Publications by authors named "Lora L Arnold"

65Publications

Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin.

Authors:
Shugo Suzuki Samuel M Cohen Lora L Arnold Karen L Pennington Min Gi Hiroyuki Kato Taku Naiki Aya Naiki-Ito Hideki Wanibuchi Satoru Takahashi

Toxicol Lett 2021 Jan 8;336:32-38. Epub 2020 Nov 8.

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.

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January 2021

Urinary crystal formation and urothelial effects of pyroxasulfone administered to male rats.

Authors:
Takahiro Kyoya Lora L Arnold Karen L Pennington Satoko Kakiuchi-Kiyota Megumi Terada Koichi Abe Samuel M Cohen

Toxicol Mech Methods 2020 Nov 4;30(9):656-671. Epub 2020 Sep 4.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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November 2020

Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo.

Authors:
Shugo Suzuki Samuel M Cohen Lora L Arnold Karen L Pennington Hiroyuki Kato Taku Naiki Aya Naiki-Ito Yoriko Yamashita Satoru Takahashi

Toxicology 2020 01 1;429:152325. Epub 2019 Nov 1.

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.

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January 2020

Mitochondrial lipid droplet formation as a detoxification mechanism to sequester and degrade excessive urothelial membranes.

Authors:
Yi Liao Daniel K L Tham Feng-Xia Liang Jennifer Chang Yuan Wei Putty-Reddy Sudhir Joseph Sall Sarah J Ren Javier U Chicote Lora L Arnold Chih-Chi Andrew Hu Rok Romih Leonardo R Andrade Michael J Rindler Samuel M Cohen Rob DeSalle Antonio Garcia-España Mingxiao Ding Xue-Ru Wu Tung-Tien Sun

Mol Biol Cell 2019 11 2;30(24):2969-2984. Epub 2019 Oct 2.

Department of Cell Biology, New York University School of Medicine, New York, NY10016.

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November 2019

Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO).

Authors:
Lance K Blevins Robert B Crawford Anthony Bach Michael D Rizzo Jiajun Zhou Joseph E Henriquez D M Isha Olive Khan Sera Sermet Lora L Arnold Karen L Pennington Nathalia P Souza Samuel M Cohen Norbert E Kaminski

Food Chem Toxicol 2019 Nov 29;133:110793. Epub 2019 Aug 29.

Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA; Center for Research on Ingredient Safety, Michigan State University, East Lansing, MI, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA. Electronic address:

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November 2019

Isolation and molecular characterization of spermatogonia from male Sprague-Dawley rats exposed and postnatally to dibutyl phthalate or acrylamide.

Authors:
Nathália P Souza Lora L Arnold Karen L Pennington Merielen G Nascimento E Pontes Helio A Miot João Lauro V de Camargo Samuel M Cohen

Toxicol Mech Methods 2019 Sep 18;29(7):488-498. Epub 2019 Jun 18.

b Department of Pathology and Microbiology , University of Nebraska Medical Center , Omaha , NE , USA.

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September 2019

Histopathology re-examination of the NTP toxicity/carcinogenicity studies of tert-butyl alcohol to identify renal tumor and toxicity modes of action.

Authors:
Gordon C Hard Samuel M Cohen Jihyun Ma Fang Yu Lora L Arnold Marcy I Banton

Regul Toxicol Pharmacol 2019 Mar 24;102:65-73. Epub 2018 Dec 24.

LyondellBasell, Houston, TX, 77010, USA.

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March 2019

Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN).

Authors:
Nathália P Souza Gordon C Hard Lora L Arnold Kirk W Foster Karen L Pennington Samuel M Cohen

Toxicol Pathol 2018 04 4;46(3):266-272. Epub 2018 Mar 4.

1 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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April 2018

Orally administered nicotine effects on rat urinary bladder proliferation and carcinogenesis.

Authors:
Shugo Suzuki Samuel M Cohen Lora L Arnold Hiroyuki Kato Satoshi Fuji Karen L Pennington Yuko Nagayasu Aya Naiki-Ito Yoriko Yamashita Satoru Takahashi

Toxicology 2018 04 6;398-399:31-40. Epub 2018 Mar 6.

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.

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April 2018

Effect of polyhexamethylene biguanide on rat liver.

