Publications by authors named "Long-De Wang"

29 Publications

  • Page 1 of 1

Thrombolytic DNT and fatality and disability rates in acute ischemic stroke: a study from Bigdata Observatory Platform for Stroke of China.

Neurol Sci 2021 Sep 3. Epub 2021 Sep 3.

The General Office of Stroke Prevention Project Committee, National Health Commission of the People's Republic of China, No. 118, Guang'anmen Inner Street, Beijing, 100053, China.

Objective: To evaluate whether shorter door-to-needle times (DNT) with intravenous tissue plasminogen activator (tPA) for acute ischemic stroke are associated with improved 1-year outcomes in Chinese patients.

Methods: From August to September 2019, all first-ever ischemic stroke patients who were treated with intravenous tPA within 4.5 h of the time they were last known to be well from 232 hospitals in China were included. Patients were divided into four groups according to DNT time (≤ 45 min; 45-60 min; 60-90 min; > 90 min). All discharged patients would receive a telephone follow-up at 12-month after admission. Death and disability events were recorded.

Results: Finally, 2370 patients were analyzed. The median age was 65 years, 66.6% were male, and 2.4% were of ethnic minorities. In the 1-year follow-up, 211 patients died (8.9%; 95%CI: 7.8-10.0%). The patients (53.1%) had DNT times of longer than 45 min, compared with those treated within 45 min, did not have significantly higher 1-year mortality (8.9% vs 8.9% [absolute difference, 0.03% {95% CI, - 0.05% to - 0.10%}, odd ratio {OR}, 1.00 {95% CI, 0.75 to 1.33}]). In addition, 385 patients (16.2%; 14.8-17.3%) out of those survivors had disability events. The patients had DNT times of longer than 45 min, compared with those treated within 45 min, did not have significantly higher 1-year disability rate (18.9% vs 16.7% [absolute difference, 1.9% {95% CI, 1.1% to 3.0%}, odd ratio {OR}, 1.22 {95% CI, 0.89 to 1.43}]).

Conclusions: The results did not show that shorter DNT for tPA administration was significantly associated with better 1-year outcomes.
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http://dx.doi.org/10.1007/s10072-021-05580-wDOI Listing
September 2021

Case-fatality, disability and recurrence rates after first-ever stroke: A study from bigdata observatory platform for stroke of China.

Brain Res Bull 2021 Oct 27;175:130-135. Epub 2021 Jul 27.

The General Office of Stroke Prevention Project Committee, National Health Commission of the People's Republic of China, Beijing, China. Electronic address:

Background: There is currently a lack of data on stroke hospitalizations and long-term outcomes in China. Therefore, we investigated 12-month stroke fatality, disability, and recurrence rates after the first-ever stroke.

Methods: This was a prospective nationwide hospital-based cohort study. From August to September 2019, all patients with first-ever stroke (ischemic stroke [IS], intracerebral hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) and with symptom onset within 14 days from 232 hospitals were included. Case fatality, disability, and recurrence rates for one year were estimated.

Results: In total, 36250 first-ever stroke patients from 194 hospitals were recruited (median age was 65(IQR, 56-73) years and 61.4 % were male). The rate of intravenous thrombolysis and endovascular treatment for IS were 9.5 % and 4.4 %, respectively. In-hospital death rate was 1.9 % (95 %CI: 1.7 %-2.0 %) for stroke inpatients, ranging from 0.9 % (0.8 %-1.1 %) for IS to 5.1 % (4.6 %-5.6 %) for ICH. The 12-month fatality rate was 8.6 % (95 %CI: 8.3 %-8.9 %) for discharged stroke patients, ranging from 6.0 % (5.7 %-6.3 %) for IS to 17.7 % (16.7 %-18.7 %) for ICH. The 12-month disability rate was 16.6 % (95 %CI: 16.2 %-17.0 %) for stroke survivors, ranging from 11.1 % (9.3 %-12.8 %) for SAH to 29.2 % (27.9 %-30.4 %) for ICH. The stroke recurrence rate was 5.7 % (5.5 %-6.0 %) for stroke survivors, ranging from 2.5 % (1.7 %-3.3 %) for SAH to 6.4 % (6.0 %-6.7 %) for IS.

