Louis Vermeulen

Louis Vermeulen

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Louis Vermeulen

Louis Vermeulen

Publications by authors named "Louis Vermeulen"

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A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue.

Nat Protoc 2019 Sep 16;14(9):2648-2671. Epub 2019 Aug 16.

LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41596-019-0194-yDOI Listing
September 2019

DeepCC: a novel deep learning-based framework for cancer molecular subtype classification.

Oncogenesis 2019 Aug 16;8(9):44. Epub 2019 Aug 16.

Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1038/s41389-019-0157-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697729PMC
August 2019

Prognostic value of low CDX2 expression in colorectal cancers with a high stromal content - a short report.

Cell Oncol (Dordr) 2019 Jun 8;42(3):397-403. Epub 2019 Mar 8.

Department of Surgery, Leiden University Medical Centrum, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s13402-019-00436-0DOI Listing
June 2019

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts.

Proc Natl Acad Sci U S A 2019 03 8;116(13):6140-6145. Epub 2019 Mar 8.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1813417116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442578PMC
March 2019

Stem cells in homeostasis and cancer of the gut.

Mol Cancer 2019 03 30;18(1):66. Epub 2019 Mar 30.

Amsterdam UMC, University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology and Metabolism, Meibergdreef 9, 1105, Amsterdam, AZ, Netherlands.

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http://dx.doi.org/10.1186/s12943-019-0962-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441158PMC
March 2019

The interplay between intrinsic and extrinsic Wnt signaling in controlling intestinal transformation.

Differentiation 2019 Jul - Aug;108:17-23. Epub 2019 Feb 14.

Amsterdam UMC, University of Amsterdam, LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Meibergdreef 9, 1105AZ Amsterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717105PMC
February 2019

Classification of Colorectal Cancer in Molecular Subtypes by Immunohistochemistry.

Methods Mol Biol 2018 ;1765:179-191

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center & Cancer Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-7765-9_11DOI Listing
January 2019

Cancer stem cells: here, there, and everywhere.

Mol Cell Oncol 2019 4;6(1):1540235. Epub 2018 Dec 4.

Amsterdam UMC, LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1080/23723556.2018.1540235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370381PMC
December 2018

Itraconazole targets cell cycle heterogeneity in colorectal cancer.

J Exp Med 2018 07 31;215(7):1891-1912. Epub 2018 May 31.

Cancer Research UK (CRUK) Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, England, UK

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http://dx.doi.org/10.1084/jem.20171385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028508PMC
July 2018

Turning Cold Tumors Hot by Blocking TGF-β.

Trends Cancer 2018 05 30;4(5):335-337. Epub 2018 Mar 30.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.03.005DOI Listing
May 2018

What Will We Expect From Novel Therapies to Esophageal and Gastric Malignancies?

Am Soc Clin Oncol Educ Book 2018 May;38:249-261

From the Department of Biomedical Sciences and Medicine, Division of Oncology, University of Algarve, Faro, Portugal; Algarve Biomedical Center, Campus Gambelas, Faro, Portugal; Faculty of Medicine, University of Porto, Porto, Portugal; Research Centre, Division of Medical Oncology, Hospital São Mateus, NOHC Clinic, Fortaleza, CE, Brazil; Algarve Hospital and University Center, Department of Oncology, Faro, Portugal; Portuguese Public Health School, Nova University, Lisbon, Portugal; Centre for Biomedical Research, University of Algarve, Faro, Portugal; Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal; Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal; Academic Medical Center Amsterdam, Center for Experimental Molecular Medicine, Amsterdam, The Netherlands; and the Division of Medical Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL.

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http://dx.doi.org/10.1200/EDBK_198805DOI Listing
May 2018

Young GI angle: how to write a good conference abstract.

United European Gastroenterol J 2018 Apr 22;6(3):482-484. Epub 2018 Mar 22.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/2050640618765848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949980PMC
April 2018

Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.

Int J Mol Sci 2017 Oct 24;18(10). Epub 2017 Oct 24.

Tumor Biology, Immunology, and Therapy Section, Immunology, Inflammation, and Metabolism Department, Division of Translational Medicine, Sidra Medical and Research Center, PO Box 26999 Doha, Qatar.

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http://dx.doi.org/10.3390/ijms18102229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666908PMC
October 2017

Stem Cells: All that Is Solid Melts into Air.

Cell Stem Cell 2017 07;21(1):5-7

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine (CEMM), Cancer Center Amsterdam (CCA), Amsterdam Institute for Gastroenterology & Metabolism (AGM), and Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909173023
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http://dx.doi.org/10.1016/j.stem.2017.06.009DOI Listing
July 2017

Molecular subtypes in cancers of the gastrointestinal tract.

Nat Rev Gastroenterol Hepatol 2017 Jun 12;14(6):333-342. Epub 2017 Apr 12.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrgastro.2017.33DOI Listing
June 2017

From tumour heterogeneity to advances in precision treatment of colorectal cancer.