Authors:
Aparajita Chowdhury Lora L Arnold Zemin Wang Karen L Pennington Puttappa Dodmane Ana Paula Farragut-Cardoso James E Klaunig Daniel Cros Edmond E Creppy Samuel M Cohen

Toxicol Lett 2018 Mar 2;285:94-103. Epub 2018 Jan 2.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, United States; Havlik-Wall Professor of Oncology, United States. Electronic address:

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March 2018

Low-dose dose-response for reduced cell viability after exposure of human keratinocyte (HEK001) cells to arsenite.

Authors:
Kenneth T Bogen Lora L Arnold Aparajita Chowdhury Karen L Pennington Samuel M Cohen

Toxicol Rep 2017 14;4:32-38. Epub 2016 Dec 14.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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December 2016

Inorganic arsenic: A non-genotoxic carcinogen.

Authors:
Samuel M Cohen Aparajita Chowdhury Lora L Arnold

J Environ Sci (China) 2016 Nov 17;49:28-37. Epub 2016 May 17.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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November 2016

Response to Druwe and Burgoon, 2016 Letter to the Editor in Archives of Toxicology.

Authors:
Samuel M Cohen Jay I Goodman James E Klaunig Lora L Arnold

Arch Toxicol 2017 02 9;91(2):999-1000. Epub 2016 Nov 9.

University of Nebraska Medical Center, Omaha, NE, USA.

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February 2017

Critical role of toxicologic pathology in a short-term screen for carcinogenicity.

Authors:
Samuel M Cohen Lora L Arnold

J Toxicol Pathol 2016 Oct 23;29(4):215-227. Epub 2016 May 23.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Omaha, NE 68198-3135, USA.

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October 2016

Response to Druwe and Burgoon : Re: Druwe, I.L. and Burgoon, L.: revisiting Cohen et al. 2015, Cohen et al. 2014 and Waalkes et al. 2014: a bayesian re-analysis of tumor incidences.

Authors:
Samuel M Cohen Lora L Arnold James E Klaunig Jay I Goodman

Arch Toxicol 2016 12 19;90(12):3129-3130. Epub 2016 Aug 19.

Michigan State University, East Lansing, MI, USA.

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December 2016

Identification of Methylated Dithioarsenicals in the Urine of Rats Fed with Sodium Arsenite.

Authors:
Baowei Chen Xiufen Lu Lora L Arnold Samuel M Cohen X Chris Le

Chem Res Toxicol 2016 09 8;29(9):1480-7. Epub 2016 Aug 8.

Analytical and Environmental Toxicology Division, Department of Laboratory Medicine and Pathology, University of Alberta , Edmonton, Alberta T6G 2G3, Canada.

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September 2016

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells.

Authors:
Puttappa R Dodmane Lora L Arnold Karen L Pennington Rakesh K Singh Ana Paula Ferragut Cardoso Samuel M Cohen

Toxicol Rep 2015 21;2:833-837. Epub 2015 May 21.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.

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May 2015

Re: Waalkes et al.: Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses, Arch Toxicol, 2014.

Authors:
Samuel M Cohen Lora L Arnold James E Klaunig Jay I Goodman

Arch Toxicol 2014 Nov 12;88(11):2061-2. Epub 2014 Aug 12.

University of Nebraska Medical Center, Omaha, NE, USA,

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November 2014

Diuron-induced rat urinary bladder carcinogenesis: mode of action and human relevance evaluations using the International Programme on Chemical Safety framework.

Authors:
Mitscheli Sanches Da Rocha Lora L Arnold Maria Luiza Cotrim Sartor De Oliveira Shadia M Ihlaseh Catalano Ana Paula Ferragut Cardoso Merielen G N Pontes Bianca Ferrucio Puttappa R Dodmane Samuel M Cohen João Lauro V De Camargo

Crit Rev Toxicol 2014 May 11;44(5):393-406. Epub 2014 Feb 11.

University of Nebraska Medical Center , Omaha, NE , USA.

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May 2014

Orally administered nicotine induces urothelial hyperplasia in rats and mice.

Authors:
Puttappa R Dodmane Lora L Arnold Karen L Pennington Samuel M Cohen

Toxicology 2014 Jan 19;315:49-54. Epub 2013 Nov 19.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA; Havlik-Wall Professor of Oncology. Electronic address:

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January 2014

Diuron metabolites and urothelial cytotoxicity: in vivo, in vitro and molecular approaches.

