Louis M Staudt

Louis M Staudt

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Louis M Staudt

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CRISPR-based technology to silence the expression of IncRNAs.

Proc Natl Acad Sci U S A 2020 Apr 3. Epub 2020 Apr 3.

Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1073/pnas.2003702117DOI Listing
April 2020

Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14.

Proc Natl Acad Sci U S A 2020 Mar 3;117(11):6092-6102. Epub 2020 Mar 3.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1921187117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084139PMC
March 2020

Pathogenic B-cell receptor signaling in lymphoid malignancies: New insights to improve treatment.

Immunol Rev 2019 09;291(1):190-213

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1111/imr.12792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693651PMC
September 2019

Defining, Identifying, and Understanding "Exceptional Responders" in Oncology Using the Tools of Precision Medicine.

Cancer J 2019 Jul/Aug;25(4):296-299

Early Clinical Trials Development Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1097/PPO.0000000000000392DOI Listing
July 2019

TLR Signaling Is Activated in Lymph Node-Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib.

Cancer Res 2019 01 29;79(2):360-371. Epub 2018 Nov 29.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342512PMC
January 2019

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.

J Nat Prod 2019 01 2;82(1):154-162. Epub 2019 Jan 2.

Molecular Targets Program, Center of Cancer Research , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00871
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http://dx.doi.org/10.1021/acs.jnatprod.8b00871DOI Listing
January 2019

Genetics of Diffuse Large B-Cell Lymphoma.

N Engl J Med 2018 08;379(5):493-494

National Cancer Institute, Bethesda, MD

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http://dx.doi.org/10.1056/NEJMc1806191DOI Listing
August 2018

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.

N Engl J Med 2018 04;378(15):1396-1407

From the Lymphoid Malignancies Branch (R.S., D.W.H., J.D.P., J.Q.W., S.R., M.K., R.M.Y., A.L.S., D.J.H., W. Xiao, X.Y., Y.Y., H.Z., W. Xu, W.H.W., L.M.S.), the Biometric Research Program, Division of Cancer Diagnosis and Treatment (G.W.W.), and the Laboratory of Pathology, Center for Cancer Research (E.S.J., S.P.), National Cancer Institute, and the Office of Intramural Research, Center for Information Technology (C.A.J., X.L., B.Z., W.D.), National Institutes of Health, Bethesda, and the Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick (B.T., J.S., Y.Z., D.R.S.) - all in Maryland; the Department of Pathology, City of Hope National Medical Center, Duarte, CA (W.C.C.); the BC Cancer Agency, Vancouver, BC (R.D.G., J.M.C.), and the University Health Network, Laboratory Medicine Program, Toronto General Hospital and University of Toronto, Toronto (J.D.) - both in Canada; the Hospital Clinic of Barcelona, University of Barcelona, Institute for Biomedical Research August Pi I Sunyer, Barcelona (E.C., A.L.-G.); the Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken, Würzburg (A.R.), and the Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart (G.O.) - all in Germany; the Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ (L.M.R.); the National Cancer Centre of Singapore, Singapore (K.T.K.W.); Memorial Sloan Kettering Cancer Center (A.D.Z.) and Weill Cornell Medicine (J.P.L.) - both in New York; the Department of Medicine, Washington University School of Medicine, St. Louis (N.L.B.); and the Alliance for Clinical Trials in Oncology, Chicago (A.D.Z., J.P.L., N.L.B.).

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http://www.nejm.org/doi/10.1056/NEJMoa1801445
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http://dx.doi.org/10.1056/NEJMoa1801445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010183PMC
April 2018

PI3Kδ inhibition causes feedback activation of PI3Kα in the ABC subtype of diffuse large B-cell lymphoma.

Oncotarget 2017 Oct 13;8(47):81794-81802. Epub 2017 Sep 13.

Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.20864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669848PMC
October 2017

Lkb1 deletion in murine B lymphocytes promotes cell death and cancer.

