Publications by authors named "Lorenzo Beretta"

100Publications

The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET.

Authors:
Rosaria Talarico Silvia Aguilera Tobias Alexander Zahir Amoura Ana M Antunes Laurent Arnaud Tadej Avcin Lorenzo Beretta Stefano Bombardieri Gerd R Burmester Sara Cannizzo Lorenzo Cavagna Benjamin Chaigne Alain Cornet Nathalie Costedoat-Chalumeau Andrea Doria Alessandro Ferraris Rebecca Fischer-Betz João E Fonseca Charissa Frank Andrea Gaglioti Ilaria Galetti Jürgen Grunert Vera Guimarães Eric Hachulla Frederic Houssiau Luca Iaccarino Thomas Krieg Marteen Limper Fransiska Malfait Xavier Mariette Diana Marinello Thierry Martin Lisa Matthews Marco Matucci-Cerinic Alain Meyer Carlomaurizio Montecucco Luc Mouthon Ulf Müller-Ladner Simona Rednic Vasco C Romão Matthias Schneider Vanessa Smith Alberto Sulli Farah Tamirou Domenica Taruscio Anna V Taulaigo Enrique Terol Angela Tincani Simone Ticciati Giuseppe Turchetti P Martin van Hagen Jacob M van Laar Ana Vieira Jeska K de Vries-Bouwstra Maurizio Cutolo Marta Mosca

Nat Rev Rheumatol 2021 Jan 6. Epub 2021 Jan 6.

Rheumatology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.

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January 2021

Angiopoietin-2 Promotes Inflammatory Activation in Monocytes of Systemic Sclerosis Patients.

Authors:
Tiago Carvalheiro Ana P Lopes Maarten van der Kroef Beatriz Malvar-Fernandez Carlos Rafael-Vidal Anneline C Hinrichs Nila H Servaas Femke Bonte-Mineur Marc R Kok Lorenzo Beretta Maili Zimmermann Wioleta Marut Jose M Pego-Reigosa Timothy R D J Radstake Samuel Garcia

Int J Mol Sci 2020 Dec 15;21(24). Epub 2020 Dec 15.

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.

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December 2020

Genomic Risk Score impact on susceptibility to systemic sclerosis.

Authors:
Lara Bossini-Castillo Gonzalo Villanueva-Martin Martin Kerick Marialbert Acosta-Herrera Elena López-Isac Carmen P Simeón Norberto Ortego-Centeno Shervin Assassi Nicolas Hunzelmann Armando Gabrielli J K de Vries-Bouwstra Yannick Allanore Carmen Fonseca Christopher P Denton Timothy Rdj Radstake Marta Eugenia Alarcón-Riquelme Lorenzo Beretta Maureen D Mayes Javier Martin

Ann Rheum Dis 2021 Jan 1;80(1):118-127. Epub 2020 Oct 1.

Instituto de Parasitologia y Biomedicina Lopez-Neyra, Granada, Andalucía, Spain

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January 2021

COVID-19 in systemic lupus erythematosus: Data from a survey on 417 patients.

Authors:
Giuseppe A Ramirez Maria Gerosa Lorenzo Beretta Chiara Bellocchi Lorenza M Argolini Luca Moroni Emanuel Della Torre Carolina Artusi Selene Nicolosi Roberto Caporali Enrica P Bozzolo Lorenzo Dagna

Semin Arthritis Rheum 2020 10 30;50(5):1150-1157. Epub 2020 Jun 30.

Università Vita-Salute San Raffaele, Milan, Italy; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.

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October 2020

Systemic lupus erythematosus and COVID-19: what we know so far.

Authors:
Giuseppe A Ramirez Luca Moroni Emanuel Della-Torre Maria Gerosa Lorenzo Beretta Enrica P Bozzolo Lorenzo Dagna

Ann Rheum Dis 2020 Aug 28. Epub 2020 Aug 28.

Università Vita Salute San Raffaele, Milano, Italy.

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August 2020

Letter to the editor: Immunomodulation by phosphodiesterase-4 inhibitor in COVID-19 patients.

Authors:
Alessandro Santaniello Barbara Vigone Lorenzo Beretta

Metabolism 2020 09 20;110:154300. Epub 2020 Jun 20.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Via Pace 9, 20122 Milan, Italy. Electronic address:

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September 2020

Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patients.

Authors:
Lorenzo Beretta Guillermo Barturen Barbara Vigone Chiara Bellocchi Nicolas Hunzelmann Ellen De Langhe Ricard Cervera Maria Gerosa László Kovács Rafaela Ortega Castro Isabel Almeida Divi Cornec Carlo Chizzolini Jacques-Olivier Pers Zuzanna Makowska Ralf Lesche Martin Kerick Marta Eugenia Alarcón-Riquelme Javier Martin

Ann Rheum Dis 2020 09 19;79(9):1218-1226. Epub 2020 Jun 19.

Instituto de Parasitologia y Biomedicina Lopez-Neyra, Granada, Spain.

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September 2020

Autoantibodies to stratify systemic sclerosis patients into clinically actionable subsets.

Authors:
Michael Mahler Marie Hudson Chelsea Bentow Fabrece Roup Lorenzo Beretta Carmen Pilar Simeón Alfredo Guillén-Del-Castillo Sílvia Casas Marvin J Fritzler

Autoimmun Rev 2020 Aug 14;19(8):102583. Epub 2020 Jun 14.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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August 2020

Systemic sclerosis Progression INvestiGation (SPRING) Italian registry: demographic and clinico-serological features of the scleroderma spectrum.

Authors:
Clodoveo Ferri Dilia Giuggioli Serena Guiducci Federica Lumetti Gianluigi Bajocchi Luca Magnani Veronica Codullo Alarico Ariani Francesco Girelli Valeria Riccieri Greta Pellegrino Silvia Bosello Rosario Foti Elisa Visalli Giorgio Amato Alessia Benenati Giovanna Cuomo Florenzo Iannone Fabio Cacciapaglia Rossella De Angelis Francesca Ingegnoli Rossella Talotta Corrado Campochiaro Lorenzo Dagna Giacomo De Luca Silvia Bellando-Randone Amelia Spinella Giuseppe Murdaca Nicoletta Romeo Maria De Santis Elena Generali Simone Barsotti Alessandra Della Rossa Ilaria Cavazzana Francesca Dall'Ara Maria G Lazzaroni Franco Cozzi Andrea Doria Erika Pigatto Elisabetta Zanatta Giovanni Ciano Lorenzo Beretta Giuseppina Abignano Salvatore D'Angelo Gianna Mennillo Gianluca Bagnato Francesca Calabrese Maurizio Caminiti Giuseppa Pagano Mariano Elisabetta Battaglia Ennio Lubrano Giovanni Zanframundo Annamaria Iuliano Federica Furini Anna Zanetti Greta Carrara Federica Rumi Carlo Alberto Scirè Marco Matucci-Cerinic

Clin Exp Rheumatol 2020 May-Jun;38 Suppl 125(3):40-47. Epub 2020 Apr 14.

University of Florence, Italy.

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September 2020

CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis.

Authors:
Maarten van der Kroef Tiago Carvalheiro Marzia Rossato Floor de Wit Marta Cossu Eleni Chouri Catharina G K Wichers Cornelis P J Bekker Lorenzo Beretta Nadia Vazirpanah Elena Trombetta Timothy R D J Radstake Chiara Angiolilli

J Autoimmun 2020 07 10;111:102444. Epub 2020 Apr 10.

Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:

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July 2020

Safety and effectiveness of abatacept in systemic sclerosis: The EUSTAR experience.

Authors:
Ivan Castellví Muriel Elhai Cosimo Bruni Paolo Airò Suzana Jordan Lorenzo Beretta Veronica Codullo Carlo Maurizio Montecucco Maria Bokarewa Florenzo Iannonne Alexandra Balbir Vivien M Hsu Oliver Distler Marco Matucci-Cerinic Yannick Allanore

Semin Arthritis Rheum 2020 12 3;50(6):1489-1493. Epub 2020 Feb 3.

Paris Descartes University, INSERM U1016, Sorbone Paris Cité, Rheumatology A Department, Cochin Hospital, Paris, France.

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December 2020

Belimumab may decrease flare rate and allow glucocorticoid withdrawal in lupus nephritis (including dialysis and transplanted patient).

Authors:
Valentina Binda Barbara Trezzi Nicoletta Del Papa Lorenzo Beretta Giulia Frontini Giulia Porata Paolo Fabbrini Maria Rosa Pozzi Piergiorgio Messa Renato Alberto Sinico Gabriella Moroni

J Nephrol 2020 Oct 30;33(5):1019-1025. Epub 2020 Jan 30.

Divisione Di Nefrologia E Dialisi-Padiglione Croff, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico Di Milano, via della Commenda 15, 20122, Milan, Italy.

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October 2020

Discovering new metabolite alterations in primary sjögren's syndrome in urinary and plasma samples using an HPLC-ESI-QTOF-MS methodology.

