Publications by authors named "Loretta Tuosto"

33Publications

T Helper Cells: The Modulators of Inflammation in Multiple Sclerosis.

Cells 2020 02 19;9(2). Epub 2020 Feb 19.

Department of Biology and Biotechnology Charles Darwin, Sapienza University, 00185 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells9020482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072830PMC
February 2020

Editorial: Membrane Lipids in T Cell Functions.

Front Immunol 2018 9;9:1608. Epub 2018 Jul 9.

State Key Laboratory of Molecular Biology, Chinese Academy Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.01608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046407PMC
July 2018

CD28 between tolerance and autoimmunity: the side effects of animal models.

F1000Res 2018 30;7. Epub 2018 May 30.

Department of Biology and Biotechnology Charles Darwin, Sapienza University, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.14046.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981186PMC
May 2018

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28.

Nat Commun 2018 03 14;9(1):1080. Epub 2018 Mar 14.

Department of Biology and Biotechnology Charles Darwin, Laboratory Affiliated at Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, 00185, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-03385-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852078PMC
March 2018

ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes.

Front Immunol 2017 26;8:502. Epub 2017 Apr 26.

Department of Biology and Biotechnology Charles Darwin, Sapienza University, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2017.00502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405084PMC
April 2017

Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation.

Front Immunol 2016 13;7:186. Epub 2016 May 13.

Department of Biology and Biotechnology Charles Darwin, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University , Rome , Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2016.00186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865508PMC
May 2016

CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling.

Cytokine Growth Factor Rev 2016 Apr 4;28:11-9. Epub 2016 Mar 4.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2016.02.004DOI Listing
April 2016

Phosphatidylinositol 4-Phosphate 5-Kinase β Controls Recruitment of Lipid Rafts into the Immunological Synapse.

J Immunol 2016 Feb 15;196(4):1955-63. Epub 2016 Jan 15.

Department of Biomedical Sciences, University of Padua and Venetian Institute of Molecular Medicine, 35131 Padua, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1501788DOI Listing
February 2016

The multifaceted role of PIP2 in leukocyte biology.

Cell Mol Life Sci 2015 Dec 12;72(23):4461-74. Epub 2015 Aug 12.

Department of Experimental Medicine, Sapienza University, Viale Regina Elena 324, 00185, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-015-2013-0DOI Listing
December 2015

Phosphatidylinositol 4-phosphate 5-kinase α and Vav1 mutual cooperation in CD28-mediated actin remodeling and signaling functions.

J Immunol 2015 Feb 24;194(3):1323-33. Epub 2014 Dec 24.

Department of Biology and Biotechnology "Charles Darwin," Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University, 00185 Rome, Italy;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1401643DOI Listing
February 2015

CD28 ligation in the absence of TCR stimulation up-regulates IL-17A and pro-inflammatory cytokines in relapsing-remitting multiple sclerosis T lymphocytes.

Immunol Lett 2014 Mar-Apr;158(1-2):134-42. Epub 2014 Jan 8.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Biology and Biotechnology Charles Darwin, Sapienza University, Via dei sardi 70, 00185 Rome, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2013.12.020DOI Listing
November 2014

p53 death signal is mainly mediated by Nuc1(EndoG) in the yeast Saccharomyces cerevisiae.

FEMS Yeast Res 2013 Nov 12;13(7):682-8. Epub 2013 Aug 12.

Pasteur Institute-Cenci Bolognetti Foundation, Department of Biology and Biotechnology "Charles Darwin", University "Sapienza" of Rome, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1567-1364.12067DOI Listing
November 2013

Phosphatidylinositol 4-phosphate 5-kinase α activation critically contributes to CD28-dependent signaling responses.

J Immunol 2013 May 15;190(10):5279-86. Epub 2013 Apr 15.

Department of Biology and Biotechnology Charles Darwin, Fondazione Cenci Bolognetti Pasteur Institute, Sapienza University, 00185 Rome, Italy.

View Article

Download full-text PDF

Source
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1203157
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1203157DOI Listing
May 2013

The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein.

