Louise van der Weyden

Louise van der Weyden

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Louise van der Weyden

Louise van der Weyden

Publications by authors named "Louise van der Weyden"

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Companion canines: an under-utilised model to aid in translating anti-metastatics to the clinic.

Clin Exp Metastasis 2020 Feb 5;37(1):7-12. Epub 2019 Nov 5.

Pathobiology Department, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada.

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http://dx.doi.org/10.1007/s10585-019-10002-5DOI Listing
February 2020

Metastasis in the wild: investigating metastasis in non-laboratory animals.

Clin Exp Metastasis 2019 02 9;36(1):15-28. Epub 2019 Feb 9.

Experimental Cancer Genetics (T113), Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

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http://dx.doi.org/10.1007/s10585-019-09956-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394581PMC
February 2019

Pulmonary metastatic colonisation and granulomas in NOX2-deficient mice.

J Pathol 2018 11 19;246(3):300-310. Epub 2018 Sep 19.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1002/path.5140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221033PMC
November 2018

CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation.

PLoS Pathog 2018 04 26;14(4):e1006968. Epub 2018 Apr 26.

Department of Microbiology and Immunology, Viral Oncology Program, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, FL, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919438PMC
April 2018

Widespread spontaneous hyperproliferation, melanosis and melanoma in Hgf-Cdk4R24C mice.

Melanoma Res 2018 02;28(1):76-78

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge.

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http://dx.doi.org/10.1097/CMR.0000000000000414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739287PMC
February 2018

A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization.

Nat Protoc 2017 Dec 2;12(12):2465-2477. Epub 2017 Nov 2.

Experimental Cancer Genetics Group, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/nprot.2017.118DOI Listing
December 2017

Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.

Sci Data 2017 09 12;4:170129. Epub 2017 Sep 12.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.

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http://dx.doi.org/10.1038/sdata.2017.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827107PMC
September 2017

Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.

Proc Natl Acad Sci U S A 2016 07 29;113(29):8290-5. Epub 2016 Jun 29.

Cancer Research UK Beatson Institute, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1601571113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961202PMC
July 2016

Cross-species models of human melanoma.

J Pathol 2016 Jan 9;238(2):152-65. Epub 2015 Oct 9.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.

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http://dx.doi.org/10.1002/path.4632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832391PMC
January 2016

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

J Exp Med 2015 Sep 24;212(10):1551-69. Epub 2015 Aug 24.

Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0XY, England, UK Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1TN, England, UK

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http://jem.rupress.org/content/212/10/1551.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20141661
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http://dx.doi.org/10.1084/jem.20141661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577832PMC
September 2015

Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.

PLoS Pathog 2015 Mar 16;11(3):e1004721. Epub 2015 Mar 16.

Department of Microbiology and Immunology, Viral Oncology Program, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, Florida, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361615PMC
March 2015

Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice.

Blood 2014 Dec 25;124(24):3624-35. Epub 2014 Sep 25.

Department of Haematology, University of Cambridge, and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;

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http://dx.doi.org/10.1182/blood-2014-04-566760DOI Listing
December 2014

Cancer gene discovery goes mobile.

Nat Genet 2014 Sep;46(9):928-9

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3072DOI Listing
September 2014

Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.

PLoS Genet 2014 Feb 27;10(2):e1004167. Epub 2014 Feb 27.

Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937229PMC
February 2014

Cancer of mice and men: old twists and new tails.

J Pathol 2013 May;230(1):4-16

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1002/path.4184DOI Listing
May 2013

Using mice to unveil the genetics of cancer resistance.

Biochim Biophys Acta 2012 Dec 19;1826(2):312-30. Epub 2012 May 19.

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1016/j.bbcan.2012.05.003DOI Listing
December 2012

Generation of the Sotos syndrome deletion in mice.

Mamm Genome 2012 Dec 29;23(11-12):749-57. Epub 2012 Aug 29.

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH, UK.

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http://dx.doi.org/10.1007/s00335-012-9416-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510424PMC
December 2012

Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.

Cancer Res 2012 Aug 18;72(15):3817-3827. Epub 2012 Jun 18.

Gray Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus, Oxford OX3 7DQ, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067151PMC
August 2012

Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1.

Mol Cancer 2012 May 3;11:29. Epub 2012 May 3.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK.

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http://dx.doi.org/10.1186/1476-4598-11-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489691PMC
May 2012

Cancer gene discovery in the mouse.

Curr Opin Genet Dev 2012 Feb 20;22(1):14-20. Epub 2012 Jan 20.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambs CB10 1HH, UK.

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http://dx.doi.org/10.1016/j.gde.2011.12.003DOI Listing
February 2012

High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors.

Genome Res 2011 Dec 18;21(12):2181-9. Epub 2011 Aug 18.