Authors:
Mitscheli S Da Rocha Lora L Arnold Puttappa R Dodmane Karen L Pennington Fang Qiu João Lauro V De Camargo Samuel M Cohen

Toxicology 2013 Dec 27;314(2-3):238-46. Epub 2013 Oct 27.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Center for the Evaluation of the Environmental Impact on Human Health (TOXICAM), Department of Pathology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil. Electronic address:

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December 2013

Characterization of intracellular inclusions in the urothelium of mice exposed to inorganic arsenic.

Authors:
Puttappa R Dodmane Lora L Arnold David E Muirhead Shugo Suzuki Masanao Yokohira Karen L Pennington Bhavana J Dave Xiufen Lu X Chris Le Samuel M Cohen

Toxicol Sci 2014 Jan 4;137(1):36-46. Epub 2013 Oct 4.

* Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135;

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January 2014

Pathogenesis of human hemangiosarcomas and hemangiomas.

Authors:
Liping Liu Satoko Kakiuchi-Kiyota Lora L Arnold Sonny L Johansson David Wert Samuel M Cohen

Hum Pathol 2013 Oct;44(10):2302-11

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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October 2013

Evaluation of the carcinogenicity of inorganic arsenic.

Authors:
Samuel M Cohen Lora L Arnold Barbara D Beck Ari S Lewis Michal Eldan

Crit Rev Toxicol 2013 Oct;43(9):711-52

Department of Pathology and Microbiology, University of Nebraska Medical Center , Omaha, NE , USA .

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October 2013

Cytotoxicity and gene expression changes induced by inorganic and organic trivalent arsenicals in human cells.

Authors:
Puttappa R Dodmane Lora L Arnold Satoko Kakiuchi-Kiyota Fang Qiu Xiangde Liu Stephen I Rennard Samuel M Cohen

Toxicology 2013 Oct 19;312:18-29. Epub 2013 Jul 19.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA. Electronic address:

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October 2013

Urothelial cell intracytoplasmic inclusions after treatment of promyelocytic leukemia with arsenic trioxide.

Authors:
Whitney R Wedel David E Muirhead Lora L Arnold Puttappa R Dodmane Subodh M Lele Lori Maness-Harris Rose Hoyt Samuel M Cohen

Toxicol Sci 2013 Aug 6;134(2):271-5. Epub 2013 Jun 6.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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August 2013

Arsenic speciation in the blood of arsenite-treated F344 rats.

Authors:
Baowei Chen Xiufen Lu Shengwen Shen Lora L Arnold Samuel M Cohen X Chris Le

Chem Res Toxicol 2013 Jun 4;26(6):952-62. Epub 2013 Jun 4.

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.

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June 2013

Time course of urothelial changes in rats and mice orally administered arsenite.

Authors:
Lora L Arnold Shugo Suzuki Masanao Yokohira Satoko Kakiuchi-Kiyota Karen L Pennington Samuel M Cohen

Toxicol Pathol 2014 Jul 20;42(5):855-62. Epub 2013 May 20.

Department of Pathology and Microbiology and the Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA

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July 2014

Effect of dietary treatment with dimethylarsinous acid (DMA(III)) on the urinary bladder epithelium of arsenic (+3 oxidation state) methyltransferase (As3mt) knockout and C57BL/6 wild type female mice.

Authors:
Puttappa R Dodmane Lora L Arnold Karen L Pennington David J Thomas Samuel M Cohen

Toxicology 2013 Mar 30;305:130-5. Epub 2013 Jan 30.

University of Nebraska Medical Center, Omaha, NE, USA.

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March 2013

Evaluation of gene expression changes in human primary uroepithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites.

Authors:
Janice W Yager P Robinan Gentry Russell S Thomas Linda Pluta Alina Efremenko Michael Black Lora L Arnold James M McKim Paul Wilga Gary Gill Key-Young Choe Harvey J Clewell

Environ Mol Mutagen 2013 Mar 29;54(2):82-98. Epub 2012 Nov 29.

Department of Internal Medicine, Division of Epidemiology, Biostatistics and Preventive Medicine, University of New Mexico, Albuquerque, New Mexico 87131-00001, USA.

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March 2013

Evaluation of expression profiles of hematopoietic stem cell, endothelial cell, and myeloid cell antigens in spontaneous and chemically induced hemangiosarcomas and hemangiomas in mice.

