Publications by authors named "Longchuan Bai"

42Publications

Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression.

Authors:
Jianyong Chen Yunlong Zhou Xuyuan Dong Liu Liu Longchuan Bai Donna McEachern Sally Przybranowski Chao-Yie Yang Jeanne Stuckey Xiaoqin Li Bo Wen Ting Zhao Siwei Sun Duxin Sun Lingling Jiao Yu Jing Ming Guo Dajun Yang Shaomeng Wang

J Med Chem 2020 11 13;63(22):13994-14016. Epub 2020 Nov 13.

Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

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November 2020

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein.

Authors:
Haibin Zhou Longchuan Bai Renqi Xu Yujun Zhao Jianyong Chen Donna McEachern Krishnapriya Chinnaswamy Bo Wen Lipeng Dai Praveen Kumar Chao-Yie Yang Zhaomin Liu Mi Wang Liu Liu Jennifer L Meagher Han Yi Duxin Sun Jeanne A Stuckey Shaomeng Wang

J Med Chem 2019 12 10;62(24):11280-11300. Epub 2019 Dec 10.

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December 2019

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.

Authors:
Longchuan Bai Haibin Zhou Renqi Xu Yujun Zhao Krishnapriya Chinnaswamy Donna McEachern Jianyong Chen Chao-Yie Yang Zhaomin Liu Mi Wang Liu Liu Hui Jiang Bo Wen Praveen Kumar Jennifer L Meagher Duxin Sun Jeanne A Stuckey Shaomeng Wang

Cancer Cell 2019 11;36(5):498-511.e17

Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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November 2019

Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins - A review.

Authors:
Chao-Yie Yang Chong Qin Longchuan Bai Shaomeng Wang

Drug Discov Today Technol 2019 Apr 1;31:43-51. Epub 2019 May 1.

The Rogel Cancer Center, Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address:

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April 2019

MCL-1 inhibition in cancer treatment.

Authors:
Weiguo Xiang Chao-Yie Yang Longchuan Bai

Onco Targets Ther 2018 23;11:7301-7314. Epub 2018 Oct 23.

Department of Internal Medicine, University of Michigan Medical School,

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October 2018

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.

Authors:
Chong Qin Yang Hu Bing Zhou Ester Fernandez-Salas Chao-Yie Yang Liu Liu Donna McEachern Sally Przybranowski Mi Wang Jeanne Stuckey Jennifer Meagher Longchuan Bai Zhuo Chen Mei Lin Jiuling Yang Danya N Ziazadeh Fuming Xu Jiantao Hu Weiguo Xiang Liyue Huang Siwei Li Bo Wen Duxin Sun Shaomeng Wang

J Med Chem 2018 Aug 18;61(15):6685-6704. Epub 2018 Jul 18.

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August 2018

Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.

Authors:
Yujun Zhao Bing Zhou Longchuan Bai Liu Liu Chao-Yie Yang Jennifer L Meagher Jeanne A Stuckey Donna McEachern Sally Przybranowski Mi Wang Xu Ran Angelo Aguilar Yang Hu Jeff W Kampf Xiaoqin Li Ting Zhao Siwei Li Bo Wen Duxin Sun Shaomeng Wang

J Med Chem 2018 07 17;61(14):6110-6120. Epub 2018 Jul 17.

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July 2018

Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.

Authors:
Yujun Zhao Longchuan Bai Liu Liu Donna McEachern Jeanne A Stuckey Jennifer L Meagher Chao-Yie Yang Xu Ran Bing Zhou Yang Hu Xiaoqin Li Bo Wen Ting Zhao Siwei Li Duxin Sun Shaomeng Wang

J Med Chem 2017 05 2;60(9):3887-3901. Epub 2017 May 2.

Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan , Ann Arbor, Michigan 48109, United States.

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May 2017

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.

Authors:
Bing Zhou Jiantao Hu Fuming Xu Zhuo Chen Longchuan Bai Ester Fernandez-Salas Mei Lin Liu Liu Chao-Yie Yang Yujun Zhao Donna McEachern Sally Przybranowski Bo Wen Duxin Sun Shaomeng Wang

J Med Chem 2018 01 24;61(2):462-481. Epub 2017 Mar 24.

University of Michigan Comprehensive Cancer Center, and Departments of ‡Internal Medicine, §Pathology, ∥Pharmaceutical Sciences, ⊥Medicinal Chemistry, and #Pharmacology, University of Michigan , Ann Arbor, Michigan 48109, United States.

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January 2018

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.

