Lorenzo Trippa

Lorenzo Trippa

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Lorenzo Trippa

Lorenzo Trippa

Publications by authors named "Lorenzo Trippa"

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Ribociclib Plus Trastuzumab in Advanced HER2-Positive Breast Cancer: Results of a Phase 1b/2 Trial.

Clin Breast Cancer 2019 Dec 30;19(6):399-404. Epub 2019 May 30.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.clbc.2019.05.010DOI Listing
December 2019

Lessons Learned from Deescalation Trials in Favorable Risk HPV-Associated Squamous Cell Head and Neck Cancer-A Perspective on Future Trial Designs.

Clin Cancer Res 2019 Dec 16;25(24):7281-7286. Epub 2019 Sep 16.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0945DOI Listing
December 2019

Deviation from the Proportional Hazards Assumption in Randomized Phase 3 Clinical Trials in Oncology: Prevalence, Associated Factors, and Implications.

Clin Cancer Res 2019 Nov 25;25(21):6339-6345. Epub 2019 Jul 25.

Department of Radiation Oncology, Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3999DOI Listing
November 2019

Frequentist operating characteristics of Bayesian optimal designs via simulation.

Stat Med 2019 Sep 19;38(21):4026-4039. Epub 2019 Jun 19.

Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/sim.8279DOI Listing
September 2019

A phase II study of cabozantinib alone or in combination with trastuzumab in breast cancer patients with brain metastases.

Breast Cancer Res Treat 2019 Sep 20. Epub 2019 Sep 20.

Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s10549-019-05445-zDOI Listing
September 2019

Design and Evaluation of an External Control Arm Using Prior Clinical Trials and Real-World Data.

Clin Cancer Res 2019 Aug 7;25(16):4993-5001. Epub 2019 Jun 7.

Dana-Farber Program in Regulatory Science, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697596PMC
August 2019

Multi-study factor analysis.

Biometrics 2019 03 8;75(1):337-346. Epub 2019 Mar 8.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://doi.wiley.com/10.1111/biom.12974
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http://dx.doi.org/10.1111/biom.12974DOI Listing
March 2019

Bayesian adaptive design: the future for regional anesthesia trials?

Reg Anesth Pain Med 2019 Mar 2. Epub 2019 Mar 2.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1136/rapm-2018-100248DOI Listing
March 2019

Bayesian Adaptive Randomization in Dose-Finding Trials.

JAMA Netw Open 2018 12 7;1(8):e186075. Epub 2018 Dec 7.

Dana-Farber Cancer Institute, Department of Biostatistics and Computational Biology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.6075DOI Listing
December 2018

Efficient computation of the joint probability of multiple inherited risk alleles from pedigree data.

Genet Epidemiol 2018 09 25;42(6):528-538. Epub 2018 Jun 25.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/gepi.22130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129424PMC
September 2018

Adding experimental arms to platform clinical trials: randomization procedures and interim analyses.

Biostatistics 2018 04;19(2):199-215

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02115, USA and Department of Biostatistics, Harvard T. H. Chan School of Public Health, 655 Huntington Ave, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1093/biostatistics/kxx030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862294PMC
April 2018

Hazards of Hazard Ratios - Deviations from Model Assumptions in Immunotherapy.

N Engl J Med 2018 03;378(12):1158-1159

Dana-Farber Cancer Institute, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1716612DOI Listing
March 2018

Unbiased estimation for response adaptive clinical trials.

Stat Methods Med Res 2017 Oct 11;26(5):2376-2388. Epub 2015 Aug 11.

3 Dana-Farber Cancer Institute, Boston, USA.

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http://dx.doi.org/10.1177/0962280215597716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395089PMC
October 2017

Bayesian response-adaptive designs for basket trials.

Biometrics 2017 09 17;73(3):905-915. Epub 2017 Feb 17.

Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1111/biom.12668DOI Listing
September 2017

Designing Clinical Trials That Accept New Arms: An Example in Metastatic Breast Cancer.