Authors:
Satoko Kakiuchi-Kiyota Torrie A Crabbs Lora L Arnold Karen L Pennington Jon C Cook David E Malarkey Samuel M Cohen

Toxicol Pathol 2013 Jul 2;41(5):709-21. Epub 2012 Nov 2.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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July 2013

Diuron-induced rat bladder epithelial cytotoxicity.

Authors:
Mitscheli S Da Rocha Lora L Arnold Karen L Pennington David Muirhead Puttappa R Dodmane Muhammad M Anwar Michael Battalora João Lauro V De Camargo Samuel M Cohen

Toxicol Sci 2012 Dec 24;130(2):281-8. Epub 2012 Aug 24.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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December 2012

Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice.

Authors:
Hardeep S Oberoi Natalia V Nukolova Frederic C Laquer Larisa Y Poluektova Jiangeng Huang Yazen Alnouti Masanao Yokohira Lora L Arnold Alexander V Kabanov Samuel M Cohen Tatiana K Bronich

Int J Nanomedicine 2012 8;7:2557-71. Epub 2012 Jun 8.

Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-5830, USA.

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January 2013

Effects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium.

Authors:
Shugo Suzuki Lora L Arnold Karen L Pennington Satoko Kakiuchi-Kiyota Baowei Chen Xiufen Lu X Chris Le Samuel M Cohen

Toxicology 2012 Sep 1;299(2-3):155-9. Epub 2012 Jun 1.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, United States.

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September 2012

Mode of action of pulegone on the urinary bladder of F344 rats.

Authors:
Mitscheli S Da Rocha Puttappa R Dodmane Lora L Arnold Karen L Pennington Muhammad M Anwar Bret R Adams Sean V Taylor Clint Wermes Timothy B Adams Samuel M Cohen

Toxicol Sci 2012 Jul 12;128(1):1-8. Epub 2012 Apr 12.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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July 2012

Evaluation of direct and indirect effects of the PPARγ agonist troglitazone on mouse endothelial cell proliferation.

Authors:
Satoko Kakiuchi-Kiyota Lora L Arnold Masanao Yokohira Petra Koza-Taylor Shugo Suzuki Michelle Varney Karen L Pennington Samuel M Cohen

Toxicol Pathol 2011 Dec 21;39(7):1032-45. Epub 2011 Sep 21.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska, USA.

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December 2011

Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water.

Authors:
Baowei Chen Lora L Arnold Samuel M Cohen David J Thomas X Chris Le

Toxicol Sci 2011 Dec 20;124(2):320-6. Epub 2011 Sep 20.

Analytical and Environmental Toxicology Division, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, T6G 2G3, Canada.

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December 2011

Evaluation of PPARγ agonists on rodent endothelial cell proliferation.

Authors:
Satoko Kakiuchi-Kiyota Lora L Arnold Masanao Yokohira Shugo Suzuki Karen L Pennington Samuel M Cohen

Toxicology 2011 Sep 12;287(1-3):91-8. Epub 2011 Jun 12.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, Omaha, NE 68198-3135, USA.

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September 2011

Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice.

Authors:
Masanao Yokohira Lora L Arnold Karen L Pennington Shugo Suzuki Satoko Kakiuchi-Kiyota Karen Herbin-Davis David J Thomas Samuel M Cohen

Toxicol Sci 2011 Jun 7;121(2):257-66. Epub 2011 Mar 7.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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June 2011

The effects of oral treatment with transfluthrin on the urothelium of rats and its metabolite, tetrafluorobenzoic acid on urothelial cells in vitro.

Authors:
Masanao Yokohira Lora L Arnold Sophie Lautraite Larry Sheets Sheila Wason Bernhard Stahl David Eigenberg Karen L Pennington Satoko Kakiuchi-Kiyota Samuel M Cohen

Food Chem Toxicol 2011 Jun 4;49(6):1215-23. Epub 2011 Mar 4.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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June 2011

Chemical carcinogenesis.

Authors:
Samuel M Cohen Lora L Arnold

Toxicol Sci 2011 Mar 8;120 Suppl 1:S76-92. Epub 2010 Dec 8.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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March 2011

Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report.

Authors:
Masanao Yokohira Lora L Arnold Karen L Pennington Shugo Suzuki Satoko Kakiuchi-Kiyota Karen Herbin-Davis David J Thomas Samuel M Cohen

Toxicol Appl Pharmacol 2010 Jul 25;246(1-2):1-7. Epub 2010 Apr 25.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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July 2010

Dietary administration of sodium arsenite to rats: relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium.

