Lorenzo Silengo

Lorenzo Silengo

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Lorenzo Silengo

Lorenzo Silengo

Publications by authors named "Lorenzo Silengo"

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Characterization of Human Mesenchymal Stem Cells Isolated from the Testis.

Stem Cells Int 2018 3;2018:4910304. Epub 2018 Sep 3.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy.

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https://www.hindawi.com/journals/sci/2018/4910304/
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http://dx.doi.org/10.1155/2018/4910304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140008PMC
September 2018

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis.

Cell Death Differ 2018 Mar 11;25(3):573-588. Epub 2017 Dec 11.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1038/s41418-017-0001-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864215PMC
March 2018

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake.

PLoS One 2013 27;8(6):e68146. Epub 2013 Jun 27.

Molecular Biotechnology Center, University of Torino, Torino, Italy ; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068146PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694894PMC
October 2017

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Free Radic Biol Med 2017 07 8;108:452-464. Epub 2017 Apr 8.

Dept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.04.003DOI Listing
July 2017

APL-1, an altered peptide ligand derived from heat-shock protein, alone or combined with methotrexate attenuates murine collagen-induced arthritis.

Clin Exp Med 2017 May 9;17(2):209-216. Epub 2016 May 9.

Biomedical Research Department, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 10600, Havana, Cuba.

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http://link.springer.com/10.1007/s10238-016-0412-7
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http://dx.doi.org/10.1007/s10238-016-0412-7DOI Listing
May 2017

Prospects for Adult Stem Cells in the Treatment of Liver Diseases.

Stem Cells Dev 2016 Sep 7. Epub 2016 Sep 7.

2 Molecular Biotechnology Center, University of Turin , Turin, Italy .

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http://dx.doi.org/10.1089/scd.2016.0144DOI Listing
September 2016

Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells.

PLoS One 2015 31;10(8):e0136762. Epub 2015 Aug 31.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556379PMC
June 2016

Alteration of heme metabolism in a cellular model of Diamond-Blackfan anemia.

Eur J Haematol 2016 Apr 25;96(4):367-74. Epub 2015 Jun 25.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1111/ejh.12599DOI Listing
April 2016

Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis.

Antioxid Redox Signal 2015 Dec 20;23(18):1410-23. Epub 2015 Jul 20.

1 Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , Torino, Italy .

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http://dx.doi.org/10.1089/ars.2014.6216DOI Listing
December 2015

Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.

J Pathol 2014 Oct 6;234(2):152-63. Epub 2014 Aug 6.

Department of Biotechnology and Health Sciences, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1002/path.4341DOI Listing
October 2014

Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.

Biochim Biophys Acta 2014 24;1839(4):259-64. Epub 2014 Feb 24.

Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.02.010DOI Listing
June 2014

Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

Gastroenterology 2014 May 31;146(5):1325-38. Epub 2014 Jan 31.

Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.01.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000440PMC
May 2014

Renal cells from spermatogonial germline stem cells protect against kidney injury.

J Am Soc Nephrol 2014 Feb 17;25(2):316-28. Epub 2013 Oct 17.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, and.

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http://dx.doi.org/10.1681/ASN.2013040367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904562PMC
February 2014

Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development.

J Immunol 2013 Dec 23;191(11):5451-9. Epub 2013 Oct 23.

Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy;

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http://dx.doi.org/10.4049/jimmunol.1203076DOI Listing
December 2013

Extracellular vesicles as an emerging mechanism of cell-to-cell communication.

Endocrine 2013 Aug 1;44(1):11-9. Epub 2012 Dec 1.

Department of Molecular Biotechnology and Health Science, Translational Center for Regenerative Medicine, University of Torino, Via Nizza 52, Turin, Italy.

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http://dx.doi.org/10.1007/s12020-012-9839-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726927PMC
August 2013

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.

Circulation 2013 Mar 27;127(12):1317-29. Epub 2013 Feb 27.

Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.130179DOI Listing
March 2013

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.

Blood Cells Mol Dis 2013 Jan 24;50(1):25-30. Epub 2012 Aug 24.

