Publications by authors named "Louis Scampavia"

63Publications

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR.

SLAS Discov 2020 Oct 5:2472555220962001. Epub 2020 Oct 5.

Department of Molecular Medicine, Scripps Florida, The Scripps Research Institute Molecular Screening Center, Jupiter, FL, USA.

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October 2020

Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity.

Sci Rep 2020 06 29;10(1):10579. Epub 2020 Jun 29.

Department of Molecular Medicine, The Scripps Research Molecular Screening Center, Scripps Research Florida, 130 Scripps Way #1A1, Jupiter, FL, 33458, USA.

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June 2020

Applications for Open Source Microplate-Compatible Illumination Panels.

J Vis Exp 2019 10 3(152). Epub 2019 Oct 3.

The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Florida;

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October 2019

A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.

Sci Rep 2019 06 21;9(1):9000. Epub 2019 Jun 21.

The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Research, Jupiter, Florida, 33458, USA.

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June 2019

Automating a Magnetic 3D Spheroid Model Technology for High-Throughput Screening.

SLAS Technol 2019 08 21;24(4):420-428. Epub 2019 Jun 21.

1 The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Florida, Jupiter, FL, USA.

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August 2019

Design of Microplate-Compatible Illumination Panels for a Semiautomated Benchtop Pipetting System.

SLAS Technol 2019 08 30;24(4):399-407. Epub 2019 Jan 30.

1 The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Florida, Jupiter, Florida, USA.

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August 2019

Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins.

ACS Infect Dis 2019 02 14;5(2):250-259. Epub 2018 Dec 14.

Department of Molecular Medicine , Scripps Research Molecular Screening Center, Scripps Research , 130 Scripps Way , Jupiter , Florida 33458 , United States.

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February 2019

Chemical validation and optimization of pharmacoperones targeting vasopressin type 2 receptor mutant.

Biochem J 2018 09 25;475(18):2941-2953. Epub 2018 Sep 25.

Lead Identification Division, Translational Research Institute and Department of Molecular Medicine, Scripps Research Institute, Jupiter, FL 33458, U.S.A.

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September 2018

A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells.

SLAS Discov 2018 09 11;23(8):842-849. Epub 2018 May 11.

1 Department of Molecular Medicine, Scripps Florida, Jupiter, FL, USA.

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September 2018

Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening.

SLAS Discov 2018 07 19;23(6):574-584. Epub 2018 Apr 19.

1 The Scripps Research Institute Molecular Screening Center, Department of Molecular Medicine, Scripps Florida, Jupiter, FL, USA.

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July 2018

IoT for Real-Time Measurement of High-Throughput Liquid Dispensing in Laboratory Environments.

SLAS Technol 2018 10 12;23(5):440-447. Epub 2018 Apr 12.

1 The Scripps Research Institute Molecular Screening Center and Department of Molecular Medicine, Scripps Florida, Jupiter, FL, USA.

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October 2018

Using bead injection to model dispensing of 3-D multicellular spheroids into microtiter plates.

Talanta 2018 Jan 9;177:74-76. Epub 2017 Sep 9.

The Scripps Research Institute Molecular Screening Center, Department of Molecular Medicine, Scripps Florida, 130 Scripps Way, Jupiter, FL, USA.

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January 2018

High-Throughput Screening for Protein Synthesis Inhibitors Targeting Aminoacyl-tRNA Synthetases.

SLAS Discov 2018 02 11;23(2):174-182. Epub 2017 Oct 11.

2 Department of Cancer Biology, Scripps Research Institute, Scripps Florida, Jupiter, FL, USA.

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February 2018

A Rapid Phenotypic Whole-Cell Screening Approach for the Identification of Small-Molecule Inhibitors That Counter β-Lactamase Resistance in Pseudomonas aeruginosa.

SLAS Discov 2018 01 29;23(1):55-64. Epub 2017 Aug 29.

1 The Scripps Research Institute Molecular Screening Center, Department of Molecular Medicine, Scripps Florida, Jupiter, FL, USA.

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January 2018

Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.

