features are input into the extreme gradient boosting (XGBoost) algorithm to improve their detection capabilities. Finally, extensive experiments show that our method can effectively and efficiently predict the doctor's experience score for specific diseases and has good performance compared with other algorithms.
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http://dx.doi.org/10.3934/mbe.2021271DOI Listing
June 2021

Percutaneous penetration and dermal exposure risk assessment of chlorinated paraffins.

J Hazard Mater 2021 08 23;416:126178. Epub 2021 May 23.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

The widespread occurrence of chlorinated paraffins (CPs) in environmental matrices has resulted in a high frequency exposure to CPs via dermal contact. To quantitatively estimate percutaneous penetration of CPs, Episkin® human skin equivalents (HSE) was applied as an in vitro model to evaluate the mechanism of percutaneous penetration of CPs. The co-exposure of CPs mixtures to HSE showed that about 11.7% and 10.2% of short-chain CPs (SCCPs) and medium-chain CPs (MCCPs) could penetrate the HSE and enter the receptor fluid, while no long-chain CPs (LCCPs) (C>17) were able to penetrate the HSE during the 36-h assay period. The experimentally obtained permeability coefficient (K) values for CPs were significantly (p < 0.01) negatively correlated with their log octanol-water partition coefficient (log K). Furthermore, 24 participants were recruited to assess direct human dermal exposure to CPs in China with the total CPs collected onto hand wipes and forehead wipes being 96,600 and 30,400 ng/person, respectively. The proportion of total SCCPs and MCCPs intake via dermal penetration (skin area investigated in this study) accounting for 2.0% of the total intake of CPs. Considering the total skin surface of human body is around 20 times of the area studied, the total intake of CPs through dermal penetration could be a significant exposure pathway.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126178DOI Listing
August 2021

Characteristics of size-segregated aerosols emitted from an aerobic moving bed biofilm reactor at a full-scale wastewater treatment plant.

J Hazard Mater 2021 08 20;416:125833. Epub 2021 Apr 20.

School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao 266033, PR China. Electronic address:

Aerosol emissions from wastewater treatment plants (WWTPs) have been associated with health reverberation but studies about characteristics of size-segregated aerosol particulate matter (PM) are scarce. In this study, the measurement of particulate number size distribution in the range of < 10 µm, and the collection of PM, PM and PM, were conducted from an aerobic moving bed biofilm reactor (MBBR) at a full-scale WWTP. MBBR aerosols showed a unimodal number size distribution, with the majority of particles (>94%) in the ultrafine size range (<100 nm). For toxic metal(loid)s or potential pathogens, significant differences were found within MBBR aerosols (PM, PM, and PM), and also between MBBR aerosols and wastewater. Both wastewater and ambient air had important source contributions for MBBR aerosols. The compositions of toxic metal(loid)s in PM, and the populations of potential bacterial or fungal pathogens in PM and PM, were dominated by that from wastewater. Compared to PM and PM, PM had the highest aerosolization potential for the toxic metal(loid)s of As, Cd, Co, Cr, Li, Mn, Ni, U, and Zn, and the genera of Acinetobacter, Pseudomonas and Fusarium. Due to the size-segregated specialty, targeted measures should be employed to reduce the health risks. CAPSULE: The compositions of toxic metal(loid)s in PM, and the populations of potential pathogens in PM and PM, were dominated by that from wastewater.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125833DOI Listing
August 2021

Fetal malnutrition is associated with impairment of endogenous melatonin synthesis in pineal via hyper-methylation of promoters of protein kinase C alpha and cAMP-response element-binding.

J Pineal Res 2021 Sep 6:e12764. Epub 2021 Sep 6.

National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, 150081, P. R. China.

This study investigated whether and how fetal-malnutrition would influence endogenous melatonin synthesis, and whether such effect of fetal-malnutrition would transmit to the next generation. We enrolled 2466 participants and 1313 their offspring. The urine 6-hydroxymelatonin-sulfate and serum melatonin-rhythm were measured. Methylation microarrays detection and bioinformatics analysis were performed to identify hub methylated-sites. Additionally, rat experiment was performed to elucidate mechanisms. The participants with fetal-malnutrition had lower 6-hydroxymelatonin-sulfate(16.59±10.12μg/24h vs. 24.29±11.99μg/24h, P<0.001) and arear under curve of melatonin-rhythm(67.11±8.16pg/ml vs. 77.11±8.04pg/ml, P<0.001). We identified 961 differentially methylated-sites, in which the hub methylated-sites were locating on protein kinase-C alpha(PRKCA) and cAMP-response element-binding protein(CREB1) promoters, mediating the association of fetal-malnutrition with impaired melatonin secretion. However, such effects were not observed in the offspring(all P>0.05). Impaired histomorphology of pineal, decreased melatonin in serum, pineal and pinealocyte were also found in the vivo- and vitro-experiments(P<0.05 for the differences of the indicators). Hyper-methylation of 10 CpG-sites on the PRKCA-promoter, and 8 CpG-sites on the CREB1-promoter were identified(all P<0.05), which down-regulated PRKCA and CREB1 expressions, leading to decreased expression of AANAT, and then resulting in the impaired melatonin synthesis. Collectively, fetal-malnutrition can impair melatonin synthesis through hyper-methylation of PRKCA and CREB1 promoters, and such effects cannot be transmitted to the next generation.
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http://dx.doi.org/10.1111/jpi.12764DOI Listing
September 2021

Epigenetic regulation of ion channels in the sense of taste.