Authors:
Shugo Suzuki Lora L Arnold Karen L Pennington Baowei Chen Hua Naranmandura X Chris Le Samuel M Cohen

Toxicol Appl Pharmacol 2010 Apr 4;244(2):99-105. Epub 2010 Jan 4.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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April 2010

Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat.

Authors:
Shugo Suzuki Lora L Arnold Karen L Pennington Satoko Kakiuchi-Kiyota Min Wei Hideki Wanibuchi Samuel M Cohen

Toxicol Sci 2010 Feb 25;113(2):349-57. Epub 2009 Oct 25.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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February 2010

Effects of an epidermal growth factor receptor inhibitor on arsenic associated toxicity in the rat bladder epithelium.

Authors:
Shugo Suzuki Lora L Arnold Karen L Pennington Baowei Chen X Chris Le Samuel M Cohen

Toxicol Lett 2009 Jun 3;187(2):124-9. Epub 2009 Mar 3.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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June 2009

Effects of co-administration of dietary sodium arsenite and an NADPH oxidase inhibitor on the rat bladder epithelium.

Authors:
Shugo Suzuki Lora L Arnold Karen L Pennington Satoko Kakiuchi-Kiyota Samuel M Cohen

Toxicology 2009 Jun 3;261(1-2):41-6. Epub 2009 May 3.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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June 2009

Strain-related differences in urine composition of male rats of potential relevance to urolithiasis.

Authors:
Sarah H Tannehill-Gregg Mark A Dominick Amy J Reisinger Jeffrey D Moehlenkamp C Robbie Waites David A Stock Thomas P Sanderson Samuel M Cohen Lora L Arnold Beth E Schilling

Toxicol Pathol 2009 Apr;37(3):293-305

Bristol-Myers Squibb Research & Development, Department of Drug Safety Evaluation, Mount Vernon, Indiana, USA.

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April 2009

Effects of the PPARgamma agonist troglitazone on endothelial cells in vivo and in vitro: differences between human and mouse.

Authors:
Satoko Kakiuchi-Kiyota Joseph A Vetro Shugo Suzuki Michelle L Varney Huai-Yun Han Merielen Nascimento Karen L Pennington Lora L Arnold Rakesh K Singh Samuel M Cohen

Toxicol Appl Pharmacol 2009 May 11;237(1):83-90. Epub 2009 Mar 11.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.

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May 2009

Inorganic arsenic-induced intramitochondrial granules in mouse urothelium.

Authors:
Shugo Suzuki Lora L Arnold David Muirhead Xiufen Lu X Chris Le James A Bjork Kendall B Wallace Takamasa Ohnishi Satoko Kakiuchi-Kiyota Karen L Pennington Samuel M Cohen

Toxicol Pathol 2008 Dec;36(7):999-1005

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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December 2008

Effects of inorganic arsenic on the rat and mouse urinary bladder.

Authors:
Shugo Suzuki Lora L Arnold Takamasa Ohnishi Samuel M Cohen

Toxicol Sci 2008 Dec 26;106(2):350-63. Epub 2008 Aug 26.

Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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December 2008

Cytotoxicity of combinations of arsenicals on rat urinary bladder urothelial cells in vitro.

Authors:
Merielen G Nascimento Shugo Suzuki Min Wei Ashish Tiwari Lora L Arnold Xiufen Lu X Chris Le Samuel M Cohen

Toxicology 2008 Jul 22;249(1):69-74. Epub 2008 Apr 22.

Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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July 2008

Comparison of endothelial cell proliferation in normal liver and adipose tissue in B6C3F1 mice, F344 rats, and humans.

Authors:
Takamasa Ohnishi Lora L Arnold Nicole M Clark James L Wisecarver Samuel M Cohen

Toxicol Pathol 2007 Dec;35(7):904-9

Department of Pathology and Microbiology and the UNMC/Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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December 2007

Inhalation of tobacco smoke induces increased proliferation of urinary bladder epithelium and endothelium in female C57BL/6 mice.

Authors:
Takamasa Ohnishi Lora L Arnold Jun He Nicole M Clark Shin Kawasaki Stephen I Rennard Craig W Boyer Samuel M Cohen

Toxicology 2007 Nov 19;241(1-2):58-65. Epub 2007 Aug 19.