Conclusion: Our results support the hypothesis that the prognosis of Chinese stroke patients appears to have improved and is not very bad.
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http://dx.doi.org/10.1016/j.brainresbull.2021.07.020DOI Listing
October 2021

Stroke unit care for ischemic stroke in China: results of a nation-based study.

Intensive Care Med 2020 07 27;46(7):1489-1491. Epub 2020 Apr 27.

The General Office of Stroke Prevention Project Committee, National Health Commission of the People's Republic of China, No. 118, Guang'anmen Inner Street, Beijing, 100053, People's Republic of China.

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http://dx.doi.org/10.1007/s00134-020-06046-xDOI Listing
July 2020

Stroke prevention and control system in China: CSPPC-Stroke Program.

Int J Stroke 2021 04 29;16(3):265-272. Epub 2020 Mar 29.

The General Office of Stroke Prevention Project Committee, National Health Commission of the People's Republic of China, Beijing, China.

In China, stroke is a major cause of mortality, and long-term physical and cognitive impairment. To meet this challenge, the Ministry of Health China Stroke Prevention Project Committee (CSPPC) was established in April 2011. This committee actively promotes stroke prevention and control in China. With government financial support of 838.4 million CNY, 8.352 million people from 536 screening points in 31 provinces have received stroke screening and follow-up over the last seven years (2012-2018). In 2016, the CSPPC issued a plan to establish stroke centers. To shorten the pre-hospital period, the CSPPC established a stroke center network, stroke map, and stroke "Green Channel" to create three 1-h gold rescue circles, abbreviated as "1-1-1" (onset to call time <1 h; pre-hospital transfer time < 1 h, and door-to-needle time < 1 h). From 2017 to 2018, the median door-to-needle time dropped by 4.0% (95% confidence interval (CI), 1.4-9.4) from 50 min to 48 min, and the median onset-to-needle time dropped by 2.8% (95% CI, 0.4-5.2) from 180 min to 175 min. As of 31 December 2018, the CSPPC has established 380 stroke centers in mainland China. From 1 November 2018, the CSPPC has monitored the quality of stroke care in stroke center hospitals through the China Stroke Data Center Data Reporting Platform. The CSPPC Stroke program has led to a significant improvement in stroke care. This program needs to be further promoted nationwide.
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http://dx.doi.org/10.1177/1747493020913557DOI Listing
April 2021

Stroke Center Care and Outcome: Results from the CSPPC Stroke Program.

Transl Stroke Res 2020 06 8;11(3):377-386. Epub 2019 Sep 8.

The General Office of Stroke Prevention Project Committee, National Health Commission of the People's Republic of China, No. 118, Guang'anmen Inner Street, Beijing, 100053, People's Republic of China.

The aim of this study was to assess the association between admission to stroke centers for acute ischemic stroke and complications and mortality during hospitalization in a Chinese population by means of an observational study using data from the China Stroke Center Data-Sharing Platform. We compared in-hospital complications and mortality for patients admitted with acute ischemic stroke (N = 13,236) between November 1, 2018 and December 31, 2018 at stroke center (SH) and non-stroke center (CH) hospitals using distance to hospitals as an instrumental variable to adjust for potential prehospital selection bias. The results showed that complication rates during hospitalization among ischemic stroke patients who received thrombolytic therapy (n = 11,203) were lower in the SH group than in the CH group: 11.1% vs 15.7% (absolute difference, - 5.11% [95% CI, - 6.05 to - 3.99%], odds ratio [OR] 0.85 [95% CI, 0.74 to 0.92]). The incidence of intracranial hemorrhage was reduced from 4.2 to 3.2%: SH group vs CH group, 3.2% vs 4.2% (absolute difference, - 1.24% [95% CI, - 1.65 to - 0.82%], OR 0.83 [95% CI, 0.69 to 0.0.98]). Furthermore, the total mortality rate in the SH group was also lower than in the CH group: SH group vs CH group, 2.2% vs 3.0% (absolute difference, - 0.92% [95% CI, - 1.48 to - 0.53%], OR 0.85 [95% CI, 0.73 to 0.96]). The data showed that admission to SH hospitals was associated with a lower risk of treatment complications and death for patients with an acute ischemic stroke receiving thrombolytic therapy.
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http://dx.doi.org/10.1007/s12975-019-00727-6DOI Listing
June 2020

Resveratrol and genistein inhibition of rat isolated gastrointestinal contractions and related mechanisms.

