Publications by authors named "Longchuan Bai"

42Publications

Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression.

J Med Chem 2020 11 13;63(22):13994-14016. Epub 2020 Nov 13.

Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

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November 2020

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.

Cancer Cell 2019 11;36(5):498-511.e17

Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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November 2019

Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins - A review.

Drug Discov Today Technol 2019 Apr 1;31:43-51. Epub 2019 May 1.

The Rogel Cancer Center, Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address:

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April 2019

MCL-1 inhibition in cancer treatment.

Onco Targets Ther 2018 23;11:7301-7314. Epub 2018 Oct 23.

Department of Internal Medicine, University of Michigan Medical School,

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October 2018

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.

J Med Chem 2018 01 24;61(2):462-481. Epub 2017 Mar 24.

University of Michigan Comprehensive Cancer Center, and Departments of ‡Internal Medicine, §Pathology, ∥Pharmaceutical Sciences, ⊥Medicinal Chemistry, and #Pharmacology, University of Michigan , Ann Arbor, Michigan 48109, United States.

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January 2018

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.

ACS Med Chem Lett 2016 Dec 13;7(12):1092-1096. Epub 2016 Sep 13.

Departments of Internal Medicine and Biological Chemistry and Life Sciences Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.

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December 2016

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.

J Med Chem 2015 Jun 16;58(12):4927-39. Epub 2015 Jun 16.

†Departments of Medicinal Chemistry, ‡Internal Medicine, §Pharmacology, and ∥Biological Chemistry, ⊥Life Sciences Institute, and #Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.

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June 2015

BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo.

PLoS One 2014 5;9(6):e99404. Epub 2014 Jun 5.

University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America; University of Michigan Comprehensive Cancer Center and Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States of America; University of Michigan Comprehensive Cancer Center and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America.

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October 2015

Small-molecule SMAC mimetics as new cancer therapeutics.

Pharmacol Ther 2014 Oct 16;144(1):82-95. Epub 2014 May 16.

Comprehensive Cancer Center, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Pharmacology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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October 2014

Targeting apoptosis pathways for new cancer therapeutics.

Annu Rev Med 2014 4;65:139-55. Epub 2013 Nov 4.

University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109; email:

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September 2014

Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.

PLoS One 2013 8;8(3):e58935. Epub 2013 Mar 8.

Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America.

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September 2013

A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.

J Med Chem 2013 Apr 22;56(7):3048-3067. Epub 2013 Mar 22.

Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0934, USA.

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April 2013

Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics.

J Mammary Gland Biol Neoplasia 2012 Dec 29;17(3-4):217-28. Epub 2012 Sep 29.

Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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December 2012