Department of Pathology and Microbiology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-3135, United States.

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November 2007

Investigations of rodent urinary bladder carcinogens: collection, processing, and evaluation of urine and bladders.

Authors:
Samuel M Cohen Takamasa Ohnishi Nicole M Clark Jun He Lora L Arnold

Toxicol Pathol 2007 Apr;35(3):337-47

Department of Pathology and Microbiology, and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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April 2007

Rodent carcinogenicity profile of the antidiabetic dual PPAR alpha and gamma agonist muraglitazar.

Authors:
Sarah H Tannehill-Gregg Thomas P Sanderson Daniel Minnema Richard Voelker Borge Ulland Samuel M Cohen Lora L Arnold Beth E Schilling C Robbie Waites Mark A Dominick

Toxicol Sci 2007 Jul 10;98(1):258-70. Epub 2007 Apr 10.

Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Drug Safety Evaluation Mt. Vernon, Indiana 47721, USA.

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July 2007

Binding of dimethylarsinous acid to cys-13alpha of rat hemoglobin is responsible for the retention of arsenic in rat blood.

Authors:
Meiling Lu Hailin Wang Xing-Fang Li Lora L Arnold Samuel M Cohen X Chris Le

Chem Res Toxicol 2007 Jan;20(1):27-37

Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada.

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January 2007

Subchronic urinary bladder effects of muraglitazar in male rats.

Authors:
Terry R Van Vleet M Randy White Thomas P Sanderson Samuel M Cohen Martin Cano Lora L Arnold C Robbie Waites Beth E Schilling James Mitroka Mark A Dominick

Toxicol Sci 2007 Mar 28;96(1):58-71. Epub 2006 Nov 28.

Departments of Drug Safety Evaluation, Bristol-Myers Squibb Company, Mt Vernon, Indiana 47721, USA.

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March 2007

Arsenic-induced bladder cancer in an animal model.

Authors:
Samuel M Cohen Takamasa Ohnishi Lora L Arnold X Chris Le

Toxicol Appl Pharmacol 2007 Aug 17;222(3):258-63. Epub 2006 Oct 17.

Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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August 2007

Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment.

Authors:
Samuel M Cohen Lora L Arnold Michal Eldan Ari S Lewis Barbara D Beck

Crit Rev Toxicol 2006 Feb;36(2):99-133

Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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February 2006

Dimethylarsinic acid: results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice.

Authors:
Lora L Arnold Michal Eldan Abraham Nyska Marcia van Gemert Samuel M Cohen

Toxicology 2006 Jun 29;223(1-2):82-100. Epub 2006 Mar 29.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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June 2006

Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood.

Authors:
Meiling Lu Hailin Wang Xing-Fang Li Xiufen Lu William R Cullen Lora L Arnold Samuel M Cohen X Chris Le

Chem Res Toxicol 2004 Dec;17(12):1733-42

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.

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December 2004

Speciation of dimethylarsinous acid and trimethylarsine oxide in urine from rats fed with dimethylarsinic acid and dimercaptopropane sulfonate.

Authors:
Xiufen Lu Lora L Arnold Samuel M Cohen William R Cullen X Chris Le

Anal Chem 2003 Dec;75(23):6463-8

Department of Public Health Sciences, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.

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December 2003

Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice.

Authors:
Lora L Arnold Michal Eldan Marcia van Gemert Charles C Capen Samuel M Cohen

Toxicology 2003 Aug;190(3):197-219

Department of Pathology and Microbiology, University of Nebraska Medical Center 983135, Omaha, NE 68198-3135, USA.

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August 2003

Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat.

Authors:
Samuel M Cohen Lora L Arnold Eva Uzvolgyi Martin Cano Margaret St John Shinji Yamamoto Xiufen Lu X Chris Le

Chem Res Toxicol 2002 Sep;15(9):1150-7

Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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September 2002

Dissimilatory arsenate reductase activity and arsenate-respiring bacteria in bovine rumen fluid, hamster feces, and the termite hindgut.

Authors:
Mitchell J Herbel Jodi Switzer Blum Shelley E Hoeft Samuel M Cohen Lora L Arnold Joy Lisak John F Stolz Ronald S Oremland

FEMS Microbiol Ecol 2002 Jul;41(1):59-67

US Geological Survey, ms 480, 345 Middlefield Road, Menlo Park, CA 94025, USA.

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July 2002