Authors:
Longchuan Bai Bing Zhou Chao-Yie Yang Jiao Ji Donna McEachern Sally Przybranowski Hui Jiang Jiantao Hu Fuming Xu Yujun Zhao Liu Liu Ester Fernandez-Salas Jing Xu Yali Dou Bo Wen Duxin Sun Jennifer Meagher Jeanne Stuckey Daniel F Hayes Shunqiang Li Matthew J Ellis Shaomeng Wang

Cancer Res 2017 05 16;77(9):2476-2487. Epub 2017 Feb 16.

University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan.

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May 2017

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.

Authors:
Chao-Yie Yang James G Phillips Jeanne A Stuckey Longchuan Bai Haiying Sun James Delproposto William Clay Brown Krishnapriya Chinnaswamy

ACS Med Chem Lett 2016 Dec 13;7(12):1092-1096. Epub 2016 Sep 13.

Departments of Internal Medicine and Biological Chemistry and Life Sciences Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.

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December 2016

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.

Authors:
Xu Ran Yujun Zhao Liu Liu Longchuan Bai Chao-Yie Yang Bing Zhou Jennifer L Meagher Krishnapriya Chinnaswamy Jeanne A Stuckey Shaomeng Wang

J Med Chem 2015 Jun 16;58(12):4927-39. Epub 2015 Jun 16.

†Departments of Medicinal Chemistry, ‡Internal Medicine, §Pharmacology, and ∥Biological Chemistry, ⊥Life Sciences Institute, and #Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.

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June 2015

SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.

Authors:
Shaomeng Wang Wei Sun Yujun Zhao Donna McEachern Isabelle Meaux Cédric Barrière Jeanne A Stuckey Jennifer L Meagher Longchuan Bai Liu Liu Cassandra Gianna Hoffman-Luca Jianfeng Lu Sanjeev Shangary Shanghai Yu Denzil Bernard Angelo Aguilar Odette Dos-Santos Laurent Besret Stéphane Guerif Pascal Pannier Dimitri Gorge-Bernat Laurent Debussche

Cancer Res 2014 Oct 21;74(20):5855-65. Epub 2014 Aug 21.

Sanofi Oncology, Vitry-sur-Seine, France.

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October 2014

BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo.

Authors:
Longchuan Bai Jianfang Chen Donna McEachern Liu Liu Haibin Zhou Angelo Aguilar Shaomeng Wang

PLoS One 2014 5;9(6):e99404. Epub 2014 Jun 5.

University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America; University of Michigan Comprehensive Cancer Center and Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States of America; University of Michigan Comprehensive Cancer Center and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America.

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October 2015

Small-molecule SMAC mimetics as new cancer therapeutics.

Authors:
Longchuan Bai David C Smith Shaomeng Wang

Pharmacol Ther 2014 Oct 16;144(1):82-95. Epub 2014 May 16.

Comprehensive Cancer Center, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Pharmacology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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October 2014

Targeting apoptosis pathways for new cancer therapeutics.

Authors:
Longchuan Bai Shaomeng Wang

Annu Rev Med 2014 4;65:139-55. Epub 2013 Nov 4.

University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109; email:

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September 2014

Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.

Authors:
Mohamad El-Zaatari John Y Kao Art Tessier Longchuan Bai Michael M Hayes Clinton Fontaine Kathryn A Eaton Juanita L Merchant

PLoS One 2013 8;8(3):e58935. Epub 2013 Mar 8.

Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America.

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September 2013

A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.

Authors:
Angelo Aguilar Haibin Zhou Jianfang Chen Liu Liu Longchuan Bai Donna McEachern Chao-Yie Yang Jennifer Meagher Jeanne Stuckey Shaomeng Wang

J Med Chem 2013 Apr 22;56(7):3048-3067. Epub 2013 Mar 22.

Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0934, USA.

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April 2013

Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics.

Authors:
Shaomeng Wang Longchuan Bai Jianfeng Lu Liu Liu Chao-Yie Yang Haiying Sun

J Mammary Gland Biol Neoplasia 2012 Dec 29;17(3-4):217-28. Epub 2012 Sep 29.

Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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December 2012

Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

Authors:
Jianfang Chen Haibin Zhou Angelo Aguilar Liu Liu Longchuan Bai Donna McEachern Chao-Yie Yang Jennifer L Meagher Jeanne A Stuckey Shaomeng Wang

J Med Chem 2012 Oct 2;55(19):8502-14. Epub 2012 Oct 2.

Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0934, USA.

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October 2012