Lorena Orozco

Lorena Orozco

UNVERIFIED PROFILE

Are you Lorena Orozco?   Register this Author

Register author
Lorena Orozco

Lorena Orozco

Publications by authors named "Lorena Orozco"

Are you Lorena Orozco?   Register this Author

62Publications

2085Reads

15Profile Views

Analysis of the dynamic aberrant landscape of DNA methylation and gene expression during arsenic-induced cell transformation.

Gene 2019 Aug 23;711:143941. Epub 2019 Jun 23.

Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Ciudad de México, Mexico. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.143941DOI Listing
August 2019

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Authors:
Jason Flannick Josep M Mercader Christian Fuchsberger Miriam S Udler Anubha Mahajan Jennifer Wessel Tanya M Teslovich Lizz Caulkins Ryan Koesterer Francisco Barajas-Olmos Thomas W Blackwell Eric Boerwinkle Jennifer A Brody Federico Centeno-Cruz Ling Chen Siying Chen Cecilia Contreras-Cubas Emilio Córdova Adolfo Correa Maria Cortes Ralph A DeFronzo Lawrence Dolan Kimberly L Drews Amanda Elliott James S Floyd Stacey Gabriel Maria Eugenia Garay-Sevilla Humberto García-Ortiz Myron Gross Sohee Han Nancy L Heard-Costa Anne U Jackson Marit E Jørgensen Hyun Min Kang Megan Kelsey Bong-Jo Kim Heikki A Koistinen Johanna Kuusisto Joseph B Leader Allan Linneberg Ching-Ti Liu Jianjun Liu Valeriya Lyssenko Alisa K Manning Anthony Marcketta Juan Manuel Malacara-Hernandez Angélica Martínez-Hernández Karen Matsuo Elizabeth Mayer-Davis Elvia Mendoza-Caamal Karen L Mohlke Alanna C Morrison Anne Ndungu Maggie C Y Ng Colm O'Dushlaine Anthony J Payne Catherine Pihoker Wendy S Post Michael Preuss Bruce M Psaty Ramachandran S Vasan N William Rayner Alexander P Reiner Cristina Revilla-Monsalve Neil R Robertson Nicola Santoro Claudia Schurmann Wing Yee So Xavier Soberón Heather M Stringham Tim M Strom Claudia H T Tam Farook Thameem Brian Tomlinson Jason M Torres Russell P Tracy Rob M van Dam Marijana Vujkovic Shuai Wang Ryan P Welch Daniel R Witte Tien-Yin Wong Gil Atzmon Nir Barzilai John Blangero Lori L Bonnycastle Donald W Bowden John C Chambers Edmund Chan Ching-Yu Cheng Yoon Shin Cho Francis S Collins Paul S de Vries Ravindranath Duggirala Benjamin Glaser Clicerio Gonzalez Ma Elena Gonzalez Leif Groop Jaspal Singh Kooner Soo Heon Kwak Markku Laakso Donna M Lehman Peter Nilsson Timothy D Spector E Shyong Tai Tiinamaija Tuomi Jaakko Tuomilehto James G Wilson Carlos A Aguilar-Salinas Erwin Bottinger Brian Burke David J Carey Juliana C N Chan Josée Dupuis Philippe Frossard Susan R Heckbert Mi Yeong Hwang Young Jin Kim H Lester Kirchner Jong-Young Lee Juyoung Lee Ruth J F Loos Ronald C W Ma Andrew D Morris Christopher J O'Donnell Colin N A Palmer James Pankow Kyong Soo Park Asif Rasheed Danish Saleheen Xueling Sim Kerrin S Small Yik Ying Teo Christopher Haiman Craig L Hanis Brian E Henderson Lorena Orozco Teresa Tusié-Luna Frederick E Dewey Aris Baras Christian Gieger Thomas Meitinger Konstantin Strauch Leslie Lange Niels Grarup Torben Hansen Oluf Pedersen Philip Zeitler Dana Dabelea Goncalo Abecasis Graeme I Bell Nancy J Cox Mark Seielstad Rob Sladek James B Meigs Steve S Rich Jerome I Rotter David Altshuler Noël P Burtt Laura J Scott Andrew P Morris Jose C Florez Mark I McCarthy Michael Boehnke

Nature 2019 06 22;570(7759):71-76. Epub 2019 May 22.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41586-019-1231-2
Publisher Site
http://dx.doi.org/10.1038/s41586-019-1231-2DOI Listing
June 2019

Next-generation sequencing for identifying a novel/de novo pathogenic variant in a Mexican patient with cystic fibrosis: a case report.