World J Gastroenterol 2014 Nov;20(41):15335-42

Li-Xue Zhang, Shan Jin, Xing-Cheng Dou, Department of Physiology, College of Basic Medicine, Lanzhou University, Lanzhou 730000, Gansu Province, China.

Aim: To investigate the effects and underlying mechanisms of resveratrol and genistein on contractile responses of rat gastrointestinal smooth muscle.

Methods: Isolated strips of gastrointestinal smooth muscle from Spraque-Dawley rats were suspended in organ baths containing Kreb's solution, and the contractility of smooth muscles was measured before and after incubation with resveratrol and genistein, and the related mechanisms were studied by co-incubation with various inhibitors.

Results: Resveratrol and genistein dose-dependently decreased the resting tension, and also reduced the mean contractile amplitude of gastrointestinal smooth muscle. Estrogen receptor blockades (ICI 182780 and tamoxifen) failed to alter the inhibitory effects induced by resveratrol and genistein. However, their effects were attenuated by inhibitions of α-adrenergic receptor (phentolamine), nitric oxide synthase (levorotatory-NG-nitroarginine), ATP-sensitive potassium channels (glibenclamide), and cyclic adenosine monophosphate (SQ22536). In high K(+)/Ca(2+)-free Kreb's solution containing 0.01 mmol/L egtazic acid, resveratrol and genistein reduced the contractile responses of CaCl2, and shifted its cumulative concentration-response curves rightward.

Conclusion: Resveratrol and genistein relax gastrointestinal smooth muscle via α-adrenergic receptors, nitric oxide and cyclic adenosine monophosphate pathways, ATP-sensitive potassium channels, and inhibition of L-type Ca(2+) channels.
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http://dx.doi.org/10.3748/wjg.v20.i41.15335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223267PMC
November 2014

Optical properties of Ag nanoparticle-polymer composite film based on two-dimensional Au nanoparticle array film.

Nanoscale Res Lett 2014 Mar 31;9(1):155. Epub 2014 Mar 31.

Key Laboratory of Micro-Inertial Instrument and Advanced Navigation Technology, Ministry of Education, and School of Electronic Science and Engineering, Southeast University, Nanjing 210096, People's Republic of China.

The nanocomposite polyvinyl pyrrolidone (PVP) films containing Ag nanoparticles and Rhodamine 6G are prepared on the two-dimensional distinctive continuous ultrathin gold nanofilms. We investigate the optical properties and the fluorescence properties of silver nanoparticles-PVP polymer composite films influenced by Ag nanoparticles and Au nanoparticles. Absorption spectral analysis suggests that the prominently light absorption in Ag nanowire/PVP and Ag nanowire/PVP/Au film arises from the localized surface plasmon resonance of Ag nanowire and Au nanofilm. The enhanced fluorescence is observed in the presence of Ag nanowire and Au nanofilm, which is attributed to the excitation of surface plasmon polariton resonance of Ag nanowire and Au nanofilm. The gold nanofilm is proven to be very effective fluorescence resonance energy transfer donors. The fabricated novel structure, gold ultrathin continuous nanofilm, possesses high surface plasmon resonance properties and prominent fluorescence enhancement effect. Therefore, the ultrathin continuous gold nanofilm is an active substrate on nanoparticle-enhanced fluorescence.
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http://dx.doi.org/10.1186/1556-276X-9-155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974418PMC
March 2014

Effects of estrogen and phytoestrogens on endometrial leakage in ovariectomized rats and the related mechanisms.

Sheng Li Xue Bao 2013 Feb;65(1):8-18

Department of Physiology, College of Basic Medicine, Lanzhou University, China.

