Loren D Walensky

Loren D Walensky

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Loren D Walensky

Loren D Walensky

Publications by authors named "Loren D Walensky"

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Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX.

Cell Rep 2020 Mar;30(10):3229-3239.e6

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.02.057DOI Listing
March 2020

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.

Nat Biotechnol 2019 10 19;37(10):1186-1197. Epub 2019 Aug 19.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0222-zDOI Listing
October 2019

Targeting BAX to drug death directly.

Authors:
Loren D Walensky

Nat Chem Biol 2019 07 17;15(7):657-665. Epub 2019 Jun 17.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41589-019-0306-6DOI Listing
July 2019

Targeting BAX to drug death directly.

Authors:
Loren D Walensky

Nat Chem Biol 2019 07 17;15(7):657-665. Epub 2019 Jun 17.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41589-019-0306-6DOI Listing
July 2019

Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.

Cell Rep 2018 09;24(13):3393-3403.e5

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.08.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365304PMC
September 2018

Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.

Structure 2018 01 21;26(1):153-160.e4. Epub 2017 Dec 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947960PMC
January 2018

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.

Cancer Cell 2017 10;32(4):490-505.e10

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793879PMC
October 2017

Paclitaxel Reduces Axonal Bclw to Initiate IPR1-Dependent Axon Degeneration.

Neuron 2017 Oct;96(2):373-386.e6

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Departments of Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680044PMC
October 2017

Allosteric sensitization of proapoptotic BAX.

Nat Chem Biol 2017 Sep 10;13(9):961-967. Epub 2017 Jul 10.

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.2433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675120PMC
September 2017

gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development.

FASEB J 2017 08 26;31(8):3540-3554. Epub 2017 Apr 26.

Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA;

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http://www.fasebj.org/doi/10.1096/fj.201700010R
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http://dx.doi.org/10.1096/fj.201700010RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503708PMC
August 2017

Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides.

ACS Chem Biol 2016 11 4;11(11):3146-3153. Epub 2016 Oct 4.

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute , Boston, Massachusetts 02215, United States.

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http://dx.doi.org/10.1021/acschembio.6b00465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534327PMC
November 2016

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices.

Nat Chem Biol 2016 10 22;12(10):845-52. Epub 2016 Aug 22.

Department of Pediatric Oncology, Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nchembio.2153
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055751PMC
http://dx.doi.org/10.1038/nchembio.2153DOI Listing
October 2016

Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors.

Cell Chem Biol 2016 Sep 8;23(9):1123-1134. Epub 2016 Sep 8.

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055752PMC
http://dx.doi.org/10.1016/j.chembiol.2016.07.022DOI Listing
September 2016

Allosteric inhibition of antiapoptotic MCL-1.

Nat Struct Mol Biol 2016 06 9;23(6):600-7. Epub 2016 May 9.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.3223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900187PMC
June 2016

Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation.

Proc Natl Acad Sci U S A 2016 Feb 25;113(5):E494-5. Epub 2016 Jan 25.

Department of Pathology, Yale School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1521979113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747777PMC
February 2016

Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics.

Anal Chem 2015 Oct 4;87(19):9855-63. Epub 2015 Sep 4.

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School , Charlestown, Massachusetts 02129, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b02307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890644PMC
October 2015

Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide.

ACS Chem Biol 2015 Sep 21;10(9):2149-57. Epub 2015 Jul 21.

Department of Pediatric Oncology, Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute , Boston, Massachusetts 02215, United States.

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http://dx.doi.org/10.1021/acschembio.5b00214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839450PMC
September 2015

Regulation of mitochondrial ceramide distribution by members of the BCL-2 family.

J Lipid Res 2015 Aug 9;56(8):1501-10. Epub 2015 Jun 9.

Clayton Foundation Laboratories for Peptide Biology, Helmsley Center for Genomic Medicine, Salk Institute for Biological Studies, San Diego, CA 92037.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M058750
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http://dx.doi.org/10.1194/jlr.M058750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513991PMC
August 2015

A nonapoptotic role for BAX and BAK in eicosanoid metabolism.

ACS Chem Biol 2015 Jun 6;10(6):1398-403. Epub 2015 Apr 6.

†Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acschembio.5b00168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599777PMC
June 2015

BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress.

Proc Natl Acad Sci U S A 2015 Jun 26;112(23):7201-6. Epub 2015 May 26.

Department of Pathology, Yale School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1421063112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466744PMC
June 2015

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Mol Cell 2015 Mar 12;57(5):873-886. Epub 2015 Feb 12.

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384643PMC
March 2015

Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry.

Methods Enzymol 2014 ;544:25-48

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-417158-9.00002-9DOI Listing
February 2015

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices.

Proc Natl Acad Sci U S A 2015 Feb 26;112(6):1761-6. Epub 2015 Jan 26.

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215; and

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http://dx.doi.org/10.1073/pnas.1413185112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330742PMC
February 2015

Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes.

Cell Rep 2015 Feb 29;10(4):497-504. Epub 2015 Jan 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/cms/attachment/2033129422/2049295395/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221112471401123
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http://dx.doi.org/10.1016/j.celrep.2014.12.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991214PMC
February 2015

Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.

Nat Struct Mol Biol 2014 Dec 24;21(12):1058-67. Epub 2014 Nov 24.

1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.2922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304871PMC
December 2014

Hydrocarbon-stapled peptides: principles, practice, and progress.

J Med Chem 2014 Aug 6;57(15):6275-88. Epub 2014 Mar 6.

Department of Pediatric Oncology, Dana-Farber Cancer Institute , Boston, Massachusetts 02215, United States.

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http://pubs.acs.org/doi/10.1021/jm4011675
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http://dx.doi.org/10.1021/jm4011675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136684PMC
August 2014

Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies.

ACS Chem Biol 2014 Mar 3;9(3):831-7. Epub 2014 Jan 3.

Department of Pediatric Oncology, Dana-Farber Cancer Institute , Boston, Massachusetts 02215, United States.

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http://dx.doi.org/10.1021/cb4003305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131438PMC
March 2014

Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells.

Blood 2014 Feb 18;123(6):884-93. Epub 2013 Dec 18.

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA;

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http://dx.doi.org/10.1182/blood-2013-04-499079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916879PMC
February 2014

A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators.

Nat Struct Mol Biol 2014 Jan 8;21(1):36-42. Epub 2013 Dec 8.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.2717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084830PMC
January 2014

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer.

Nat Chem Biol 2013 Oct 25;9(10):643-50. Epub 2013 Aug 25.

1] Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778130PMC
October 2013

Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3.

Chem Biol 2013 Jul;20(7):888-902

Department of Pediatric Oncology, Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.chembiol.2013.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781208PMC
July 2013

Playing fullBAK.

Authors:
Loren D Walensky

Cell Cycle 2013 May 11;12(9):1333-4. Epub 2013 Apr 11.

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http://dx.doi.org/10.4161/cc.24607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674057PMC
May 2013

The retinoblastoma protein induces apoptosis directly at the mitochondria.

Genes Dev 2013 May 25;27(9):1003-15. Epub 2013 Apr 25.

David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.211326.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656319PMC
May 2013

Direct BAKtivation.

Authors:
Loren D Walensky

Nat Struct Mol Biol 2013 May;20(5):536-8

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http://dx.doi.org/10.1038/nsmb.2579DOI Listing
May 2013

Direct activation of full-length proapoptotic BAK.

Proc Natl Acad Sci U S A 2013 Mar 12;110(11):E986-95. Epub 2013 Feb 12.

Department of Pediatric Oncology and the Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1073/pnas.1214313110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600461PMC
March 2013

A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.

Chem Biol 2012 Sep;19(9):1175-86

Departments of Pediatric Oncology and the Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107455211200271
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http://dx.doi.org/10.1016/j.chembiol.2012.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582387PMC
September 2012

Interview with Loren D Walensky.

Authors:
Loren D Walensky

Future Med Chem 2012 Aug;4(12):1537-9

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http://dx.doi.org/10.4155/fmc.12.86DOI Listing
August 2012

Direct and selective small-molecule activation of proapoptotic BAX.

Nat Chem Biol 2012 Jul 27;8(7):639-45. Epub 2012 May 27.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617124PMC
July 2012

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

J Clin Invest 2012 Jun 24;122(6):2018-31. Epub 2012 May 24.