BMC Med Genomics 2019 05 22;12(1):68. Epub 2019 May 22.

Laboratorio de Inmunogenómica y enfermedades metabólicas, Instituto Nacional de Medicina Genómica,SS, Periférico Sur No. 4809, Arenal Tepepan,Tlalpan, 14610. CDMX, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12920-019-0528-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532186PMC
May 2019

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant.

Sci Immunol 2018 12;3(30)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.

View Article

Download full-text PDF

Source
http://immunology.sciencemag.org/lookup/doi/10.1126/sciimmun
Publisher Site
http://dx.doi.org/10.1126/sciimmunol.aau8714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341984PMC
December 2018

Influence of SNPs in Genes that Modulate Lung Disease Severity in a Group of Mexican Patients with Cystic Fibrosis.

Arch Med Res 2018 01 24;49(1):18-26. Epub 2018 Apr 24.

Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Ciudad de México, México.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2018.04.010DOI Listing
January 2018

A Loss-of-Function Splice Acceptor Variant in Is Protective for Type 2 Diabetes.

Diabetes 2017 11 24;66(11):2903-2914. Epub 2017 Aug 24.

Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db17-0187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652606PMC
November 2017

Transancestral mapping and genetic load in systemic lupus erythematosus.

Authors:
Carl D Langefeld Hannah C Ainsworth Deborah S Cunninghame Graham Jennifer A Kelly Mary E Comeau Miranda C Marion Timothy D Howard Paula S Ramos Jennifer A Croker David L Morris Johanna K Sandling Jonas Carlsson Almlöf Eduardo M Acevedo-Vásquez Graciela S Alarcón Alejandra M Babini Vicente Baca Anders A Bengtsson Guillermo A Berbotto Marc Bijl Elizabeth E Brown Hermine I Brunner Mario H Cardiel Luis Catoggio Ricard Cervera Jorge M Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D'Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C Edberg Emőke Endreffy Jorge A Esquivel-Valerio Paul R Fortin Barry I Freedman Johan Frostegård Mercedes A García Ignacio García de la Torre Gary S Gilkeson Dafna D Gladman Iva Gunnarsson Joel M Guthridge Jennifer L Huggins Judith A James Cees G M Kallenberg Diane L Kamen David R Karp Kenneth M Kaufman Leah C Kottyan László Kovács Helle Laustrup Bernard R Lauwerys Quan-Zhen Li Marco A Maradiaga-Ceceña Javier Martín Joseph M McCune David R McWilliams Joan T Merrill Pedro Miranda José F Moctezuma Swapan K Nath Timothy B Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A Pineau Bernardo A Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D Reveille Laurie P Russell José M Sabio Carlos A Aguilar-Salinas Hugo R Scherbarth Raffaella Scorza Michael F Seldin Christopher Sjöwall Elisabet Svenungsson Susan D Thompson Sergio M A Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M Vilá Daniel J Wallace Michael H Weisman Joan E Wither Tushar Bhangale Jorge R Oksenberg John D Rioux Peter K Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A Criswell Chaim O Jacob Kathy L Sivils Betty P Tsao Laura E Schanberg Timothy W Behrens Earl D Silverman Marta E Alarcón-Riquelme Robert P Kimberly John B Harley Edward K Wakeland Robert R Graham Patrick M Gaffney Timothy J Vyse

Nat Commun 2017 07 17;8:16021. Epub 2017 Jul 17.

Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms16021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520018PMC
July 2017

A transcriptome-based model of central memory CD4 T cell death in HIV infection.

BMC Genomics 2016 11 22;17(1):956. Epub 2016 Nov 22.

Department of Research in Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-016-3308-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120471PMC
November 2016

Analysis of protein-coding genetic variation in 60,706 humans.

Nature 2016 08;536(7616):285-91

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nature19057
Publisher Site
http://dx.doi.org/10.1038/nature19057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018207PMC
August 2016

Transcriptome landmarks of the functional maturity of rat beta-cells, from lactation to adulthood.

J Mol Endocrinol 2016 07 24;57(1):45-59. Epub 2016 May 24.

Department of Neurodevelopment and PhysiologyNeuroscience Division, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JME-16-0052DOI Listing
July 2016

NFE2L2 Gene Variants and Arsenic Susceptibility: A Lymphoblastoid Model.

J Toxicol Environ Health A 2015 ;78(10):628-34

a Universidad Autónoma de la Ciudad de México, Posgrado en Ciencias Genómicas , Mexico City , Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15287394.2015.1004146DOI Listing
August 2015

The NRF2-KEAP1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells.