Phytoestrogens, a group of plant-derived non-steroidal compounds that can behave as estrogens by binding to estrogen receptors, have drawn great attention for their potentially beneficial effects on human health. However, there are few studies investigating the potential side effects of phytoestrogens on the reproductive system. The present study was to elucidate the effects of 17β-estradiol (E2), progesterone (P4), and phytoestrogens genistein (Gen), resveratrol (Res), and phloretin (Phl) on eosinophilic infiltration of the ovariectomized rat uterus and endometrial vascular permeability, and to analyze the underlying mechanisms. The ovariectomized rats received daily subcutaneous injections of E2, E2+P4, P4, Gen, Res, Phl, or an equivalent volume of vehicle for 21 days, and sham-operated animals (Sham rats) were used as the controls. Hematoxylin-eosin staining revealed a marked increase in uterine eosinophilic infiltrations in ovariectomized rats treated with E2, E2+P4 or P4, which was associated with increased expression of vascular endothelial growth factor (VEGF), nuclear factor-κB (NF-κB), and tumor necrosis factor-α (TNF-α) proteins as determined by immunohistochemical and Western blot analysis. However, all three phytoestrogens had no markedly effect on the uterine eosinophilic infiltration and the expressions of VEGF, NF-κB, and TNF-α in the uterus of ovariectomized rats. Our data demonstrate that E2 alone or in combination with P4 increases uterine eosinophilic infiltration which is related with vascular hyperpermeability caused by VEGF, NF-κB and TNF-α, whereas phytoestrogens Gen, Res, and Phl, have no such an effect.
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February 2013

Two-dimensional ultrathin gold film composed of steadily linked dense nanoparticle with surface plasmon resonance.

Nanoscale Res Lett 2012 Dec 21;7(1):683. Epub 2012 Dec 21.

School of Electronic Science and Engineering and Key Laboratory of Micro-Inertial Instrument and Advanced Navigation Technology, Ministry of Education, Southeast University, Nanjing, 210096, People's Republic of China.

Unlabelled:

Background: Noble metallic nanoparticles have prominent optical local-field enhancement and light trapping properties in the visible light region resulting from surface plasmon resonances.

Results: We investigate the optical spectral properties and the surface-enhanced Raman spectroscopy of two-dimensional distinctive continuous ultrathin gold nanofilms. Experimental results show that the one- or two-layer nanofilm obviously increases absorbance in PEDOT:PSS and P3HT:PCBM layers and the gold nanofilm acquires high Raman-enhancing capability.

Conclusions: The fabricated novel structure of the continuous ultrathin gold nanofilms possesses high surface plasmon resonance properties and boasts a high surface-enhanced Raman scattering (SERS) enhancement factor, which can be a robust and cost-efficient SERS substrate. Interestingly, owing to the distinctive morphology and high light transmittance, the peculiar nanofilm can be used in multilayer photovoltaic devices to trap light without affecting the physical thickness of solar photovoltaic absorber layers and yielding new options for solar cell design.
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http://dx.doi.org/10.1186/1556-276X-7-683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552831PMC
December 2012

Fabrication and spectroscopic investigation of branched silver nanowires and nanomeshworks.

Nanoscale Res Lett 2012 Oct 27;7(1):596. Epub 2012 Oct 27.

School of Electronic Science and Engineering, Southeast University, Nanjing 210096, People's Republic of China.

Wide wavelength ranges of light localization and scattering characteristics can be attributed to shape-dependent longitude surface plasmon resonance in complicated nanostructures. We have studied this phenomenon by spectroscopic measurement and a three-dimensional numerical simulation, for the first time, on the high-density branched silver nanowires and nanomeshworks at room temperature. These nanostructures were fabricated with simple light-induced colloidal method. In the range from the visible to the near-infrared wavelengths, light has been found effectively trapped in those trapping sites which were randomly distributed at the corners, the branches, and the junctions of the nanostructures in those nanostructures in three dimensions. The broadened bandwidth electromagnetic field enhancement property makes these branched nanostructures useful in optical processing and photovoltaic applications.
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http://dx.doi.org/10.1186/1556-276X-7-596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577568PMC
October 2012

Toward sustainable and comprehensive control of schistosomiasis in China: lessons from Sichuan.

PLoS Negl Trop Dis 2011 Oct 25;5(10):e1372. Epub 2011 Oct 25.

