Lorne Zinman

Lorne Zinman

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Lorne Zinman

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Glymphatics Visualization after Focused Ultrasound-Induced Blood-Brain Barrier Opening in Humans.

Ann Neurol 2019 Dec 17;86(6):975-980. Epub 2019 Oct 17.

Division of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto.

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http://dx.doi.org/10.1002/ana.25604DOI Listing
December 2019

First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound.

Nat Commun 2019 Sep 26;10(1):4373. Epub 2019 Sep 26.

Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, M4N 3M5, Canada.

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http://dx.doi.org/10.1038/s41467-019-12426-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763482PMC
September 2019

Speech network regional involvement in bulbar ALS: a multimodal structural MRI study.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Aug 14;20(5-6):385-395. Epub 2019 May 14.

a Department of Speech Language Pathology , University of Toronto , Ontario , Canada.

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https://www.tandfonline.com/doi/full/10.1080/21678421.2019.1
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http://dx.doi.org/10.1080/21678421.2019.1612920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648678PMC
August 2019

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 Jun 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://link.springer.com/10.1007/s00401-019-01962-9
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http://dx.doi.org/10.1007/s00401-019-01962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533145PMC
June 2019

Somatic expansion of the hexanucleotide repeat does not occur in ALS spinal cord tissues.

Neurol Genet 2019 Apr 19;5(2):e317. Epub 2019 Mar 19.

Department of Human Genetics (J.P.R., G.A.R.), McGill University, Montréal, Quebec, Canada; Montreal Neurological Institute and Hospital (J.P.R., H.C., P.A.D., G.A.R.), McGill University, Montréal, Quebec, Canada; Pasteur Institute (C.S.L.), University Paris Diderot, Sorbonne Paris Cité, Paris, France; Department of Neurology and Neurosurgery (H.C., P.A.D., G.A.R.), McGill University, Montréal, Quebec, Canada; Department of Clinical Neurological Sciences and Robarts Research Institute (K.V., M.S.A.N.N.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Sunnybrook Health Sciences Centre (L.Z.); and Tanz Centre for Research in Neurodegenerative Diseases (J.R.), University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1212/NXG.0000000000000317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454309PMC
April 2019

Finger Extension Weakness and Downbeat Nystagmus Motor Neuron Disease Syndrome: A Series of Two Cases.

J Neuroophthalmol 2019 Mar;39(1):115-116

Department of Neurology (AM), University of Toronto, Toronto, Canada; Department of Neurology (LZ, ANES), Sunnybrook Health Sciences Centre, Toronto, University of Toronto, Canada; Department of Neurology (PA), Toronto Western Hospital, University of Toronto, Toronto, Canada; and Department of Ophthalmology and Vision Sciences (ANES), University of Toronto, Toronto, Canada.

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http://Insights.ovid.com/crossref?an=00041327-900000000-9920
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http://dx.doi.org/10.1097/WNO.0000000000000723DOI Listing
March 2019

Optimal E2 (reference) electrode placement in fibular motor nerve conduction studies recording from the tibialis anterior muscle.

Muscle Nerve 2019 02 18;59(2):249-253. Epub 2018 Nov 18.

Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, 04039-002, Brazil.

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http://doi.wiley.com/10.1002/mus.26366
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http://dx.doi.org/10.1002/mus.26366DOI Listing
February 2019

A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers.

Brain 2018 10;141(10):2895-2907

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/brain/awy238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158742PMC
October 2018

Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis.

Muscle Nerve 2018 Aug 12;58(2):204-212. Epub 2018 Feb 12.

Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, 04039-002, São Paulo, SP, Brazil.

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http://doi.wiley.com/10.1002/mus.26087
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http://dx.doi.org/10.1002/mus.26087DOI Listing
August 2018

Clinical Reasoning: A 42-year-old man with unilateral leg weakness.

Neurology 2018 03;90(12):e1085-e1090

From the Department of Medicine, Division of Neurology (R.S., L.Z.), and Department of Anatomical Pathology (J.K.), Sunnybrook Health Sciences Centre, and Tanz Centre for Research in Neurodegenerative Disease (R.S., A.W., E.R., J.R.), University of Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000005179DOI Listing
March 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Unaffected mosaic case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression.