J Clin Oncol 2017 Sep 22;35(27):3160-3168. Epub 2017 May 22.

Steffen Ventz, University of Rhode Island, Kingstown, RI; Brian M. Alexander, Giovanni Parmigiani, Richard D. Gelber, and Lorenzo Trippa, Dana-Farber Cancer Institute; Brian M. Alexander and Richard D. Gelber, Harvard Medical School; Giovanni Parmigiani, Richard D. Gelber, and Lorenzo Trippa, Harvard TH Chan School of Public Health; Richard D. Gelber, Frontier Science Foundation, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2016.70.1169DOI Listing
September 2017

Leveraging molecular datasets for biomarker-based clinical trial design in glioblastoma.

Neuro Oncol 2017 Jul;19(7):908-917

Department of Radiation Oncology, Department of Pathology, Center for Neuro-Oncology, Dana-Farber/Brigham & Women's Cancer Center (DF/BWCC), Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts; Accelerate Brain Cancer Cure (ABC2), Washington, DC; Harvard Program in Therapeutic Science, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/now312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570228PMC
July 2017

A Bayesian response-adaptive trial in tuberculosis: The endTB trial.

Clin Trials 2017 Feb 23;14(1):17-28. Epub 2016 Sep 23.

1 Department of Biostatistics, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1177/1740774516665090DOI Listing
February 2017

Bayesian Baskets: A Novel Design for Biomarker-Based Clinical Trials.

J Clin Oncol 2017 Feb 3;35(6):681-687. Epub 2017 Jan 3.

Lorenzo Trippa and Brian Michael Alexander, Dana-Farber Cancer Institute; Lorenzo Trippa, Harvard School of Public Health; and Brian Michael Alexander, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2016.68.2864DOI Listing
February 2017

Bayesian Nonparametric Ordination for the Analysis of Microbial Communities.

J Am Stat Assoc 2017 28;112(520):1430-1442. Epub 2017 Feb 28.

Assistant Professor, Department of Biostatistics, Harvard University, Boston, MA 02115.

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http://dx.doi.org/10.1080/01621459.2017.1288631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804367PMC
February 2017

Robust lineage reconstruction from high-dimensional single-cell data.

Nucleic Acids Res 2016 08 20;44(14):e122. Epub 2016 May 20.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA Harvard Stem Cell Institute, Cambridge, MA 02138, USA

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http://dx.doi.org/10.1093/nar/gkw452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001598PMC
August 2016

Optimal Bayesian adaptive trials when treatment efficacy depends on biomarkers.

Biometrics 2016 06 17;72(2):414-21. Epub 2015 Nov 17.

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, U.S.A.

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http://dx.doi.org/10.1111/biom.12437DOI Listing
June 2016

Subgroup-Based Adaptive (SUBA) Designs for Multi-Arm Biomarker Trials.

Stat Biosci 2016 Jun 17;8(1):159-180. Epub 2014 Jul 17.

Center for Clinical and Research Informatics, NorthShore University Health System Evanston, IL, U.S.A; Department of Health Studies, The University of Chicago, Chicago, IL, U.S.A.

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http://dx.doi.org/10.1007/s12561-014-9117-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014435PMC
June 2016

On the restricted mean survival time curve in survival analysis.

Biometrics 2016 Mar 24;72(1):215-21. Epub 2015 Aug 24.

Department of Biostatistics, Harvard University, Boston, Massachusetts 02115, U.S.A.

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http://dx.doi.org/10.1111/biom.12384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114026PMC
March 2016

Mitigating Bias in Generalized Linear Mixed Models: The Case for Bayesian Nonparametrics.

Stat Sci 2016 Feb 10;31(1):80-95. Epub 2016 Feb 10.

Associate Professor, Department of Biostatistics, Harvard Chan School of Public Health, 655 Huntington Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1214/15-STS533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624537PMC
February 2016

A toolbox for spatiotemporal analysis of voltage-sensitive dye imaging data in brain slices.