School of Public Health, University of California, Berkeley, California, United States of America.

Triggered by a fascinating publication in the New England Journal of Medicine detailing China's new multi-pronged strategy to control and eventually interrupt the transmission of Schistosoma japonicum, this PLoS Neglected Tropical Diseases Debate critically examines the generalizability and financial costs of the studies presented from the marshlands of the lake region. Edmund Seto from the University of California and colleagues emphasize that the epidemiology and control of schistosomiasis varies according to the social-ecological context. They conjecture that the successful intervention packages piloted in the lake region is not fully fit for the hilly and mountainous environments in Sichuan and Yunnan provinces, and hence call for more flexible, setting-specific, and less expensive control strategies. In response, Xiao-Nong Zhou from the National Institute of Parasitic Diseases at the Chinese Center of Disease Control and Prevention and colleagues explain the steps from designing pilot studies to the articulation and implementation of a new national control strategy through a careful process of scaling-up and adaptations. Finally, the two opponents converge. The need for integrated, intersectoral, and setting-specific control measures is stressed, supported by rigorous surveillance and continuous research. Experiences and lessons from China are important for shaping the schistosomiasis elimination agenda.
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http://dx.doi.org/10.1371/journal.pntd.0001372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201916PMC
October 2011

China's new strategy to block Schistosoma japonicum transmission: experiences and impact beyond schistosomiasis.

Trop Med Int Health 2009 Dec 27;14(12):1475-83. Epub 2009 Sep 27.

School of Public Health, Peking University, Beijing, China.

Despite sustained efforts for its control made over the past 50+ years, the re-emergence of schistosomiasis in China was noted around the turn of the new millennium. Consequently, a new integrated strategy was proposed to stop the contamination of schistosome eggs to the environment, which emphasizes health education, access to clean water and adequate sanitation, mechanization of agriculture and fencing of water buffaloes, along with chemotherapy. Validation of this integrated control strategy in four pilot counties in the provinces of Anhui, Hubei, Hunan and Jiangxi revealed significant reductions in the rate of Schistosoma japonicum infection in humans and intermediate host snails. Importantly, this strategy showed an impact on diseases beyond schistosomiasis, signified by concomitant reductions in the prevalence of soil-transmitted helminth infections. In view of China's new integrated strategy for transmission control of schistosomiasis showing an ancillary benefit on other helminthic diseases, we encourage others to investigate the scope and limits of integrated control of neglected tropical diseases.
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http://dx.doi.org/10.1111/j.1365-3156.2009.02403.xDOI Listing
December 2009

A strategy to control transmission of Schistosoma japonicum in China.

N Engl J Med 2009 Jan;360(2):121-8

Ministry of Health, Beijing, China.

Background: Schistosoma japonicum causes an infection involving humans, livestock, and snails and is a significant cause of morbidity in China.

Methods: We evaluated a comprehensive control strategy in two intervention villages and two control villages along Poyang Lake in the southeastern province of Jiangxi, where annual synchronous chemotherapy is routinely used. New interventions, implemented from 2005 through 2007, included removing cattle from snail-infested grasslands, providing farmers with mechanized farm equipment, improving sanitation by supplying tap water and building lavatories and latrines, providing boats with fecal-matter containers, and implementing an intensive health-education program. During the intervention period, we observed changes in S. japonicum infection in humans, measured the rate of infection in snails, and tested the infectivity of lake water in mice.

Results: After three transmission seasons, the rate of infection in humans decreased to less than 1.0% in the intervention villages, from 11.3% to 0.7% in one village and from 4.0% to 0.9% in the other (P<0.001 for both comparisons). The rate of infection in humans in control villages fluctuated but remained at baseline levels. In intervention villages, the percentage of sampling sites with infected snails decreased from 2.2% to 0.1% in one grassland area and from 0.3% to no infection in the other (P<0.001 for both comparisons). The rate of infection in mice after exposure to lake water decreased from 79% to no infection (P<0.001).

Conclusions: A comprehensive control strategy based on interventions to reduce the rate of transmission of S. japonicum infection from cattle and humans to snails was highly effective. These interventions have been adopted as the national strategy to control schistosomiasis in China.
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http://dx.doi.org/10.1056/NEJMoa0800135DOI Listing
January 2009

Inhibitory effects of genistein and resveratrol on guinea pig gallbladder contractility in vitro.