Neurology 2018 01 27;90(4):e323-e331. Epub 2017 Dec 27.

From the Tanz Centre for Research in Neurodegenerative Diseases (P.M., M.Z., C.S., D.M., S.X., A.B.Z., P.M.M., A.W., R.S., J.R., E.R.), Department of Medicine (L.Z., E.R.), Division of Neurology, and Department of Laboratory Medicine and Pathobiology (J.R.), University of Toronto, Ontario, Canada; Department of Neuroscience (M.v.B., L.P., R.R.), Mayo Clinic, Jacksonville, FL; and Sunnybrook Health Sciences Centre (J.K., L.Z.), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000004865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798652PMC
January 2018

Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.

Hum Mol Genet 2017 11;26(21):4142-4152

Department of Neurology and Neurosurgery and the Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B3, Canada.

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http://academic.oup.com/hmg/article/26/21/4142/4036437/Dysre
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http://dx.doi.org/10.1093/hmg/ddx301DOI Listing
November 2017

DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients.

Acta Neuropathol 2017 08 24;134(2):271-279. Epub 2017 Apr 24.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Ave., Toronto, ON, M5T 2S8, Canada.

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http://dx.doi.org/10.1007/s00401-017-1713-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508035PMC
August 2017

Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems.

PLoS One 2016 5;11(5):e0154971. Epub 2016 May 5.

Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154971PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858181PMC
July 2017

Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28.

J Neurol Neurosurg Psychiatry 2016 11 6;87(11):1268-1270. Epub 2016 May 6.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jnnp-2016-313592DOI Listing
November 2016

C9orf72 isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.

Brain Res 2016 09 29;1647:43-49. Epub 2016 Apr 29.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00068993163031
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http://dx.doi.org/10.1016/j.brainres.2016.04.062DOI Listing
September 2016

Physician-assisted death: A Canada-wide survey of ALS health care providers.

Neurology 2016 Sep 13;87(11):1152-60. Epub 2016 May 13.

From Sunnybrook Health Sciences Centre (A.A., H.P., A.I., W.K., N.P., A.T., L.Z.), University of Toronto, Canada; Universidade Federal de São Paulo (A.A.), Brazil; Critical Care and Palliative Care (J.D.), University Health Network, Toronto; Clinic of Neuromuscular & Neurogenetic Diseases (N.D.), CHU de Québec, Faculty of Medicine, Laval University; Department of Clinical Neurosciences (L.K.), Hotchkiss Brain Institute, University of Calgary; Dalhousie University Faculty of Medicine (C.O.), Stan Cassidy Centre for Rehabilitation; Department of Clinical Neurological Sciences (C.S.), Schulich School of Medicine and Dentistry, University of Western Ontario, Canada; and Division of Rheumatology (A.B.V.-S.), Internal Medicine Department, Universidade do Estado do Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1212/WNL.0000000000002786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027804PMC
September 2016

MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.

Brain 2016 Jan 2;139(Pt 1):86-100. Epub 2015 Nov 2.

1 Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, M5T 2S8, Canada 2 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A1, Canada

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http://dx.doi.org/10.1093/brain/awv308DOI Listing
January 2016

Electrical impedance myography in the evaluation of the tongue musculature in amyotrophic lateral sclerosis.

Muscle Nerve 2015 Oct 3;52(4):584-91. Epub 2015 Jun 3.

ALS/MND Clinic, Sunnybrook Health Sciences Centre, Department of Neurology, University of Toronto, Toronto, Canada.

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http://doi.wiley.com/10.1002/mus.24565
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http://dx.doi.org/10.1002/mus.24565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499330PMC
October 2015

Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis.

Ann Neurol 2015 Oct 29;78(4):568-83. Epub 2015 Aug 29.

Tanz Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ana.24469DOI Listing
October 2015

Mutation analysis of CHCHD10 in different neurodegenerative diseases.

Brain 2015 Sep 31;138(Pt 9):e380. Epub 2015 Mar 31.

1 Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Street, Toronto, Ontario, Canada, M5T 2S8 8 Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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http://dx.doi.org/10.1093/brain/awv082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547051PMC
September 2015

The economic impact of amyotrophic lateral sclerosis: a systematic review.