PLoS One 2014 26;9(9):e108686. Epub 2014 Sep 26.

Department of Pediatrics, Division of Pediatric Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America; Department of Neurology, Division of Pediatric Neurology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108686PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178182PMC
January 2016

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.

Neuro Oncol 2015 Oct 9;17(10):1344-55. Epub 2015 Mar 9.

Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.H.R., L.A.R., S.H., D.K., Y.J.K., K.L.L.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.E.S., L.B., M.B., D.A.R., E.Q.L., M.L.R., A.D.N., L.N., S.R., L.M.D., D.C.L., P.K., B.J.R., P.Y.W., R.B., K.L.L.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (W.L.B., E.B.C, O.A.-M., M.D.J., A.J.G., I.F.D., E.A.C.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (L.T.); Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts (M.H., A.A.A., N.D.A., B.M.A.); Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (M.H., A.A.A., N.D.A., B.M.A.); Harvard Radiation Oncology Program, Boston, Massachusetts (A.R.); Kravis Center for Molecular Oncology & Department of Epidemiology and Biostatistics, Memorial Sloan- Kettering Cancer Center, New York, New York (N.S.); Broad Institute, Cambridge, Massachusetts (R.B.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (K.L.L.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., A.D., J.B.C., M.A., S.S., R.D.F., N.I.L., A.H.L., K.L.L.)

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http://dx.doi.org/10.1093/neuonc/nov015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578577PMC
October 2015

Combining progression-free survival and overall survival as a novel composite endpoint for glioblastoma trials.

Neuro Oncol 2015 Aug 7;17(8):1106-13. Epub 2015 Jan 7.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (L.T., G.P.); Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts (L.T., G.P.); Center for Neuro-Oncology Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, (P.Y.W., B.M.A.); Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts (B.M.A.); Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas (D.A.B.).

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http://dx.doi.org/10.1093/neuonc/nou345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490868PMC
August 2015

Getting it first versus getting it right: weighing the value of and evidence for progression-free survival as a surrogate endpoint for overall survival in glioblastoma.

Neuro Oncol 2015 May;17(5):765-6

Dana-Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts (B.M.A.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (L.T.); Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts (L.T.).

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http://dx.doi.org/10.1093/neuonc/nov024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482865PMC
May 2015

Bayesian designs and the control of frequentist characteristics: a practical solution.

Biometrics 2015 Mar 5;71(1):218-226. Epub 2014 Sep 5.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Department of Biostatistics Harvard School of Public Health, Boston, Massachusetts, 02115, U.S.A.

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http://dx.doi.org/10.1111/biom.12226DOI Listing
March 2015

Brain Malignancy Steering Committee clinical trials planning workshop: report from the Targeted Therapies Working Group.

Neuro Oncol 2015 Feb 26;17(2):180-8. Epub 2014 Aug 26.

Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (B.M.A., L.T., K.L.L., P.Y.W.); Mayo Clinic, Rochester, Minnesota (E.G., K.V.B., B.P.O., J.N.S.); The University of Texas M.D. Anderson Cancer Center, Houston, Texas (W.K.A.Y., J.F.D., D.A.B.); St. Jude Children's Research Hospital, Memphis, Tennessee (J.M.B.); University of California, Los Angeles, California (T.F.C.); Memorial Sloan-Kettering Cancer Center, New York, New York (J.T.H., I.K.M.); National Cancer Institute, Bethesda, Maryland (B.M., A.T.-A.); Princess Margaret Cancer Centre, Toronto, Ontario, Canada (W.M.); Henry Ford Hospital, Detroit, Michigan (T.M.); University of California, San Diego, La Jolla, California (P.S.M.); University of California, San Francisco, California (M.D.P.); Johns Hopkins University, Baltimore, Maryland (X.Y.).

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http://dx.doi.org/10.1093/neuonc/nou154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288520PMC
February 2015

Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape.