Pharmacol Res 2021 Aug 24;172:105760. Epub 2021 Aug 24.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Electronic address:

There are five fundamental tastes discovered so far: sweet, bitter, umami, sour and salty. Taste is mediated by the specialized neuroepithelial cells mainly located at the tongue papillae, namely taste receptor cells, which can be classified into type I, type II, type III and type IV. Ion channels are necessary for diverse cell physiological activities including taste sensing, smell experience and temperature perception. Existing evidences have demonstrated distinct structures and working models of ion channels. Epigenetic modifications regulate gene expression mainly through histone modifications, DNA methylation and non-coding RNA-mediated regulation, without altering DNA sequence. This review summarizes how ion channels work during the transduction of multiple tastes, as well as the recent progressions in the epigenetic regulation of ion channels.
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http://dx.doi.org/10.1016/j.phrs.2021.105760DOI Listing
August 2021

Arabidopsis cryptochrome 1 undergoes COP1 and LRBs-dependent degradation in response to high blue light.

New Phytol 2021 Aug 27. Epub 2021 Aug 27.

Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China.

Arabidopsis CRY1 is an important blue light photoreceptor that promotes photomorphogenesis under blue light. The blue light photoreceptors CRY2 and PHOT1, and the red/far-red light photoreceptors phyB and phyA undergo degradation in response to blue and red light, respectively. The present study investigated whether and how CRY1 might undergo degradation in response to high intensity blue light (HBL). We demonstrated that CRY1 is ubiquitinated and degraded through the 26S proteasome pathway in response to HBL. We found that the E3 ubiquitin ligase COP1 is involved in mediating HBL-induced ubiquitination and degradation of CRY1. We also found that the E3 ubiquitin ligases LRBs physically interact with CRY1 and are also involved in mediating CRY1 ubiquitination and degradation in response to HBL. We further demonstrated that BIC1 interacts with CRY1 in a blue light-dependent manner to inhibit CRY1 dimerization/oligomerization, leading to the repression of HBL-induced degradation of CRY1. Our findings indicate that the regulation of CRY1 stability in HBL is coordinated by COP1 and LRBs, which provides a mechanism by which CRY1 attenuates its own signaling and optimize photomorphogenesis under HBL.
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http://dx.doi.org/10.1111/nph.17695DOI Listing
August 2021

Molybdenum and cadmium co-induce mitophagy and mitochondrial dysfunction via ROS-mediated PINK1/Parkin pathway in Hepa1-6 cells.

Ecotoxicol Environ Saf 2021 Aug 12;224:112618. Epub 2021 Aug 12.

Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang 330045, Jiangxi, PR China. Electronic address:

Excessive molybdenum (Mo) and Cadmium (Cd) can adversely affect health status. However, the correlation between mitophagy and mitochondrial dysfunction caused by Mo and Cd and the underlying mechanisms are still unknown. The aim of this study was to investigate the relationship between mitophagy and mitochondrial dysfunction via the ROS-mediated PINK1/Parkin pathway caused by Mo and Cd. Here, Hepa1-6 cells were incubated with (NH)MoO.4 HO (600.0 μM Mo), CdCl (10.0 μM Cd), and the combination of reactive oxygen species (ROS) scavenger (N-acetyl-L-cysteine, NAC, 100.0 μM), or mitophagy inhibitor (Cyclosporin A, CsA, 1.0 μM) for 24 h. Results revealed that Mo or/and Cd elevated the level of intracellular ROS and malondialdehyde (MDA) content, reduced superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities. Additionally, Mo or/and Cd could observably increase the percentage of cells with low membrane potential and decrease the content of ATP, elevate the number of autophagosomes and LC3 puncta, upregulate the mRNA and protein levels of LC3II/LC3I, Parkin, Pink1, VDAC1, downregulate mRNA and protein levels of P62. Moreover, treatments with NAC could significantly alleviate the changes of the above factors co-induced by Mo and Cd, and CsA intensify the changes of the above factors. In summary, our results reveal that Mo and Cd co-exposure can cause oxidative stress and mitophagy via the ROS-mediated PINK1/Parkin pathway in Hepa1-6 cells, and inhibition of mitophagy aggravates Mo and Cd co-induced mitochondrial dysfunction.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112618DOI Listing
August 2021

The Application of Targeted RNA Sequencing for KMT2A-Partial Tandem Duplication Identification and Integrated Analysis of Molecular Characterization in Acute Myeloid Leukemia.

J Mol Diagn 2021 Aug 10. Epub 2021 Aug 10.

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

The partial tandem duplication of histone-lysine N-methyltransferase 2A (KMT2A-PTD) is an important genetic alteration in acute myeloid leukemia (AML) and is associated with poor clinical outcome. Accurate and rapid detection of KMT2A-PTD is important for outcome prediction and clinical management, but next-generation sequencing-based quantitative research is still lacking. In this study, we developed a targeted RNA-based next-generation sequencing panel, together with single primer enrichment and unique molecular identifiers, to identify KMT2A-PTD as well as AML-related gene fusions and other driver mutations. Our panel showed high sensitivity, accuracy, and reproducibility in detecting the fusion ratio of KMT2A-PTD. We characterized the mutation profile of KMT2A-PTD-positive patients with AML and found different distribution patterns of driver mutations according to KMT2A-PTD fusion ratio level. Survival analyses revealed that the fusion ratio of KMT2A-PTD did not affect clinical outcome, but a novel molecular combination, namely, KMT2A-PTD/DNMT3A/FMS-like tyrosine kinase 3-internal tandem duplication, was associated with poor prognosis. Finally, we proved that the dynamic changes in the KMT2A-PTD fusion ratio were consistent with the overall process of disease progression. In summary, we applied the unique molecular identifier-based RNA panel to quantitatively detect KMT2A-PTD and elucidate its clinical relevance, which complemented the integrative network of various genetic alterations in AML.
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http://dx.doi.org/10.1016/j.jmoldx.2021.07.019DOI Listing
August 2021

Closing-wedge distal femoral osteotomy combined with medial patellofemoral ligament reconstruction for recurrent patellar dislocation with genu valgum.

