Lorenz Deserno

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Lorenz Deserno

Publications by authors named "Lorenz Deserno"

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39Publications

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Dopaminergic modulation of hemodynamic signal variability and the functional connectome during cognitive performance.

Neuroimage 2018 May 2;172:341-356. Epub 2018 Feb 2.

Department of Psychology, University of Lübeck, 23562 Lübeck, Germany; Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany. Electronic address:

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May 2018

Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence.

Neuroimage Clin 2017 17;15:80-94. Epub 2017 Apr 17.

Department of Software Engineering and Theoretical Computer Science, Technische Universität Berlin, 10587 Berlin, Germany.

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March 2018

Prefrontal-parietal effective connectivity during working memory in older adults.

Neurobiol Aging 2017 Sep 10;57:18-27. Epub 2017 May 10.

Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1A, Leipzig, Germany; Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig 04103, Germany.

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September 2017

Inhibition of Information Flow to the Default Mode Network During Self-Reference Versus Reference to Others.

Cereb Cortex 2017 Aug;27(8):3930-3942

Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany.

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August 2017

Computational approaches to schizophrenia: A perspective on negative symptoms.

Schizophr Res 2017 08 13;186:46-54. Epub 2016 Dec 13.

Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaptation', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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August 2017

Linking social context and addiction neuroscience: a computational psychiatry approach.

Nat Rev Neurosci 2017 06;18(7):450

Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, 04103 Leipzig, Germany; and at the Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.

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June 2017

Targeted intervention: Computational approaches to elucidate and predict relapse in alcoholism.

Neuroimage 2017 May 29;151:33-44. Epub 2016 Jul 29.

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Germany; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Neurology, Otto-von-Guericke University, 39118 Magdeburg, Germany.

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May 2017

The role of dopamine in positive and negative prediction error utilization during incidental learning - Insights from Positron Emission Tomography, Parkinson's disease and Huntington's disease.

Cortex 2017 05 19;90:149-162. Epub 2016 Sep 19.

Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany. Electronic address:

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May 2017

Impaired Flexible Reward-Based Decision-Making in Binge Eating Disorder: Evidence from Computational Modeling and Functional Neuroimaging.

Neuropsychopharmacology 2017 Feb 15;42(3):628-637. Epub 2016 Jun 15.

Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaptation', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

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February 2017

Reversal learning strategy in adolescence is associated with prefrontal cortex activation.

Eur J Neurosci 2017 01 5;45(1):129-137. Epub 2016 Oct 5.

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin, 10117, Germany.

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January 2017

Slips of Action and Sequential Decisions: A Cross-Validation Study of Tasks Assessing Habitual and Goal-Directed Action Control.

Front Behav Neurosci 2016 20;10:234. Epub 2016 Dec 20.

Department of Neurology, Max-Planck Institute for Human Cognitive and Brain SciencesLeipzig, Germany; Integrated Research and Treatment Center Adiposity Diseases, Leipzig University Medical CenterLeipzig, Germany.

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December 2016

Behavioral and Neural Signatures of Reduced Updating of Alternative Options in Alcohol-Dependent Patients during Flexible Decision-Making.

J Neurosci 2016 10;36(43):10935-10948

Max Planck Fellow Group "Cognitive and Affective Control of Behavioral Adaptation", Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.

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October 2016

Model-Free Temporal-Difference Learning and Dopamine in Alcohol Dependence: Examining Concepts From Theory and Animals in Human Imaging.

Biol Psychiatry Cogn Neurosci Neuroimaging 2016 Sep 23;1(5):401-410. Epub 2016 Jun 23.

Charité Universitätsmedizin, Campus Charité Mitte, Berlin.

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September 2016

The Feedback-related Negativity Codes Components of Abstract Inference during Reward-based Decision-making.

J Cogn Neurosci 2016 Aug 31;28(8):1127-38. Epub 2016 Mar 31.

Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

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August 2016

A hierarchical model for integrating unsupervised generative embedding and empirical Bayes.

J Neurosci Methods 2016 08 30;269:6-20. Epub 2016 Apr 30.

Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Switzerland; Wellcome Trust Centre for Neuroimaging, University College London, UK; Max Planck Institute for Metabolism Research, Cologne, Germany.

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August 2016

Risk Factors for Addiction and Their Association with Model-Based Behavioral Control.

Front Behav Neurosci 2016 17;10:26. Epub 2016 Mar 17.

Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaptation,' Max Planck Institute for Human Cognitive and Brain SciencesLeipzig, Germany; Department of Psychiatry and Psychotherapy, Campus Charité MitteCharité - Universitätsmedizin Berlin, Germany.

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March 2016

Striatal dopamine, reward, and decision making in schizophrenia.

Dialogues Clin Neurosci 2016 Mar;18(1):77-89

Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite - Universitatsmedizin Berlin, Germany.

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March 2016

Aberrant Salience Is Related to Dysfunctional Self-Referential Processing in Psychosis.

Schizophr Bull 2016 Jan 20;42(1):67-76. Epub 2015 Jul 20.

Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany; Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaption', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany;

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January 2016

Frontal glutamate and reward processing in adolescence and adulthood.

Brain Struct Funct 2015 Nov 10;220(6):3087-99. Epub 2014 Jul 10.

Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.

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November 2015

Model-based and model-free decisions in alcohol dependence.

Neuropsychobiology 2014 30;70(2):122-31. Epub 2014 Oct 30.

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.

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July 2015

Prefrontal and Striatal Glutamate Differently Relate to Striatal Dopamine: Potential Regulatory Mechanisms of Striatal Presynaptic Dopamine Function?

J Neurosci 2015 Jul;35(26):9615-21

Department of Psychiatry and Psychotherapy and Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany.

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July 2015

Aberrant Salience Is Related to Reduced Reinforcement Learning Signals and Elevated Dopamine Synthesis Capacity in Healthy Adults.

J Neurosci 2015 Jul;35(28):10103-11

Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, 10117 Berlin, Germany, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.

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July 2015

Reduced default mode network connectivity in schizophrenia patients.

Schizophr Res 2015 Jun 16;165(1):90-3. Epub 2015 Apr 16.

Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany.

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June 2015

Dissecting psychiatric spectrum disorders by generative embedding.

Neuroimage Clin 2014 16;4:98-111. Epub 2013 Nov 16.

Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Switzerland ; Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom ; Laboratory for Social and Neural Systems Research (SNS), University of Zurich, Switzerland.

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May 2015

The interaction of acute and chronic stress impairs model-based behavioral control.

Psychoneuroendocrinology 2015 Mar 7;53:268-80. Epub 2015 Jan 7.

Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaptation', Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, 10115 Berlin, Germany.

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March 2015

Chronic alcohol intake abolishes the relationship between dopamine synthesis capacity and learning signals in the ventral striatum.

Eur J Neurosci 2015 Feb 26;41(4):477-86. Epub 2014 Dec 26.

Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany.

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February 2015

Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making.

Proc Natl Acad Sci U S A 2015 Feb 20;112(5):1595-600. Epub 2015 Jan 20.

Max Planck Fellow Group "Cognitive and Affective Control of Behavioral Adaptation", Max Planck Institute for Human Cognitive and Brain Sciences, 04130 Leipzig, Germany; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany;

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February 2015

Response inhibition and its relation to multidimensional impulsivity.

Neuroimage 2014 Dec 18;103:241-248. Epub 2014 Sep 18.

Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin,Germany.

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December 2014

How music alters a kiss: superior temporal gyrus controls fusiform-amygdalar effective connectivity.

Soc Cogn Affect Neurosci 2014 Nov 2;9(11):1770-8. Epub 2013 Dec 2.

Cluster of Excellence 'Languages of Emotion', Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany, Department of Education and Psychology, Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany, Department of Psychology, Stanford University, Stanford, CA 94305, USA, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany, Department of Philosophy and Humanities, Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany, Department of Psychology, Princeton University, Princeton, NJ 08540, USA, Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany, Institute for Psychoacoustics and Electronic Music (IPEM), Blandijnberg 2, B-9000 Ghent, Belgium and Department of Psychology, Experimental Psychology and Methods, Ruhr-Universität Bochum, Universitätsstraße 150, 44801 Bochum, Germany Cluster of Excellence 'Languages of Emotion', Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany, Department of Education and Psychology, Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany, Department of Psychology, Stanford University, Stanford, CA 94305, USA, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany, Department of Philosophy and Humanities, Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germ

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November 2014

Devaluation and sequential decisions: linking goal-directed and model-based behavior.

Front Hum Neurosci 2014 4;8:587. Epub 2014 Aug 4.

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Germany ; Max Planck-Fellow Group "Cognitive and Affective Control of Behavioural Adaptation," Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.

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August 2014

Attentional modulation of reward processing in the human brain.

Hum Brain Mapp 2014 Jul 5;35(7):3036-51. Epub 2013 Dec 5.

Department of Psychiatry, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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July 2014

Striatal dysfunction during reversal learning in unmedicated schizophrenia patients.

Neuroimage 2014 Apr 27;89:171-80. Epub 2013 Nov 27.

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Germany; Cluster of Excellence NeuroCure, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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April 2014

Reinforcement learning and dopamine in schizophrenia: dimensions of symptoms or specific features of a disease group?

Front Psychiatry 2013 Dec 23;4:172. Epub 2013 Dec 23.

Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany ; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin , Berlin , Germany.

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December 2013

Urbanicity, social adversity and psychosis.

World Psychiatry 2013 Oct;12(3):187-97

Department of Psychiatry, Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Berlin, Germany.

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October 2013

Decline in prefrontal catecholamine synthesis explains age-related changes in cognitive speed beyond regional grey matter atrophy.

Eur J Nucl Med Mol Imaging 2012 Sep 19;39(9):1462-6. Epub 2012 Jun 19.

Department of Psychiatry and Psychotherapy, Campus Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

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September 2012

Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia.

J Neurosci 2012 Jan;32(1):12-20

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

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January 2012