Long P Le

Long P Le

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Long P Le

Long P Le

Publications by authors named "Long P Le"

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Clinical Validation of a Cell-Free DNA Gene Panel.

J Mol Diagn 2019 Jul 23;21(4):632-645. Epub 2019 Apr 23.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.02.008DOI Listing
July 2019

A Nanopore Sequencing-Based Assay for Rapid Detection of Gene Fusions.

J Mol Diagn 2019 Jan 28;21(1):58-69. Epub 2018 Sep 28.

Department of Pathology, Massachusetts General Hospital, Boston; and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.08.003DOI Listing
January 2019

Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer.

J Clin Oncol 2018 04 26;36(12):1199-1206. Epub 2018 Jan 26.

Jessica J. Lin, Satoshi Yoda, Beow Y. Yeap, Ibiayi Dagogo-Jack, Nicholas A. Jessop, Ginger Y. Jiang, Long P. Le, Aaron N. Hata, Justin F. Gainor, Anthony J. Iafrate, and Alice T. Shaw, Massachusetts General Hospital, Boston; Alexa B. Schrock, Kyle Gowen, Philip J. Stephens, Jeffrey S. Ross, Siraj M. Ali, and Vincent A. Miller, Foundation Medicine, Cambridge, MA; Viola W. Zhu and Sai-Hong Ignatius Ou, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, CA; Melissa L. Johnson, Sarah Cannon Research Institute; and Christine M. Lovly, Vanderbilt-Ingram Cancer Center, Nashville, TN.

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http://dx.doi.org/10.1200/JCO.2017.76.2294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903999PMC
April 2018

Next-generation sequencing adds value to the preoperative diagnosis of pancreatic cysts.

Cancer Cytopathol 2017 Jan 20;125(1):41-47. Epub 2016 Sep 20.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncy.21775DOI Listing
January 2017

Acquired Resistance to Crizotinib in NSCLC with MET Exon 14 Skipping.

J Thorac Oncol 2016 08 22;11(8):1242-1245. Epub 2016 Jun 22.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jtho.2016.06.013DOI Listing
August 2016

Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer.

J Thorac Oncol 2015 Dec;10(12):1670-4

*Department of Medicine, Massachusetts General Hospital, Boston, MA; †Department of Pathology, Massachusetts General Hospital, Boston, MA; ‡Memorial Sloan Kettering Cancer Center, New York, NY; ‖Sarah Cannon Research Institute/Florida Cancer Specialists, Sarasota, FL; §Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN; ¶Department of Medicine, Georgetown University Medical Center, Washington, DC; #University of California Irving Health, Orange, CA; **Dana-Farber Cancer Institute, Boston, MA; ††Beth Israel Deaconess Medical Center, Boston, MA; and ‡‡Ignyta, Inc., San Diego, CA.

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http://ignyta.com/wp-content/uploads/2016/01/Durable-Clinica
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http://linkinghub.elsevier.com/retrieve/pii/S155608641535087
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http://dx.doi.org/10.1097/01.JTO.0000473485.38553.f0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643748PMC
December 2015

Inconsistency and features of single nucleotide variants detected in whole exome sequencing versus transcriptome sequencing: A case study in lung cancer.

Methods 2015 Jul 23;83:118-27. Epub 2015 Apr 23.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37203, United States; Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37232, United States; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509831PMC
July 2015

Computational pathology: an emerging definition.

Arch Pathol Lab Med 2014 Sep;138(9):1133-8

From the Partners Program in Computational Pathology and the Department of Pathology, Massachusetts General Hospital, Boston (Drs Louis, Baron, Dighe, Getz, Higgins, Michaelson, Le, Mermel, and Gilbertson); the Department of Pathology, Brigham and Women's Hospital, Boston (Drs Gerber, Bry, Kuo, Lane, and Golden); the Departments of Pathology (Drs Louis, Gerber, Baron, Bry, Dighe, Getz, Kuo, Lane, Michaelson, Le, Mermel, Gilbertson, and Golden) and Systems Biology (Dr Higgins), Harvard Medical School, Boston; and the Broad Institute, Cambridge, Massachusetts (Drs Getz, Le, and Mermel). Drs Louis, Gilbertson, and Golden are co-senior authors.

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http://www.archivesofpathology.org/doi/abs/10.5858/arpa.2014
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http://dx.doi.org/10.5858/arpa.2014-0034-EDDOI Listing
September 2014

Standardized decision support in next generation sequencing reports of somatic cancer variants.