BMC Musculoskelet Disord 2021 Aug 9;22(1):668. Epub 2021 Aug 9.

Department of Orthopedics, Affiliated Hospital to Shandong University of Traditional Chinese Medicine, Jinan, 250011, China.

Background: Medial patellofemoral ligament reconstruction (MPFLR) is a well-established procedure for addressing recurrent patellar dislocation (RPD) in young patients. However, despite being a promising procedure for RPD with genu valgum, there is a scarcity of reports on simultaneous MPFLR and closing-wedge distal femoral osteotomy (CWDFO). The purpose of the present study was to observe and analyse the clinical and imaging findings of CWDFO combined with MPFLR for RPD with genu valgum.

Methods: From May 2015 to April 2018, 25 patients with RPD and genu valgum were surgically treated in our department. Anteroposterior long-leg, weight-bearing, lower-extremity radiographs, lateral radiographs and computed tomography (CT) scans of the patellofemoral joint were obtained, and the anatomical femorotibial angle (aFTA), mechanical lateral distal femoral angle (mLDFA), weight-bearing line rate (WBLR), patellar height, patellar lateral shift (PLS) and tibial tubercle-trochlear groove (TT-TG) distance were analysed. Validated knee scores, such as the Kujala, Lysholm, visual analogue scale (VAS) scores and Tegner socres, were evaluated preoperatively and 2 years postoperatively.

Results: 25 patients, with an average age of 19.8 years (14-27), were evaluated. During the 2-year follow-up period, all patients were able to achieve a better sports level without any problems, with no recurrence of patellar instability. Compared with preoperation, the aFTA, mLDFA, WBLR and PLS showed statistically significant improvement following the procedure (p < 0.001). Meanwhile, no significant differences in the Insall index and TT-TG distance were found. The mean Kujala score, average Lysholm score, VAS score and Tegner socres showed significant postoperative improvement.

Conclusions: CWDFO combined with MPFLR is a suitable treatment for RPD with genu valgum, and can lead to significant improvement in the clinical and imaging findings of the knee in the short term.
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http://dx.doi.org/10.1186/s12891-021-04554-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351451PMC
August 2021

Heterotic quantitative trait loci analysis and genomic prediction of seedling biomass-related traits in maize triple testcross populations.

Plant Methods 2021 Jul 30;17(1):85. Epub 2021 Jul 30.

Jiangsu Provincial Key Laboratory of Agrobiology, Institute of Germplasm Resources and Biotechnology, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.

Background: Heterosis has been widely used in maize breeding. However, we know little about the heterotic quantitative trait loci and their roles in genomic prediction. In this study, we sought to identify heterotic quantitative trait loci for seedling biomass-related traits using triple testcross design and compare their prediction accuracies by fitting molecular markers and heterotic quantitative trait loci.

Results: A triple testcross population comprised of 366 genotypes was constructed by crossing each of 122 intermated B73 × Mo17 genotypes with B73, Mo17, and B73 × Mo17. The mid-parent heterosis of seedling biomass-related traits involved in leaf length, leaf width, leaf area, and seedling dry weight displayed a large range, from less than 50 to ~ 150%. Relationships between heterosis of seedling biomass-related traits showed congruency with that between performances. Based on a linkage map comprised of 1631 markers, 14 augmented additive, two augmented dominance, and three dominance × additive epistatic quantitative trait loci for heterosis of seedling biomass-related traits were identified, with each individually explaining 4.1-20.5% of the phenotypic variation. All modes of gene action, i.e., additive, partially dominant, dominant, and overdominant modes were observed. In addition, ten additive × additive and six dominance × dominance epistatic interactions were identified. By implementing the general and special combining ability model, we found that prediction accuracy ranged from 0.29 for leaf length to 0.56 for leaf width. Different number of marker analysis showed that ~ 800 markers almost capture the largest prediction accuracies. When incorporating the heterotic quantitative trait loci into the model, we did not find the significant change of prediction accuracy, with only leaf length showing the marginal improvement by 1.7%.

Conclusions: Our results demonstrated that the triple testcross design is suitable for detecting heterotic quantitative trait loci and evaluating the prediction accuracy. Seedling leaf width can be used as the representative trait for seedling prediction. The heterotic quantitative trait loci are not necessary for genomic prediction of seedling biomass-related traits.
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http://dx.doi.org/10.1186/s13007-021-00785-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325263PMC
July 2021

Fish oil-based lipid emulsion alleviates parenteral nutrition-associated liver diseases and intestinal injury in piglets.

JPEN J Parenter Enteral Nutr 2021 Jul 21. Epub 2021 Jul 21.

Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Thisstudy aimed to investigate the impact of fish oil-based lipid emulsion (FO) on enterohepatic injuries and intestinal microbiota in piglets of parenteral nutrition (PN).

