Lou Yu

Lou Yu

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Lou Yu

Publications by authors named "Lou Yu"

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Effect of a High-Fat Meal on the Pharmacokinetics of the HIV Integrase Inhibitor Cabotegravir.

Clin Pharmacol Drug Dev 2019 May 19;8(4):443-448. Epub 2018 Sep 19.

ViiV Healthcare, Research Triangle Park, NC, USA.

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http://doi.wiley.com/10.1002/cpdd.620
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http://dx.doi.org/10.1002/cpdd.620DOI Listing
May 2019

Correction: Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer.

Oncogene 2019 May 8. Epub 2019 May 8.

Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.1038/s41388-019-0830-6DOI Listing
May 2019

High-dose PPI-amoxicillin dual therapy with or without bismuth for first-line Helicobacter pylori therapy: A randomized trial.

Helicobacter 2019 May 20:e12596. Epub 2019 May 20.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1111/hel.12596DOI Listing
May 2019

Cost-effectiveness analysis of screen-and-treat strategy in asymptomatic Chinese for preventing Helicobacter pylori-associated diseases.

Helicobacter 2019 Apr 22;24(2):e12563. Epub 2019 Jan 22.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China.

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http://doi.wiley.com/10.1111/hel.12563
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http://dx.doi.org/10.1111/hel.12563DOI Listing
April 2019

Effect of rifabutin on the pharmacokinetics of oral cabotegravir in healthy subjects.

Antivir Ther 2019 03 21. Epub 2019 Mar 21.

ViiV Healthcare, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.3851/IMP3306DOI Listing
March 2019

Blockage of macrophage migration inhibitory factor (MIF) suppressed uric acid-induced vascular inflammation, smooth muscle cell de-differentiation, and remodeling.

Biochem Biophys Res Commun 2019 01 28;508(2):440-444. Epub 2018 Nov 28.

Department of Cardiology, Second Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.10.093DOI Listing
January 2019

Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer.

Oncogene 2018 11 10;37(47):6105-6118. Epub 2018 Jul 10.

Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.1038/s41388-018-0391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250679PMC
November 2018

Immunometabolism: A novel perspective of liver cancer microenvironment and its influence on tumor progression.

World J Gastroenterol 2018 Aug;24(31):3500-3512

Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.

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http://dx.doi.org/10.3748/wjg.v24.i31.3500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102497PMC
August 2018

Bismuth improves efficacy of proton-pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance.

Helicobacter 2018 Jun 25;23(3):e12485. Epub 2018 Apr 25.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1111/hel.12485DOI Listing
June 2018

Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment.

Hepatology 2018 05 26;67(5):1872-1889. Epub 2018 Mar 26.

Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine.

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http://dx.doi.org/10.1002/hep.29681DOI Listing
May 2018

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer.

Mol Cancer 2017 07 14;16(1):119. Epub 2017 Jul 14.

Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, China.

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http://dx.doi.org/10.1186/s12943-017-0689-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512744PMC
July 2017

Hook1 inhibits malignancy and epithelial-mesenchymal transition in hepatocellular carcinoma.

Tumour Biol 2017 Jul;39(7):1010428317711098

1 Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.1177/1010428317711098DOI Listing
July 2017

Meta-analysis of invagination and duct-to-mucosa pancreaticojejunostomy after pancreaticoduodenectomy: An update.

Int J Surg 2016 Dec 5;36(Pt A):240-247. Epub 2016 Nov 5.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2016.11.008DOI Listing
December 2016

Effect of Cabotegravir on Cardiac Repolarization in Healthy Subjects.

Clin Pharmacol Drug Dev 2016 Nov 22;5(6):509-516. Epub 2016 Jun 22.

ViiV Healthcare, Research Triangle Park, Durham, NC, USA.

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http://dx.doi.org/10.1002/cpdd.272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132079PMC
November 2016

The hepatitis B virus X protein promotes pancreatic cancer through modulation of the PI3K/AKT signaling pathway.

Cancer Lett 2016 09 21;380(1):98-105. Epub 2016 Jun 21.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang University; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835163037
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http://dx.doi.org/10.1016/j.canlet.2016.06.011DOI Listing
September 2016

LB-100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation.

Tumour Biol 2016 Jun 14;37(6):7277-86. Epub 2015 Dec 14.

Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.

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http://dx.doi.org/10.1007/s13277-015-4560-2DOI Listing
June 2016

Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the Sirt1 pathway.

Int J Mol Med 2015 Sep 20;36(3):873-80. Epub 2015 Jul 20.

