Publications by authors named "Lorin Crawford"

13Publications

The Landscape of Glycogen Synthase Kinase-3 Beta Genomic Alterations in Cancer.

Authors:
Brittany A Borden Yasmine Baca Joanne Xiu Fabio Tavora Ira Winer Benjamin A Weinberg Ari M Vanderwalde Sourat Darabi W Michael Korn Andrew P Mazar Francis J Giles Lorin Crawford Howard Safran Wafik S El-Deiry Benedito A Carneiro

Mol Cancer Ther 2021 01 21;20(1):183-190. Epub 2020 Oct 21.

The Warren Alpert Medical School of Brown University, Providence, Rhode Island.

View Article and Find Full Text PDF
January 2021

VARIABLE PRIORITIZATION IN NONLINEAR BLACK BOX METHODS: A GENETIC ASSOCIATION CASE STUDY.

Authors:
Lorin Crawford Seth R Flaxman Daniel E Runcie Mike West

Ann Appl Stat 2019 Jun 17;13(2):958-989. Epub 2019 Jun 17.

Duke University.

View Article and Find Full Text PDF
June 2019

Estimation of non-null SNP effect size distributions enables the detection of enriched genes underlying complex traits.

Authors:
Wei Cheng Sohini Ramachandran Lorin Crawford

PLoS Genet 2020 06 15;16(6):e1008855. Epub 2020 Jun 15.

Center for Computational Molecular Biology, Brown University, Providence, Rhode Island, United States of America.

View Article and Find Full Text PDF
June 2020

Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues.

Authors:
Jessica S Sadick Lorin A Crawford Harry C Cramer Christian Franck Shane A Liddelow Eric M Darling

Ann Biomed Eng 2020 Aug 17;48(8):2218-2232. Epub 2020 Apr 17.

Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, 02912, USA.

View Article and Find Full Text PDF
August 2020

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Authors:
Kevin H Lin Justine C Rutter Abigail Xie Bryann Pardieu Emily T Winn Reinaldo Dal Bello Antoine Forget Raphael Itzykson Yeong-Ran Ahn Ziwei Dai Raiyan T Sobhan Grace R Anderson Katherine R Singleton Amy E Decker Peter S Winter Jason W Locasale Lorin Crawford Alexandre Puissant Kris C Wood

Nat Genet 2020 04 16;52(4):408-417. Epub 2020 Mar 16.

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.

View Article and Find Full Text PDF
April 2020

Stem cells and extracellular vesicles: biological regulators of physiology and disease.

Authors:
Theodor Borgovan Lorin Crawford Chibuikem Nwizu Peter Quesenberry

Am J Physiol Cell Physiol 2019 08 27;317(2):C155-C166. Epub 2019 Mar 27.

Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University , Providence, Rhode Island.

View Article and Find Full Text PDF
August 2019

Bayesian Approximate Kernel Regression with Variable Selection.

Authors:
Lorin Crawford Kris C Wood Xiang Zhou Sayan Mukherjee

J Am Stat Assoc 2018 19;113(524):1710-1721. Epub 2018 Jun 19.

Department of Statistical Science, Duke University, Durham, NC, USA.

View Article and Find Full Text PDF
June 2018

Fast and flexible linear mixed models for genome-wide genetics.

Authors:
Daniel E Runcie Lorin Crawford

PLoS Genet 2019 02 8;15(2):e1007978. Epub 2019 Feb 8.

Department of Biostatistics, Brown University, Providence, Rhode Island, United States of America.

View Article and Find Full Text PDF
February 2019

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity.

Authors:
Ryan S Soderquist Lorin Crawford Esther Liu Min Lu Anika Agarwal Grace R Anderson Kevin H Lin Peter S Winter Merve Cakir Kris C Wood

Nat Commun 2018 08 29;9(1):3513. Epub 2018 Aug 29.

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, 27710, USA.

View Article and Find Full Text PDF
August 2018

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.

Authors:
Katherine R Singleton Lorin Crawford Elizabeth Tsui Haley E Manchester Ophelia Maertens Xiaojing Liu Maria V Liberti Anniefer N Magpusao Elizabeth M Stein Jennifer P Tingley Dennie T Frederick Genevieve M Boland Keith T Flaherty Shannon J McCall Clemens Krepler Katrin Sproesser Meenhard Herlyn Drew J Adams Jason W Locasale Karen Cichowski Sayan Mukherjee Kris C Wood

Cell Rep 2017 Dec;21(10):2796-2812

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. Electronic address:

View Article and Find Full Text PDF
December 2017

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.

Authors:
Grace R Anderson Peter S Winter Kevin H Lin Daniel P Nussbaum Merve Cakir Elizabeth M Stein Ryan S Soderquist Lorin Crawford Jim C Leeds Rachel Newcomb Priya Stepp Catherine Yip Suzanne E Wardell Jennifer P Tingley Moiez Ali Mengmeng Xu Meagan Ryan Shannon J McCall Autumn J McRee Christopher M Counter Channing J Der Kris C Wood

Cell Rep 2017 07;20(4):999-1015

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. Electronic address:

View Article and Find Full Text PDF
July 2017

Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits.

Authors:
Lorin Crawford Ping Zeng Sayan Mukherjee Xiang Zhou

PLoS Genet 2017 Jul 26;13(7):e1006869. Epub 2017 Jul 26.

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.

View Article and Find Full Text PDF
July 2017

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.

Authors:
Grace R Anderson Suzanne E Wardell Merve Cakir Lorin Crawford Jim C Leeds Daniel P Nussbaum Pallavi S Shankar Ryan S Soderquist Elizabeth M Stein Jennifer P Tingley Peter S Winter Elizabeth K Zieser-Misenheimer Holly M Alley Alexander Yllanes Victoria Haney Kimberly L Blackwell Shannon J McCall Donald P McDonnell Kris C Wood

Sci Transl Med 2016 12;8(369):369ra175

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.

View Article and Find Full Text PDF
December 2016