Lothar Elling

Lothar Elling

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Lothar Elling

Publications by authors named "Lothar Elling"

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Identifying Efficient Toxin A Binders with a Multivalent Neo-Glycoprotein Glycan Library.

Bioconjug Chem 2019 Sep 9;30(9):2373-2383. Epub 2019 Sep 9.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering , RWTH Aachen University , Pauwelsstrasse 20 , 52074 Aachen , Germany.

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00486DOI Listing
September 2019

Enzymatic Cascades for Tailored C and N Enriched Human Milk Oligosaccharides.

Molecules 2019 Sep 25;24(19). Epub 2019 Sep 25.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/molecules24193482DOI Listing
September 2019

Microgels Sopping Up Toxins-GM1a-Functionalized Microgels as Scavengers for Cholera Toxin.

ACS Appl Mater Interfaces 2019 Jul 2;11(28):25017-25023. Epub 2019 Jul 2.

DWI-Leibniz Institute for Interactive Materials , RWTH Aachen University , Forckenbeckstraße 50 , 52076 Aachen , Germany.

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http://dx.doi.org/10.1021/acsami.9b06413DOI Listing
July 2019

Repetitive Batch Mode Facilitates Enzymatic Synthesis of the Nucleotide Sugars UDP-Gal, UDP-GlcNAc, and UDP-GalNAc on a Multi-Gram Scale.

Biotechnol J 2019 Apr 23;14(4). Epub 2018 Nov 23.

Laboratory for Biomaterials and Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering RWTH Aachen University, Pauwelstrasse 20, Aachen 52074, Germany.

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http://dx.doi.org/10.1002/biot.201800386DOI Listing
April 2019

Galectin-Carbohydrate Interactions in Biomedicine and Biotechnology.

Trends Biotechnol 2019 04 6;37(4):402-415. Epub 2018 Nov 6.

Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Prague 4, Czech Republic. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01677799183026
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http://dx.doi.org/10.1016/j.tibtech.2018.10.001DOI Listing
April 2019

Enzymatic Cascade Synthesis Provides Novel Linear Human Milk Oligosaccharides as Reference Standards for xCGE-LIF Based High-Throughput Analysis.

Biotechnol J 2019 Mar 23;14(3):e1800305. Epub 2018 Aug 23.

Laboratory for Biomaterials and Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany.

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http://dx.doi.org/10.1002/biot.201800305DOI Listing
March 2019

A Compartmented Flow Microreactor System for Automated Optimization of Bioprocesses Applying Immobilized Enzymes.

Front Bioeng Biotechnol 2018 4;6:189. Epub 2018 Dec 4.

Institute of Functional Interfaces, Karlsruhe Institute of Technology, Karlsruhe, Germany.

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http://dx.doi.org/10.3389/fbioe.2018.00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288360PMC
December 2018

KnowVolution Campaign of an Aryl Sulfotransferase Increases Activity toward Cellobiose.

Chemistry 2018 Nov 24;24(64):17117-17124. Epub 2018 Oct 24.

DWI-Leibniz Institute for Interactive Materials, Forckenbeckstraße 50, 52056, Aachen, Germany.

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http://dx.doi.org/10.1002/chem.201803729DOI Listing
November 2018

Directed Evolution of Hyaluronic Acid Synthase from Pasteurella multocida towards High-Molecular-Weight Hyaluronic Acid.

Chembiochem 2018 07 18;19(13):1414-1423. Epub 2018 May 18.

DWI-Leibniz-Institute for Interactive Materials, Forckenbeckstrasse 50, 52056, Aachen, Germany.

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http://dx.doi.org/10.1002/cbic.201800093DOI Listing
July 2018

Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors.

Bioconjug Chem 2018 04 7;29(4):1266-1275. Epub 2018 Mar 7.

Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences , Utrecht University , Universiteitsweg 99 , 3584 CG Utrecht , The Netherlands.

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http://dx.doi.org/10.1021/acs.bioconjchem.8b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909177PMC
April 2018

Poly-N-Acetyllactosamine Neo-Glycoproteins as Nanomolar Ligands of Human Galectin-3: Binding Kinetics and Modeling.

