Publications by authors named "Lorne Hofseth"

81Publications

Pharmacokinetics of Panaxynol in Mice.

J Cancer Sci Clin Ther 2020 1;4(2):133-143. Epub 2020 Jun 1.

Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.

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June 2020

Molecules from American Ginseng Suppress Colitis through Nuclear Factor Erythroid-2-Related Factor 2.

Nutrients 2020 Jun 21;12(6). Epub 2020 Jun 21.

Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.

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June 2020

Early-onset colorectal cancer: initial clues and current views.

Nat Rev Gastroenterol Hepatol 2020 06 21;17(6):352-364. Epub 2020 Feb 21.

Center for Colon Cancer Research, University of South Carolina, Columbia, SC, USA.

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June 2020

Maternal stress and early-onset colorectal cancer.

Med Hypotheses 2018 Dec 21;121:152-159. Epub 2018 Sep 21.

Department of Drug Discovery and Biomedical Science, College of Pharmacy, University of South Carolina, Columbia, SC, USA. Electronic address:

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December 2018

The Dietary Inflammatory Index is associated with elevated white blood cell counts in the National Health and Nutrition Examination Survey.

Brain Behav Immun 2018 03 5;69:296-303. Epub 2017 Dec 5.

Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Suite 200, Columbia, SC 29208, United States; Department of Epidemiology and Biostatistics, University of South Carolina, 915 Greene Street, Suite 200, Columbia, SC 29208, United States; Connecting Health Innovations, LLC, 915 Greene Street, Suite 200, Columbia, SC 29208, United States.

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March 2018

Getting rigorous with scientific rigor.

Authors:
Lorne J Hofseth

Carcinogenesis 2018 01;39(1):21-25

College of Pharmacy, University of South Carolina, Columbia, SC, USA.

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January 2018

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation.

PLoS One 2017 22;12(3):e0172914. Epub 2017 Mar 22.

Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, United States of America.

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August 2017

Dietary inflammatory index and odds of colorectal cancer in a case-control study from Jordan.

Appl Physiol Nutr Metab 2017 Jul 22;42(7):744-749. Epub 2017 Feb 22.

j Department of Nutrition and Food Technology, The University of Jordan, Faculty of Agriculture, P.O. Box 2920, Amman 11941, Jordan.

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July 2017

Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties.

Oncotarget 2016 Aug;7(33):52928-52939

Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC, USA.

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August 2016

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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December 2015

Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer.

Oncotarget 2015 Nov;6(34):36053-62

Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC, USA.

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November 2015

Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy.

J Ethnopharmacol 2015 Jun 14;168:326-36. Epub 2015 Apr 14.

Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA; Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, China. Electronic address:

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June 2015

A novel chemopreventive strategy based on therapeutic microRNAs produced in plants.

Cell Res 2015 Apr 27;25(4):521-4. Epub 2015 Feb 27.

Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA;

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April 2015

Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation.

Curr Drug Targets 2015 ;16(7):700-10

Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy 770 Sumter St., Coker Life Sciences, Rm. 513C University of South Carolina Columbia, SC 29208.

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May 2016

Inhibiting protein arginine deiminases has antioxidant consequences.

J Pharmacol Exp Ther 2015 Apr 29;353(1):64-70. Epub 2015 Jan 29.

Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina (E.E.W., X.C., A.B.H., L.J.H.); Shanxi Medical University, Taiyuan, Shanxi, China (X.C.); Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, Florida (V.S.); Department of Chemistry, University of North Florida, Jacksonville, Florida (C.P.C.); and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts (P.R.T.)

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April 2015

A key role of microRNA-29b for the suppression of colon cancer cell migration by American ginseng.

PLoS One 2013 9;8(10):e75034. Epub 2013 Oct 9.

Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States of America.

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June 2014

The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.

PLoS One 2013 7;8(1):e53791. Epub 2013 Jan 7.

Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States of America.

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July 2013

Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination.