Methods: Newborn piglets were divided into three groups, including enteral diet (the controls), PN with 100% FO and PN with medium-chain triglyceride/long-chain triglyceride-based lipid emulsion (MCT/LCT) for 14 days. Serum biochemical indicators, hepatic and intestinal histology, and expression of genes associated with inflammation, oxidative stress, and lipid metabolism were measured. The bile acid (BA) profiles in serum and the taxonomic composition of the gut microbiome in different intestinal segments were analyzed.

Results: Compared with MCT/LCT-piglets, FO reduced inflammation, promoted fatty acid oxidation, and decreased oxidative stress in the liver. In the intestine, FO decreased intestinal inflammation and intestinal permeability, leading to reduced lipopolysaccharide entry into the blood circulation relative to MCT/LCT-piglets. PN groups have dominant contents of Proteobacteria and Bacteroides, whereas the control group have Firmicutes at the phylum level. FO altered the taxonomic compositions of the gut microbiome in different segments, increased the relative abundance of Bacteroidaceae in ileum, and Rikenellaceae and Ruminococcaceae in the colon. FO treatment shifted BA composition ratio in serum and had a lower ratio of secondary BAs to primary BAs.

Conclusion: FO alleviates PNLAD and intestinal injury by regulating the homeostasis of BAs' enterohepatic circulation and altering microbiota composition in different intestinal segments.
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http://dx.doi.org/10.1002/jpen.2229DOI Listing
July 2021

Silencing of a putative alanine aminotransferase (ALT) gene influences free amino acid composition in hemolymph and fecundity of the predatory bug, Cyrtorhinus lividipennis Reuter.

Arch Insect Biochem Physiol 2021 Jul 19:e21836. Epub 2021 Jul 19.

College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu Province, China.

In Asian rice systems, Cyrtorhinus lividipennis Reuter is an important predator that preys on rice planthopper eggs and young nymphs, as a primary food source. Alanine aminotransferase (ALT) acts in many physiological and biochemical processes in insects. We cloned the full-length complementary DNA of C. lividipennis ClALT. Expression analysis showed higher expression in the fat body and midgut compared to other tissues. It is expressed in all C. lividipennis developmental stages and at least four organs. Silencing of ClALT by RNA interference significantly decreased the ClALT enzyme activity and ClALT expression compared to dsGFP-treated controls at 2 days after emergence (DAE). Silencing of ClALT influenced free hemolymph amino acid compositions, resulting in a reduction of Aspartic acid (Asp) and Alanine (Ala) proportions, and increased Cysteine (Cys) and Valine (Val) proportions in females at 2 DAE. dsClALT treatments led to decreased soluble total protein concentrations in ovary and fat body, and to lower reduced vitellogenin (Vg) expression, body weight, and the numbers of laid eggs. The double-stranded RNA viruse treatments also led to prolonged preoviposition periods and hindered ovarian development. Western blot analysis indicated that silencing ClALT also led to reduced fat body Vg protein abundance at 2 DAE. These data support our hypothesis that ClALT influences amino acid metabolism and fecundity in C. lividipennis.
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http://dx.doi.org/10.1002/arch.21836DOI Listing
July 2021

The incidence and location of epicardial connections in the era of contact force guided ablation for pulmonary vein isolation.

J Cardiovasc Electrophysiol 2021 Sep 27;32(9):2381-2390. Epub 2021 Jul 27.

Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The effects of epicardial connections (ECs) involving pulmonary veins (PVs) in atrial fibrillation (AF) ablation have been revealed recently. However, no systematic approaches to identify and ablate the ECs were established.

Methods: Patients with AF undergoing radiofrequency (RF) catheter ablation were retrospectively analyzed. ECs were identified when (1) PV isolation (PVI) cannot be achieved after first-pass isolation; (2) PVI was still absent although the conduction gap was detected and ablated; (3) the earliest activation area (EAA) was revealed located within the PV antrum distant from the initial ablation line using high-density mapping (HDM) technique; (4) focal ablation at the EAA was effective to achieve PVI. Relevant pacing maneuvers were performed to elucidate ECs' bidirectional conduction.

Results: Overall, 36 ECs were identified and ablated in 35/597 (5.86%) patients. Among the 35 patients with ECs, at least one PV insertion of ECs was located at the carina region. The most common pattern was a single breakthrough in 31 (88.6%) patients, followed by multiple breakthroughs in 3 and wide breakthroughs in 1. The median distance from EAA to the initial ablation line was 10.0 mm. The average number of RF energy delivery was 1.75 ± 1.00, and single RF delivery was adequate in 16/36 (44.4%) patients. Continuous potentials were present at the EAA in 9/34 (26.5%) patients.

Conclusion: ECs were confirmed and ablated successfully in 5.86% (35/597) AF patients using HDM. PV insertions of ECs were mainly located at the carina region. Continuous potentials might assist in the prediction of ECs.
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http://dx.doi.org/10.1111/jce.15174DOI Listing
September 2021

Eu-doped layered gadolinium hydroxides as drug carriers and their bactericidal behavior.

Mater Sci Eng C Mater Biol Appl 2021 Aug 31;127:112213. Epub 2021 May 31.

Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, 19-Xinjiekouwai Street, Haidian District, Beijing 100875, China. Electronic address:

Layered rare earth hydroxides (LRHs) due to outstanding photoluminescence (PL) properties and anion exchangeability are extensively reported in multiple fields. In this work, the drug-loaded and bactericidal behaviors of Eu-doped layered gadolinium hydroxides (LGdHs:Eu) as optical carriers were explored through intercalation and release of cephalexin (CE). In the intercalation state, the PL intensity of CE--LGdHs:Eu obviously decreased because of the quenching effect of CE-. And the PL intensity of LGdHs:Eu was restored with the release of CE- ions in phosphate buffer solutions (PBS). A significant functional relationship between the drug releasing amount and PL intensity ratio was found, providing a novel optical method to specify the drug dosage. And CE--LGdHs:Eu showed the excellent bactericidal properties in both in vivo and in vitro experiments.
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http://dx.doi.org/10.1016/j.msec.2021.112213DOI Listing
August 2021

Spectroscopic and docking studies of the interaction mechanisms of xylitol with α-casein and κ-casein.

Colloids Surf B Biointerfaces 2021 Oct 17;206:111930. Epub 2021 Jun 17.

College of Food Science, Shenyang Agriculture University, Shenyang, 110866, China. Electronic address:

The molecular interactions of xylitol (XY) with α-casein (α-CN) and κ-casein (κ-CN) at pH 7.4 as a function of temperature (298, 308, and 318 K) were characterized by multispectral techniques and molecular docking. The fluorescence results showed that XY strongly quenched the intrinsic fluorescence of α- and κ-CN by static quenching, as well as the presence of a single binding site for XY on both proteins with a binding constant value of ∼10 L/mol. The binding affinity of both proteins for XY decreased with increasing temperature, and Van der Waals forces, hydrogen bonding and protonation were the key forces in the interactions. The addition of XY altered the polarity of the microenvironment of proteins and changed their secondary structure from ordered to disordered. The molecular docking results showed that XY had different binding sites to α- and κ-CN, with several amino acids involved in the binding processes.
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http://dx.doi.org/10.1016/j.colsurfb.2021.111930DOI Listing
October 2021

Application of medical magnifying loupes in diagnosis of oral mucosal diseases.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 04;50(2):205-211

Department of Oral Medicine.

: To evaluate the application of medical magnifying loupes in diagnosis of oral mucosal diseases. Twenty-four patients with plaque-type oral lichen planus or homogeneous oral leukoplakia were inspected by naked eyes or assistance with magnifying loupes. Histopathological results were used as the gold standard to evaluate the sensitivity, specificity and accuracy of the two methods in clinical diagnosis. Questionnaires were used to evaluate the subjective effect of magnifying loupes on the diagnosis efficiency of oral mucosal diseases and to explore the most suitable parameters for application. The sensitivity, specificity and accuracy of medical magnifying loupes for the identification of plaque-type oral lichen planus and homogeneous oral leukoplakia were 94.74%, 100.00% and 95.83%, respectively, which were significantly higher than those of naked eye inspection (89.47%, 80.00% and 87.50%). The effective rate of magnifying loupes assisted diagnosis was 91.76% according to physicians' subjective evaluation. The most suitable parameters were 3.5 times magnification and working distance. The medical magnifying loupes can effectively improve the efficiency of the inspection and diagnosis of oral mucosal diseases, and have the characteristics of convenience and real-time. The recommended clinical parameters are 3.5 times magnification and working distance.
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http://dx.doi.org/10.3724/zdxbyxb-2021-0132DOI Listing
April 2021

Analysis of microbial community diversity of muscadine grape skins.

Food Res Int 2021 07 19;145:110417. Epub 2021 May 19.

Guangxi Crop Genetic Improvement and Biotechnology Key Lab, Guangxi Academy of Agricultural Sciences, Nanning 530007, Guangxi, China. Electronic address:

Microorganisms in grape skins play vital roles in grapevine health, productivity, wine quality and organoleptic properties. To investigate microbial diversity of muscadine grape skins, 16S and ITS sequences of 30 samples from six muscadine (Muscadinia rotundifolia Michx.) cultivars grown in Guangxi, China, were sequenced using Illumina Novaseq platform. A total of 7,317 bacterial operational taxonomic units (OTUs) and 1,611 fungal OTUs were obtained, and clustered into 38 bacterial and 7 known fungal phyla. The dominant bacterial phyla were Proteobacteria, Firmicutes, Bacteroidetes, Planctomycetes, Actinobacteria, Verrucomicrobia, Acidobacteria, and Patescibacteria, and the dominant genera were Lelliottia, Prevotella_9, Escherichia-Shigella, Lactobacillus, Pseudomonas, Akkermansia, Faecalibacterium, Rahnella, and Acinetobacter. For fungi, the dominant phyla were Ascomycota, Basidiomycota, and Mortierellomycota, and the dominant genera were Acaromyces, Uwebraunia, Penicillium, Zygosporium, Ilyonectria, Aspergillus, Neodevriesia, Strelitziana, Mortierella, and Fusarium. Alpha diversity analysis and Kruskal-Wallis H test demonstrated that microbial diversity and composition were affected by the cultivar. The Pearson correlation analysis of species revealed complex interactions among microbes. PICRUSt2 predicted that the metabolism of carbohydrates, cofactors, vitamins, amino acids, terpenoids, polyketides, lipids and biosynthesis of other secondary metabolites were abundant. These results contribute to understanding the uniqueness of muscadine grapes and the links among microorganisms in grape skins.
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http://dx.doi.org/10.1016/j.foodres.2021.110417DOI Listing
July 2021

Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19.

Cell Discov 2021 Jun 8;7(1):42. Epub 2021 Jun 8.