Int J Mol Sci 2018 Jan 26;19(2). Epub 2018 Jan 26.

Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic.

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http://www.mdpi.com/1422-0067/19/2/372
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http://dx.doi.org/10.3390/ijms19020372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855594PMC
January 2018

Tailored Multivalent Neo-Glycoproteins: Synthesis, Evaluation, and Application of a Library of Galectin-3-Binding Glycan Ligands.

Bioconjug Chem 2017 11 18;28(11):2832-2840. Epub 2017 Oct 18.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University , Pauwelsstrasse 20, 52074 Aachen, Germany.

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http://dx.doi.org/10.1021/acs.bioconjchem.7b00520DOI Listing
November 2017

Development of a colourimetric assay for glycosynthases.

J Biotechnol 2017 Sep 11;257:162-170. Epub 2017 Feb 11.

Heinrich-Heine-Universität Düsseldorf, Institut für Bioorganische Chemie im Forschungszentrum Jülich, Gebäude: 15.8, 52426 Jülich, Germany; Forschungszentrum Jülich, IBG-1: Biotechnology, 52425 Jülich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2017.02.005DOI Listing
September 2017

Characterization of a new UDP-sugar pyrophosphorylase from Hordeum vulgare (barley).

J Biotechnol 2017 Sep 24;258:51-55. Epub 2017 Mar 24.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2017.03.025DOI Listing
September 2017

Enzymatic Synthesis of N-Acetyllactosamine (LacNAc) Type 1 Oligomers and Characterization as Multivalent Galectin Ligands.

Molecules 2017 Aug 10;22(8). Epub 2017 Aug 10.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/molecules22081320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152129PMC
August 2017

Binding characteristics of galectin-3 fusion proteins.

Glycobiology 2017 05;27(5):457-468

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstrasse 20, 52074 Aachen, Germany.

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http://dx.doi.org/10.1093/glycob/cwx007DOI Listing
May 2017

Glycan-Functionalized Microgels for Scavenging and Specific Binding of Lectins.

Biomacromolecules 2017 May 7;18(5):1460-1465. Epub 2017 Apr 7.

DWI - Leibniz Institute for Interactive Materials, RWTH Aachen University , Forckenbeckstraße 50, 52076 Aachen, Germany.

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http://dx.doi.org/10.1021/acs.biomac.6b01754DOI Listing
May 2017

Biotinylated N-Acetyllactosamine- and N,N-Diacetyllactosamine-Based Oligosaccharides as Novel Ligands for Human Galectin-3.

Bioengineering (Basel) 2017 Apr 5;4(2). Epub 2017 Apr 5.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstrasse 20, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/bioengineering4020031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590477PMC
April 2017

Multiplexed Capillary Electrophoresis as Analytical Tool for Fast Optimization of Multi-Enzyme Cascade Reactions - Synthesis of Nucleotide Sugars: Dedicated to Prof. Dr. Vladimir Křen on the occasion of his 60 birthday.

Biotechnol J 2016 Oct 1;11(10):1298-1308. Epub 2016 Jul 1.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1002/biot.201600265DOI Listing
October 2016

Simultaneous Electrochemical Impedance Spectroscopy and Localized Surface Plasmon Resonance in a Microfluidic Chip: New Insights into the Spatial Origin of the Signal.

Anal Chem 2016 10 22;88(19):9590-9596. Epub 2016 Sep 22.

Institute of Materials in Electrical Engineering 1, RWTH Aachen University , Sommerfeldstrasse 24, 52074 Aachen, Germany.

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http://dx.doi.org/10.1021/acs.analchem.6b02307DOI Listing
October 2016

Lectin binding studies on a glycopolymer brush flow-through biosensor by localized surface plasmon resonance.

Anal Bioanal Chem 2016 Aug 8;408(20):5633-40. Epub 2016 Jun 8.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074, Aachen, Germany.

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http://dx.doi.org/10.1007/s00216-016-9667-9DOI Listing
August 2016

Microwave-Assisted Synthesis of Glycoconjugates by Transgalactosylation with Recombinant Thermostable β-Glycosidase from Pyrococcus.