PLoS One 2017 2;12(8):e0181830. Epub 2017 Aug 2.

Departments of Internal Medicine and Cell Biology/Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America.

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October 2017

Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease.

SLAS Discov 2017 08 31;22(7):887-896. Epub 2017 Jan 31.

1 Department of Molecular Therapeutics, Scripps Research Institute Molecular Screening Center, Scripps Research Institute, Jupiter, FL, USA.

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August 2017

A 1536-Well 3D Viability Assay to Assess the Cytotoxic Effect of Drugs on Spheroids.

SLAS Discov 2017 06 13;22(5):516-524. Epub 2017 Jan 13.

1 Department of Molecular Medicine, Scripps Florida, Jupiter, FL, USA.

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June 2017

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity.

Mol Cell Endocrinol 2016 10 4;434:176-85. Epub 2016 Jul 4.

Departments of Internal Medicine and Cell Biology/Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, United States. Electronic address:

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October 2016

Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus.

J Biomol Screen 2016 Sep 8;21(8):824-31. Epub 2016 Jun 8.

The Scripps Research Institute Molecular Screening Center, Department of Molecular Therapeutics, Scripps Florida, Jupiter, FL, USA

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September 2016

An Automated Miniaturized Method to Perform and Analyze Antimicrobial Drug Synergy Assays.

Assay Drug Dev Technol 2016 Jan-Feb;14(1):58-66. Epub 2015 Dec 15.

Lead Identification, Department of Molecular Therapeutics, The Scripps Research Institute , Scripps Florida, Jupiter, Florida.

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December 2016

Assay strategies for identification of therapeutic leads that target protein trafficking.

Trends Pharmacol Sci 2015 Aug 8;36(8):498-505. Epub 2015 Jun 8.

Department of Internal Medicine, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX, USA; Department of Cell Biology/Biochemistry, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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August 2015

Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.

PLoS One 2015 26;10(3):e0121833. Epub 2015 Mar 26.

Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.

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February 2016

Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.

Biopolymers 2014 Sep;102(5):396-406

Lead Identification Division, Translational Research Institute, The Scripps Research Institute, 130 Scripps Way, Jupiter, Fl, 34987.

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September 2014

A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor.

Assay Drug Dev Technol 2014 May;12(4):238-46

1 Departments of Internal Medicine and Cell Biology/Biochemistry, Texas Tech University Health Sciences Center , Lubbock, Texas.

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May 2014

Monitoring of HTS compound library quality via a high-resolution image acquisition and processing instrument.

J Lab Autom 2011 Jun 16;16(3):197-203. Epub 2011 May 16.

Lead Identification Division, Translational Research Institute, Scripps Research Institute Molecular Screening Center, Jupiter, FL 33458, USA.

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June 2011

Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition.

Anal Sci 2006 Jan;22(1):9-14

Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195, USA.

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January 2006

On-line flow cytometry for real-time surgical guidance.

Neurosurgery 2004 Sep;55(3):551-60; discussion 560-1

Department of Neurological Surgery, University of Washington, Seattle, Washington, USA.

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September 2004

A novel approach for monitoring extracellular acidification rates: based on bead injection spectrophotometry and the lab-on-valve system.

Analyst 2004 Mar 2;129(3):205-12. Epub 2004 Feb 2.

Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, USA.

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March 2004

Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus.

Analyst 2003 Sep;128(9):1157-62

Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195, USA.

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September 2003

Micro sequential injection: automated insulin derivatization and separation using a lab-on-valve capillary electrophoresis system.

Analyst 2003 Sep;128(9):1123-30

Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, USA.

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September 2003

Real-time monitoring of lactate extrusion and glucose consumption of cultured cells using a lab-on-valve system.

Analyst 2002 Dec;127(12):1583-8

University of Washington, Department of Chemistry, PO Box 351700, Seattle, WA 98195, USA.

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December 2002

Microsequential injection: anion separations using 'lab-on-valve' coupled with capillary electrophoresis.

Analyst 2002 Jul;127(7):898-905

Department of Chemistry, University of Washington, Seattle 98195-1700, USA.

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July 2002