Authors:
Álvaro Fernández-Ochoa Isabel Borrás-Linares Rosa Quirantes-Piné Marta E Alarcón-Riquelme Lorenzo Beretta Antonio Segura-Carretero

J Pharm Biomed Anal 2020 Feb 20;179:112999. Epub 2019 Nov 20.

Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avd. Fuentenueva s/n, 18071, Granada, Spain; Research and Development of Functional Food Centre (CIDAF), Health Science Technological Park, Avd. del Conocimiento, nº 37, 18016, Granada, Spain. Electronic address:

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February 2020

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.

Authors:
Elena López-Isac Marialbert Acosta-Herrera Martin Kerick Shervin Assassi Ansuman T Satpathy Jeffrey Granja Maxwell R Mumbach Lorenzo Beretta Carmen P Simeón Patricia Carreira Norberto Ortego-Centeno Ivan Castellvi Lara Bossini-Castillo F David Carmona Gisela Orozco Nicolas Hunzelmann Jörg H W Distler Andre Franke Claudio Lunardi Gianluca Moroncini Armando Gabrielli Jeska de Vries-Bouwstra Cisca Wijmenga Bobby P C Koeleman Annika Nordin Leonid Padyukov Anna-Maria Hoffmann-Vold Benedicte Lie Susanna Proudman Wendy Stevens Mandana Nikpour Timothy Vyse Ariane L Herrick Jane Worthington Christopher P Denton Yannick Allanore Matthew A Brown Timothy R D J Radstake Carmen Fonseca Howard Y Chang Maureen D Mayes Javier Martin

Nat Commun 2019 10 31;10(1):4955. Epub 2019 Oct 31.

Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain.

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October 2019

Cardiopulmonary exercise testing in a combined screening approach to individuate pulmonary arterial hypertension in systemic sclerosis.

Authors:
Alessandro Santaniello Rosa Casella Marco Vicenzi Irene Rota Gaia Montanelli Maria De Santis Chiara Bellocchi Federico Lombardi Lorenzo Beretta

Rheumatology (Oxford) 2020 07;59(7):1581-1586

Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases.

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July 2020

IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis.

Authors:
Mayada Metwally Khaled Thabet Ali Bayoumi Mandana Nikpour Wendy Stevens Joanne Sahhar Jane Zochling Janet Roddy Kathleen Tymms Gemma Strickland Susan Lester Maureen Rischmueller Gene-Siew Ngian Jennifer Walker Pravin Hissaria Olfat Shaker Christopher Liddle Nicholas Manolios Lorenzo Beretta Susanna Proudman Jacob George Mohammed Eslam

Sci Rep 2019 10 16;9(1):14834. Epub 2019 Oct 16.

Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia.

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October 2019

Identification of a Shared Microbiomic and Metabolomic Profile in Systemic Autoimmune Diseases.

Authors:
Chiara Bellocchi Álvaro Fernández-Ochoa Gaia Montanelli Barbara Vigone Alessandro Santaniello Rosa Quirantes-Piné Isabel Borrás-Linares Maria Gerosa Carolina Artusi Roberta Gualtierotti Antonio Segura-Carrettero Marta E Alarcón-Riquelme Lorenzo Beretta

J Clin Med 2019 Aug 23;8(9). Epub 2019 Aug 23.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy.

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August 2019

Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome.

Authors:
Maarten van der Kroef Lucas L van den Hoogen Jorre S Mertens Sofie L M Blokland Scott Haskett Abhinandan Devaprasad Tiago Carvalheiro Eleni Chouri Nadia Vazirpanah Marta Cossu Catherina G K Wichers Sandra C Silva-Cardoso Alsya J Affandi Cornelis P J Bekker Ana P Lopes Maarten R Hillen Femke Bonte-Mineur Marc R Kok Lorenzo Beretta Marzia Rossato Michaël Mingueneau Joel A G van Roon Timothy R D J Radstake

Eur J Immunol 2020 01 11;50(1):119-129. Epub 2019 Sep 11.

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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January 2020

Cardiac autonomic modulation at rest and during orthostatic stress among different systemic sclerosis subsets.

Authors:
Gabriel Dias Rodrigues Eleonora Tobaldini Chiara Bellocchi Alessandro Santaniello Monica Caronni Adriana Severino Marco Froldi Lorenzo Beretta Pedro Paulo da Silva Soares Nicola Montano

Eur J Intern Med 2019 Aug 13;66:75-80. Epub 2019 Jun 13.

Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Electronic address:

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August 2019

Iloprost use and medical management of systemic sclerosis-related vasculopathy in Italian tertiary referral centers: results from the PROSIT study.

Authors:
Simone Negrini Ottavia Magnani Marco Matucci-Cerinic Renato Carignola Valeria Data Erika Montabone Alessandro Santaniello Giuditta Adorni Giuseppe Murdaca Francesco Puppo Francesco Indiveri Alessandra Della Rossa Anna D'Ascanio Simone Barsotti Dilia Giuggioli Clodoveo Ferri Federica Lumetti Silvia Laura Bosello Giovanni Canestrari Silvia Bellando Randone Cosimo Bruni Serena Guiducci Elisabetta Battaglia Maria Ilenia De Andres Alessandra Azzurra Russo Lorenzo Beretta

Clin Exp Med 2019 Aug 15;19(3):357-366. Epub 2019 Apr 15.

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.

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August 2019

Undifferentiated connective tissue disease: state of the art on clinical practice guidelines.

Authors:
Margarida Antunes Carlo Alberto Scirè Rosaria Talarico Tobias Alexander Tadej Avcin Chiara Belocchi Andrea Doria Franco Franceschini Ilaria Galetti Marcello Govoni Eric Hachulla David Launay Gemma Lepri Carla Macieira Marco Matucci-Cerinic Carlo Maurizio Montecucco Maria Francisca Moraes-Fontes Luc Mouthon Sabrina Paolino Veronique Ramoni Chiara Tani Sander W Tas Angela Tincani Ronald Van Vollenhoven Margherita Zen Joao Fonseca Stefano Bombardieri João Eurico Fonseca Matthias Schneider Vanessa Smith Maurizio Cutolo Marta Mosca Lorenzo Beretta

RMD Open 2018 26;4(Suppl 1):e000786. Epub 2019 Feb 26.

Referral Center for Systemic Autoimmue Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.

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February 2019

Idiopathic inflammatory myopathies: state of the art on clinical practice guidelines [corrected].

Authors:
Alain Meyer Carlo Alberto Scirè Rosaria Talarico Tobias Alexander Zahir Amoura Tadej Avcin Simone Barsotti Lorenzo Beretta Jelena Blagojevic Gerd Burmester Ilaria Cavazzana Patrick Cherrin Laura Damian Andrea Doria João Eurico Fonseca Federica Furini Ilaria Galetti Frederic Houssiau Thomas Krieg Larosa Maddalena David Launay Raquel Campanilho-Marques Thierry Martin Marco Matucci-Cerinic Pia Moinzadeh Carlomaurizio Montecucco Maria Francisca Moraes-Fontes Luc Mouthon Rossella Neri Sabrina Paolino Yves Piette Simona Rednic Farah Tamirou Angela Tincani Natasa Toplak Stefano Bombardieri Eric Hachulla Ulf Mueller-Ladner Matthias Schneider Vanessa Smith Ana Vieira Maurizio Cutolo Marta Mosca Lorenzo Cavagna

RMD Open 2018 26;4(Suppl 1):e000784. Epub 2019 Feb 26.

Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.

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February 2019

The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis.

Authors:
Barbara Mariotti Nila Hendrika Servaas Marzia Rossato Nicola Tamassia Marco A Cassatella Marta Cossu Lorenzo Beretta Maarten van der Kroef Timothy R D J Radstake Flavia Bazzoni

Front Immunol 2019 31;10:100. Epub 2019 Jan 31.

General Pathology Section, Department of Medicine, University of Verona, Verona, Italy.

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December 2019

Histone modifications underlie monocyte dysregulation in patients with systemic sclerosis, underlining the treatment potential of epigenetic targeting.

Authors:
Maarten van der Kroef Monica Castellucci Michal Mokry Marta Cossu Marianna Garonzi Lara M Bossini-Castillo Eleni Chouri Catharina G K Wichers Lorenzo Beretta Elena Trombetta Sandra Silva-Cardoso Nadia Vazirpanah Tiago Carvalheiro Chiara Angiolilli Cornelis P J Bekker Alsya J Affandi Kris A Reedquist Femke Bonte-Mineur Els J M Zirkzee Flavia Bazzoni Timothy R D J Radstake Marzia Rossato

Ann Rheum Dis 2019 04 6;78(4):529-538. Epub 2019 Feb 6.

Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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April 2019

A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility.

Authors:
David González-Serna Elio G Carmona Norberto Ortego-Centeno Carmen P Simeón Roser Solans José Hernández-Rodríguez Carlos Tolosa Santos Castañeda Javier Narváez Ferran Martinez-Valle Torsten Witte Thomas Neumann Julia Holle Lorenzo Beretta Luigi Boiardi Giacomo Emmi Marco A Cimmino Augusto Vaglio Ariane L Herrick Christopher P Denton Carlo Salvarani María C Cid Ann W Morgan Carmen Fonseca Miguel A González-Gay Javier Martín Ana Márquez

PLoS One 2018 26;13(12):e0209343. Epub 2018 Dec 26.