Exp Hematol 2017 07 21;51:63-70.e1. Epub 2017 Apr 21.

Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554940PMC
July 2017

The NCI Genomic Data Commons as an engine for precision medicine.

Blood 2017 07 9;130(4):453-459. Epub 2017 Jun 9.

Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-03
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http://dx.doi.org/10.1182/blood-2017-03-735654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533202PMC
July 2017

New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies.

J Clin Oncol 2017 May 14;35(15):1668-1677. Epub 2017 Mar 14.

David W. Scott, Pau Abrisqueta, Graham W. Slack, Anja Mottok, Diego Villa, Merrill Boyle, Fong Chun Chan, Christian Steidl, Joseph M. Connors, and Randy D. Gascoyne, BC Cancer Agency; Anja Mottok, Christian Steidl, and Randy D. Gascoyne, University of British Columbia, Vancouver, British Columbia; Jan Delabie, University of Toronto, Toronto, Ontario, Canada; Pau Abrisqueta, Vall d'Hebron University Hospital; Pedro Jares, Cristina Royo, Guillem Clot, Magda Pinyol, and Elias Campo, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; George W. Wright, Elaine S. Jaffe, and Louis M. Staudt, National Institutes of Health, Bethesda, MD; Hilka Rauert-Wunderlich and Andreas Rosenwald, University of Würzburg, Würzburg; German Ott, Robert Bosch Hospital and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Rita M. Braziel, Oregon Health & Sciences University, Portland, OR; Wing C. Chan and Dennis D. Weisenburger, City of Hope, Duarte, CA; James R. Cook, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH; Timothy C. Greiner and Kai Fu, University of Nebraska Medical Center, Omaha, NE; Erlend B. Smeland and Harald Holte, Oslo University Hospital, Oslo, Norway; and Lisa M. Rimsza, Mayo Clinic, Phoenix, AZ.

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http://dx.doi.org/10.1200/JCO.2016.70.7901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455765PMC
May 2017

Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification.

Immunity 2017 01 13;46(1):65-77. Epub 2016 Dec 13.

Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243153PMC
January 2017

General Biomarker Recommendations for Lymphoma.

J Natl Cancer Inst 2016 12 16;108(12). Epub 2016 Dec 16.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ (LR), Department of Pathology and Laboratory Medicine, University of North Carolina Medical School, Chapel Hill, NC (YF), Center for Cancer Research, National Cancer Institute, Bethesda, MD (LMS), Department of Medicine, Weill Cornell Medical College, New York, NY (AM), Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada (RG), Clinical Cancer Research Unit, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada (MC), Coordinating Center for Clinical Trials, National Cancer Institute, Bethesda, MD (LB), Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE (KF), Department of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, Cleveland, OH (ED), Department of Pathology, City of Hope Medical Center, Duarte, CA (JWCC), Biometrics Research Branch, National Cancer Institute, Bethesda, MD (LM), Department of Medicine, Weill Cornell Medicine, New York, NY (JPL), Department of Medicine, Oncology Division, Washington University, St. Louis, MO (BSK), Clinical Investigations Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD (RFL), Wilmot Cancer Center and Division of Hematology/Oncology, University of Rochester, Rochester, NY (JWF), Department of Radiology, Mount Sinai Medical Center New York, NY (LK).

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http://dx.doi.org/10.1093/jnci/djw250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080362PMC
December 2016

Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma.

Proc Natl Acad Sci U S A 2016 11 31;113(46):E7260-E7267. Epub 2016 Oct 31.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1610970113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135360PMC
November 2016

Toward a Shared Vision for Cancer Genomic Data.

N Engl J Med 2016 Sep;375(12):1109-12

From the Center for Data Intensive Science, University of Chicago, Chicago (R.L.G., A.P.H.); the Ontario Institute for Cancer Research, Toronto (V.F.); Weill Cornell Medicine, Cornell University, New York (H.E.V.); and the National Cancer Institute, Bethesda, MD (D.R.L., W.A.K., L.M.S.).