Int J Mol Sci 2016 Feb 4;17(2):210. Epub 2016 Feb 4.

Laboratory for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/ijms17020210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783942PMC
February 2016

Evaluating the Thickness of Multivalent Glycopolymer Brushes for Lectin Binding.

Macromol Rapid Commun 2015 Aug 22;36(16):1472-8. Epub 2015 Jun 22.

Institute of Materials in Electrical Engineering 1, RWTH Aachen University, Sommerfeldstr. 24, 52074, Aachen, Germany.

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http://dx.doi.org/10.1002/marc.201500118DOI Listing
August 2015

Galectin Binding to Neo-Glycoproteins: LacDiNAc Conjugated BSA as Ligand for Human Galectin-3.

Biomolecules 2015 Jul 24;5(3):1671-96. Epub 2015 Jul 24.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074 Aachen, Germany.

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http://www.mdpi.com/2218-273X/5/3/1671
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http://dx.doi.org/10.3390/biom5031671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598770PMC
July 2015

Glycopolymer brushes for specific lectin binding by controlled multivalent presentation of N-acetyllactosamine glycan oligomers.

Macromol Rapid Commun 2015 Jan 29;36(1):45-54. Epub 2014 Oct 29.

DWI - Leibniz-Institut für Interaktive Materialien, Lehrstuhl für Makromolekulare Materialien und Oberflächen, RWTH Aachen University, Forckenbeckstr. 50, 52074, Aachen, Germany.

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http://dx.doi.org/10.1002/marc.201400453DOI Listing
January 2015

Rational design of a glycosynthase by the crystal structure of β-galactosidase from Bacillus circulans (BgaC) and its use for the synthesis of N-acetyllactosamine type 1 glycan structures.

J Biotechnol 2014 Dec 14;191:78-85. Epub 2014 Jul 14.

Laboratory for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, 52074 Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2014.07.003DOI Listing
December 2014

Fluorescent SNAP-tag galectin fusion proteins as novel tools in glycobiology.

Curr Pharm Des 2013 ;19(30):5457-67

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany.

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http://dx.doi.org/10.2174/1381612811319300017DOI Listing
March 2014

WbgL: a novel bacterial α1,2-fucosyltransferase for the synthesis of 2'-fucosyllactose.

Glycobiology 2014 Feb 17;24(2):170-8. Epub 2013 Nov 17.

Laboratory for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany.

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http://dx.doi.org/10.1093/glycob/cwt096DOI Listing
February 2014

Enzymatic preparation of silybin phase II metabolites: sulfation using aryl sulfotransferase from rat liver.

Appl Microbiol Biotechnol 2013 Dec 14;97(24):10391-8. Epub 2013 Mar 14.

Institute of Microbiology, Laboratory of Biotransformation, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ 14220, Prague, Czech Republic.

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http://dx.doi.org/10.1007/s00253-013-4794-0DOI Listing
December 2013

Enzymatic glycosylation of multivalent scaffolds.

Chem Soc Rev 2013 Jun;42(11):4774-97

Institute of Microbiology, Center for Biocatalysis and Biotransformation, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ 142 20, Prague 4, Czech Republic.

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http://dx.doi.org/10.1039/c2cs35395dDOI Listing
June 2013

The next step in biomimetic material design: poly-LacNAc-mediated reversible exposure of extra cellular matrix components.

Adv Healthc Mater 2013 Feb 2;2(2):306-11. Epub 2012 Oct 2.

Department of Functional Materials in Medicine and Dentistry, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/adhm.201200080DOI Listing
February 2013

Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment.

Beilstein J Org Chem 2012 9;8:712-25. Epub 2012 May 9.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, Aachen, 52074, Germany.

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http://dx.doi.org/10.3762/bjoc.8.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388858PMC
September 2012

A hydrogel-based versatile screening platform for specific biomolecular recognition in a well plate format.

Anal Bioanal Chem 2012 Apr 26;403(2):517-26. Epub 2012 Feb 26.

Department of Functional Materials in Medicine and Dentistry, University of Würzburg, Würzburg, Germany.