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The pathophysiology of coronavirus disease 19 (COVID-19) involves a multitude of host responses, yet how they unfold during the course of disease progression remains unclear. Here, through integrative analysis of clinical laboratory tests, targeted proteomes, and transcriptomes of 963 patients in Shanghai, we delineate the dynamics of multiple circulatory factors within the first 30 days post-illness onset and during convalescence. We show that hypercortisolemia represents one of the probable causes of acute lymphocytopenia at the onset of severe/critical conditions. Comparison of the transcriptomes of the bronchoalveolar microenvironment and peripheral blood indicates alveolar macrophages, alveolar epithelial cells, and monocytes in lungs as the potential main sources of elevated cytokines mediating systemic immune responses and organ damages. In addition, the transcriptomes of patient blood cells are characterized by distinct gene regulatory networks and alternative splicing events. Our study provides a panorama of the host responses in COVID-19, which may serve as the basis for developing further diagnostics and therapy.
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http://dx.doi.org/10.1038/s41421-021-00274-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185699PMC
June 2021

Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model.

Cell Death Dis 2021 06 2;12(6):568. Epub 2021 Jun 2.

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University (SJTU) School of Medicine, Shanghai, China.

GATA2, a key transcription factor in hematopoiesis, is frequently mutated in hematopoietic malignancies. How the GATA2 mutants contribute to hematopoiesis and malignant transformation remains largely unexplored. Here, we report that Gata2-L359V mutation impeded hematopoietic differentiation in murine embryonic and adult hematopoiesis and blocked murine chronic myeloid leukemia (CML) cell differentiation. We established a Gata2-L359V knockin mouse model in which the homozygous Gata2-L359V mutation caused major defects in primitive erythropoiesis with an accumulation of erythroid precursors and severe anemia, leading to embryonic lethality around E11.5. During adult life, the Gata2-L359V heterozygous mice exhibited a notable decrease in bone marrow (BM) recovery under stress induction with cytotoxic drug 5-fluorouracil. Using RNA sequencing, it was revealed that homozygous Gata2-L359V suppressed genes related to embryonic hematopoiesis in yolk sac, while heterozygous Gata2-L359V dysregulated genes related to cell cycle and proliferation in BM LinSca1c-kit cells. Furthermore, through chromatin immunoprecipitation sequencing and transactivation experiments, we found that this mutation enhanced the DNA-binding capacity and transcriptional activities of Gata2, which was likely associated with the altered expression of some essential genes during embryonic and adult hematopoiesis. In mice model harboring BCR/ABL, single-cell RNA-sequencing demonstrated that Gata2-L359V induced additional gene expression profile abnormalities and partially affected cell differentiation at the early stage of myelomonocytic lineage, evidenced by the increase of granulocyte-monocyte progenitors and monocytosis. Taken together, our study unveiled that Gata2-L359V mutation induces defective hematopoietic development and blocks the differentiation of CML cells.
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http://dx.doi.org/10.1038/s41419-021-03826-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173010PMC
June 2021

The influence mechanism of dissolved organic matter on the adsorption of Cd (II) by calcite.

Environ Sci Pollut Res Int 2021 Jul 1;28(28):37120-37129. Epub 2021 Jun 1.

School of Environment and Energy, South China University of Technology, Guangzhou, 510006, People's Republic of China.

Dissolved organic matter (DOM) has been widely existed in the soil, which has great influence on the adsorption of heavy metals by minerals. In this paper, the effects of DOM on Cd (II) adsorption by calcite were studied. In the presence of DOM (5 mg/L, 10 mg/L, and 20 mg/L), the maximum sorption of Cd (II) by calcite reduced from 48.94 mg/g to 44.14 mg/g, 28.11 mg/g, and 22.30 mg/g, respectively. The characterizations (XRD, SEM, XPS, FTIR, 3D-EEM, and UHPLC-Q-Orbitrap) were used to further study the mechanism about the effects of DOM on the adsorption of Cd (II) by calcite. These results showed calcite exhibited a significant adsorption capacity for Cd (II) at pH = 6.0, and CdCO was formed on the surface of calcite after calcite reaction with Cd (II). Meanwhile, the fractionation of DOM by calcite could change the binding characteristics of DOM to calcite, which would increase the migration of Cd (II) in the solution. After the reaction of DOM with Cd (II) and calcite, Cd (II)-DOM complex was formed, and part of calcite was dissolved in the solution which would further increase the migration of Cd (II) and decrease the adsorption of Cd (II) by calcite. This paper might help further understand the effect of calcite and DOM on the environmental behavior of Cd (II) in the soil environment.
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http://dx.doi.org/10.1007/s11356-021-14585-zDOI Listing
July 2021

Management of oral leukoplakia: a position paper of the Society of Oral Medicine, Chinese Stomatological Association.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jul 26;132(1):32-43. Epub 2021 Mar 26.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Medicine of West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objective: The objective of this study was to develop the first edition of a Chinese evidence-based position paper on the management of oral leukoplakia (OLK).

Study Design: The consultant group for drafting the position paper consisted of 31 oral medicine specialists and 2 evidence-based medicine specialists. English studies (searched in PubMed, EMBASE, and the Cochrane Library) and Chinese studies (searched in China National Knowledge Infrastructure and WanFang) published before January 2018 were used. The quality of the study was assessed using the Grading of Recommendations Assessment, Development, and Evaluation grid, and the strength of the recommendations was determined based on the results of 3 rounds of voting among the consultant group members using the Delphi method.

Results: Twenty-two evidence-based guidelines for clinical management and monitoring of OLK were established in this position paper. A clinical path diagram for oral health practitioners was constructed based on the recommendations.