Expert Rev Pharmacoecon Outcomes Res 2015 Jun 30;15(3):439-50. Epub 2015 Apr 30.

Department of Medicine, Sunnybrook Health Sciences Centre, Queen's University, Ontario, Canada.

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http://dx.doi.org/10.1586/14737167.2015.1039941DOI Listing
June 2015

Mutation analysis of patients with neurodegenerative disorders using NeuroX array.

Neurobiol Aging 2015 Jan 1;36(1):545.e9-14. Epub 2014 Aug 1.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580140050
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http://dx.doi.org/10.1016/j.neurobiolaging.2014.07.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268030PMC
January 2015

Hypermethylation of the CpG-island near the C9orf72 G₄C₂-repeat expansion in FTLD patients.

Hum Mol Genet 2014 Nov 6;23(21):5630-7. Epub 2014 Jun 6.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Street, Toronto, Ontario, Canada M5T 2S8, Department of Medicine, Division of Neurology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 and

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http://dx.doi.org/10.1093/hmg/ddu279DOI Listing
November 2014

Identical twins with the C9orf72 repeat expansion are discordant for ALS.

Neurology 2014 Oct 10;83(16):1476-8. Epub 2014 Sep 10.

From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.

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http://dx.doi.org/10.1212/WNL.0000000000000886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206161PMC
October 2014

Economic burden of amyotrophic lateral sclerosis: a Canadian study of out-of-pocket expenses.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Sep 15;15(5-6):426-32. Epub 2014 Jul 15.

Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto , Ontario , Canada.

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http://dx.doi.org/10.3109/21678421.2014.932382DOI Listing
September 2014

Venous thromboembolism in amyotrophic lateral sclerosis: a prospective study.

Neurology 2014 May 11;82(19):1674-7. Epub 2014 Apr 11.

From the Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000000405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032202PMC
May 2014

Bulbar and speech motor assessment in ALS: challenges and future directions.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Dec 30;14(7-8):494-500. Epub 2013 Jul 30.

The Department of Communication Sciences and Disorders, MGH Institute of Health Professions , Massachusetts , USA.

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http://dx.doi.org/10.3109/21678421.2013.817585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833808PMC
December 2013

Hypermethylation of the CpG island near the G4C2 repeat in ALS with a C9orf72 expansion.

Am J Hum Genet 2013 Jun 23;92(6):981-9. Epub 2013 May 23.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queen's Park Crescent West, Toronto, ON M5S 3H2, Canada.

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http://dx.doi.org/10.1016/j.ajhg.2013.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675239PMC
June 2013

Speech in ALS: Longitudinal Changes in Lips and Jaw Movements and Vowel Acoustics.

J Med Speech Lang Pathol 2013 Mar;21(1):1-13

Department of Speech-Language Pathology, University of Toronto, Sunnybrook Health Science Centre, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955603PMC
March 2013

Enhancing clinical trials in neurodegenerative disorders: lessons from amyotrophic lateral sclerosis.

Curr Opin Neurol 2012 Dec;25(6):735-42

Department of Medicine, University of Toronto Medical School, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/WCO.0b013e32835a309dDOI Listing
December 2012

Tongue movements and their acoustic consequences in amyotrophic lateral sclerosis.

Folia Phoniatr Logop 2012 27;64(2):94-102. Epub 2012 Apr 27.

Department of Speech-Language Pathology, University of Toronto, Toronto, Ont., Canada.

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https://www.karger.com/Article/FullText/336890
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http://dx.doi.org/10.1159/000336890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369262PMC
September 2012

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Neuron 2011 Oct 21;72(2):257-68. Epub 2011 Sep 21.

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200438PMC
October 2011

RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS.

Mol Cell Neurosci 2011 Jul 21;47(3):167-80. Epub 2011 Mar 21.

Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine and Pathobiology, University of Toronto, 6 Queen's Park Crescent West, Toronto, Ontario, Canada M5S 3H2.

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http://dx.doi.org/10.1016/j.mcn.2011.02.013DOI Listing
July 2011

Emerging targets and treatments in amyotrophic lateral sclerosis.

Lancet Neurol 2011 May;10(5):481-90

Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S1474-4422(11)70024-2DOI Listing
May 2011

A protocol for comprehensive assessment of bulbar dysfunction in amyotrophic lateral sclerosis (ALS).