Instituto de Parasitología y Biomedicina "López-Neyra", CSIC, PTS Granada, Granada, Spain.

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May 2019

Mixed connective tissue disease: state of the art on clinical practice guidelines.

Authors:
Benjamin Chaigne Carlo Alberto Scirè Rosaria Talarico Tobias Alexander Zahir Amoura Tadej Avcin Lorenzo Beretta Andrea Doria Aurelien Guffroy Vera Guimarães Éric Hachulla Thomas Krieg David Launay Gemma Lepri Pia Moinzadeh Ulf Müller-Ladner Simona Rednic Ana Rodrigues Sander W Tas Ronald F van Vollenhoven Ana Vieira Stefano Bombardieri João Eurico Fonseca Ilaria Galetti Matthias Schneider Vanessa Smith Maurizio Cutolo Marta Mosca Rebecca Fischer-Betz

RMD Open 2018 18;4(Suppl 1):e000783. Epub 2018 Oct 18.

Department of Rheumatology, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.

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October 2018

Urinary and plasma metabolite differences detected by HPLC-ESI-QTOF-MS in systemic sclerosis patients.

Authors:
Álvaro Fernández-Ochoa Rosa Quirantes-Piné Isabel Borrás-Linares David Gemperline Marta E Alarcón Riquelme Lorenzo Beretta Antonio Segura-Carretero

J Pharm Biomed Anal 2019 Jan 11;162:82-90. Epub 2018 Sep 11.

Research and Development of Functional Food Centre (CIDAF), Health Science Technological Park, Granada, Spain; Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Granada, Spain.

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January 2019

Microbial and metabolic multi-omic correlations in systemic sclerosis patients.

Authors:
Chiara Bellocchi Álvaro Fernández-Ochoa Gaia Montanelli Barbara Vigone Alessandro Santaniello Christian Milani Rosa Quirantes-Piné Isabel Borrás-Linares Marco Ventura Antonio Segura-Carrettero Marta Eugenia Alarcón-Riquelme Lorenzo Beretta

Ann N Y Acad Sci 2018 06 11;1421(1):97-109. Epub 2018 May 11.

Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.

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June 2018

Moving towards a molecular taxonomy of autoimmune rheumatic diseases.

Authors:
Guillermo Barturen Lorenzo Beretta Ricard Cervera Ronald Van Vollenhoven Marta E Alarcón-Riquelme

Nat Rev Rheumatol 2018 Feb;14(3):180

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February 2018

Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis.

Authors:
Eleni Chouri Nila H Servaas Cornelis P J Bekker Alsya J Affandi Marta Cossu Maarten R Hillen Chiara Angiolilli Jorre S Mertens Lucas L van den Hoogen Sandra Silva-Cardoso Maarten van der Kroef Nadia Vazirpanah Catharina G K Wichers Tiago Carvalheiro Sofie L M Blokland Barbara Giovannone Laura Porretti Wioleta Marut Barbara Vigone Joel A G van Roon Lorenzo Beretta Marzia Rossato Timothy R D J Radstake

J Autoimmun 2018 05 20;89:162-170. Epub 2018 Jan 20.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address:

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May 2018

Moving towards a molecular taxonomy of autoimmune rheumatic diseases.

Authors:
Guillermo Barturen Lorenzo Beretta Ricard Cervera Ronald Van Vollenhoven Marta E Alarcón-Riquelme

Nat Rev Rheumatol 2018 01;14(2):75-93

GENYO Centre for Genomics and Oncological Research: Pfizer - University of Granada - Andalusian Government, Avenida de la Ilustración 114, P.T.S., 18016 Granada, Spain.

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January 2018

FOXP3, ICOS and ICOSL gene polymorphisms in systemic sclerosis: FOXP3 rs2294020 is associated with disease progression in a female Italian population.

Authors:
Fabio D'Amico Giovanni Fiorito Evangelia Skarmoutsou Mariagrazia Granata Giulio A Rossi Chiara Trovato Chiara Bellocchi Maurizio Marchini Lorenzo Beretta Maria Clorinda Mazzarino

Immunobiology 2018 01 5;223(1):112-117. Epub 2017 Oct 5.

Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 97, 95123 Catania, Italy.

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January 2018

Unmet Needs in Systemic Sclerosis Understanding and Treatment: the Knowledge Gaps from a Scientist's, Clinician's, and Patient's Perspective.

Authors:
Marta Cossu Lorenzo Beretta Petra Mosterman Maria J H de Hair Timothy R D J Radstake

Clin Rev Allergy Immunol 2018 Dec;55(3):312-331

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

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December 2018

Earliest Phase of Systemic Sclerosis Typified by Increased Levels of Inflammatory Proteins in the Serum.

Authors:
Marta Cossu Lenny van Bon Carlo Preti Marzia Rossato Lorenzo Beretta Timothy R D J Radstake

Arthritis Rheumatol 2017 12 30;69(12):2359-2369. Epub 2017 Oct 30.

University Medical Center Utrecht, Utrecht, The Netherlands.

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December 2017

An MIF Promoter Polymorphism Is Associated with Susceptibility to Pulmonary Arterial Hypertension in Diffuse Cutaneous Systemic Sclerosis.

Authors:
Lara Bossini-Castillo Diana Campillo-Davó Elena López-Isac Francisco David Carmona Carmen P Simeon Patricia Carreira José Luis Callejas-Rubio Iván Castellví Antonio Fernández-Nebro Luis Rodríguez-Rodríguez Manel Rubio-Rivas Francisco J García-Hernández Ana Belén Madroñero Lorenzo Beretta Alessandro Santaniello Claudio Lunardi Paolo Airó Anna-Maria Hoffmann-Vold Alexander Kreuter Gabriela Riemekasten Torsten Witte Nicolas Hunzelmann Madelon C Vonk Alexandre E Voskuyl J de Vries-Bouwstra Paul Shiels Ariane Herrick Jane Worthington Timothy R D J Radstake Javier Martin

J Rheumatol 2017 Oct 1;44(10):1453-1457. Epub 2017 Jul 1.

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October 2017

Preliminary safety and efficacy profile of prucalopride in the treatment of systemic sclerosis (SSc)-related intestinal involvement: results from the open label cross-over PROGASS study.

Authors:
Barbara Vigone Monica Caronni Adriana Severino Chiara Bellocchi Anna Rita Baldassarri Mirella Fraquelli Gaia Montanelli Alessandro Santaniello Lorenzo Beretta

Arthritis Res Ther 2017 06 20;19(1):145. Epub 2017 Jun 20.

Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Via Pace 9, 20122, Milano, Italy.

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June 2017

Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis.

Authors:
Marzia Rossato Alsya J Affandi Soley Thordardottir Catharina G K Wichers Marta Cossu Jasper C A Broen Frederique M Moret Lara Bossini-Castillo Eleni Chouri Lenny van Bon Femke Wolters Wioleta Marut Maarten van der Kroef Sandra Silva-Cardoso Cornelis P J Bekker Harry Dolstra Jacob M van Laar Javier Martin Joel A G van Roon Kris A Reedquist Lorenzo Beretta Timothy R D J Radstake

Arthritis Rheumatol 2017 09 25;69(9):1891-1902. Epub 2017 Jul 25.

University Medical Center Utrecht, Utrecht, The Netherlands.

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September 2017

Analysis of ATP8B4 F436L Missense Variant in a Large Systemic Sclerosis Cohort.

Authors:
Elena López-Isac Lara Bossini-Castillo Ana B Palma Shervin Assassi Maureen D Mayes Carmen P Simeón Norberto Ortego-Centeno Esther Vicente Carlos Tolosa Manuel Rubio-Rivas José A Román-Ivorra Lorenzo Beretta Gianluca Moroncini Nicolas Hunzelmann Jörg H W Distler Gabriella Riemekasten Jeska de Vries-Bouwstra Alexandre E Voskuyl Timothy R D J Radstake Ariane Herrick Christopher P Denton Carmen Fonseca Javier Martín

Arthritis Rheumatol 2017 06 9;69(6):1337-1338. Epub 2017 May 9.

Institute of Parasitology and Biomedicine López-Neyra, Granada, Spain.

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June 2017

A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.