Conclusion: Current evidence suggests that management and monitoring of patients with OLK should be performed by experienced clinicians to control the lesion and for early detection of malignant transformation. However, all recommendations are based on evidence of low or extremely low quality and may require further modification as new evidence is produced.
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http://dx.doi.org/10.1016/j.oooo.2021.03.009DOI Listing
July 2021

Post-cesarean section pemphigus vegetans in a young woman treated with methylprednisolone and thalidomide.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Aug 11;132(2):e62-e68. Epub 2021 Feb 11.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Pemphigus vegetans is a rare variant of pemphigus vulgaris. Here, we report a rare case of postparturition pemphigus vegetans in a young woman without any prior medical history. The patient presented with extensive oral mucosal erosion, conjunctivitis, and fingernail dystrophy. A histopathological biopsy taken from the tongue showed pseudoepitheliomatous hyperplasia of the epidermis with eosinophilic spongiosis, and an intraepidermal cleft and direct immunofluorescence showed intercellular immunoglobulin G and complement component C3 deposition. A final diagnosis of pemphigus vegetans was made on the basis of clinical and histopathological features and laboratory findings. Complete remission was achieved by a combination of methylprednisolone and thalidomide. This case report indicates that the occurrence of postparturition pemphigus vegetans is strongly associated with immune status related to hormone levels throughout pregnancy and postparturition. Furthermore, it suggests that a combination of methylprednisolone and thalidomide may be an effective option for pemphigus vegetans treatment.
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http://dx.doi.org/10.1016/j.oooo.2021.02.004DOI Listing
August 2021

PD-1 blockade prevents the progression of oral carcinogenesis.

Carcinogenesis 2021 Jun;42(6):891-902

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in the head and neck with a poor prognosis. Oral cancer development is a multistep process involving carcinogenesis. Though significant advances in cancer immunotherapy over the years, there is lack of evidence for T-cell exhaustion during oral carcinogenesis. Clinical specimens from healthy donors and patients diagnosed with oral leukoplakia (OLK) or OSCC were collected for immunohistochemical staining with PD-L1, CD86, CD8, PD-1 and CTLA-4 antibodies. Meanwhile, chemically induced mouse models of oral carcinogenesis were constructed with 4-nitroquinolone-N-oxide induction. Exhaustion status of T cells was measured by flow cytometry for spleens and by multiplex immunohistochemistry for formalin-fixed paraffin-embedded lesions in multiple stages of oral carcinogenesis. The efficacy of PD-1 blockade with or without cisplatin treatment was evaluated on the mice in precancerous and OSCC stages. We observed higher expression of PD-1 in the human OLK and OSCC tissues compared with the normal, while low expression CTLA-4 in all oral mucosa tissues. Animal experiments showed that the exhausted CD4+ T cells existed much earlier than exhausted CD8+ T cells, and an increased ratio of stem-like exhausted T cells and partially exhausted T cells were detected in the experimental groups. Besides, the expression of immune checkpoint markers (PDCD1, CTLA4 and HAVCR2) was strongly positively correlated with cytokines (IFNG and IL-2). In summary, T-cell exhaustion plays a vital role in oral carcinogenesis, and PD-1 blockade can prevent the progression of oral carcinogenesis.
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http://dx.doi.org/10.1093/carcin/bgab035DOI Listing
June 2021

What factors affect the water saving behaviors of farmers in the Loess Hilly Region of China?

J Environ Manage 2021 Aug 11;292:112683. Epub 2021 May 11.

Key Lab of Pollution Ecology & Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, 110016, China; College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, 730000, China. Electronic address:

Water shortage has become one of the most serious challenges faced by humans. Thus, improving water use behaviors and saving water are critical. In this paper, based on the extended Value-Belief-Norm (VBN) theory, we used the structural equation model and the survey data of 558 households in the Loess Hilly Region to analyze the key factors affecting water saving behaviors of farmers. The domestic water consumption of farmers in Loess Hilly Region is mainly for diet and personal hygiene. The water-saving behaviors of farmers are significantly affected by their willingness, knowledge and age. Personal habits, policy incentives, egocentric values and biospheric values indirectly affect the willingness to save water by acting on personal water-saving norms. Gender and annual household income also have a significant impact on water-saving willingness of farmers. The estimation results of multi-group structural equation model and full-sample structural equation model are generally consistent, and there are significant differences in the influence of gender and water source adjustment variables on water-saving behaviors among different hypothetical paths. Among them, female, cellar water and well water groups have the greater impact on water-saving behaviors. These results provide references for policy makers to formulate effective rural water-saving strategies. Policymakers should strengthen the propagandize of water-saving knowledge and skills, popularize knowledge about water resources and ecological environment changes, encourage farmers to develop good water use habits, and actively promote the subsidy system for water-saving appliances. Then they should establish a supervision and management mechanism of water resources to stimulate farmers to save water, which realize the sustainable use of local water resources.
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http://dx.doi.org/10.1016/j.jenvman.2021.112683DOI Listing
August 2021

The U.S. food and drug administration's role in improving radiation dose management for medical x-ray imaging devices.

Br J Radiol 2021 May 14:20210373. Epub 2021 May 14.

Center for Devices and Radiological Health U.S. Food and Drug Administration Silver Spring, MD, USA.

