Publications by authors named "Louis Chesler"

63Publications

Subclonal reconstruction of tumors by using machine learning and population genetics.

Nat Genet 2020 09 2;52(9):898-907. Epub 2020 Sep 2.

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41588-020-0675-5DOI Listing
September 2020

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.

EBioMedicine 2020 Sep 23;59:102971. Epub 2020 Aug 23.

Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, Sutton, Surrey SM2 5PT United Kingdom.

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http://dx.doi.org/10.1016/j.ebiom.2020.102971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452577PMC
September 2020

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma.

Oncotarget 2020 Jun 9;11(23):2141-2159. Epub 2020 Jun 9.

Academic Unit of Molecular Oncology, Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.18632/oncotarget.27329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289530PMC
June 2020

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity.

J Med Chem 2019 03 21;62(5):2618-2637. Epub 2019 Feb 21.

Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research , London SM2 5NG , U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421522PMC
March 2019

Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform.

Br J Cancer 2017 Sep 8;117(6):791-800. Epub 2017 Aug 8.

Division of Radiotherapy &Imaging, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1038/bjc.2017.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589996PMC
September 2017

Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma.

Mol Oncol 2017 08 31;11(8):996-1006. Epub 2017 May 31.

Paediatric Solid Tumour Biology and Therapeutics Team, Division of Clinical Studies and Cancer Therapeutics Division, The Institute of Cancer Research, Sutton, Surrey, UK.

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http://doi.wiley.com/10.1002/1878-0261.12069
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http://dx.doi.org/10.1002/1878-0261.12069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537911PMC
August 2017

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.

Proc Natl Acad Sci U S A 2016 11 11;113(48):13726-13731. Epub 2016 Nov 11.

Astbury Centre for Structural and Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1610626113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137718PMC
November 2016

Novel pharmacodynamic biomarkers for MYCN protein and PI3K/AKT/mTOR pathway signaling in children with neuroblastoma.

Mol Oncol 2016 Apr 19;10(4):538-52. Epub 2015 Nov 19.

Division of Cancer Therapeutics, The Institute of Cancer Research, London, SM2 5NG, United Kingdom; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423144PMC
April 2016

Tackling Crizotinib Resistance: The Pathway from Drug Discovery to the Pediatric Clinic.

Cancer Res 2015 Jul 29;75(14):2770-4. Epub 2015 Jun 29.

Paediatric Solid Tumour Biology and Therapeutics Team, Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-3817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539575PMC
July 2015

Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer.

Front Oncol 2015 12;5:111. Epub 2015 May 12.

Department of Pediatrics, University of California San Francisco , San Francisco, CA , USA ; Department of Pediatric Hematology and Oncology, University of California San Francisco , San Francisco, CA , USA ; Hellen Diller Family Comprehensive Cancer Center, University of California San Francisco , San Francisco, CA , USA.

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http://dx.doi.org/10.3389/fonc.2015.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429235PMC
June 2015

Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma.

Mol Oncol 2015 Aug 29;9(7):1484-500. Epub 2015 Apr 29.

Children's Cancer Institute Australia, University of New South Wales, Sydney, Australia; Kids Cancer Centre, Sydney Children's Hospital, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528804PMC
August 2015

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma.

Sci Signal 2014 Oct 28;7(349):ra102. Epub 2014 Oct 28.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-405 30 Göteborg, Sweden.

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http://dx.doi.org/10.1126/scisignal.2005470DOI Listing
October 2014

Paraneoplasia, cancer development and immunity: what are the connections?

Authors:
Louis Chesler

Nat Rev Cancer 2014 07;14(7):447-8

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http://dx.doi.org/10.1038/nrc3766DOI Listing
July 2014

Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma.

PLoS One 2014 25;9(3):e92886. Epub 2014 Mar 25.

Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092886PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965493PMC
December 2014

MDM2-p53 interaction in paediatric solid tumours: preclinical rationale, biomarkers and resistance.

Curr Drug Targets 2014 Jan;15(1):114-23

The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, United Kingdom.

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http://dx.doi.org/10.2174/13894501113149990194DOI Listing
January 2014

New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.

Clin Cancer Res 2013 Nov 21;19(21):5814-21. Epub 2013 Aug 21.

Authors' Affiliations: Paediatric Solid Tumour Biology and Therapeutics Team, Division of Clinical Studies, The Institute of Cancer Research; Children's and Young People's Unit Royal Marsden NHS Trust, Sutton; and Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818140PMC
November 2013

Evaluation of clinically translatable MR imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of neuroblastoma.

Radiology 2013 Jan 20;266(1):130-40. Epub 2012 Nov 20.

Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, 15 Cotswold Road, Sutton, Surrey SM2 5NG, England.

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http://dx.doi.org/10.1148/radiol.12120128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298658PMC
January 2013

Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.

Cancer Cell 2012 May;21(5):601-13

University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360885PMC
May 2012

Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma.

Semin Cancer Biol 2011 Oct 21;21(4):245-55. Epub 2011 Sep 21.

Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research & The Royal Marsden NHS Trust, Sutton, Surrey SM2 5NG, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S1044579X1100060
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http://dx.doi.org/10.1016/j.semcancer.2011.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504935PMC
October 2011

Preclinical drug development for childhood cancer.

Expert Opin Drug Discov 2011 Jan 24;6(1):49-64. Epub 2010 Nov 24.

The Royal Marsden NHS Foundation Trust, Children and Young People's Unit, Sutton, Surrey, UK.

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http://dx.doi.org/10.1517/17460441.2011.537652DOI Listing
January 2011

Use of tissue plasminogen activator (rt-PA) in young children with cancer and dysfunctional central venous catheters.

J Pediatr Hematol Oncol 2002 Nov;24(8):653-6

Department of Hematology/Oncology, Oakland Children's Hospital, 747 52nd Street, Oakland, CA 94609-1809, USA.

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http://dx.doi.org/10.1097/00043426-200211000-00010DOI Listing
November 2002