Lorraine N Clark

Lorraine N Clark

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Lorraine N Clark

Publications by authors named "Lorraine N Clark"

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Whole genome sequencing and rare variant analysis in essential tremor families.

PLoS One 2019 12;14(8):e0220512. Epub 2019 Aug 12.

Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220512PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690583PMC
August 2019

Copy number variation of in familial dystonic tremor.

Neurol Genet 2019 Feb 4;5(1):e307. Epub 2019 Feb 4.

Medical Research (Level 4) (V.A., B.A.C., G.V.H., H.H., A.S.-N., J.K.C., E.L.B., A.H.C.), University of Exeter Medical School, RILD Wellcome Wolfson Centre, Royal Devon & Exeter NHS Foundation Trust, United Kingdom; Reta Lila Weston Institute of Neurological Studies (V.A., T.T.W.), UCL Institute of Neurology, London, United Kingdom; Department of Neurology (T.I.), Government Medical College, Thiruvananthapuram, Kerala, India; Department of Anatomy and Microbiology (R.S.), Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; Clinical Neuroscience (C.P.), Royal Free Campus, UCL Institute of Neurology, London, United Kingdom; Institute of Psychological Medicine and Clinical Neurosciences (K.P.), Cardiff University, Cardiff, United Kingdom; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (L.N.C.), Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY; Institute of Biomedical and Clinical Science (R.C., H.L.A., M.W.), University of Exeter Medical School, United Kingdom; and Departments of Neurology and Chronic Disease Epidemiology and Center for Neuroepidemiology and Clinical Neurological Research (E.D.L.), Yale School of Medicine and Yale School of Public Health, Yale University, New Haven, CT.

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http://dx.doi.org/10.1212/NXG.0000000000000307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384021PMC
February 2019

Genetic Testing Preferences of Individuals in Families with Essential Tremor.

Tremor Other Hyperkinet Mov (N Y) 2018 27;8:545. Epub 2018 Mar 27.

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.7916/D8B296RKDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876471PMC
November 2018

Validity of probands' reports and self-reports of essential tremor: Data from a large family study in North America.

J Neurol Sci 2018 10 6;393:45-50. Epub 2018 Aug 6.

G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.

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http://dx.doi.org/10.1016/j.jns.2018.08.006DOI Listing
October 2018

Essential tremor.

Handb Clin Neurol 2018 ;147:229-239

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York; and Departments of Neurology and of Chronic Disease Epidemiology and Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, New Haven, CT, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/B97804446323330
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http://dx.doi.org/10.1016/B978-0-444-63233-3.00015-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898616PMC
July 2018

A Drosophila Model of Essential Tremor.

Sci Rep 2018 May 16;8(1):7664. Epub 2018 May 16.

Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.

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http://dx.doi.org/10.1038/s41598-018-25949-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955955PMC
May 2018

Knowledge about Essential Tremor: A Study of Essential Tremor Families.

Front Neurol 2018 26;9:27. Epub 2018 Jan 26.

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, United States.

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http://dx.doi.org/10.3389/fneur.2018.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790790PMC
January 2018

Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

Neurobiol Aging 2017 08 3;56:150-158. Epub 2017 May 3.

Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603247PMC
August 2017

Action Tremor Asymmetry Profile Does Not Aggregate in Families with Essential Tremor.

Front Neurol 2017 19;8:148. Epub 2017 Apr 19.

G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.3389/fneur.2017.00148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395646PMC
April 2017

Early Head Tremor in Essential Tremor: A Case Series and Commentary.

Tremor Other Hyperkinet Mov (N Y) 2017 25;7:453. Epub 2017 Mar 25.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.7916/D8KW5MRGDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374515PMC
March 2017

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Neurobiol Aging 2017 01 2;49:214.e13-214.e15. Epub 2016 Sep 2.

Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154872PMC
January 2017

Familial Aggregation of the Cerebellar Signs in Familial Essential Tremor.

Tremor Other Hyperkinet Mov (N Y) 2017 13;7:439. Epub 2017 Jan 13.

G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.

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http://dx.doi.org/10.7916/D8KK9C8QDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288993PMC
January 2017

Identification of candidate genes for familial early-onset essential tremor.

Eur J Hum Genet 2016 07 28;24(7):1009-15. Epub 2015 Oct 28.

Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1038/ejhg.2015.228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070884PMC
July 2016

The effect of MAPT haplotype on neocortical Lewy body pathology in Parkinson disease.

J Neural Transm (Vienna) 2016 06 20;123(6):583-8. Epub 2016 Apr 20.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.

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http://dx.doi.org/10.1007/s00702-016-1552-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939803PMC
June 2016

A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.

J Cell Sci 2016 05 31;129(10):1975-80. Epub 2016 Mar 31.

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA

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http://dx.doi.org/10.1242/jcs.187302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878994PMC
May 2016

Familial versus Sporadic Essential Tremor: What Patterns Can One Decipher in Age of Onset?

Neuroepidemiology 2015 7;44(3):166-72. Epub 2015 May 7.

Department of Neurology, Yale School of Medicine, Yale University, New Haven, Conn., USA.