The U.S. Food and Drug Administration (FDA) has been concerned with minimizing the unnecessary radiation exposure of people for half a century. Manufacturers of medical X-ray imaging devices are important partners in this effort. Medical X-ray imaging devices are regulated under both FDA's electronic product regulations and FDA's medical device regulations. FDA also publishes guidance documents that represent FDA's current thinking on a topic and provide a suggested or recommended approach to meet the requirements of a regulation or statute. FDA encourages manufacturers to develop medical devices that conform to voluntary consensus standards. Use of these standards is a central element of FDA's system to ensure that all medical devices marketed in the U.S. meet safety and effectiveness requirements. FDA staff participate actively in the development and maintenance of these standards, often advancing or introducing new safety and dose management requirements. Use of voluntary consensus standards reduces the amount of time necessary to evaluate a premarket submission and reduces the burden on manufacturers. FDA interacts with industry and other stakeholders through meetings with industry groups, public meetings, public communications, and through the development of voluntary consensus standards. In these interactions, FDA staff introduce new concepts for improving the safety of these devices and provide support for similar initiatives from professional organizations. FDA works with all stakeholders to achieve its mission of protecting and promoting the public health.
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http://dx.doi.org/10.1259/bjr.20210373DOI Listing
May 2021

Preparation of V-type porous starch by amylase hydrolysis of V-type granular starch in aqueous ethanol solution.

Int J Biol Macromol 2021 Jul 6;183:890-897. Epub 2021 May 6.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China. Electronic address:

In this paper, a novel porous starch with a V-type crystalline structure and high adsorption capacity was obtained by enzymatic hydrolysis of V-type granular starch (VGS) in an aqueous ethanol solution. The effects of different starch concentrations, reaction temperatures, and ethanol concentrations on the microstructure, crystal morphology, crystallinity and adsorption properties of VGS before and after enzymatic hydrolysis were studied, and native normal corn starch (NNCS) and A-type porous starch (APS) prepared by enzymatic hydrolysis of NNCS were used as controls. The results showed that compared with NNCS, VGS was easier to hydrolyze with a higher hydrolysis degree and the corresponding V-type porous starch (VPS) had more and larger pores and thus showed better adsorption performance than APS. Under the same enzymatic hydrolysis time, temperature and rotation speed, VPS prepared with a starch concentration of 20%, reaction temperature of 140 °C and ethanol concentration of 70% showed an irregular spongelike porous structure, highest V-type relative crystallinity of 25.09%, highest oil adsorption capacity of 241.70% and water adsorption capacity of 805.59%.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.05.006DOI Listing
July 2021

The EGFR Polymorphism Increased the Risk of Hepatocellular Carcinoma Through the miR-3196-Dependent Approach in Chinese Han Population.

Pharmgenomics Pers Med 2021 23;14:469-476. Epub 2021 Apr 23.

Department of Hepatobiliary and Pancreatic Surgery, LiYang People's Hospital, LiYang, 213300, Jiangsu, People's Republic of China.

Background: Previous studies have shown that epidermal growth factor receptor (EGFR) promotes cell proliferation through the PI3K-Akt-mTOR signaling pathway and participates in the occurrence and development of hepatocellular carcinoma (HCC). Here, we focused on the functional polymorphism of EGFR in the 3'-untranslated region (UTR), aiming to reveal the potential mechanisms by which functional polymorphism is associated with the risk and development of HCC in the Han Chinese population.

Methods: This study was a hospital-based case-control study. A total of 600 patients were enrolled, and another 600 healthy volunteers served as controls. The miR-associated SNPs in EGFR were screened, and genotyping was performed by TaqMan allele differential analysis. In this study, genotyping, real-time PCR, cell transfection and double luciferase reporter gene were used for subsequent analysis.

Results: HBV/HCV infection instead of alcohol exposure, smoking exposure, hypertension or diabetes mellitus was associated with an increased risk of HCC. Compared with TT genotypes, TG and GG genotypes of EGFR rs884225 were significantly associated with reduced HCC risk. The stratified analysis of association between rs884225 and HCC subgroup feature reveal a highly correlation with tumor size. Furthermore, qRT-PCR confirmed that EGFR rs884225, TG and GG genotypes were more likely to bind to miR-3196 and down-regulate EGFR level in cells, thereby inhibiting cell proliferation.

Conclusion: This study suggested that EGFR rs884225 is associated with a reduced risk of liver cancer and may be a developing biomarker.
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http://dx.doi.org/10.2147/PGPM.S304524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079348PMC
April 2021

High-Energy-Density Magnesium-Air Battery Based on Dual-Layer Gel Electrolyte.

Angew Chem Int Ed Engl 2021 Jul 9;60(28):15317-15322. Epub 2021 Jun 9.

National Laboratory of Solid State Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), Collaborative Innovation Center of Advanced Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing, 210023, China.

Mg-air batteries are explored as the next-generation power systems for wearable and implantable electronics as they could work stably in neutral electrolytes and are also biocompatible. However, high corrosion rate and low utilization of Mg anode largely impair the performance of Mg-air battery with low discharge voltage, poor specific capacity and low energy density. Here, to the best of our knowledge, we first report a dual-layer gel electrolyte to simultaneously solve the above two problems by preventing the corrosion of Mg anode and the production of dense passive layer, respectively. The resulting Mg-air batteries produced an average specific capacity of 2190 mAh g based on the total Mg anode (99.3 % utilization rate of Mg anode) and energy density of 2282 Wh kg based on the total anode and air electrode, both of which are the highest among the reported Mg-air batteries. Besides, our Mg-air batteries could be made into a fiber shape, and they were flexible to work stably under various deformations such as bending and twisting.
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http://dx.doi.org/10.1002/anie.202104536DOI Listing
July 2021
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