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http://dx.doi.org/10.1056/NEJMp1607591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309165PMC
September 2016

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.

Blood 2016 06 5;127(22):2732-41. Epub 2016 Apr 5.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Center of Integrated Oncology, University Hospital of Cologne, Cologne, Germany; and Center of Molecular Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2015-11-684183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891954PMC
June 2016

Dynamic monitoring of circulating tumor DNA in non-Hodgkin lymphoma.

Blood 2016 06 14;127(25):3127-32. Epub 2016 Apr 14.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2016-03-635219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920019PMC
June 2016

Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2.

Proc Natl Acad Sci U S A 2016 Apr 18;113(14):E2039-46. Epub 2016 Mar 18.

Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1600557113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833274PMC
April 2016

Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1.

Proc Natl Acad Sci U S A 2016 Feb 19;113(5):E577-86. Epub 2016 Jan 19.

Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712;

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http://dx.doi.org/10.1073/pnas.1524677113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747717PMC
February 2016

Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy.

J Exp Med 2015 Dec 30;212(13):2189-201. Epub 2015 Nov 30.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1084/jem.20151074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689168PMC
December 2015

Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens.

Proc Natl Acad Sci U S A 2015 Nov 19;112(44):13447-54. Epub 2015 Oct 19.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1514944112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640740PMC
November 2015

Bill Paul: The heart of immunology.

Proc Natl Acad Sci U S A 2015 Nov 2;112(46):14117-8. Epub 2015 Nov 2.

Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1519815112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655560PMC
November 2015

Primary diffuse large B-cell lymphoma associated with clonally-related monoclonal B lymphocytosis indicates a common precursor cell.

Haematologica 2015 Oct 22;100(10):e415-8. Epub 2015 May 22.

Laboratory Medicine Program, University Health Network and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada Center for Cancer Biomedicine, University of Oslo, Norway

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http://www.haematologica.org/cgi/doi/10.3324/haematol.2015.1
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http://dx.doi.org/10.3324/haematol.2015.126656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591779PMC
October 2015

Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling.

Am J Surg Pathol 2015 Oct;39(10):1322-30

*Department of Pathology and Microbiology ¶Department of Biostatistics, College of Public Health ##Department of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE †Metabolism Branch **Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD ∥Department of Pathology, City of Hope National Medical Center, Duarte, CA #Department of Pathology, University of Arizona, Tucson, AZ §§Department of Clinical Pathology, Oregon Health and Science University, Portland, OR ∥∥Department of Molecular Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH ‡Institute of Pathology, Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg ¶¶Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany §British Columbia Cancer Agency, Centre for Lymphoid Cancer, University of British Columbia, Vancouver, BC, Canada ††Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain ‡‡Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1097/PAS.0000000000000473DOI Listing
October 2015

Prognostic Significance of Diffuse Large B-Cell Lymphoma Cell of Origin Determined by Digital Gene Expression in Formalin-Fixed Paraffin-Embedded Tissue Biopsies.

J Clin Oncol 2015 Sep 3;33(26):2848-56. Epub 2015 Aug 3.

David W. Scott, Anja Mottok, Daisuke Ennishi, Pedro Farinha, Susana Ben-Neriah, Robert Kridel, Garrett S. Barry, Christoffer Hother, Pau Abrisqueta, Merrill Boyle, Barbara Meissner, Adele Telenius, Kerry J. Savage, Laurie H. Sehn, Graham W. Slack, Christian Steidl, Joseph M. Connors, and Randy D. Gascoyne, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; George W. Wright and Louis M. Staudt, National Cancer Institute, Bethesda, MD; and Lisa M. Rimsza, University of Arizona, Tucson, AZ.

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http://dx.doi.org/10.1200/JCO.2014.60.2383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554747PMC
September 2015

Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.