Authors:
F David Carmona Augusto Vaglio Sarah L Mackie José Hernández-Rodríguez Paul A Monach Santos Castañeda Roser Solans Inmaculada C Morado Javier Narváez Marc Ramentol-Sintas Colin T Pease Bhaskar Dasgupta Richard Watts Nader Khalidi Carol A Langford Steven Ytterberg Luigi Boiardi Lorenzo Beretta Marcello Govoni Giacomo Emmi Francesco Bonatti Marco A Cimmino Torsten Witte Thomas Neumann Julia Holle Verena Schönau Laurent Sailler Thomas Papo Julien Haroche Alfred Mahr Luc Mouthon Øyvind Molberg Andreas P Diamantopoulos Alexandre Voskuyl Elisabeth Brouwer Thomas Daikeler Christoph T Berger Eamonn S Molloy Lorraine O'Neill Daniel Blockmans Benedicte A Lie Paul Mclaren Timothy J Vyse Cisca Wijmenga Yannick Allanore Bobby P C Koeleman Jennifer H Barrett María C Cid Carlo Salvarani Peter A Merkel Ann W Morgan Miguel A González-Gay Javier Martín

Am J Hum Genet 2017 Jan 29;100(1):64-74. Epub 2016 Dec 29.

Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain.

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January 2017

The magnitude of cytokine production by stimulated CD56 cells is associated with early stages of systemic sclerosis.

Authors:
Marta Cossu Lenny van Bon Stefan Nierkens Chiara Bellocchi Alessandro Santaniello Harry Dolstra Lorenzo Beretta Timothy R D J Radstake

Clin Immunol 2016 Dec 9;173:76-80. Epub 2016 Sep 9.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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December 2016

Nearest neighbor imputation algorithms: a critical evaluation.

Authors:
Lorenzo Beretta Alessandro Santaniello

BMC Med Inform Decis Mak 2016 07 25;16 Suppl 3:74. Epub 2016 Jul 25.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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July 2016

Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies.

Authors:
Elena López-Isac Jose-Ezequiel Martín Shervin Assassi Carmen P Simeón Patricia Carreira Norberto Ortego-Centeno Mayka Freire Emma Beltrán Javier Narváez Juan J Alegre-Sancho Benjamín Fernández-Gutiérrez Alejandro Balsa Ana M Ortiz Miguel A González-Gay Lorenzo Beretta Alessandro Santaniello Chiara Bellocchi Claudio Lunardi Gianluca Moroncini Armando Gabrielli Torsten Witte Nicolas Hunzelmann Jörg H W Distler Gabriella Riekemasten Annette H van der Helm-van Mil Jeska de Vries-Bouwstra Cesar Magro-Checa Alexandre E Voskuyl Madelon C Vonk Øyvind Molberg Tony Merriman Roger Hesselstrand Annika Nordin Leonid Padyukov Ariane Herrick Steve Eyre Bobby P C Koeleman Christopher P Denton Carmen Fonseca Timothy R D J Radstake Jane Worthington Maureen D Mayes Javier Martín

Arthritis Rheumatol 2016 09;68(9):2338-44

Institute of Parasitology and Biomedicine López-Neyra CSIC, Granada, Spain.

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September 2016

Serum levels of vascular dysfunction markers reflect disease severity and stage in systemic sclerosis patients.

Authors:
Marta Cossu Romina Andracco Alessandro Santaniello Maurizio Marchini Adriana Severino Monica Caronni Timothy Radstake Lorenzo Beretta

Rheumatology (Oxford) 2016 Jun 17;55(6):1112-6. Epub 2016 Mar 17.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Referral Center for Systemic Autoimmune Diseases, Milano, Italy

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June 2016

The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis.

Authors:
Zana Brkic Lenny van Bon Marta Cossu Cornelia G van Helden-Meeuwsen Madelon C Vonk Hanneke Knaapen Wim van den Berg Virgil A Dalm Paul L Van Daele Adriana Severino Naomi I Maria Samara Guillen Willem A Dik Lorenzo Beretta Marjan A Versnel Timothy Radstake

Ann Rheum Dis 2016 08 14;75(8):1567-73. Epub 2015 Sep 14.

Department of Rheumatology, Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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August 2016

Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

Authors:
Elena López-Isac Diana Campillo-Davo Lara Bossini-Castillo Sandra G Guerra Shervin Assassi Carmen Pilar Simeón Patricia Carreira Norberto Ortego-Centeno Paloma García de la Peña Lorenzo Beretta Alessandro Santaniello Chiara Bellocchi Claudio Lunardi Gianluca Moroncini Armando Gabrielli Gabriela Riemekasten Torsten Witte Nicolas Hunzelmann Alexander Kreuter Jörg Hw Distler Alexandre E Voskuyl Jeska de Vries-Bouwstra Ariane Herrick Jane Worthington Christopher P Denton Carmen Fonseca Timothy Rdj Radstake Maureen D Mayes Javier Martín

Ann Rheum Dis 2016 Aug 2;75(8):1521-6. Epub 2015 Sep 2.

Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, PTS Granada, Granada, Spain.

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August 2016

Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis.

Authors:
Eguzkine Ochoa José-Ezequiel Martin Shervin Assasi Lorenzo Beretta Patricia Carreira Alfredo Guillén Carmen Pilar Simeón Eugénie Koumakis Philippe Dieude Yannick Allanore Francisco J García-Hernández Gerard Espinosa Ivan Castellví Jose Luis Trapiella Luis Rodriguez Miguel Ángel González-Gay María Victoria Egurbide Luis Sáez Jose Luis Callejas-Rubio Jose Antonio Vargas-Hitos Nicolas Hunzelmann Gabriela Riemekasten Torsten Witte Jörg H W Distler Alexander Kreuter Claudio Lunardi Alessandro Santaniello Filemon K Tan Paul G Shiels Ariane Herrick Jane Worthington Madelon C Vonk Bobby P Koeleman Timothy R D J Radstake Maureen D Mayes Javier Martin

Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 91):S31-5. Epub 2015 Aug 27.

Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain.

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October 2015

Reply to J. Magalon et al.

Authors:
Nicoletta Del Papa Gabriele Di Luca Domenico Sambataro Eleonora Zaccara Wanda Maglione Armando Gabrielli Paolo Fraticelli Gianluca Moroncini Lorenzo Beretta Alessandro Santaniello Gianluca Sambataro Roberto Ferraresi Claudio Vitali

Cell Transplant 2015 20;24(12):2669-70. Epub 2015 May 20.

U.O.C. Day Hospital Reumatologia, Ospedale G. Pini, Milano, Italy.

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August 2016

A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility.

Authors:
F David Carmona Sarah L Mackie Jose-Ezequiel Martín John C Taylor Augusto Vaglio Stephen Eyre Lara Bossini-Castillo Santos Castañeda Maria C Cid José Hernández-Rodríguez Sergio Prieto-González Roser Solans Marc Ramentol-Sintas M Francisca González-Escribano Lourdes Ortiz-Fernández Inmaculada C Morado Javier Narváez José A Miranda-Filloy Lorenzo Beretta Claudio Lunardi Marco A Cimmino Davide Gianfreda Daniele Santilli Giuseppe A Ramirez Alessandra Soriano Francesco Muratore Giulia Pazzola Olga Addimanda Cisca Wijmenga Torsten Witte Jan H Schirmer Frank Moosig Verena Schönau Andre Franke Øyvind Palm Øyvind Molberg Andreas P Diamantopoulos Simon Carette David Cuthbertson Lindsy J Forbess Gary S Hoffman Nader A Khalidi Curry L Koening Carol A Langford Carol A McAlear Larry Moreland Paul A Monach Christian Pagnoux Philip Seo Robert Spiera Antoine G Sreih Kenneth J Warrington Steven R Ytterberg Peter K Gregersen Colin T Pease Andrew Gough Michael Green Lesley Hordon Stephen Jarrett Richard Watts Sarah Levy Yusuf Patel Sanjeet Kamath Bhaskar Dasgupta Jane Worthington Bobby P C Koeleman Paul I W de Bakker Jennifer H Barrett Carlo Salvarani Peter A Merkel Miguel A González-Gay Ann W Morgan Javier Martín

Am J Hum Genet 2015 Apr 26;96(4):565-80. Epub 2015 Mar 26.

Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain.

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April 2015

Regional implantation of autologous adipose tissue-derived cells induces a prompt healing of long-lasting indolent digital ulcers in patients with systemic sclerosis.

Authors:
Nicoletta Del Papa Gabriele Di Luca Domenico Sambataro Eleonora Zaccara Wanda Maglione Armando Gabrielli Paolo Fraticelli Gianluca Moroncini Lorenzo Beretta Alessandro Santaniello Gianluca Sambataro Roberto Ferraresi Claudio Vitali

Cell Transplant 2015 12;24(11):2297-305. Epub 2014 Dec 12.

U.O.C. Day Hospital Reumatologia, Ospedale G. Pini, Milano, Italy.

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October 2016

A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA.

Authors:
Ana Márquez Roser Solans José Hernández-Rodríguez Maria C Cid Santos Castañeda Marc Ramentol Luis Rodriguez-Rodriguez Javier Narváez Ricardo Blanco Norberto Ortego-Centeno Oyvind Palm Andreas P Diamantopoulos Niko Braun Frank Moosig Torsten Witte Lorenzo Beretta Claudio Lunardi Marco A Cimmino Augusto Vaglio Carlo Salvarani Miguel A González-Gay Javier Martín

PLoS One 2014 19;9(11):e113476. Epub 2014 Nov 19.

Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain.

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December 2015

Role of class II human leucocyte antigens in the progression from early to definite systemic sclerosis.

Authors:
Barbara Vigone Alessandro Santaniello Maurizio Marchini Gaia Montanelli Monica Caronni Adriana Severino Lorenzo Beretta

Rheumatology (Oxford) 2015 Apr 16;54(4):707-11. Epub 2014 Sep 16.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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April 2015

Identification of IL12RB1 as a novel systemic sclerosis susceptibility locus.

Authors:
Elena López-Isac Lara Bossini-Castillo Sandra G Guerra Christopher Denton Carmen Fonseca Shervin Assassi Xiaodong Zhou Maureen D Mayes Carmen Pilar Simeón Norberto Ortego-Centeno Iván Castellví Patricia Carreira Olga Gorlova Lorenzo Beretta Alessandro Santaniello Claudio Lunardi Roger Hesselstrand Annika Nordin Gabriela Riemekasten Torsten Witte Nicolas Hunzelmann Alexander Kreuter Jörg H W Distler Alexandre E Voskuyl Jeska de Vries-Bouwstra Bobby P Koeleman Ariane Herrick Jane Worthington Timothy R D J Radstake Javier Martin

Arthritis Rheumatol 2014 Dec;66(12):3521-3

Institute of Parasitology and Biomedicine, López-Neyra, Consejo Superior de Investigaciones Cientificas and Parque Tecnologico de la Salud, Granada, Spain.

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December 2014

Validation of a novel radiographic scoring system for calcinosis affecting the hands of patients with systemic sclerosis.

Authors:
Lorinda Chung Antonia Valenzuela David Fiorentino Kathryn Stevens Shufeng Li Jonathan Harris Charles Hutchinson Shervin Assassi Lorenzo Beretta Santhanam Lakshminarayanan Tatiana S Rodriguez-Reyna Christopher P Denton Rebecca G Taillefer Ariane L Herrick Murray Baron

Arthritis Care Res (Hoboken) 2015 Mar;67(3):425-30

Stanford University School of Medicine, Palo Alto, California

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March 2015

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility.

Authors:
Elena López-Isac Lara Bossini-Castillo Carmen P Simeon María Victoria Egurbide Juan José Alegre-Sancho Jose Luis Callejas José Andrés Roman-Ivorra Mayka Freire Lorenzo Beretta Alessandro Santaniello Paolo Airó Claudio Lunardi Nicolas Hunzelmann Gabriela Riemekasten Torsten Witte Alexander Kreuter Jörg H W Distler Annemie J Schuerwegh Madelon C Vonk Alexandre E Voskuyl Paul G Shiels Jacob M van Laar Carmen Fonseca Christopher Denton Ariane Herrick Jane Worthington Shervin Assassi Bobby P Koeleman Maureen D Mayes Timothy R D J Radstake Javier Martin

Arthritis Res Ther 2014 Jan 9;16(1):R6. Epub 2014 Jan 9.

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January 2014

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.

Authors:
Maureen D Mayes Lara Bossini-Castillo Olga Gorlova José Ezequiel Martin Xiaodong Zhou Wei V Chen Shervin Assassi Jun Ying Filemon K Tan Frank C Arnett John D Reveille Sandra Guerra María Teruel Francisco David Carmona Peter K Gregersen Annette T Lee Elena López-Isac Eguzkine Ochoa Patricia Carreira Carmen Pilar Simeón Iván Castellví Miguel Ángel González-Gay Alexandra Zhernakova Leonid Padyukov Marta Alarcón-Riquelme Cisca Wijmenga Matthew Brown Lorenzo Beretta Gabriela Riemekasten Torsten Witte Nicolas Hunzelmann Alexander Kreuter Jörg H W Distler Alexandre E Voskuyl Annemie J Schuerwegh Roger Hesselstrand Annika Nordin Paolo Airó Claudio Lunardi Paul Shiels Jacob M van Laar Ariane Herrick Jane Worthington Christopher Denton Fredrick M Wigley Laura K Hummers John Varga Monique E Hinchcliff Murray Baron Marie Hudson Janet E Pope Daniel E Furst Dinesh Khanna Kristin Phillips Elena Schiopu Barbara M Segal Jerry A Molitor Richard M Silver Virginia D Steen Robert W Simms Robert A Lafyatis Barri J Fessler Tracy M Frech Firas Alkassab Peter Docherty Elzbieta Kaminska Nader Khalidi Henry Niall Jones Janet Markland David Robinson Jasper Broen Timothy R D J Radstake Carmen Fonseca Bobby P Koeleman Javier Martin

Am J Hum Genet 2014 Jan;94(1):47-61

Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada 18016, Spain.

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January 2014

Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis.

Authors:
Lenny van Bon Alsya J Affandi Jasper Broen Romy B Christmann Renoud J Marijnissen Lukasz Stawski Giuseppina A Farina Giuseppina Stifano Allison L Mathes Marta Cossu Michael York Cindy Collins Mark Wenink Richard Huijbens Roger Hesselstrand Tore Saxne Mike DiMarzio Dirk Wuttge Sandeep K Agarwal John D Reveille Shervin Assassi Maureen Mayes Yanhui Deng Joost P H Drenth Jacqueline de Graaf Martin den Heijer Cees G M Kallenberg Marc Bijl Arnoud Loof Wim B van den Berg Leo A B Joosten Vanessa Smith Filip de Keyser Rafaella Scorza Claudio Lunardi Piet L C M van Riel Madelon Vonk Waander van Heerde Stephan Meller Bernhard Homey Lorenzo Beretta Mark Roest Maria Trojanowska Robert Lafyatis Timothy R D J Radstake

N Engl J Med 2014 Jan 18;370(5):433-43. Epub 2013 Dec 18.

The authors' affiliations are listed in the Appendix.

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January 2014

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.

Authors:
Jose-Ezequiel Martin Shervin Assassi Lina-Marcela Diaz-Gallo Jasper C Broen Carmen P Simeon Ivan Castellvi Esther Vicente-Rabaneda Vicente Fonollosa Norberto Ortego-Centeno Miguel A González-Gay Gerard Espinosa Patricia Carreira Mayte Camps Jose M Sabio Sandra D'alfonso Madelon C Vonk Alexandre E Voskuyl Annemie J Schuerwegh Alexander Kreuter Torsten Witte Gabriella Riemekasten Nicolas Hunzelmann Paolo Airo Lorenzo Beretta Raffaella Scorza Claudio Lunardi Jacob Van Laar Meng May Chee Jane Worthington Arianne Herrick Christopher Denton Carmen Fonseca Filemon K Tan Frank Arnett Xiaodong Zhou John D Reveille Olga Gorlova Bobby P C Koeleman Timothy R D J Radstake Timothy Vyse Maureen D Mayes Marta E Alarcón-Riquelme Javier Martin

Hum Mol Genet 2013 Oct 4;22(19):4021-9. Epub 2013 Jun 4.

These authors contributed equally to this work.

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October 2013

Carbohydrate antigen 15.3 as a serum biomarker of interstitial lung disease in systemic sclerosis patients.

Authors:
Stefania Celeste Alessandro Santaniello Monica Caronni Jurij Franchi Adirana Severino Raffaella Scorza Lorenzo Beretta

Eur J Intern Med 2013 Oct 19;24(7):671-6. Epub 2013 May 19.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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October 2013

The role of the NLRP1 gene in systemic sclerosis: a replication study.

Authors:
María Teruel Carmen P Simeon Jasper Broen Patricia Carreira Paloma García de la Peña M Ángeles Aguirre Lorenzo Beretta Torsten Witte Alexander Kreuter Madelon C Vonk Alexandre E Voskuyl Annemie J Schuerwegh Timothy R D J Radstake Javier Martin

Clin Exp Rheumatol 2013 Mar-Apr;31(2 Suppl 76):187-8. Epub 2013 Feb 1.

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September 2013

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.

Authors:
F David Carmona Jose-Ezequiel Martin Lorenzo Beretta Carmen P Simeón Patricia E Carreira José Luis Callejas Mónica Fernández-Castro Luis Sáez-Comet Emma Beltrán María Teresa Camps María Victoria Egurbide Paolo Airó Raffaella Scorza Claudio Lunardi Nicolas Hunzelmann Gabriela Riemekasten Torsten Witte Alexander Kreuter Jörg H W Distler Rajan Madhok Paul Shiels Jacob M van Laar Carmen Fonseca Christopher Denton Ariane Herrick Jane Worthington Annemie J Schuerwegh Madelon C Vonk Alexandre E Voskuyl Timothy R D J Radstake Javier Martín

PLoS One 2013 23;8(1):e54419. Epub 2013 Jan 23.

Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain.

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July 2013

Effect of dihydropyridine calcium channel blockers and glucocorticoids on the prevention and development of scleroderma renal crisis in an Italian case series.

Authors:
Gaia Montanelli Lorenzo Beretta Alessandro Santaniello Raffaella Scorza

Clin Exp Rheumatol 2013 Mar-Apr;31(2 Suppl 76):135-9. Epub 2012 Dec 13.