Division of Molecular Biology and Cancer Systems Biology Center, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1101/gr.112763.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227106PMC
December 2011

Computational identification of insertional mutagenesis targets for cancer gene discovery.

Nucleic Acids Res 2011 Aug 7;39(15):e105. Epub 2011 Jun 7.

Bioinformatics and Statistics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkr447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159484PMC
August 2011

The mouse genetics toolkit: revealing function and mechanism.

Genome Biol 2011 Jun 24;12(6):224. Epub 2011 Jun 24.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1186/gb-2011-12-6-224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218837PMC
June 2011

Acute sensitivity of the oral mucosa to oncogenic K-ras.

J Pathol 2011 May 7;224(1):22-32. Epub 2011 Mar 7.

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1HH, UK.

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http://dx.doi.org/10.1002/path.2853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627303PMC
May 2011

Cadm1 expression and function in the mouse lens.

Invest Ophthalmol Vis Sci 2011 Apr 8;52(5):2293-9. Epub 2011 Apr 8.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1167/iovs.10-6677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080734PMC
April 2011

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice.

J Clin Invest 2010 Oct 20;120(10):3555-67. Epub 2010 Sep 20.

Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103-2714, USA.

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http://dx.doi.org/10.1172/JCI43569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947240PMC
October 2010

Cancer gene discovery in mouse and man.

Biochim Biophys Acta 2009 Dec 12;1796(2):140-61. Epub 2009 Mar 12.

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH, UK.

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http://dx.doi.org/10.1016/j.bbcan.2009.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756404PMC
December 2009

Chromosome engineering in ES cells.

Methods Mol Biol 2009 ;530:49-77

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1007/978-1-59745-471-1_4DOI Listing
May 2009

Megaoesophagus in Rassf1a-null mice.

Int J Exp Pathol 2009 Apr;90(2):101-8

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1365-2613.2008.00635.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676702PMC
April 2009

Contemporary approaches for modifying the mouse genome.

Physiol Genomics 2008 Aug 17;34(3):225-38. Epub 2008 Jun 17.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom.

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http://dx.doi.org/10.1152/physiolgenomics.90242.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519963PMC
August 2008

Mouse chromosome engineering for modeling human disease.

Annu Rev Genomics Hum Genet 2006 ;7:247-76

Mouse Genomics Lab, Wellcome Trust Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom.

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http://www.annualreviews.org/doi/10.1146/annurev.genom.7.080
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http://dx.doi.org/10.1146/annurev.genom.7.080505.115741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597817PMC
April 2008

The Ras-association domain family (RASSF) members and their role in human tumourigenesis.

Biochim Biophys Acta 2007 Sep 4;1776(1):58-85. Epub 2007 Jul 4.

Experimental Cancer Genetics Laboratory, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, UK.

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http://dx.doi.org/10.1016/j.bbcan.2007.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586335PMC
September 2007

Renin enhancer is critical for control of renin gene expression and cardiovascular function.

J Biol Chem 2006 Oct 8;281(42):31753-61. Epub 2006 Aug 8.

School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia.

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http://dx.doi.org/10.1074/jbc.M605720200DOI Listing
October 2006

Null and conditional semaphorin 3B alleles using a flexible puroDeltatk loxP/FRT vector.

Genesis 2005 Apr;41(4):171-8

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/gene.20111DOI Listing
April 2005

Mutagenic insertion and chromosome engineering resource (MICER).

Nat Genet 2004 Aug 4;36(8):867-71. Epub 2004 Jul 4.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambs, CB10 1SA, UK.

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http://dx.doi.org/10.1038/ng1388DOI Listing
August 2004

HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression.

J Biol Chem 2003 Nov 21;278(45):44894-903. Epub 2003 Aug 21.

Basic & Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, New South Wales 2006, Australia.

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http://dx.doi.org/10.1074/jbc.M307782200DOI Listing
November 2003

The structure of the zinc finger domain from human splicing factor ZNF265 fold.

J Biol Chem 2003 Jun 25;278(25):22805-11. Epub 2003 Mar 25.

Basic and Clinical Genomics Laboratory, School of Medical Science, University of Sydney, New South Wales 2006, Australia.

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http://dx.doi.org/10.1074/jbc.M301896200DOI Listing
June 2003

Tools for targeted manipulation of the mouse genome.

Physiol Genomics 2002 Dec 3;11(3):133-64. Epub 2002 Dec 3.

The Wellcome Trust Sanger Institute, Hinxton, Cambs CB10 1SA, United Kingdom.

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http://www.physiology.org/doi/10.1152/physiolgenomics.00074.
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http://dx.doi.org/10.1152/physiolgenomics.00074.2002DOI Listing
December 2002

Cancer: stuck at first base.

Nature 2002 Sep;419(6903):127-8

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http://www.nature.com/doifinder/10.1038/419127a
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http://dx.doi.org/10.1038/419127aDOI Listing
September 2002