Dept. of Genetics, Biology and Biochemistry, University of Torino, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2012.08.002DOI Listing
January 2013

Assessment of iron absorption in mice by ICP-MS measurements of (57)Fe levels.

Eur J Nutr 2012 Oct 19;51(7):783-9. Epub 2011 Oct 19.

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126, Turin, Italy.

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http://link.springer.com/content/pdf/10.1007/s00394-011-0256
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http://link.springer.com/10.1007/s00394-011-0256-6
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http://dx.doi.org/10.1007/s00394-011-0256-6DOI Listing
October 2012

The aging effect of chemotherapy on cultured human mesenchymal stem cells.

Exp Hematol 2011 Dec 22;39(12):1171-81. Epub 2011 Aug 22.

Department of Medical Oncology Sp., University of Torino, Italy.

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http://dx.doi.org/10.1016/j.exphem.2011.08.009DOI Listing
December 2011

ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.

J Cell Sci 2011 Oct;124(Pt 20):3515-24

Dipartimento di Genetica, Biologia e Biochimica, Università di Torino, Molecular Biotechnology Center, via Nizza, 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1242/jcs.091140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706035PMC
October 2011

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

Cardiovasc Res 2011 Aug 14;91(3):456-64. Epub 2011 Apr 14.

Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, Università di Torino, via Nizza 52, Turin, Italy.

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http://dx.doi.org/10.1093/cvr/cvr103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294280PMC
August 2011

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

Stem Cells Dev 2010 Aug;19(8):1183-94

Department of Genetics, Biology and Biochemistry and Molecular Biotechnology Center, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1089/scd.2009.0496DOI Listing
August 2010

Therapeutic efficacy and immunological response of CCL5 antagonists in models of contact skin reaction.

PLoS One 2010 Jan 15;5(1):e8725. Epub 2010 Jan 15.

Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008725PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806914PMC
January 2010

Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression.

J Cell Physiol 2009 Feb;218(2):294-303

Centro di Biotecnologie Molecolari and Dipartimento di Genetica, Biologia e Biochimica, Università di Torino, Torino, Italy.

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http://dx.doi.org/10.1002/jcp.21603DOI Listing
February 2009

Lack of plasma protein hemopexin dampens mercury-induced autoimmune response in mice.

J Immunol 2008 Aug;181(3):1937-47

Department of Genetics, Biology and Biochemistry, and Molecular Biotechnology Center, University of Turin, Turin, Italy.

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August 2008

Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload.

Am J Pathol 2008 Jul 13;173(1):289-99. Epub 2008 Jun 13.

Molecular Biotechnology Center, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.2353/ajpath.2008.071130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438305PMC
July 2008

The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1.

FEBS Lett 2008 Jun 12;582(13):1788-94. Epub 2008 May 12.

Department of Genetics, Biology and Biochemistry, University of Torino, Molecular Biotechnology Center, via Nizza, 52, Torino, Italy.

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http://dx.doi.org/10.1016/j.febslet.2008.04.058DOI Listing
June 2008

Prediction of human disease genes by human-mouse conserved coexpression analysis.

PLoS Comput Biol 2008 Mar 28;4(3):e1000043. Epub 2008 Mar 28.

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy.

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https://dx.plos.org/10.1371/journal.pcbi.1000043
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http://dx.doi.org/10.1371/journal.pcbi.1000043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268251PMC
March 2008

Magnetically enriched bone marrow-derived macrophages loaded in vitro with iron oxide can migrate to inflammation sites in mice.

NMR Biomed 2008 Feb;21(2):120-8

Department of Genetics, Biology and Biochemistry and CERMS, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1002/nbm.1168DOI Listing
February 2008

Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression.

Gastroenterology 2007 Oct;133(4):1261-1271

Department of Genetics, Biology and Biochemistry, and Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1053/j.gastro.2007.07.004DOI Listing
October 2007

The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.

J Cell Sci 2007 Jun 8;120(Pt 11):1859-67. Epub 2007 May 8.