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https://www.karger.com/Article/FullText/381807
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764084PMC
http://dx.doi.org/10.1159/000381807DOI Listing
March 2016

Gene-wise association of variants in four lysosomal storage disorder genes in neuropathologically confirmed Lewy body disease.

PLoS One 2015 1;10(5):e0125204. Epub 2015 May 1.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America; Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America; Center for Human Genetics, Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125204PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416714PMC
January 2016

Estrogen receptor β variants modify risk for Alzheimer's disease in a multiethnic female cohort.

J Alzheimers Dis 2014 ;40(1):83-93

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA Center for Human Genetics, College of Physicians & Surgeons, Columbia University, New York, NY, USA Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.3233/JAD-130551DOI Listing
October 2014

The spiral axis as a clinical tool to distinguish essential tremor from dystonia cases.

Parkinsonism Relat Disord 2014 May 7;20(5):541-4. Epub 2014 Feb 7.

GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13538020140003
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http://dx.doi.org/10.1016/j.parkreldis.2014.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028420PMC
May 2014

Clinical classification of borderline cases in the family study of essential tremor: an analysis of phenotypic features.

Tremor Other Hyperkinet Mov (N Y) 2014 10;4:220. Epub 2014 Feb 10.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America ; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America.

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http://dx.doi.org/10.7916/D8CF9N23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925876PMC
March 2014

Familial aggregation of cranial tremor in familial essential tremor.

Neuroepidemiology 2013 25;41(1):48-53. Epub 2013 May 25.

G.H. Sergievsky Center, New York, N.Y., USA.

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http://dx.doi.org/10.1159/000348553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770156PMC
February 2014

Essential Tremor in a Charcot-Marie-Tooth Type 2C Kindred Does Not Segregate with the TRPV4 R269H Mutation.

Case Rep Neurol 2014 Jan 22;6(1):1-6. Epub 2014 Jan 22.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, N.Y., USA ; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, N.Y., USA.

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https://www.karger.com/Article/FullText/357665
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http://dx.doi.org/10.1159/000357665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934698PMC
January 2014

Predicting age of onset in familial essential tremor: how much does age of onset run in families?

Neuroepidemiology 2013 24;40(4):269-73. Epub 2013 Jan 24.

Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032, USA. EDL2 @ columbia.edu

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http://dx.doi.org/10.1159/000345253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718305PMC
December 2013

Prevalence and features of unreported dystonia in a family study of "pure" essential tremor.

Parkinsonism Relat Disord 2013 Mar 23;19(3):359-62. Epub 2012 Oct 23.

GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2012.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565033PMC
March 2013

Does rate of progression run in essential tremor families? Slower vs. faster progressors.

Parkinsonism Relat Disord 2013 Mar 31;19(3):363-6. Epub 2012 Oct 31.

GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S13538020120038
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http://dx.doi.org/10.1016/j.parkreldis.2012.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578031PMC
March 2013

Lack of association between cancer history and PARKIN genotype: a family based study in PARKIN/Parkinson's families.

Genes Chromosomes Cancer 2012 Dec 24;51(12):1109-13. Epub 2012 Aug 24.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1002/gcc.21995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465486PMC
December 2012

The MAPT H1 haplotype is associated with tangle-predominant dementia.

Acta Neuropathol 2012 Nov 17;124(5):693-704. Epub 2012 Jul 17.

Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York 10032, USA.

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http://link.springer.com/10.1007/s00401-012-1017-1
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http://dx.doi.org/10.1007/s00401-012-1017-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608475PMC
November 2012

Clinical and pathological characteristics of LRRK2 G2019S patients with PD.

J Mol Neurosci 2012 May 23;47(1):139-43. Epub 2011 Dec 23.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1007/s12031-011-9696-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335886PMC
May 2012

Polyamine pathway contributes to the pathogenesis of Parkinson disease.

Proc Natl Acad Sci U S A 2010 Sep 13;107(39):16970-5. Epub 2010 Sep 13.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1011751107
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http://dx.doi.org/10.1073/pnas.1011751107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947879PMC
September 2010

Replication of the LINGO1 gene association with essential tremor in a North American population.

Eur J Hum Genet 2010 Jul 7;18(7):838-43. Epub 2010 Apr 7.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://www.nature.com/articles/ejhg201027
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http://dx.doi.org/10.1038/ejhg.2010.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987362PMC
July 2010

Mutations in the Parkinson's disease genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor.

Parkinsonism Relat Disord 2010 Feb 13;16(2):132-5. Epub 2009 Jun 13.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, NY, NY 10032, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2009.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822079PMC
February 2010

Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.

Am J Pathol 2009 Aug 23;175(2):736-47. Epub 2009 Jul 23.

Dept of Pathology, Columbia University Medical Center, 630 W168th St Rm 12-461, New York NY 10032, USA.

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http://dx.doi.org/10.2353/ajpath.2009.080928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716969PMC
August 2009

Case-control study of the parkin gene in early-onset Parkinson disease.

Arch Neurol 2006 Apr;63(4):548-52

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1001/archneur.63.4.548DOI Listing
April 2006