Publications by authors named "Lora L Arnold"

65Publications

Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin.

Toxicol Lett 2021 Jan 8;336:32-38. Epub 2020 Nov 8.

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.

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January 2021

Urinary crystal formation and urothelial effects of pyroxasulfone administered to male rats.

Toxicol Mech Methods 2020 Nov 4;30(9):656-671. Epub 2020 Sep 4.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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November 2020

Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo.

Toxicology 2020 01 1;429:152325. Epub 2019 Nov 1.

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.

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January 2020

Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO).

Food Chem Toxicol 2019 Nov 29;133:110793. Epub 2019 Aug 29.

Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA; Center for Research on Ingredient Safety, Michigan State University, East Lansing, MI, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA. Electronic address:

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November 2019

Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN).

Toxicol Pathol 2018 04 4;46(3):266-272. Epub 2018 Mar 4.

1 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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April 2018

Orally administered nicotine effects on rat urinary bladder proliferation and carcinogenesis.

Toxicology 2018 04 6;398-399:31-40. Epub 2018 Mar 6.

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.

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April 2018

Effect of polyhexamethylene biguanide on rat liver.

Toxicol Lett 2018 Mar 2;285:94-103. Epub 2018 Jan 2.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, United States; Havlik-Wall Professor of Oncology, United States. Electronic address:

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March 2018

Low-dose dose-response for reduced cell viability after exposure of human keratinocyte (HEK001) cells to arsenite.

Toxicol Rep 2017 14;4:32-38. Epub 2016 Dec 14.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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December 2016

Inorganic arsenic: A non-genotoxic carcinogen.

J Environ Sci (China) 2016 Nov 17;49:28-37. Epub 2016 May 17.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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November 2016

Response to Druwe and Burgoon, 2016 Letter to the Editor in Archives of Toxicology.

Arch Toxicol 2017 02 9;91(2):999-1000. Epub 2016 Nov 9.

University of Nebraska Medical Center, Omaha, NE, USA.

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February 2017

Critical role of toxicologic pathology in a short-term screen for carcinogenicity.

J Toxicol Pathol 2016 Oct 23;29(4):215-227. Epub 2016 May 23.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Omaha, NE 68198-3135, USA.

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October 2016

Identification of Methylated Dithioarsenicals in the Urine of Rats Fed with Sodium Arsenite.

Chem Res Toxicol 2016 09 8;29(9):1480-7. Epub 2016 Aug 8.

Analytical and Environmental Toxicology Division, Department of Laboratory Medicine and Pathology, University of Alberta , Edmonton, Alberta T6G 2G3, Canada.

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September 2016

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells.

Toxicol Rep 2015 21;2:833-837. Epub 2015 May 21.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.

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May 2015

Orally administered nicotine induces urothelial hyperplasia in rats and mice.

Toxicology 2014 Jan 19;315:49-54. Epub 2013 Nov 19.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA; Havlik-Wall Professor of Oncology. Electronic address:

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January 2014

Diuron metabolites and urothelial cytotoxicity: in vivo, in vitro and molecular approaches.

Toxicology 2013 Dec 27;314(2-3):238-46. Epub 2013 Oct 27.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Center for the Evaluation of the Environmental Impact on Human Health (TOXICAM), Department of Pathology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil. Electronic address:

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December 2013

Characterization of intracellular inclusions in the urothelium of mice exposed to inorganic arsenic.

Toxicol Sci 2014 Jan 4;137(1):36-46. Epub 2013 Oct 4.

* Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135;

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January 2014

Pathogenesis of human hemangiosarcomas and hemangiomas.

Hum Pathol 2013 Oct;44(10):2302-11

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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October 2013

Evaluation of the carcinogenicity of inorganic arsenic.

Crit Rev Toxicol 2013 Oct;43(9):711-52

Department of Pathology and Microbiology, University of Nebraska Medical Center , Omaha, NE , USA .

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October 2013

Cytotoxicity and gene expression changes induced by inorganic and organic trivalent arsenicals in human cells.

Toxicology 2013 Oct 19;312:18-29. Epub 2013 Jul 19.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA. Electronic address:

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October 2013

Urothelial cell intracytoplasmic inclusions after treatment of promyelocytic leukemia with arsenic trioxide.

Toxicol Sci 2013 Aug 6;134(2):271-5. Epub 2013 Jun 6.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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August 2013

Arsenic speciation in the blood of arsenite-treated F344 rats.

Chem Res Toxicol 2013 Jun 4;26(6):952-62. Epub 2013 Jun 4.

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.

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June 2013

Time course of urothelial changes in rats and mice orally administered arsenite.

Toxicol Pathol 2014 Jul 20;42(5):855-62. Epub 2013 May 20.

Department of Pathology and Microbiology and the Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA

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July 2014

Evaluation of gene expression changes in human primary uroepithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites.

Environ Mol Mutagen 2013 Mar 29;54(2):82-98. Epub 2012 Nov 29.

Department of Internal Medicine, Division of Epidemiology, Biostatistics and Preventive Medicine, University of New Mexico, Albuquerque, New Mexico 87131-00001, USA.