Immunity 2015 Aug 28;43(2):277-88. Epub 2015 Jul 28.

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547994PMC
August 2015

B-cell receptor signaling in diffuse large B-cell lymphoma.

Semin Hematol 2015 Apr 15;52(2):77-85. Epub 2015 Jan 15.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2015.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374122PMC
April 2015

A roadmap for discovery and translation in lymphoma.

Blood 2015 Mar;125(13):2175-7

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2015-01-623777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375113PMC
March 2015

Protein ubiquitination in lymphoid malignancies.

Immunol Rev 2015 Jan;263(1):240-56

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/imr.12247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269229PMC
January 2015

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma.

Nature 2014 Dec 28;516(7530):254-8. Epub 2014 Sep 28.

1] Department of Microbiology and Immunology, University of California, San Francisco, California, 94143, USA [2] Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature13765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267955PMC
December 2014

Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma.

J Exp Med 2014 Dec 8;211(13):2497-505. Epub 2014 Dec 8.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1084/jem.20140987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267233PMC
December 2014

ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2.

J Exp Med 2014 Jul 30;211(8):1623-35. Epub 2014 Jun 30.

Department of Microbiology and Immunology, Center for Computational Biology and Bioinformatics, Institute for Cancer Genetics, Department of Pathology, and Department of Pediatrics, Columbia University Medical Center and Department of Biological Sciences and Department of Electrical Engineering, Columbia University, New York, NY 10032

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http://dx.doi.org/10.1084/jem.20132121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113936PMC
July 2014

Ibrutinib treatment of CLL: the cancer fights back.

Cancer Cell 2014 Jul;26(1):11-3

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199743PMC
July 2014

Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.

Cancer Discov 2014 Apr 3;4(4):480-93. Epub 2014 Feb 3.

1Lymphoid Malignancies Branch, 2Laboratory of Pathology, 3Experimental Immunology Branch, Center for Cancer Research; 4Biometric Research Branch, DCTD, National Cancer Institute; 5Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland; 6Department of Pathology, University of Arizona, Tucson, Arizona; 7Oregon Health and Science University, Portland, Oregon; 8Cleveland Clinic Pathology and Laboratory Medicine Institute, Cleveland, Ohio; 9Department of Pathology, City of Hope National Medical Center, Duarte, California; 10Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska; 11Department of Pathology, University of Würzburg, Würzburg; 12Department of Clinical Pathology, Robert-Bosch-Krankenhaus; 13Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, Germany; 14British Columbia Cancer Agency, Vancouver, British Columbia, Canada; 15Hospital Clinic, University of Barcelona, Barcelona, Spain; 16Pathology Clinic, 17Institute for Cancer Research, Rikshospitalet University Hospital; 18Center for Cancer Biomedicine, Faculty Division of the Norwegian Radium Hospital, University of Oslo, Oslo, Norway; and 19Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-13-0915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992927PMC
April 2014

Dendritic cell fate is determined by BCL11A.

Proc Natl Acad Sci U S A 2014 Mar 3;111(11):E998-1006. Epub 2014 Mar 3.

Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712.

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http://dx.doi.org/10.1073/pnas.1319228111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964079PMC
March 2014

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.

Proc Natl Acad Sci U S A 2014 Feb 27;111(6):2349-54. Epub 2014 Jan 27.

Division of Preclinical Innovation, National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, Metabolism Branch, Center for Cancer Research, and Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1311846111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926026PMC
February 2014

Oncogenic mechanisms in Burkitt lymphoma.

Cold Spring Harb Perspect Med 2014 Feb 1;4(2). Epub 2014 Feb 1.

Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1101/cshperspect.a014282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904095PMC
February 2014

Diffuse large B-cell lymphoma-treatment approaches in the molecular era.

Nat Rev Clin Oncol 2014 Jan 12;11(1):12-23. Epub 2013 Nov 12.

Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10 Room 4N115, Bethesda, MD 20892, USA.