Referral Centre for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.

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September 2013

KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor.

Authors:
Lara Bossini-Castillo Carmen P Simeon Lorenzo Beretta Jasper Broen Madelon C Vonk José Luis Callejas Patricia Carreira Luis Rodríguez-Rodríguez Rosa García-Portales Miguel A González-Gay Ivan Castellví María Teresa Camps Carlos Tolosa Esther Vicente-Rabaneda María Victoria Egurbide Annemie J Schuerwegh Roger Hesselstrand Claudio Lunardi Jacob M van Laar Paul Shiels Ariane Herrick Jane Worthington Christopher Denton Timothy R D J Radstake Carmen Fonseca Javier Martin

Arthritis Res Ther 2012 Dec 27;14(6):R273. Epub 2012 Dec 27.

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December 2012

Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility.

Authors:
Lina-Marcela Diaz-Gallo Carmen P Simeon Jasper C Broen Norberto Ortego-Centeno Lorenzo Beretta Madelon C Vonk Patricia E Carreira Sofia Vargas José Andrés Román-Ivorra Miguel A González-Gay Carlos Tolosa Francisco Javier López-Longo Gerard Espinosa Esther F Vicente Roger Hesselstrand Gabriela Riemekasten Torsten Witte Jörg H W Distler Alexandre E Voskuyl Annemie J Schuerwegh Paul G Shiels Annika Nordin Leonid Padyukov Anna-Maria Hoffmann-Vold Raffaella Scorza Claudio Lunardi Paolo Airo Jacob M van Laar Nicolas Hunzelmann Birgit S Gathof Alexander Kreuter Ariane Herrick Jane Worthington Christopher P Denton Xiaodong Zhou Frank C Arnett Carmen Fonseca Bobby P C Koeleman Shervin Assasi Timothy R D J Radstake Maureen D Mayes Javier Martín

Ann Rheum Dis 2013 Jul 21;72(7):1233-8. Epub 2012 Nov 21.

Cellular Biology and Immunology Department, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain.

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July 2013

Extension of the survival dimensionality reduction algorithm to detect epistasis in competing risks models (SDR-CR).

Authors:
Lorenzo Beretta Alessandro Santaniello

J Biomed Inform 2013 Feb 12;46(1):174-80. Epub 2012 Nov 12.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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February 2013

Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study.

Authors:
Lara Bossini-Castillo Jose Ezequiel Martin Jasper Broen Carmen P Simeon Lorenzo Beretta Olga Y Gorlova Madelon C Vonk Norberto Ortego-Centeno Gerard Espinosa Patricia Carreira Paloma García de la Peña Natividad Oreiro José Andrés Román-Ivorra María Jesús Castillo Miguel A González-Gay Luis Sáez-Comet Ivan Castellví Annemie J Schuerwegh Alexandre E Voskuyl Anna-Maria Hoffmann-Vold Roger Hesselstrand Annika Nordin Claudio Lunardi Raffaella Scorza Jacob M van Laar Paul G Shiels Ariane Herrick Jane Worthington Carmen Fonseca Christopher Denton Filemon K Tan Frank C Arnett Shervin Assassi Bobby P Koeleman Maureen D Mayes Timothy R D J Radstake Javier Martin

Ann Rheum Dis 2013 Apr 15;72(4):602-7. Epub 2012 Aug 15.

Department of Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Consejo Superior de Investigaciones Científicas, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento s/n 18100-Armilla, Granada, Spain.

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April 2013

Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis.

Authors:
María Teruel Carmen P Simeon Jasper Broen Madelon C Vonk Patricia Carreira Maria Teresa Camps Rosa García-Portales Esmeralda Delgado-Frías Maria Gallego Gerard Espinosa Lorenzo Beretta Paolo Airó Claudio Lunardi Gabriela Riemekasten Torsten Witte Thomas Krieg Alexander Kreuter Jörg H W Distler Nicolas Hunzelmann Bobby P Koeleman Alexandre E Voskuyl Annemie J Schuerwegh Miguel Angel González-Gay Timothy R D J Radstake Javier Martin

Arthritis Res Ther 2012 Jun 25;14(3):R154. Epub 2012 Jun 25.

Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Avda, del Conocimiento s/n, 18010, Granada, SpainArmilla (Granada), Spain.

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June 2012

A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis.

Authors:
Lara Bossini-Castillo Carmen P Simeon Lorenzo Beretta Jasper C Broen Madelon C Vonk Raquel Ríos-Fernández Gerard Espinosa Patricia Carreira María T Camps Maria J Castillo Miguel A González-Gay Emma Beltrán María del Carmen Freire Javier Narváez Carlos Tolosa Torsten Witte Alexander Kreuter Annemie J Schuerwegh Anna-Maria Hoffmann-Vold Roger Hesselstrand Claudio Lunardi Jacob M van Laar Meng May Chee Ariane Herrick Bobby Pc Koeleman Christopher P Denton Carmen Fonseca Timothy Rdj Radstake Javier Martin

Arthritis Res Ther 2012 Apr 24;14(2):R85. Epub 2012 Apr 24.

Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Avenida del Conocimiento s/n, Granada, 18100, Spain.

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April 2012

Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up.

Authors:
Jose-Ezequiel Martin Jasper C Broen F David Carmona Maria Teruel Carmen P Simeon Madelon C Vonk Ruben van 't Slot Luis Rodriguez-Rodriguez Esther Vicente Vicente Fonollosa Norberto Ortego-Centeno Miguel A González-Gay Francisco J García-Hernández Paloma García de la Peña Patricia Carreira Alexandre E Voskuyl Annemie J Schuerwegh Piet L C M van Riel Alexander Kreuter Torsten Witte Gabriella Riemekasten Paolo Airo Raffaella Scorza Claudio Lunardi Nicolas Hunzelmann Jörg H W Distler Lorenzo Beretta Jacob van Laar Meng May Chee Jane Worthington Ariane Herrick Christopher Denton Filemon K Tan Frank C Arnett Shervin Assassi Carmen Fonseca Maureen D Mayes Timothy R D J Radstake Bobby P C Koeleman Javier Martin

Hum Mol Genet 2012 Jun 9;21(12):2825-35. Epub 2012 Mar 9.

Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada, Spain.

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June 2012

Analysis of Class II human leucocyte antigens in Italian and Spanish systemic sclerosis.

Authors:
Lorenzo Beretta Blanca Rueda Maurizio Marchini Alessandro Santaniello Carmen P Simeón Vicente Fonollosa Monica Caronni Raquel Rios-Fernandez Patricia Carreira Luis Rodriguez-Rodriguez Antonia Moreno Miguel A López-Nevot Ana Escalera Maria F González-Escribano Javier Martin Raffaella Scorza

Rheumatology (Oxford) 2012 Jan 15;51(1):52-9. Epub 2011 Nov 15.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Via Pace 9, 20122 Milan, Italy.

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January 2012

A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations.

Authors:
Lara Bossini-Castillo Jose-Ezequiel Martin Jasper Broen Olga Gorlova Carmen P Simeón Lorenzo Beretta Madelon C Vonk Jose Luis Callejas Ivan Castellví Patricia Carreira Francisco José García-Hernández Mónica Fernández Castro Marieke J H Coenen Gabriela Riemekasten Torsten Witte Nicolas Hunzelmann Alexander Kreuter Jörg H W Distler Bobby P Koeleman Alexandre E Voskuyl Annemie J Schuerwegh Øyvind Palm Roger Hesselstrand Annika Nordin Paolo Airó Claudio Lunardi Raffaella Scorza Paul Shiels Jacob M van Laar Ariane Herrick Jane Worthington Christopher Denton Filemon K Tan Frank C Arnett Sandeep K Agarwal Shervin Assassi Carmen Fonseca Maureen D Mayes Timothy R D J Radstake Javier Martin

Hum Mol Genet 2012 Feb 10;21(4):926-33. Epub 2011 Nov 10.

Instituto de ParasitologÍa y Biomedicina López-Neyra, IPBLN-CSIC, Granada 18100, Spain.

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February 2012

Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.

Authors:
Jasper C A Broen Phillipe Dieude Madelon C Vonk Lorenzo Beretta Francisco D Carmona Ariane Herrick Jane Worthington Nicholas Hunzelmann Gabriela Riemekasten Hans Kiener Rafaella Scorza Carmen P Simeon Vicent Fonollosa Patricia Carreira Norberto Ortego-Centeno Miguel A Gonzalez-Gay Paolo Airo' Marieke J Coenen Kelly Tsang Antonios O Aliprantis Javier Martin Yannick Allanore Timothy R D J Radstake

J Rheumatol 2012 Jan 1;39(1):112-8. Epub 2011 Nov 1.

Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands.

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January 2012

Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population.