Department of Cardiovascular Medicine, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

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http://dx.doi.org/10.3892/ijmm.2015.2291DOI Listing
September 2015

Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors.

Sci Rep 2015 Sep 2;5:13664. Epub 2015 Sep 2.

Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.1038/srep13664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556988PMC
September 2015

Exercise training preserves ischemic preconditioning in aged rat hearts by restoring the myocardial polyamine pool.

Oxid Med Cell Longev 2014 23;2014:457429. Epub 2014 Oct 23.

Department of Pathophysiology, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150086, China.

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http://dx.doi.org/10.1155/2014/457429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227379PMC
June 2015

Metal-Free Oxidative Spirocyclization of Alkynes with Sulfonylhydrazides Leading to 3-Sulfonated Azaspiro[4,5]trienones.

J Org Chem 2015 May 7;80(10):4966-72. Epub 2015 May 7.

The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China.

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http://dx.doi.org/10.1021/acs.joc.5b00361DOI Listing
May 2015

Pharmacokinetics, safety, and tolerability with repeat doses of GSK1265744 and rilpivirine (TMC278) long-acting nanosuspensions in healthy adults.

J Acquir Immune Defic Syndr 2014 Dec;67(5):487-92

*GlaxoSmithKline, Infectious Diseases Research & Development, Research Triangle Park, NC; and †Janssen Infectious Diseases BVBA, Beerse, Belgium.

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http://dx.doi.org/10.1097/QAI.0000000000000365DOI Listing
December 2014

Effects of omeprazole and ritonavir on absorption and elimination of the hepatitis C virus NS5A inhibitor GSK2336805 in healthy adults.

Clin Pharmacol Drug Dev 2014 09 18;3(5):338-45. Epub 2014 Feb 18.

GlaxoSmithKline, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1002/cpdd.104DOI Listing
September 2014

Pharmacokinetics, safety and antiviral activity of fosamprenavir/ritonavir-containing regimens in HIV-infected children aged 4 weeks to 2 years-48-week study data.

Pediatr Infect Dis J 2014 Jan;33(1):57-62

From the *Department of Pediatrics and Child Health, Children's Infectious Diseases Clinical Research Unit, Stellenbosch University, Tygerberg; †Perinatal HIV Research Unit, Johannesburg, South Africa; ‡Universidad Nacional Autonoma de Mexico, Mexico City, Mexico; §GlaxoSmithKline, Research Triangle Park, NC; and ¶GlaxoSmithKline, Uxbridge, United Kingdom.

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http://dx.doi.org/10.1097/INF.0b013e3182a1123aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882303PMC
January 2014

Pharmacokinetics and 48-week safety and antiviral activity of fosamprenavir-containing regimens in HIV-infected 2- to 18-year-old children.

Pediatr Infect Dis J 2014 Jan;33(1):50-6

From the *Sant Joan de Déu Hospital, Barcelona, Spain; †Dr. Victor Babes Hospital for Infectious and Tropical Diseases, Bucharest, Romania; ‡GlaxoSmithKline, Uxbridge, United Kingdom; §GlaxoSmithKline, Research Triangle Park, NC; ¶Tygerberg Children's Hospital, Tygerberg, South Africa; and ‖Hospital Infantil La Fe, Valencia, Spain.

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http://dx.doi.org/10.1097/INF.0b013e3182a1126aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882305PMC
January 2014

The association between circulating oestradiol levels and severity of liver disease in males with hepatitis B virus infection.

Liver Int 2013 Sep 1;33(8):1211-7. Epub 2013 Apr 1.

Department of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.

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http://dx.doi.org/10.1111/liv.12160DOI Listing
September 2013

Effect of intravenous zanamivir on cardiac repolarization.

Pharmacotherapy 2013 Jul 3;33(7):701-9. Epub 2013 Apr 3.

Infectious Diseases Medicines Discovery and Development, GlaxoSmithKline, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1002/phar.1261DOI Listing
July 2013

Pharmacokinetics of zanamivir following intravenous administration to subjects with and without renal impairment.

Antimicrob Agents Chemother 2013 Jul 15;57(7):2967-71. Epub 2013 Apr 15.

GlaxoSmithKline, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1128/AAC.02330-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697365PMC
July 2013

Steady-state pharmacokinetics, cord blood concentrations, and safety of ritonavir-boosted fosamprenavir in pregnancy.