J Vis Exp 2011 Feb 21(48). Epub 2011 Feb 21.

Department of Speech-Language Pathology, University of Toronto.

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http://dx.doi.org/10.3791/2422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197394PMC
February 2011

Distinct biochemical signatures characterize peripherin isoform expression in both traumatic neuronal injury and motor neuron disease.

J Neurochem 2010 Aug 1;114(4):1177-92. Epub 2010 Jun 1.

Department of Laboratory Medicine and Pathobiology, The University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06846.xDOI Listing
August 2010

Kinematics of disease progression in bulbar ALS.

J Commun Disord 2010 Jan-Feb;43(1):6-20. Epub 2009 Jul 24.

Department of Speech and Language Pathology, Rehabilitation Sciences Building, University of Toronto, 160 - 500 University Avenue, Toronto, ON M5G 1V7, Canada.

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http://dx.doi.org/10.1016/j.jcomdis.2009.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813314PMC
April 2010

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form.

Acta Neuropathol 2010 Mar 29;119(3):335-44. Epub 2010 Jan 29.

Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, and Department of Laboratory Medicine and Pathobiology, Toronto General Hospital, TMDT 4-305, 101 College Street, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1007/s00401-010-0646-5DOI Listing
March 2010

Non-invasive ventilation for Canadian patients with ALS: do we have consensus?

Authors:
Lorne Zinman

Can J Neurol Sci 2010 Jan;37(1)

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http://dx.doi.org/10.1017/s0317167100009586DOI Listing
January 2010

Safety of influenza vaccination in patients with myasthenia gravis: a population-based study.

Muscle Nerve 2009 Dec;40(6):947-51

Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

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http://doi.wiley.com/10.1002/mus.21440
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http://dx.doi.org/10.1002/mus.21440DOI Listing
December 2009

Lack of evidence of monomer/misfolded superoxide dismutase-1 in sporadic amyotrophic lateral sclerosis.

Ann Neurol 2009 Jul;66(1):75-80

Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ana.21704DOI Listing
July 2009

IVIG treatment for myasthenia gravis: effectiveness, limitations, and novel therapeutic strategies.

Ann N Y Acad Sci 2008 ;1132:264-70

Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1196/annals.1405.038DOI Listing
September 2008

Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis.

Neurobiol Aging 2008 Aug 23;29(8):1279-82. Epub 2007 Mar 23.

Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen's Park Crescent West, Toronto, Ontario, Canada M5S 3H2.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.02.022DOI Listing
August 2008

Are statin medications safe in patients with ALS?

Amyotroph Lateral Scler 2008 Aug;9(4):223-8

ALS/Neuromuscular Clinic, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1080/17482960802031092DOI Listing
August 2008

Surrogate therapeutic outcome measures in patients with myasthenia gravis.

Muscle Nerve 2008 Feb;37(2):172-6

Sunnybrook Health Sciences Centre, Toronto, Canada.

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http://doi.wiley.com/10.1002/mus.20908
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http://dx.doi.org/10.1002/mus.20908DOI Listing
February 2008

Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis.

J Neuropathol Exp Neurol 2007 Dec;66(12):1147-53

Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/nen.0b013e31815c5eddDOI Listing
December 2007

IV immunoglobulin in patients with myasthenia gravis: a randomized controlled trial.

Neurology 2007 Mar;68(11):837-41

Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1212/01.wnl.0000256698.69121.45DOI Listing
March 2007

Sensitivity of repetitive facial-nerve stimulation in patients with myasthenia gravis.

Muscle Nerve 2006 May;33(5):694-6

Division of Neurology, 1382-13N, Toronto General Hospital, University Health Network, 585 University Avenue, Toronto, Ontario M5G 2N2, Canada.

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http://dx.doi.org/10.1002/mus.20511DOI Listing
May 2006

Cooling detection thresholds in the assessment of diabetic sensory polyneuropathy: comparison of CASE IV and Medoc instruments.

Diabetes Care 2004 Jul;27(7):1674-9

University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/diacare.27.7.1674DOI Listing
July 2004

Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial.

Diabetes Care 2004 Apr;27(4):921-4

Toronto General Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/diacare.27.4.921DOI Listing
April 2004