Authors:
Lara Bossini-Castillo Carmen P Simeon Lorenzo Beretta Madelon C Vonk José Luis Callejas-Rubio Gerard Espinosa Patricia Carreira María T Camps Luis Rodríguez-Rodríguez Mónica Rodríguez-Carballeira Francisco J García-Hernández Francisco J López-Longo Vanesa Hernández-Hernández Luis Sáez-Comet María Victoria Egurbide Roger Hesselstrand Annika Nordin Anna-Maria Hoffmann-Vold Marie Vanthuyne Vanessa Smith Ellen De Langhe Alexander Kreuter Gabriela Riemekasten Torsten Witte Nicolas Hunzelmann Alexandre E Voskuyl Annemie J Schuerwegh Claudio Lunardi Paolo Airó Raffaella Scorza Paul Shiels Jacob M van Laar Carmen Fonseca Christopher Denton Ariane Herrick Jane Worthington Bobby P Koeleman Blanca Rueda Timothy R D J Radstake Javier Martin

Rheumatology (Oxford) 2011 Nov 28;50(11):1976-81. Epub 2011 Aug 28.

Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain.

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November 2011

Models for prediction of death in systemic sclerosis: current perspectives and future directions.

Authors:
Lorenzo Beretta Alessandro Santaniello

Expert Rev Clin Immunol 2011 Jul;7(4):391-3

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July 2011

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.

Authors:
Olga Gorlova Jose-Ezequiel Martin Blanca Rueda Bobby P C Koeleman Jun Ying Maria Teruel Lina-Marcela Diaz-Gallo Jasper C Broen Madelon C Vonk Carmen P Simeon Behrooz Z Alizadeh Marieke J H Coenen Alexandre E Voskuyl Annemie J Schuerwegh Piet L C M van Riel Marie Vanthuyne Ruben van 't Slot Annet Italiaander Roel A Ophoff Nicolas Hunzelmann Vicente Fonollosa Norberto Ortego-Centeno Miguel A González-Gay Francisco J García-Hernández María F González-Escribano Paolo Airo Jacob van Laar Jane Worthington Roger Hesselstrand Vanessa Smith Filip de Keyser Fredric Houssiau Meng May Chee Rajan Madhok Paul G Shiels Rene Westhovens Alexander Kreuter Elfride de Baere Torsten Witte Leonid Padyukov Annika Nordin Raffaella Scorza Claudio Lunardi Benedicte A Lie Anna-Maria Hoffmann-Vold Oyvind Palm Paloma García de la Peña Patricia Carreira John Varga Monique Hinchcliff Annette T Lee Pravitt Gourh Christopher I Amos Frederick M Wigley Laura K Hummers J Lee Nelson Gabriella Riemekasten Ariane Herrick Lorenzo Beretta Carmen Fonseca Christopher P Denton Peter K Gregersen Sandeep Agarwal Shervin Assassi Filemon K Tan Frank C Arnett Timothy R D J Radstake Maureen D Mayes Javier Martin

PLoS Genet 2011 Jul 14;7(7):e1002178. Epub 2011 Jul 14.

Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, USA.

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July 2011

Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension.

Authors:
Vanessa Zambelli Alessandro Santaniello Francesca Fumagalli Serge Masson Raffaella Scorza Lorenzo Beretta Roberto Latini

Eur J Pharmacol 2011 Sep 30;667(1-3):287-91. Epub 2011 May 30.

Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano (MI), Italy.

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September 2011

Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis.

Authors:
F David Carmona Carmen P Simeon Lorenzo Beretta Patricia Carreira Madelon C Vonk Raquel Ríos-Fernández Gerard Espinosa Nuria Navarrete Esther Vicente-Rabaneda Luis Rodríguez-Rodríguez Carlos Tolosa Francisco J García-Hernández Iván Castellví María Victoria Egurbide Vicente Fonollosa Miguel A González-Gay Mónica Rodríguez-Carballeira Federico Díaz-Gónzalez Luis Sáez-Comet Roger Hesselstrand Gabriela Riemekasten Torsten Witte Alexandre E Voskuyl Annemie J Schuerwegh Rajan Madhok Paul Shiels Carmen Fonseca Christopher Denton Annika Nordin Øyvind Palm Anna-Maria Hoffmann-Vold Paolo Airó Raffaella Scorza Claudio Lunardi Jacob M van Laar Nicolas Hunzelmann Alexander Kreuter Ariane Herrick Jane Worthington Bobby P C Koeleman Timothy R D J Radstake Javier Martín

Ann Rheum Dis 2011 Nov 13;70(11):2050-2. Epub 2011 May 13.

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November 2011

Prediction of pulmonary hypertension related to systemic sclerosis by an index based on simple clinical observations.

Authors:
Christophe Meune Jérôme Avouac Paolo Airò Lorenzo Beretta Philippe Dieudé Karim Wahbi Paola Caramaschi Kiet Tiev Susanna Cappelli Elisabeth Diot Alessandra Vacca Jean-Luc Cracowski Jean Sibilia André Kahan Marco Matucci-Cerinic Yannick Allanore

Arthritis Rheum 2011 Sep;63(9):2790-6

Paris Descartes University and Department of Rheumatology A, Cochin Hospital, AP-HP, Paris, France.

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September 2011

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort.

Authors:
Lara Bossini-Castillo Jasper C A Broen Carmen P Simeon Lorenzo Beretta Madelon C Vonk Norberto Ortego-Centeno Gerard Espinosa Patricia Carreira María Teresa Camps Nuria Navarrete María F González-Escribano Esther Vicente-Rabaneda Luis Rodríguez Carlos Tolosa José A Román-Ivorra Inmaculada Gómez-Gracia Francisco J García-Hernández Iván Castellví María Gallego Antonio Fernández-Nebro Rosa García-Portales María Victoria Egurbide Vicente Fonollosa Paloma García de la Peña Ana Pros Miguel A González-Gay Roger Hesselstrand Gabriela Riemekasten Torsten Witte Marieke J H Coenen Bobby P Koeleman Frederic Houssiau Vanessa Smith Filip de Keyser Rene Westhovens Ellen De Langhe Alexandre E Voskuyl Annemie J Schuerwegh Meng May Chee Rajan Madhok Paul Shiels Carmen Fonseca Christopher Denton Kathleen Claes Leonid Padykov Annika Nordin Oyvind Palm Benedicte A Lie Paolo Airó Raffaella Scorza Jacob M van Laar Nicolas Hunzelmann Alexander Kreuter Ariane Herrick Jane Worthington Timothy R D J Radstake Javier Martín Blanca Rueda

Ann Rheum Dis 2011 Apr 27;70(4):638-41. Epub 2010 Dec 27.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan. [corrected]

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April 2011

Implementing ReliefF filters to extract meaningful features from genetic lifetime datasets.

Authors:
Lorenzo Beretta Alessandro Santaniello

J Biomed Inform 2011 Apr 17;44(2):361-9. Epub 2010 Dec 17.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Via Pace 9, Milan, Italy.

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April 2011

The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.

Authors:
Jasper C A Broen Marieke J H Coenen Blanca Rueda Torsten Witte Leonid Padyukov Lars Klareskog Roger Hesselstrand Dirk M Wuttge Carmen Simeon Norberto Ortego-Centeno Miguel A González-Gay Anna Pros Nicholas Hunzelman Gabriela Riemekasten Alexander Kreuter Madelon Vonk Rafaella Scorza Lorenzo Beretta Paulo Airò Piet L C M van Riel Robert Kimberly Javier Martin Jeffrey Edberg Timothy R D J Radstake

J Rheumatol 2011 Mar 15;38(3):446-9. Epub 2010 Dec 15.

Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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March 2011

Prevalence of pulmonary hypertension in systemic sclerosis in European Caucasians and metaanalysis of 5 studies.

Authors:
Jérôme Avouac Paolo Airò Christophe Meune Lorenzo Beretta Philippe Dieude Paola Caramaschi Kiet Tiev Susanna Cappelli Elisabeth Diot Alessandra Vacca Jean-Luc Cracowski Jean Sibilia André Kahan Marco Matucci-Cerinic Yannick Allanore

J Rheumatol 2010 Nov 1;37(11):2290-8. Epub 2010 Sep 1.

Department of Rheumatology A, Paris Descartes University, Cochin Hospital, APHP, Paris, France.

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November 2010

Development of a five-year mortality model in systemic sclerosis patients by different analytical approaches.

Authors:
Lorenzo Beretta Alessandro Santaniello Francesca Cappiello Nitesh V Chawla Madelon C Vonk Patricia E Carreira Yannick Allanore D A Popa-Diaconu Marta Cossu Francesca Bertolotti Gianfranco Ferraccioli Antonino Mazzone Raffaella Scorza

Clin Exp Rheumatol 2010 Mar-Apr;28(2 Suppl 58):S18-27. Epub 2010 Jun 14.

Referral Centres for Systemic Autoimmune Diseases, Fondazione IRCCS Ospedale Maggiore Policlinico and University of Milan, Italy.

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September 2010

Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data.

Authors:
Lorenzo Beretta Alessandro Santaniello Piet L C M van Riel Marieke J H Coenen Raffaella Scorza

BMC Bioinformatics 2010 Aug 6;11:416. Epub 2010 Aug 6.