J Acquir Immune Defic Syndr 2013 Apr;62(5):550-4

Division of Infectious Diseases and Immunology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/QAI.0b013e318285d918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683080PMC
April 2013

Effects of etravirine on the pharmacokinetics of the integrase inhibitor S/GSK1265744.

Antimicrob Agents Chemother 2013 Jan 31;57(1):277-80. Epub 2012 Oct 31.

GlaxoSmithKline, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1128/AAC.01685-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535890PMC
January 2013

Effect of a single supratherapeutic dose of dolutegravir on cardiac repolarization.

Pharmacotherapy 2012 Apr 15;32(4):333-9. Epub 2012 Mar 15.

Infectious Diseases Medicines Discovery and Development, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1002/j.1875-9114.2012.01033.xDOI Listing
April 2012

The effect of lopinavir/ritonavir and darunavir/ritonavir on the HIV integrase inhibitor S/GSK1349572 in healthy participants.

J Clin Pharmacol 2011 Feb 20;51(2):237-42. Epub 2010 May 20.

GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.

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http://doi.wiley.com/10.1177/0091270010371113
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http://dx.doi.org/10.1177/0091270010371113DOI Listing
February 2011

Pharmacokinetics and safety of S/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers.

Antimicrob Agents Chemother 2010 Jan 2;54(1):254-8. Epub 2009 Nov 2.

Infectious Diseases MDC, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.

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http://aac.asm.org/cgi/doi/10.1128/AAC.00842-09
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http://dx.doi.org/10.1128/AAC.00842-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798521PMC
January 2010

Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in HIV-1-infected patients with antiretroviral resistance.

J Antimicrob Chemother 2009 Aug 10;64(2):398-410. Epub 2009 Jun 10.

Service des Maladies Infectieuses et Tropicales, Hôpital Saint-Louis and University of Paris Diderot, Paris 7, 1 Avenue Claude-Vellefaux, 75475 Paris Cedex 10, France.

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http://dx.doi.org/10.1093/jac/dkp198DOI Listing
August 2009

The ABCG2 C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects.

Br J Clin Pharmacol 2008 Aug 22;66(2):233-9. Epub 2008 Apr 22.

Clinical Pharmacokinetics Modelling and Simulation, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1111/j.1365-2125.2008.03184.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492914PMC
August 2008

Pharmacokinetic interaction between fosamprenavir-ritonavir and rifabutin in healthy subjects.

Antimicrob Agents Chemother 2008 Feb 3;52(2):534-8. Epub 2007 Dec 3.

Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1128/AAC.00724-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224730PMC
February 2008

Fosamprenavir plus ritonavir increases plasma ketoconazole and ritonavir exposure, while amprenavir exposure remains unchanged.

Antimicrob Agents Chemother 2007 Aug 21;51(8):2982-4. Epub 2007 May 21.

Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1128/AAC.00008-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1932497PMC
August 2007

Ritonavir increases plasma amprenavir (APV) exposure to a similar extent when coadministered with either fosamprenavir or APV.

Antimicrob Agents Chemother 2006 Apr;50(4):1578-80

Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, 5 Moore Dr., 17.2231.2B, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1128/AAC.50.4.1578-1580.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426966PMC
April 2006

Single-dose safety and pharmacokinetics of amprenavir (141W94), a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, in HIV-infected children.

Antimicrob Agents Chemother 2005 Jan;49(1):336-41

Division of Infectious Diseases, Children's Memorial Hospital, 2300 Children's Plaza, Box 155, Chicago, IL 60614, USA.

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http://dx.doi.org/10.1128/AAC.49.1.336-341.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC538869PMC
January 2005

Pharmacokinetic and pharmacodynamic analysis of amprenavir-containing combination therapy in HIV-1-infected children.

J Clin Pharmacol 2004 Nov;44(11):1301-8

Worldwide Clinical Pharmacology, GlaxoSmithKline, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1177/0091270004269561DOI Listing
November 2004

Pharmacokinetics and safety of GW433908 and ritonavir, with and without efavirenz, in healthy volunteers.

AIDS 2004 Apr;18(6):897-907

GlaxoSmithKline, Five Moore Drive, 17.2231.2B, Research Triangle Park, NC 27709, USA.

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http://pdfs.journals.lww.com/aidsonline/2004/04090/Pharmacok
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April 2004

Time-dependent changes in HIV nucleoside analogue phosphorylation and the effect of hydroxyurea.

AIDS 2002 Dec;16(18):2439-46

Department of Pharmacology and Therapeutics, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK.

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December 2002