World J Gastroenterol 2008 Aug;14(31):4955-60

Department of Physiology, College of Basic Medicine, Lanzhou University, Key Laboratory of Pre-clinical Study for New Drugs of Gansu Province, 199 Donggang West Road, Lanzhou, Gansu Province, China.

Aim: To observe and compare the effects of phytoestrogen genistein, resveratrol and 17beta-estradiol on the tonic contraction and the phasic contraction of isolated gallbladder muscle strips and to study the underlying mechanisms.

Methods: Isolated strips of gallbladder muscle from guinea pigs were suspended in organ baths containing Kreb's solution, and the contractilities of strips were measured before and after incubation with genistein, resveratrol and 17beta-estradiol respectively.

Results: Similar to 17beta-estradiol, genistein and resveratrol could dose-dependently inhibit the phasic contractile activities, they decreased the mean contractile amplitude and the contractile frequencies of gallbladder muscle strips, and also produced a marked reduction in resting tone. The blocker of estrogen receptor ICI 182780 failed to alter the inhibitory effects induced by genistein and resveratrol, but potassium bisperoxo (1, 10 phenanthroline) oxovanadate bpV (phen), a potent protein tyrosine phosphatase inhibitor, markedly attenuated the inhibitory effects induced by genistein and resveratrol. In calcium-free Kreb's solution containing 0.01 mmol/L egtazic acid (EGTA), genistein and resveratrol inhibited the first phasic contraction induced by acetylcholine (ACh), but did not affect the second contraction induced by CaCl(2). In addition, genistein, resveratrol and 17beta-estradiol also could reduce the contractile responses of ACh and KCl, and shift their cumulative concentration-response curves rightward.

Conclusion: Phytoestrogen genistein and resveratrol can directly inhibit the contractile activity of isolated gallbladder muscle both at rest and in response to stimulation. The mechanisms responsible for the inhibitory effects probably due mainly to inhibition of tyrosine kinase, Ca(2+) influx through potential-dependent calcium channels (PDCs) and Ca(2+) release from sarcoplasmic reticulum (SR), but were not related to the estrogen receptors.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739951PMC
http://dx.doi.org/10.3748/wjg.14.4955DOI Listing
August 2008

[Tuberculosis control in China and its prospect].

Authors:
Long-de Wang

Zhonghua Jie He He Hu Xi Za Zhi 2006 Aug;29(8):505-6

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August 2006

[A revolution in behaviors is necessary for Chinese].

Authors:
Long-de Wang

Zhonghua Yi Xue Za Zhi 2006 Aug;86(32):2236-9

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August 2006

[China being expected to lead the development tread of world public health].

Authors:
Long-de Wang

Zhonghua Yu Fang Yi Xue Za Zhi 2006 Jan;40(1):3-7

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January 2006

[Necessary changes in Chinese diet].

Authors:
Long-de Wang

Zhonghua Yi Xue Za Zhi 2005 May;85(18):1235-7

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May 2005

[Prevention and control of serious communicable diseases in China].

Authors:
Long-de Wang

Zhonghua Yi Xue Za Zhi 2004 Dec;84(23):1944-7

Minitary of Health, People's Republic of China, Beijing 100044, China

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December 2004

[Influence of menstrual and reproductive factors on the risk of lung cancer].

Zhonghua Liu Xing Bing Xue Za Zhi 2004 Jul;25(7):590-3

Radiation Epidemiology Branch, Divison of Cancer Epidemiology and Genetics, National Cancer Institute, USA.

Objective: Hypothesis showed that women have higher risks of lung cancer than men when given similar levels of tobacco exposure, implying that sex-related hormones might have a role to play. The study is to identify the influence of female hormones on risk of lung cancer.

Methods: We evaluated the association between lung cancer risk and menstrual/reproductive factors on a subset of self-responding females in a population based case-control study in Eastern Gansu, 1994 - 1998. The analysis included 109 lung cancer cases and 435 controls selected from the census list and matched to cases on age and prefecture.