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http://www.nature.com/articles/nrclinonc.2013.197
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http://dx.doi.org/10.1038/nrclinonc.2013.197DOI Listing
January 2014

Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP.

J Clin Oncol 2013 Dec 12;31(36):4520-8. Epub 2013 Nov 12.

Xin Huang, Bin Meng, Wenfeng Cao, and Kai Fu, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin; Chengfeng Bi, West China Hospital, West China School of Medicine of Sichuan University, Chengdu, China; Xin Huang, Bin Meng, Javeed Iqbal, Anamarija M. Perry, Wenfeng Cao, Lynette M. Smith, Chengfeng Bi, Chunsun Jiang, Timothy C. Greiner, Dennis D. Weisenburger, James O. Armitage, Julie M. Vose, Timothy W. McKeithan, Wing C. Chan, and Kai Fu, University of Nebraska Medical Center, Omaha, NE; B. Belinda Ding and B. Hilda Ye, Albert Einstein College of Medicine, Bronx, NY; Lisa Rimsza, University of Arizona, Tucson, AZ; Andreas Rosenwald, University of Würzburg, Würzburg, Germany; German Ott and Jan Delabie, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway; Elias Campo, Hospital Clinic, University of Barcelona, Barcelona, Spain; Rita M. Braziel, Oregon Health and Science University, Portland, OR; Randy D. Gascoyne, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; James R. Cook and Raymond R. Tubbs, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH; Elaine S. Jaffe and Louis M. Staudt, Center for Cancer Research, National Cancer Institute, Bethesda, MD.

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http://dx.doi.org/10.1200/JCO.2012.45.6004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871513PMC
December 2013

Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells.

J Exp Med 2013 Oct 7;210(11):2151-9. Epub 2013 Oct 7.

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032.

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http://dx.doi.org/10.1084/jem.20130443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804932PMC
October 2013

High-throughput RNA sequencing in B-cell lymphomas.

Methods Mol Biol 2013 ;971:295-312

Bioinformatics and Molecular Analysis Section, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-1-62703-269-8_17DOI Listing
June 2013

II. Therapy of DLBCL based on genomics.

Authors:
Louis M Staudt

Hematol Oncol 2013 Jun;31 Suppl 1:26-8

Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/hon.2062DOI Listing
June 2013

Control of autophagic cell death by caspase-10 in multiple myeloma.

Cancer Cell 2013 Apr 28;23(4):435-49. Epub 2013 Mar 28.

Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059832PMC
April 2013

Targeting pathological B cell receptor signalling in lymphoid malignancies.

Nat Rev Drug Discov 2013 Mar;12(3):229-43

Metabolism Branch, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrd3937DOI Listing
March 2013

Toll-like receptor signaling.

Cold Spring Harb Perspect Biol 2013 Jan 1;5(1):a011247. Epub 2013 Jan 1.

Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1101/cshperspect.a011247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579400PMC
January 2013

JAKs and STATs in immunity, immunodeficiency, and cancer.

N Engl J Med 2013 Jan;368(2):161-70

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1616, USA.

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http://www.nejm.org/doi/10.1056/NEJMra1202117
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http://dx.doi.org/10.1056/NEJMra1202117DOI Listing
January 2013

A new "brew" of MALT1 inhibitors.

Cancer Cell 2012 Dec;22(6):706-7

Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053348PMC
December 2012

Identification of FoxM1/Bub1b signaling pathway as a required component for growth and survival of rhabdomyosarcoma.

Cancer Res 2012 Nov 20;72(22):5889-99. Epub 2012 Sep 20.

Molecular Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500453PMC
November 2012

The case of the missing c-Myc.

Nat Immunol 2012 Nov;13(11):1029-31

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http://dx.doi.org/10.1038/ni.2455DOI Listing
November 2012

Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.

J Exp Med 2012 Nov 5;209(12):2247-61. Epub 2012 Nov 5.

Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1084/jem.20120831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501355PMC
November 2012