Department of Pediatric Oncology and 2Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1172/JCI46231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366394PMC
June 2012

Stemming danger with Golgified BAX.

Authors:
Loren D Walensky

Mol Cell 2012 Jun;46(5):554-6

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839817PMC
June 2012

From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia.

Authors:
Loren D Walensky

J Clin Oncol 2012 Feb 19;30(5):554-7. Epub 2011 Dec 19.

Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1200/JCO.2011.37.9339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879972PMC
February 2012

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore.

Trends Biochem Sci 2011 Dec 4;36(12):642-52. Epub 2011 Oct 4.

Department of Pediatric Oncology and the Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09680004110014
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http://dx.doi.org/10.1016/j.tibs.2011.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454508PMC
December 2011

Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting.

Curr Protoc Chem Biol 2011 Sep;3(3):99-117

Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/9780470559277.ch110042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879976PMC
September 2011

Tracking BAX once its trigger is pulled.

Cell Cycle 2011 Mar 15;10(6):868-70. Epub 2011 Mar 15.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100869PMC
http://dx.doi.org/10.4161/cc.10.6.15034DOI Listing
March 2011

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

Chem Biol 2010 Dec;17(12):1325-33

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.chembiol.2010.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048092PMC
December 2010

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

Mol Cell 2010 Nov;40(3):481-92

Department of Pediatric Oncology and Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050027PMC
November 2010

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

Cancer Cell 2010 Nov;18(5):411-22

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153561081000426
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http://dx.doi.org/10.1016/j.ccr.2010.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050021PMC
November 2010

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.

Nat Chem Biol 2010 Aug 20;6(8):595-601. Epub 2010 Jun 20.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033224PMC
August 2010

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.

Proc Natl Acad Sci U S A 2010 Aug 21;107(32):14093-8. Epub 2010 Jul 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1002713107
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http://dx.doi.org/10.1073/pnas.1002713107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922607PMC
August 2010

BAX activation is initiated at a novel interaction site.

Nature 2008 Oct;455(7216):1076-81

Department of Pediatric Oncology and the Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature07396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597110PMC
October 2008

Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains.

Methods Enzymol 2008 ;446:369-86

Department of Pediatric Oncology and the Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/S0076-6879(08)01622-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384008PMC
August 2008

Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains.

Methods Enzymol 2008 ;446:387-408

Department of Pediatric Oncology and the Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/S0076-6879(08)01623-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317341PMC
August 2008

The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members.

Clin Cancer Res 2007 Dec;13(24):7264-70

Department of Chemistry and Chemical Biology, and Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-2184DOI Listing
December 2007

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.

J Am Chem Soc 2007 Mar 7;129(9):2456-7. Epub 2007 Feb 7.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1021/ja0693587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333086PMC
March 2007

A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro.

J Biol Chem 2006 Dec 20;281(48):36999-7008. Epub 2006 Sep 20.

Howard Hughes Medical Institute, the Department of Pathology and Medicine, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1074/jbc.M602341200DOI Listing
December 2006

A stapled BID BH3 helix directly binds and activates BAX.

Mol Cell 2006 Oct;24(2):199-210

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.08.020DOI Listing
October 2006

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

Science 2004 Sep;305(5689):1466-70

Howard Hughes Medical Institute, Department of Pediatric Hematology/Oncology and Children's Hospital Boston, Massachusetts, USA.

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http://dx.doi.org/10.1126/science.1099191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360987PMC
September 2004

Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.

Pediatr Allergy Immunol 2003 Oct;14(5):409-11

Division of Allergy/Immunology, Children's Hospital, Boston, MA 02446, USA.

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http://dx.doi.org/10.1034/j.1399-3038.2003.00073.xDOI Listing
October 2003

Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron.

Kidney Int 2003 Apr;63(4):1321-37

Department of Subcellular Structure, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA

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http://dx.doi.org/10.1046/j.1523-1755.2003.00870.xDOI Listing
April 2003

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.

Cancer Cell 2002 Sep;2(3):183-92

Howard Hughes Medical Institute, Department of Pathology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00127-7DOI Listing
September 2002