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http://link.springer.com/10.1007/s00216-012-5850-9
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http://dx.doi.org/10.1007/s00216-012-5850-9DOI Listing
April 2012

Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors.

Carbohydr Res 2011 Sep 3;346(12):1599-609. Epub 2011 May 3.

Institute of Microbiology, Academy of Sciences of Czech Republic, Vídeňská 1083, CZ-14220 Praha 4, Czech Republic.

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http://dx.doi.org/10.1016/j.carres.2011.04.043DOI Listing
September 2011

Synthesis of a difunctional orthogonal coupler for the preparation of carbohydrate-functionalized sP(EO-stat-PO) hydrogels.

Macromol Biosci 2011 Sep 16;11(9):1201-10. Epub 2011 Jun 16.

DWI an der RWTH Aachen e.V., and Institute of Technical and Macromolecular Chemistry, RWTH Aachen, Forckenbeckstraße 50, D-52056 Aachen, Germany.

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http://dx.doi.org/10.1002/mabi.201100041DOI Listing
September 2011

Glyco-DNA-gold nanoparticles: lectin-mediated assembly and dual-stimuli response.

Small 2011 Jul 8;7(14):1954-60. Epub 2011 Jun 8.

Institute of Inorganic Chemistry and JARA-FIT (Future Information, Technology), RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.

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http://dx.doi.org/10.1002/smll.201100492DOI Listing
July 2011

Synthesis of LacdiNAc-terminated glycoconjugates by mutant galactosyltransferase--a way to new glycodrugs and materials.

Glycobiology 2009 May 29;19(5):509-17. Epub 2009 Jan 29.

Institute of Microbiology, Center for Biocatalysis and Biotransformation, Academy of Sciences of the Czech Republic, Vídenská 1083, 14220 Prague 4, Czech Republic.

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http://dx.doi.org/10.1093/glycob/cwp010DOI Listing
May 2009

Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and their characterization for CGL2-galectin-mediated binding of ECM glycoproteins to biomaterial surfaces.

Glycoconj J 2009 Feb 29;26(2):141-59. Epub 2008 Aug 29.

Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Germany.

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http://dx.doi.org/10.1007/s10719-008-9172-2DOI Listing
February 2009

SorF: a glycosyltransferase with promiscuous donor substrate specificity in vitro.

Chembiochem 2007 May;8(7):813-9

Saarland University, Department of Pharmaceutical Biotechnology, P. O. Box 151150, 66041 Saarbrücken, Germany.

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http://dx.doi.org/10.1002/cbic.200700024DOI Listing
May 2007

An enzyme module system for the synthesis of dTDP-activated deoxysugars from dTMP and sucrose.

Chembiochem 2005 Aug;6(8):1423-30

Department of Biotechnology/Biomaterial Sciences and Helmholtz Institute for Biomedical Engineering, RWTH Aachen, Worringerweg 1, 52056 Aachen, Germany.

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http://dx.doi.org/10.1002/cbic.200500037DOI Listing
August 2005

Nucleotide deoxysugars: essential tools for the glycosylation engineering of novel bioactive compounds.

Curr Med Chem 2005 ;12(14):1637-75

Department of Biotechnology/Biomaterial Sciences, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, D-52056 Aachen, Germany.

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http://dx.doi.org/10.2174/0929867054367167DOI Listing
August 2005

Expression, purification and characterization of recombinant sucrose synthase 1 from Solanum tuberosum L. for carbohydrate engineering.

J Biotechnol 2004 Jan;107(2):135-49

Department of Biotechnology/Biomaterial Sciences, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen, Germany.

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http://dx.doi.org/10.1016/j.jbiotec.2003.10.017DOI Listing
January 2004

Metabolizable and non-metabolizable sugars activate different signal transduction pathways in tomato.

Plant Physiol 2002 Apr;128(4):1480-9

Lehrstuhl für Pharmazeutische Biologie, Julius-von-Sachs Institute, Julis-von-Sachs-Platz 2, Universität Würzburg, D-97082 Würzburg, Germany.

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http://dx.doi.org/10.1104/pp.010771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154275PMC
April 2002