Nat Rev Clin Oncol 2017 04 6;14(4):235-246. Epub 2016 Dec 6.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, Netherlands.

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http://www.gastricbreastcancer.com/pdf/7.nrclinonc%202016%20
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http://dx.doi.org/10.1038/nrclinonc.2016.171DOI Listing
April 2017

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer.

Nat Rev Cancer 2017 02 4;17(2):79-92. Epub 2017 Jan 4.

Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona 08035, Spain.

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http://dx.doi.org/10.1038/nrc.2016.126DOI Listing
February 2017

Balancing signals in the intestinal niche.

EMBO J 2017 02 3;36(4):389-391. Epub 2017 Feb 3.

Laboratory of Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.15252/embj.201796431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694942PMC
February 2017

Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry.

Clin Cancer Res 2017 Jan 26;23(2):387-398. Epub 2016 Jul 26.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0680DOI Listing
January 2017

The Use of Targeted Therapies for Precision Medicine in Oncology.

Clin Chem 2016 12 27;62(12):1556-1564. Epub 2016 Sep 27.

Chief, Clinical Laboratory Genetics, University Health Network, Professor, University of Toronto, Canada.

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http://clinchem.aaccjnls.org/cgi/doi/10.1373/clinchem.2015.2
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http://dx.doi.org/10.1373/clinchem.2015.247882DOI Listing
December 2016

Cancer stem cells don't waste their time cleaning-low proteasome activity, a marker for cancer stem cell function.

Ann Transl Med 2016 Dec;4(24):519

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.21037/atm.2016.11.81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233536PMC
December 2016

Polycomb complex PRC1 as gatekeeper of intestinal stem cell identity.

Stem Cell Investig 2016 15;3:22. Epub 2016 Jun 15.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.21037/sci.2016.06.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958053PMC
August 2016

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype.

EMBO Mol Med 2016 07 1;8(7):745-60. Epub 2016 Jul 1.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands Cancer Genomics Center, Amsterdam, The Netherlands

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http://dx.doi.org/10.15252/emmm.201606184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931289PMC
July 2016

Wnt Signaling in Cancer Stem Cell Biology.

Cancers (Basel) 2016 Jun 27;8(7). Epub 2016 Jun 27.

Laboratory of Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), Amsterdam 1105AZ, The Netherlands.

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http://www.mdpi.com/2072-6694/8/7/60
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http://dx.doi.org/10.3390/cancers8070060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963802PMC
June 2016

Turning off the BCL-2 switch to prevent intestinal tumorigenesis.

Oncotarget 2016 05;7(20):28763-4

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045354PMC
May 2016

Bcl-2 is a critical mediator of intestinal transformation.

Nat Commun 2016 Mar 9;7:10916. Epub 2016 Mar 9.

Cancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1038/ncomms10916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786877PMC
March 2016

Bidirectional interconversion of stem and non-stem cancer cell populations: A reassessment of theoretical models for tumor heterogeneity.

Mol Cell Oncol 2016 Mar 2;3(2):e1098791. Epub 2015 Dec 2.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center , Amsterdam, The Netherlands.

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http://dx.doi.org/10.1080/23723556.2015.1098791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905404PMC
March 2016

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy.

Cell Rep 2015 Oct 8;13(3):489-494. Epub 2015 Oct 8.

Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)01027-X.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501027
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http://dx.doi.org/10.1016/j.celrep.2015.09.016DOI Listing
October 2015

Serrated neoplasia-role in colorectal carcinogenesis and clinical implications.

Nat Rev Gastroenterol Hepatol 2015 Jul 12;12(7):401-9. Epub 2015 May 12.

Department of Gastroenterology and Hepatology, Academic Medical Centre, Meibergdreef 9, Amsterdam, 1105AZ, Netherlands.

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http://www.nature.com/articles/nrgastro.2015.73
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http://dx.doi.org/10.1038/nrgastro.2015.73DOI Listing
July 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.ilcambiamento.it/files/carcinogenesi.pdf
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

Reconciliation of classification systems defining molecular subtypes of colorectal cancer: interrelationships and clinical implications.

Cell Cycle 2014 9;13(3):353-7. Epub 2014 Jan 9.

Laboratory for Experimental Oncology and Radiobiology; Center for Experimental Molecular Medicine; Academic Medical Center (AMC); Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/cc.27769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956531PMC
January 2015

Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes.

Cancer Res 2015 Jan;75(2):245-9

Laboratory of Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2240DOI Listing
January 2015

Stem cell competition: how speeding mutants beat the rest.

EMBO J 2014 Oct 1;33(20):2277-8. Epub 2014 Sep 1.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.15252/embj.201489823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253517PMC
October 2014

Stem cell dynamics in homeostasis and cancer of the intestine.

Nat Rev Cancer 2014 Jul 12;14(7):468-80. Epub 2014 Jun 12.