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy.

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August 2010

A 3-factor epistatic model predicts digital ulcers in Italian scleroderma patients.

Authors:
Lorenzo Beretta Alessandro Santaniello Michael Mayo Francesca Cappiello Maurizio Marchini Raffaella Scorza

Eur J Intern Med 2010 Aug 23;21(4):347-53. Epub 2010 Jun 23.

Referral Center for Systemic Autoimmune Diseases, Fondazione, Ca' granda Ospedale Maggiore Policlinico Milano, Italy.

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August 2010

Functional variants of Fc gamma receptor (FCGR2A) and FCGR3A are not associated with susceptibility to systemic sclerosis in a large European Study (EUSTAR).

Authors:
Behrooz Z Alizadeh Jasper Broen Blanca Rueda Roger Hesselstrand Dirk Wuttge Carmen Simeon Norberto Ortego-Centeno Miguel A Gonzalez-Gay Miguel Gonzalez-Gay Anna Pros Ariane Herrick Jane Worthington Christopher Denton Carmen Fonseca Gabriela Riemekasten Madelon C Vonk Frank van den Hoogen Serena Guiducci Marco Matucci-Cerinic Rafaella Scorza Lorenzo Beretta Paolo Airó Marieke Coenen Javier Martin Bobby P C Koeleman Timothy R D J Radstake

J Rheumatol 2010 Aug 15;37(8):1673-9. Epub 2010 Jun 15.

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.

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August 2010

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.

Authors:
Timothy R D J Radstake Olga Gorlova Blanca Rueda Jose-Ezequiel Martin Behrooz Z Alizadeh Rogelio Palomino-Morales Marieke J Coenen Madelon C Vonk Alexandre E Voskuyl Annemie J Schuerwegh Jasper C Broen Piet L C M van Riel Ruben van 't Slot Annet Italiaander Roel A Ophoff Gabriela Riemekasten Nico Hunzelmann Carmen P Simeon Norberto Ortego-Centeno Miguel A González-Gay María F González-Escribano Paolo Airo Jaap van Laar Ariane Herrick Jane Worthington Roger Hesselstrand Vanessa Smith Filip de Keyser Fredric Houssiau Meng May Chee Rajan Madhok Paul Shiels Rene Westhovens Alexander Kreuter Hans Kiener Elfride de Baere Torsten Witte Leonid Padykov Lars Klareskog Lorenzo Beretta Rafaella Scorza Benedicte A Lie Anna-Maria Hoffmann-Vold Patricia Carreira John Varga Monique Hinchcliff Peter K Gregersen Annette T Lee Jun Ying Younghun Han Shih-Feng Weng Christopher I Amos Fredrick M Wigley Laura Hummers J Lee Nelson Sandeep K Agarwal Shervin Assassi Pravitt Gourh Filemon K Tan Bobby P C Koeleman Frank C Arnett Javier Martin Maureen D Mayes

Nat Genet 2010 May 11;42(5):426-9. Epub 2010 Apr 11.

Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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May 2010

Comment on: Methotrexate pharmacogenomics in rheumatoid arthritis: introducing false positive report probability.

Authors:
Lorenzo Beretta

Rheumatology (Oxford) 2009 Dec 14;48(12):1619-20; author reply 1620. Epub 2009 Oct 14.

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December 2009

A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation.

Authors:
Lorenzo Beretta Marta Cossu Maurizio Marchini Francesca Cappiello Andrea Artoni Giovanna Motta Raffaella Scorza

Arthritis Res Ther 2008 1;10(5):R103. Epub 2008 Sep 1.

Referral Center for Systemic Autoimmune Diseases, University of Milan & Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Pace 9, 20122 Milan, Italy.

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February 2009

Aminaftone, a derivative of 4-aminobenzoic acid, downregulates endothelin-1 production in ECV304 Cells: an in vitro Study.

Authors:
Raffaella Scorza Alessandro Santaniello Giulia Salazar Stefania Lenna Gualtiero Colombo Flavia Turcatti Lorenzo Beretta

Drugs R D 2008 ;9(4):251-7

Referral Centre for Systemic Autoimmune Diseases, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.

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December 2008

Ability of epistatic interactions of cytokine single-nucleotide polymorphisms to predict susceptibility to disease subsets in systemic sclerosis patients.

Authors:
Lorenzo Beretta Francesca Cappiello Jason H Moore Morena Barili Casey S Greene Raffaella Scorza

Arthritis Rheum 2008 Jul;59(7):974-83

Referral Center for Systemic Autoimmune Diseases, IRCCS Fondazione Policlinico-Mangiagalli-Regina Elena and University of Milan, Milan, Italy.

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July 2008

Effects of aminaftone 75 mg TID on soluble adhesion molecules: a 12-week, randomized, open-label pilot study in patients with systemic sclerosis.

Authors:
Raffaella Scorza Alessandro Santaniello Giulia Salazar Stefania Lenna Silvia Della Bella Rita Antonioli Karen Toussoun Lorenzo Beretta

Clin Ther 2008 May;30(5):924-9

Referral Center for Systemic Autoimmune Diseases, University of Milan, Milan, Italy.

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May 2008

Interleukin-1 gene complex single nucleotide polymorphisms in systemic sclerosis: a further step ahead.

Authors:
Lorenzo Beretta Francesca Cappiello Jason H Moore Raffaella Scorza

Hum Immunol 2008 Mar 4;69(3):187-92. Epub 2008 Mar 4.

Referral Center for Systemic Autoimmune Diseases, IRCCS Fondazione Policlinico-Mangiagalli-Regina Elena and University of Milan, Milan, Italy.

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March 2008

No evidence for a role of the proximal IL-6 G/C -174 single nucleotide polymorphism in Italian patients with systemic sclerosis.

Authors:
Lorenzo Beretta Alessandro Santaniello Francesca Cappiello Morena Barili Raffaella Scorza

J Cell Mol Med 2007 Jul-Aug;11(4):896-8; author reply 898-9

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November 2007

Interleukin-1 gene complex polymorphisms in systemic sclerosis patients with severe restrictive lung physiology.

Authors:
Lorenzo Beretta Francesca Bertolotti Francesca Cappiello Morena Barili Michela Masciocchi Karen Toussoun Monica Caronni Raffaella Scorza

Hum Immunol 2007 Jul 5;68(7):603-9. Epub 2007 Apr 5.

Unit of Clinical Immunology and Allergology, IRCCS Fondazione Policlinico-Mangiagalli-Regina Elena and University of Milan, Milan, Italy.

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July 2007

HLA-B35 influences the apoptosis rate in human peripheral blood mononucleated cells and HLA-transfected cells.

Authors:
Giulia Salazar Gualtiero Colombo Stefania Lenna Rita Antonioli Lorenzo Beretta Alessandro Santaniello Raffaella Scorza

Hum Immunol 2007 Mar 6;68(3):181-91. Epub 2006 May 6.

Unit of Clinical Immunology and Allergology, University of Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy.

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March 2007

Bosentan improves functional class, pulmonary artery systolic pressure, and DLCO in scleroderma patients with pulmonary hypertension: a possible synergy with iloprost.

Authors:
Lorenzo Beretta Raffaella Scorza Nicoletta Del Papa Antonio Mazzone

J Rheumatol 2006 Sep;33(9):1915-6; author reply 1916

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September 2006

T-889C IL-1alpha promoter polymorphism influences the response to oral cyclophosphamide in scleroderma patients with alveolitis.

Authors:
Lorenzo Beretta Francesca Cappiello Morena Barili Francesca Bertolotti Raffaella Scorza

Clin Rheumatol 2007 Jan 25;26(1):88-91. Epub 2006 Apr 25.

Clinical Immunology and Allergology Unit, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Pace 9, Milano, 20122, Italy.

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January 2007

Oral cyclophosphamide improves pulmonary function in scleroderma patients with fibrosing alveolitis: experience in one centre.

Authors:
Lorenzo Beretta Monica Caronni Massimo Raimondi Alessandra Ponti Tiziana Viscuso Laura Origgi Raffaella Scorza

Clin Rheumatol 2007 Feb 14;26(2):168-72. Epub 2006 Apr 14.

Allergology, Clinical Immunology and Rheumatology Unit, University of Milan, Milan, Italy.

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February 2007

Systemic sclerosis following oral contraception.

Authors:
Lorenzo Beretta Monica Caronni Raffaella Scorza

Clin Rheumatol 2005 Jun 14;24(3):316-7. Epub 2004 Jul 14.

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June 2005

Post-menopause is the main risk factor for developing isolated pulmonary hypertension in systemic sclerosis.

Authors:
Raffaella Scorza Monica Caronni Sonia Bazzi Filippo Nador Lorenzo Beretta Rita Antonioli Laura Origgi Alessandra Ponti Maurizio Marchini Massimo Vanoli

Ann N Y Acad Sci 2002 Jun;966:238-46

Clinical Immunology and Allergology Unit, IRCCS Ospedale Maggiore and University of Milan, Milan, Italy.

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June 2002