J Biol Chem 2011 Nov 27;286(46):39693-702. Epub 2011 Sep 27.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Biology and Biotechnology, Sapienza University, 00185-Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.279539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220532PMC
November 2011

A novel association between filamin A and NF-κB inducing kinase couples CD28 to inhibitor of NF-κB kinase α and NF-κB activation.

Immunol Lett 2011 May 26;136(2):203-12. Epub 2011 Jan 26.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Biology and Biotechnology Charles Darwin, Sapienza University, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2011.01.011DOI Listing
May 2011

NF-κB family of transcription factors: biochemical players of CD28 co-stimulation.

Authors:
Loretta Tuosto

Immunol Lett 2011 Mar 21;135(1-2):1-9. Epub 2010 Sep 21.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Biology and Biotechnology Charles Darwin, Sapienza University, Via dei sardi 70, 00185 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2010.09.005DOI Listing
March 2011

Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain.

Cell Cycle 2009 Oct 24;8(20):3396-405. Epub 2009 Oct 24.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biology and Development, Sapienza University, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.8.20.9910DOI Listing
October 2009

Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells.

Mol Cancer Ther 2008 Jun;7(6):1410-9

Department of Cellular and Developmental Biology, Sapienza University of Rome, Via dei sardi 70, 00185-Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-08-0299DOI Listing
June 2008

CD28 ligation in the absence of TCR promotes RelA/NF-kappaB recruitment and trans-activation of the HIV-1 LTR.

Eur J Immunol 2008 May;38(5):1446-51

Department of Cellular and Developmental Biology, Sapienza University of Rome, Rome, Italy.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/eji.200737854
Publisher Site
http://dx.doi.org/10.1002/eji.200737854DOI Listing
May 2008

Transglutaminase type II is involved in the pathogenesis of endotoxic shock.

J Immunol 2008 Feb;180(4):2616-24

Laboratory of Electron Microscopy, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.180.4.2616DOI Listing
February 2008

CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse.

Nat Cell Biol 2006 Nov 22;8(11):1270-6. Epub 2006 Oct 22.

Venetian Institute of Molecular Medicine, Department of Biomedical Science, University of Padua, 35100 Padua, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb1492DOI Listing
November 2006

Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis.

J Leukoc Biol 2005 Aug 27;78(2):372-82. Epub 2005 May 27.

Department of Cellular and Developmental Biology, La Sapienza University, Rome, 00185, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.0804456DOI Listing
August 2005

CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes.

J Immunol 2004 Nov;173(9):5392-7

Venetian Institute of Molecular Medicine and Department of Biomedical Science, University of Padua, Padua, Italy.

View Article

Download full-text PDF

Source
http://www.jimmunol.org/content/173/9/5392.full.pdf
Web Search
http://dx.doi.org/10.4049/jimmunol.173.9.5392DOI Listing
November 2004

CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters.

Proc Natl Acad Sci U S A 2004 Apr 12;101(16):6098-103. Epub 2004 Apr 12.

Department of Cellular and Developmental Biology, University of Rome La Sapienza, 00185 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0308688101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395929PMC
April 2004

The activation of Csk by CD4 interferes with TCR-mediated activatory signaling.

Eur J Immunol 2003 Sep;33(9):2609-18

Department of Cellular and Developmental Biology, La Sapienza University, I-00185 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200324064DOI Listing
September 2003

Proximal changes in signal transduction that modify CD8+ T cell responsiveness in vivo.

Eur J Immunol 2003 Sep;33(9):2551-6

INSERM U591, Institut Necker, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200324196DOI Listing
September 2003

Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells.

Eur J Immunol 2003 Aug;33(8):2186-96

Department of Cellular and Developmental Biology, La Sapienza University, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200323682DOI Listing
August 2003

CD4-Lck through TCR and in the absence of Vav exchange factor induces Bax increase and mitochondrial damage.

J Immunol 2002 Jun;168(12):6106-12

Department of Cellular and Developmental Biology, La Sapienza University, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.168.12.6106DOI Listing
June 2002

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

Eur J Immunol 2002 02;32(2):447-56

Department of Cellular and Developmental Biology, University of Rome La Sapienza, Via del Sardi 70, I-00185 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1521-4141(200202)32:2<447::AID-IMMU447>3.0.CO;2-5DOI Listing
February 2002