PLoS One 2014 7;9(2):e88069. Epub 2014 Feb 7.

Immunogenomics and Metabolics Disease Laboratory, Instituto Nacional de Medicina Genómica, SS, México City, México ; Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad México, México City, México.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088069PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917856PMC
May 2015

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.

Diabetes 2015 May 18;64(5):1853-66. Epub 2014 Dec 18.

Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/content/early/2014/12/1
Web Search
http://diabetes.diabetesjournals.org/content/64/5/1853.full.
Web Search
http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
Publisher Site
http://dx.doi.org/10.2337/db14-0732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407862PMC
May 2015

Genomewide admixture study in Mexican Mestizos with multiple sclerosis.

Clin Neurol Neurosurg 2015 Mar 24;130:55-60. Epub 2014 Dec 24.

National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur #3877, Mexico City 14269, Mexico. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03038467140047
Publisher Site
http://dx.doi.org/10.1016/j.clineuro.2014.11.026DOI Listing
March 2015

Impact of gene dosage on gene expression, biological processes and survival in cervical cancer: a genome-wide follow-up study.

PLoS One 2014 30;9(5):e97842. Epub 2014 May 30.

Unidad de Medicina Genómica, Facultad de Medicina, Universidad Nacional Autónoma de México/Hospital General de México, México, D.F. México; Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F. México.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097842PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039463PMC
January 2015

CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients.

Mol Biol Rep 2014 16;41(4):2109-17. Epub 2014 Jan 16.

Laboratory of Immunogenomics and Metabolic Diseases, Instituto Nacional de Medicina Genómica, SS, Periférico Sur 4809, Col. Arenal Tepepan, CP. 014610, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11033-014-3060-6DOI Listing
December 2014

Small MAF genes variants and chronic myeloid leukemia.

Eur J Haematol 2014 Jan 13;92(1):35-41. Epub 2013 Nov 13.

Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genómica, SS, México City, México.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejh.12211DOI Listing
January 2014

Polymorphisms in metalloproteinase-9 are associated with the risk for asthma in Mexican pediatric patients.

Hum Immunol 2013 Aug 29;74(8):998-1002. Epub 2013 Apr 29.

Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, SS, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humimm.2013.04.036DOI Listing
August 2013

HMOX1 promoter (GT)n polymorphim is associated with childhood-onset systemic lupus erythematosus but not with juvenile rheumatoid arthritis in a Mexican population.

Clin Exp Rheumatol 2012 Mar-Apr;30(2):297-301. Epub 2012 Apr 13.

Immunogenomics and Metabolic Disease Laboratory, Instituto Nacional de Medicina Genómica, SS, Mexico City, Mexico City, Mexico.

View Article

Download full-text PDF

Source
July 2012

Molecular screening of the CFTR gene in Mexican patients with congenital absence of the vas deferens.

Genet Test Mol Biomarkers 2012 Apr 21;16(4):292-6. Epub 2011 Nov 21.

Genomic of Complex Diseases Laboratory, Instituto Nacional de Medicina Genómica, SS, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/gtmb.2011.0124DOI Listing
April 2012

NFE2L2 gene variants and susceptibility to childhood-onset asthma.

Rev Invest Clin 2011 Jul-Aug;63(4):407-11

Laboratorio de Inmunogenómica y enfermedades metabólicas, Instituto Nacional de Medicina Genómica, SSA.

View Article

Download full-text PDF

Source
April 2012

Association study of DRD3 gene in schizophrenia in Mexican sib-pairs.

Psychiatry Res 2011 Dec 6;190(2-3):367-8. Epub 2011 Jul 6.

Genetics Laboratory, Instituto Nacional de Psiquiatría Ramón de la Fuente, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psychres.2011.06.009DOI Listing
December 2011

CFTR allelic heterogeneity in Mexican patients with cystic fibrosis: implications for molecular screening.

Rev Invest Clin 2010 Nov-Dec;62(6):546-52

Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Coyoacán, México, DF.

View Article

Download full-text PDF

Source
April 2011

Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans.

Hum Genet 2007 Jul 3;121(6):721-7. Epub 2007 May 3.

Department of Genetics and Pathology, Uppsala University, Dag Hammarsjkölds väg 20, 751 85 Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00439-007-0367-6DOI Listing
July 2007

[Cystic fibrosis: molecular update and clinical implications].

Rev Invest Clin 2006 Mar-Apr;58(2):139-52

Laboratorio de Genómica de Enfermedades Multifactoriales, Instituto Nacional de Medicina Genómica, SS, México, DF.

View Article

Download full-text PDF

Source
November 2006