J Am Chem Soc 2012 Oct 3;134(41):17015-8. Epub 2012 Oct 3.

Department of Chemistry, The Scripps Research Institute, Scripps Florida, 120 Scripps Way, Jupiter, Florida 33458, USA.

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October 2012

A limited role of p53 on the ability of a Hexane fraction of American ginseng to suppress mouse colitis.

J Biomed Biotechnol 2012 30;2012:785739. Epub 2012 Jul 30.

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina and Medical University of South Carolina, Columbia, SC 29208, USA.

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November 2012

Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.

Proc Natl Acad Sci U S A 2012 Aug 14;109(35):14007-12. Epub 2012 Aug 14.

Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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August 2012

A hexane fraction of American ginseng suppresses mouse colitis and associated colon cancer: anti-inflammatory and proapoptotic mechanisms.

Cancer Prev Res (Phila) 2012 Apr 31;5(4):685-96. Epub 2012 Jan 31.

Department of Biomedical and Pharmaceutical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter St., Coker Life Sciences, Columbia, SC 29208, USA.

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April 2012

Role of resveratrol-induced CD11b(+) Gr-1(+) myeloid derived suppressor cells (MDSCs) in the reduction of CXCR3(+) T cells and amelioration of chronic colitis in IL-10(-/-) mice.

Brain Behav Immun 2012 Jan 23;26(1):72-82. Epub 2011 Jul 23.

Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208, USA.

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January 2012

Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-κB.

Mol Nutr Food Res 2011 Aug 26;55(8):1207-18. Epub 2011 Apr 26.

Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, University of South Carolina, Columbia, SC 29208, USA.

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August 2011

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.

Am J Physiol Gastrointest Liver Physiol 2011 Jun 17;300(6):G929-38. Epub 2011 Mar 17.

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, 29208, USA.

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June 2011

Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis.

Carcinogenesis 2010 Oct 20;31(10):1734-41. Epub 2010 Aug 20.

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina and Medical University of South Carolina, SC 29208, USA.

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October 2010

Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.

Carcinogenesis 2010 Oct 5;31(10):1787-93. Epub 2010 Aug 5.

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina and Medical University of South Carolina, Columbia, SC 29208, USA.

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October 2010

An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes.

J Ethnopharmacol 2010 Jul 4;130(2):222-30. Epub 2010 May 4.

Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC 29208, USA.

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July 2010

Resveratrol suppresses colitis and colon cancer associated with colitis.

Cancer Prev Res (Phila) 2010 Apr 23;3(4):549-59. Epub 2010 Mar 23.

Department of Biomedical and Pharmaceutical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter Street, Columbia, SC 29208, USA.

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April 2010

American ginseng suppresses colitis through p53-mediated apoptosis of inflammatory cells.

Cancer Prev Res (Phila) 2010 Mar 23;3(3):339-47. Epub 2010 Feb 23.

Department of Biomedical and Pharmaceutical Sciences, South Carolina College of Pharmacy, 770 Sumter Street, Coker Life Sciences, University of South Carolina, Columbia, SC 29208, USA.

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March 2010

Circadian disruption, Per3, and human cytokine secretion.

Integr Cancer Ther 2009 Dec 18;8(4):329-36. Epub 2009 Nov 18.

Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.

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December 2009

Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.

Carcinogenesis 2009 Dec;30(12):2123-9

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.

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December 2009

Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.

PLoS One 2009 Aug 5;4(8):e6493. Epub 2009 Aug 5.

Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.

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August 2009

Use of cannabinoids as a novel therapeutic modality against autoimmune hepatitis.

Vitam Horm 2009 ;81:487-504

Department of Pathology, University of South Carolina School of Medicine, Columbia, South Carolina, USA.

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September 2009

American ginseng preferentially suppresses STAT/iNOS signaling in activated macrophages.

J Ethnopharmacol 2009 Aug 6;125(1):145-50. Epub 2009 Jun 6.

Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC 29208, USA.

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August 2009

American ginseng suppresses inflammation and DNA damage associated with mouse colitis.

Carcinogenesis 2008 Dec 18;29(12):2351-9. Epub 2008 Sep 18.

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, SC 29208, USA.

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December 2008

Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer.

Authors:
Lorne J Hofseth

Cancer Lett 2008 Sep 25;268(1):10-30. Epub 2008 Apr 25.

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter Street, Coker Life Sciences, Room 513C, Columbia, SC 29208, USA.

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September 2008

Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells.

Mol Pharmacol 2008 Jul 3;74(1):20-33. Epub 2008 Apr 3.

Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, 6439 Garners Ferry Rd., Columbia, SC 29209, USA.

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July 2008

Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation.

Cancer Res 2007 Oct;67(19):9286-93

Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA.

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October 2007

An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer.

Cancer Res 2007 Feb;67(4):1407-10

Department of Basic Pharmaceutical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter Street, Columbia, SC 29208, USA.

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February 2007

Inflammation, cancer, and targets of ginseng.

J Nutr 2007 01;137(1 Suppl):183S-185S

Department of Basic Pharmaceutical Sciences, South Carolina College of Pharmacy, SC, USA.

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January 2007

Nitric oxide is a signaling molecule that regulates gene expression.

Methods Enzymol 2005 ;396:326-40

College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.

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January 2006

Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation.

Cancer Res 2005 Oct;65(20):9132-6

Laboratory of Inflammatory-Driven Carcinogenesis, Department of Basic Pharmaceutical Sciences, South Carolina College of Pharmacy.

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October 2005

Identifying and defusing weapons of mass inflammation in carcinogenesis.

Biochim Biophys Acta 2006 Jan 8;1765(1):74-84. Epub 2005 Sep 8.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, Coker Life Sciences, University of South Carolina, Columbia, SC 29208, USA.

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January 2006

Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease.

Environ Mol Mutagen 2004 ;44(1):3-9

Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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September 2004

Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide.

Proc Natl Acad Sci U S A 2004 Jun 3;101(24):8894-9. Epub 2004 Jun 3.

Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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June 2004

The adaptive imbalance to genotoxic stress: genome guardians rear their ugly heads.

Authors:
Lorne J Hofseth

Carcinogenesis 2004 Oct 27;25(10):1787-93. Epub 2004 May 27.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.

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October 2004

p53: at the crossroads of molecular carcinogenesis and molecular epidemiology.

Chest 2004 May;125(5 Suppl):83S-5S

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.

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May 2004

Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53.

Cancer Res 2004 May;64(9):3022-9

Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA.

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May 2004

p53: 25 years after its discovery.

Trends Pharmacol Sci 2004 Apr;25(4):177-81

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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April 2004

p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.

Cancer Res 2004 Apr;64(7):2350-6

Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

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April 2004

Cancer-associated molecular signature in the tissue samples of patients with cirrhosis.

Hepatology 2004 Feb;39(2):518-27

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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February 2004

The role of p53 in base excision repair following genotoxic stress.

Carcinogenesis 2004 Jan 10;25(1):11-9. Epub 2003 Oct 10.

Department of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, Israel.

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January 2004

Nitric oxide in cancer and chemoprevention.

Free Radic Biol Med 2003 Apr;34(8):955-68

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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April 2003

Radical causes of cancer.

Nat Rev Cancer 2003 Apr;3(4):276-85

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892-4255, USA.

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April 2003

TP53 and liver carcinogenesis.

Hum Mutat 2003 Mar;21(3):201-16

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

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March 2003

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.

Proc Natl Acad Sci U S A 2003 Jan 23;100(1):143-8. Epub 2002 Dec 23.

Laboratories of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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January 2003

Molecular pathogenesis of human hepatocellular carcinoma.

Toxicology 2002 Dec;181-182:43-7

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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December 2002