Molecular Cancer Research and Cancer Genomics Netherlands, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

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http://www.nature.com/articles/nrc3744
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http://dx.doi.org/10.1038/nrc3744DOI Listing
July 2014

Dissecting cancer heterogeneity--an unsupervised classification approach.

Int J Biochem Cell Biol 2013 Nov 1;45(11):2574-9. Epub 2013 Sep 1.

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2013.08.014DOI Listing
November 2013

Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas.

Cell Stem Cell 2013 Nov 12;13(5):626-33. Epub 2013 Sep 12.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1016/j.stem.2013.08.001DOI Listing
November 2013

Defining stem cell dynamics in models of intestinal tumor initiation.

Science 2013 Nov;342(6161):995-8

Cancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1126/science.1243148DOI Listing
November 2013

Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon.

Mol Cancer 2013 Oct 21;12(1):126. Epub 2013 Oct 21.

Laboratory of Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Room G2-131, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-12-126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016508PMC
October 2013

Cancer heterogeneity--a multifaceted view.

EMBO Rep 2013 Aug 12;14(8):686-95. Epub 2013 Jul 12.

Laboratory for Experimental Oncology & Radiobiology, Centre for Experimental Molecular Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/embor.2013.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736134PMC
August 2013

Intestinal label-retaining cells are secretory precursors expressing Lgr5.

Nature 2013 Mar 27;495(7439):65-9. Epub 2013 Feb 27.

Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://www.nature.com/articles/nature11965
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http://dx.doi.org/10.1038/nature11965DOI Listing
March 2013

Keeping stem cells in check: a hippo balancing act.

Authors:
Louis Vermeulen

Cell Stem Cell 2013 Jan;12(1):3-5

Cancer Research UK, Cambridge Research Institute, Cambridge, UK.

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http://dx.doi.org/10.1016/j.stem.2012.12.004DOI Listing
January 2013

Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer.

Clin Cancer Res 2012 Jun 10;18(11):3132-41. Epub 2012 Apr 10.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3066DOI Listing
June 2012

The developing cancer stem-cell model: clinical challenges and opportunities.

Lancet Oncol 2012 Feb;13(2):e83-9

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S147020451170257
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http://dx.doi.org/10.1016/S1470-2045(11)70257-1DOI Listing
February 2012

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer.

Nature 2011 Jun 15;474(7351):318-26. Epub 2011 Jun 15.

Laboratory of Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam 1105AZ, The Netherlands.

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http://dx.doi.org/10.1038/nature10212DOI Listing
June 2011

Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors.

PLoS Comput Biol 2011 May 5;7(5):e1001132. Epub 2011 May 5.

Computational Biology Group, University of Cambridge, CRUK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1001132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088646PMC
May 2011

Targeting Wnt signaling in colon cancer stem cells.

Clin Cancer Res 2011 Feb 15;17(4):647-53. Epub 2010 Dec 15.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1204DOI Listing
February 2011

Cancer stem cell niche: the place to be.

Cancer Res 2011 Feb 25;71(3):634-9. Epub 2011 Jan 25.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3220DOI Listing
February 2011

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.

Nat Cell Biol 2010 May 25;12(5):468-76. Epub 2010 Apr 25.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncb2048DOI Listing
May 2010

Exploring cancer stem cell niche directed tumor growth.

Cell Cycle 2010 Apr 15;9(8):1472-9. Epub 2010 Apr 15.

University of Cambridge, CRUK Cambridge Research Institute, Cambridge, UK.

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http://dx.doi.org/10.4161/cc.9.8.11198DOI Listing
April 2010

The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation.

Cancer Res 2010 Jan 12;70(2):719-29. Epub 2010 Jan 12.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, and Department of Pathology, Academic Medical Center, 1105AZ Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1820DOI Listing
January 2010

One renegade cancer stem cell?

Cell Cycle 2009 Mar 26;8(6):803-8. Epub 2009 Mar 26.

Laboratory for Experimental Oncology and Radiobiology, LEXOR, CEMM, AMC UvA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/cc.8.6.7935DOI Listing
March 2009

[Cancer stem cells].

Ned Tijdschr Geneeskd 2009 Feb;153(7):286-90

Center for Experimental Molecular Medicine (CEMM), Laboratorium voor Experimentele Oncologie en Radiobiologie (LEXOR), Academisch Medisch Centrum/ Universiteit van Amsterdam, Amsterdam.

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February 2009

Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer.

Cancer Res 2008 Feb;68(4):1213-20

Laboratory of Experimental Oncology, Department of Surgery, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5172DOI Listing
February 2008

Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

Cell Stem Cell 2007 Oct;1(4):389-402

Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, 90127 Palermo, Italy.

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http://dx.doi.org/10.1016/j.stem.2007.08.001DOI Listing
October 2007

Kinome analysis reveals nongenomic glucocorticoid receptor-dependent inhibition of insulin signaling.

Endocrinology 2006 Jul 30;147(7):3555-62. Epub 2006 Mar 30.

Laboratory of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1210/en.2005-1602DOI Listing
July 2006