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5643-50. Epub 2014 Dec 15.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1408993111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284553PMC
December 2014

Statistical tools and R software for cancer driver probabilities.

Methods Mol Biol 2014 ;1101:113-34

Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-62703-721-1_7DOI Listing
June 2014

A comparison of Bayesian adaptive randomization and multi-stage designs for multi-arm clinical trials.

Stat Med 2014 Jun 14;33(13):2206-21. Epub 2014 Jan 14.

MRC Biostatistics Unit, Institute of Public Health, Cambridge, U.K.

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http://dx.doi.org/10.1002/sim.6086DOI Listing
June 2014

Cross-study validation for the assessment of prediction algorithms.

Bioinformatics 2014 Jun;30(12):i105-12

Leibniz Supercomputing Center, Garching, Department for Medical Informatics, Biometry and Epidemiology, Munich, Germany, Cambridge, MA, Dana-Farber Cancer Institute, Boston, Harvard School of Public Health, Boston, USA and City University of New York School of Public Health, Hunter College, New York, USALeibniz Supercomputing Center, Garching, Department for Medical Informatics, Biometry and Epidemiology, Munich, Germany, Cambridge, MA, Dana-Farber Cancer Institute, Boston, Harvard School of Public Health, Boston, USA and City University of New York School of Public Health, Hunter College, New York, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058929PMC
June 2014

Progression-free survival: too much risk, not enough reward?

Neuro Oncol 2014 May;16(5):615-6

Dana-Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts (B.M.A.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts (L.T.).

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http://dx.doi.org/10.1093/neuonc/nou041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984564PMC
May 2014

Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples.

J Natl Cancer Inst 2014 Apr 3;106(5). Epub 2014 Apr 3.

Affiliations of authors: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA (MR, ACC, LT, FM, CH, GP); Department of Biostatistics, Harvard School of Public Health, Boston, MA (MR, ACC, LT, FM, CH, GP); Center for Cancer Research (WW, S-hK, MB) and Department of Pathology (EO), Massachusetts General Hospital, Boston, MA; City University of New York School of Public Health, Hunter College, New York, NY (LW); Sung-hoon Kim, Yonsei University College of Medicine, Seoul, Korea (S-HK).

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http://dx.doi.org/10.1093/jnci/dju048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580556PMC
April 2014

Biomarker-based adaptive trials for patients with glioblastoma--lessons from I-SPY 2.

Neuro Oncol 2013 Aug 14;15(8):972-8. Epub 2013 Jul 14.

Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/neuonc/not088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714161PMC
August 2013

Defining Predictive Probability Functions for Species Sampling Models.

Stat Sci 2013 ;28(2):209-222

Department of Biostatistics, Harvard University, and Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA ( ).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870164PMC
http://dx.doi.org/10.1214/12-sts407DOI Listing
January 2013

Bayesian adaptive randomized trial design for patients with recurrent glioblastoma.

J Clin Oncol 2012 Sep 29;30(26):3258-63. Epub 2012 May 29.

Dana-Farber Cancer Institute, Harvard School of Public Health and Dana-Farber/ Brigham and Women's Cancer Center, Boston, MA 02215, USA.

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http://jco.ascopubs.org/content/early/2012/05/29/JCO.2011.39
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2011.39.8420
Publisher Site
http://dx.doi.org/10.1200/JCO.2011.39.8420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434985PMC
September 2012

Bayesian enrichment strategies for randomized discontinuation trials.

Biometrics 2012 Mar 29;68(1):203-11. Epub 2011 Jun 29.

Harvard School of Public Health and Department of Biostatistics, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1111/j.1541-0420.2011.01623.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667626PMC
March 2012

The multivariate beta process and an extension of the Polya tree model.

Biometrika 2011 Mar 2;98(1):17-34. Epub 2011 Feb 2.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, U.S.A. ,

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http://dx.doi.org/10.1093/biomet/asq072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744636PMC
March 2011