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March 2013

Diuron-induced rat bladder epithelial cytotoxicity.

Toxicol Sci 2012 Dec 24;130(2):281-8. Epub 2012 Aug 24.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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December 2012

Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice.

Int J Nanomedicine 2012 8;7:2557-71. Epub 2012 Jun 8.

Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-5830, USA.

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January 2013

Effects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium.

Toxicology 2012 Sep 1;299(2-3):155-9. Epub 2012 Jun 1.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, United States.

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September 2012

Mode of action of pulegone on the urinary bladder of F344 rats.

Toxicol Sci 2012 Jul 12;128(1):1-8. Epub 2012 Apr 12.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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July 2012

Evaluation of direct and indirect effects of the PPARγ agonist troglitazone on mouse endothelial cell proliferation.

Toxicol Pathol 2011 Dec 21;39(7):1032-45. Epub 2011 Sep 21.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska, USA.

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December 2011

Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water.

Toxicol Sci 2011 Dec 20;124(2):320-6. Epub 2011 Sep 20.

Analytical and Environmental Toxicology Division, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, T6G 2G3, Canada.

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December 2011

Evaluation of PPARγ agonists on rodent endothelial cell proliferation.

Toxicology 2011 Sep 12;287(1-3):91-8. Epub 2011 Jun 12.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, Omaha, NE 68198-3135, USA.

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September 2011

Chemical carcinogenesis.

Toxicol Sci 2011 Mar 8;120 Suppl 1:S76-92. Epub 2010 Dec 8.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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March 2011

Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat.

Toxicol Sci 2010 Feb 25;113(2):349-57. Epub 2009 Oct 25.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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February 2010

Effects of an epidermal growth factor receptor inhibitor on arsenic associated toxicity in the rat bladder epithelium.

Toxicol Lett 2009 Jun 3;187(2):124-9. Epub 2009 Mar 3.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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June 2009

Effects of co-administration of dietary sodium arsenite and an NADPH oxidase inhibitor on the rat bladder epithelium.

Toxicology 2009 Jun 3;261(1-2):41-6. Epub 2009 May 3.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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June 2009

Effects of the PPARgamma agonist troglitazone on endothelial cells in vivo and in vitro: differences between human and mouse.

Toxicol Appl Pharmacol 2009 May 11;237(1):83-90. Epub 2009 Mar 11.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.

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May 2009

Inorganic arsenic-induced intramitochondrial granules in mouse urothelium.

Toxicol Pathol 2008 Dec;36(7):999-1005

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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December 2008

Effects of inorganic arsenic on the rat and mouse urinary bladder.

Toxicol Sci 2008 Dec 26;106(2):350-63. Epub 2008 Aug 26.

Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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December 2008

Cytotoxicity of combinations of arsenicals on rat urinary bladder urothelial cells in vitro.

Toxicology 2008 Jul 22;249(1):69-74. Epub 2008 Apr 22.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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July 2008

Comparison of endothelial cell proliferation in normal liver and adipose tissue in B6C3F1 mice, F344 rats, and humans.

Toxicol Pathol 2007 Dec;35(7):904-9

Department of Pathology and Microbiology and the UNMC/Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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December 2007

Inhalation of tobacco smoke induces increased proliferation of urinary bladder epithelium and endothelium in female C57BL/6 mice.

Toxicology 2007 Nov 19;241(1-2):58-65. Epub 2007 Aug 19.

Department of Pathology and Microbiology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-3135, United States.

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November 2007

Investigations of rodent urinary bladder carcinogens: collection, processing, and evaluation of urine and bladders.

Toxicol Pathol 2007 Apr;35(3):337-47

Department of Pathology and Microbiology, and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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April 2007

Rodent carcinogenicity profile of the antidiabetic dual PPAR alpha and gamma agonist muraglitazar.

Toxicol Sci 2007 Jul 10;98(1):258-70. Epub 2007 Apr 10.

Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Drug Safety Evaluation Mt. Vernon, Indiana 47721, USA.

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July 2007

Subchronic urinary bladder effects of muraglitazar in male rats.

Toxicol Sci 2007 Mar 28;96(1):58-71. Epub 2006 Nov 28.

Departments of Drug Safety Evaluation, Bristol-Myers Squibb Company, Mt Vernon, Indiana 47721, USA.

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March 2007

Arsenic-induced bladder cancer in an animal model.

Toxicol Appl Pharmacol 2007 Aug 17;222(3):258-63. Epub 2006 Oct 17.

Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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August 2007

Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment.

Crit Rev Toxicol 2006 Feb;36(2):99-133

Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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February 2006

Dimethylarsinic acid: results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice.

Toxicology 2006 Jun 29;223(1-2):82-100. Epub 2006 Mar 29.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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June 2006

Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood.

Chem Res Toxicol 2004 Dec;17(12):1733-42

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.

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December 2004

Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice.

Toxicology 2003 Aug;190(3):197-219

Department of Pathology and Microbiology, University of Nebraska Medical Center 983135, Omaha, NE 68198-3135, USA.

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August 2003

Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat.

Chem Res Toxicol 2002 Sep;15(9):1150-7

Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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September 2002