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Turin, Italy.

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http://dx.doi.org/10.1242/jcs.000703DOI Listing
June 2007

E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function.

J Cell Sci 2005 Oct;118(Pt 20):4765-83

Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5/bis, Torino, 10126, Italy.

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http://dx.doi.org/10.1242/jcs.02584DOI Listing
October 2005

Systematic analysis of the epidermal growth factor receptor by mass spectrometry reveals stimulation-dependent multisite phosphorylation.

Mol Cell Proteomics 2005 Aug 18;4(8):1107-21. Epub 2005 May 18.

Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

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http://dx.doi.org/10.1074/mcp.M500070-MCP200DOI Listing
August 2005

Plasma protein haptoglobin modulates renal iron loading.

Am J Pathol 2005 Apr;166(4):973-83

Department of Genetics, Biology and Biochemistry, University of Turin, Via Santena 5bis, 10126 Turin, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602399PMC
http://dx.doi.org/10.1016/S0002-9440(10)62319-XDOI Listing
April 2005

PAkt, cyclin D1 and p27/Kip.1 in glioblastomas with and without EGFR amplification and PTEN mutation.

Anticancer Res 2004 Sep-Oct;24(5A):2643-7

Department of Neuroscience, University of Turin, Via Cherasco, 15 and Turin, Italy.

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December 2004

CLOE: identification of putative functional relationships among genes by comparison of expression profiles between two species.

BMC Bioinformatics 2004 Nov 19;5:179. Epub 2004 Nov 19.

Department of Genetics, Biology and Biochemistry, Via Santena 5 bis, 10126, Torino, Italy.

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http://dx.doi.org/10.1186/1471-2105-5-179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535557PMC
November 2004

p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells.

J Cell Sci 2004 Mar;117(Pt 8):1603-11

Dipartimento di Genetica, Biologia e Biochimica, Università di Torino, Via Santena 5 bis, 10126 Turin, Italy.

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http://dx.doi.org/10.1242/jcs.01025DOI Listing
March 2004

Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma.

World J Gastroenterol 2004 Feb;10(4):598-601

Ambulatorio di Gastroenterologia, Ospedale S Giovanni Battista, Via Chiabrera 34, III piano, 10126 Torino, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716988PMC
February 2004

Identification of Krit1B: a novel alternative splicing isoform of cerebral cavernous malformation gene-1.

Gene 2004 Jan;325:63-78

Department of Genetic, Biology and Biochemistry, University of Torino and Experimental Medicine Research Centre, San Giovanni Battista Hospital, Via Santena 5/bis, 10126 Turin, Italy.

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January 2004

Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation.

Nat Cell Biol 2003 Dec 2;5(12):1071-8. Epub 2003 Nov 2.

Dipartimento di Genetica, Biologia e Biochimica, Università Degli Studi di Torino Via Santena, 5 bis, Torino, Italy.

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http://dx.doi.org/10.1038/ncb1064DOI Listing
December 2003

Chp-1 and melusin, two CHORD containing proteins in vertebrates.

FEBS Lett 2003 Sep;551(1-3):47-52

Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, 10126 Torino, Italy.

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http://www.thbiotec.com/pdf/2003-Febs-Lett-Chp1-Melusin.pdf
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September 2003

Role of citron kinase in dendritic morphogenesis of cortical neurons.

Brain Res Bull 2003 May;60(4):319-27

Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, 10126, Torino, Italy.

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May 2003

Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis.

Blood 2002 Dec 25;100(12):4201-8. Epub 2002 Jul 25.

Department of Genetics, Biology and Biochemistry, University of Turin and the San Giovanni Battista Hospital, Turin, Italy.

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http://dx.doi.org/10.1182/blood-2002-04-1270DOI Listing
December 2002

Essential role of citron kinase in cytokinesis of spermatogenic precursors.

J Cell Sci 2002 Dec;115(Pt 24):4819-26

Department of Genetics, Biology and Biochemistry, Via Santena 5 bis, Torino, Italy.

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December 2002