Results: Odds ratios were lower for later ages at menarche (trend, P = 0.015) and later ages at menopause (trend, P = 0.074).

Conclusion: Despite limitations, these findings suggested a possible role related to hormones in the etiology of lung cancer in females.
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July 2004

Phytoestrogen genistein decreases contractile response of aortic artery in vitro and arterial blood pressure in vivo.

Acta Pharmacol Sin 2004 Mar;25(3):313-8

Department of Physiology, Lanzhou Medical College, Lanzhou 730000, China.

Aim: To determine the mechanisms of effects of phytoestrogen genistein on the contracted rabbit aortic arteries in vitro, and observe the effect of genistein and 17-beta estradiol on mean arterial pressure (MAP) in ovariectomized (OVX) rats.

Methods: (1) Strips of rabbit aortic smooth muscle were suspended in organ baths containing Kreb's solution, and then isometric tension was measured. (2) Female mature Wistar rats underwent a bilateral ovariectomy (OVX). Sham-operated rats (SHAM) were used as controls. After administration of genistein (0.4 mg.kg(-1).d(-1), s.c.), 17-beta-estradiol (1 mg.kg(-1).d(-1), s.c.) or their vehicle sesame oil for 21 d, MAP was measured.

Results: (1) Similar to 17-beta-estradiol, genistein could dose-dependently relax 40 mmol/L KCl-precontracted arterial strips. Incubation with N omega-L-nitro-arginine (L-NNA), methylene blue (MB), indomethacin, propranolol or endothelium removal did not affect relaxation induced by genistein. In calcium-free solution containing 0.01 mmol/L egtazic acid (EGTA), genistein inhibited not only the first phase contraction induced by noradrenaline (NA), but also the second contraction induced by CaCl2. In addition, genistein could reduce the contractile responses of NA, KCl and CaCl2, and shift their cumulative concentration-response curves rightward. (2) MAP in OVX rats was significantly higher compared with that of SHAM rats. However, after chronically treatment with genistein or 17-beta estradiol for 21 d the baseline MAP in OVX rats was reduced significantly.

Conclusions: (1) The vasodilator effect of genistein in vitro is endothelium independent and not related to the nitric oxide, its mechanisms being probably due to inhibition of Ca2+ influx through calcium channels in a noncompetitive manner and Ca2+ release from intracellular store induced by NA. (2) Administration of genistein or 17-beta estradiol can chronically decrease MAP in OVX rats.
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March 2004

[Rethinking about the prevalence of SARS, recent work on SARS prevention and control].

Authors:
Long-de Wang

Zhonghua Yi Xue Za Zhi 2003 Oct;83(20):1753-6

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October 2003

Risk of lung cancer and residential radon in China: pooled results of two studies.

Int J Cancer 2004 Mar;109(1):132-7

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA.

Studies of radon-exposed underground miners predict that residential radon is the second leading cause of lung cancer mortality; however, case-control studies of residential radon have not provided unambiguous evidence of an association. Owing to small expected risks from residential radon and uncertainties in dosimetry, large studies or pooling of multiple studies are needed to fully evaluate effects. We pooled data from 2 case-control studies of residential radon representing 2 large radon studies conducted in China. The studies included 1050 lung cancer cases and 1996 controls. In the pooled data, odds ratios (OR) increased significantly with greater radon concentration. Based on a linear model, the OR with 95% confidence intervals (CI) at 100 Becquerel/cubic-meter (Bq/m(3)) was 1.33 (1.01,1.36). For subjects resident in the current home for 30 years or more, the OR at 100 Bq/m(3) was 1.32 (1.07,1.91). Results across studies were consistent with homogeneity. Estimates of ORs were similar to extrapolations from miner data and consistent with published residential radon studies in North American and Europe, suggesting long-term radon exposure at concentrations found in many homes increases lung cancer risk.
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http://dx.doi.org/10.1002/ijc.11683DOI Listing
March 2004

[Chronic disease and subhealth in China: the effect and the guideline of prevention and treatment].

Authors:
Long-de Wang

Zhonghua Yi Xue Za Zhi 2003 Jun;83(12):1031-4

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June 2003
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