Mol Oncol 2014 Jul 4;8(5):859-73. Epub 2014 Apr 4.

Massachusetts General Hospital and Harvard Medical School, Molecular Pathology Lab, USA.

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http://dx.doi.org/10.1016/j.molonc.2014.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528527PMC
July 2014

Inactivation of the tumor suppressor WTX in a subset of pediatric tumors.

Genes Chromosomes Cancer 2014 Jan 5;53(1):67-77. Epub 2013 Nov 5.

Department of Pathology, Massachusetts General Hospital, Boston, MA; Cancer Center, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/gcc.22118DOI Listing
January 2014

Fibrosis-associated single-nucleotide polymorphisms in TGFB1 and CAV1 are not associated with the development of nephrogenic systemic fibrosis.

Am J Dermatopathol 2013 May;35(3):351-6

Pathology Service, Diagnostic Molecular Pathology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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https://insights.ovid.com/crossref?an=00000372-201305000-000
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http://dx.doi.org/10.1097/DAD.0b013e31826c5508DOI Listing
May 2013

Microcystic adnexal carcinoma versus desmoplastic trichoepithelioma: a comparative study.

Am J Dermatopathol 2013 Feb;35(1):50-5

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1097/DAD.0b013e31825988dfDOI Listing
February 2013

Adenoviral protein V promotes a process of viral assembly through nucleophosmin 1.

Virology 2012 Oct 18;432(2):283-95. Epub 2012 Jun 18.

Division of Human Gene Therapy, Departments of Medicine, Obstetrics and Gynecology, Pathology, and Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.virol.2012.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423539PMC
October 2012

Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

Cancer Cell 2011 Dec 1;20(6):810-7. Epub 2011 Dec 1.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.11.005DOI Listing
December 2011

In vitro dynamic visualization analysis of fluorescently labeled minor capsid protein IX and core protein V by simultaneous detection.

J Mol Biol 2010 Jan 21;395(1):55-78. Epub 2009 Oct 21.

Division of Human Gene Therapy, Departments of Medicine, Obstetrics and Gynecology, Pathology, and Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787850PMC
January 2010

Derivation of a triple mosaic adenovirus based on modification of the minor capsid protein IX.

Virology 2008 Aug;377(2):391-400

Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2-502, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.virol.2008.04.023DOI Listing
August 2008

Thermostability/infectivity defect caused by deletion of the core protein V gene in human adenovirus type 5 is rescued by thermo-selectable mutations in the core protein X precursor.

J Mol Biol 2007 Mar 6;366(4):1142-60. Epub 2006 Dec 6.

Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.11.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203208PMC
March 2007

Core labeling of adenovirus with EGFP.

Virology 2006 Aug 6;351(2):291-302. Epub 2006 May 6.

Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, University of Alabama at Birmingham, 901 19th Street South, BMR2-502, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.virol.2006.03.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781517PMC
August 2006

Dynamic monitoring of oncolytic adenovirus in vivo by genetic capsid labeling.

J Natl Cancer Inst 2006 Feb;98(3):203-14

Division of Human Gene Therapy, Department of Medicine, University of Alabama, Birmingham, AL, USA.

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http://dx.doi.org/10.1093/jnci/djj022DOI Listing
February 2006

In vivo analysis of a genetically modified adenoviral vector targeted to human CD40 using a novel transient transgenic model.

J Gene Med 2005 Dec;7(12):1517-25

Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, AL 35294-2172, USA.

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http://dx.doi.org/10.1002/jgm.806DOI Listing
December 2005

Fluorescently tagged canine adenovirus via modification with protein IX-enhanced green fluorescent protein.

J Gen Virol 2005 Dec;86(Pt 12):3201-8

Division of Human Gene Therapy, Department of Medicine, and Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2-502, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1099/vir.0.80968-0DOI Listing
December 2005

Noninvasive visualization of adenovirus replication with a fluorescent reporter in the E3 region.

Cancer Res 2005 Nov;65(22):10154-8

Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1871DOI Listing
November 2005

Productive replication of human adenovirus type 5 in canine cells.

J Virol 2005 Jan;79(2):1308-11

Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1128/JVI.79.2.1308-1311.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC538546PMC
January 2005

Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma treatment.

Cancer Res 2004 Jun;64(12):4319-27

Division of Human Gene Therapy, Departments of Medicine, Pathology, and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0064DOI Listing
June 2004

Fluorescently labeled adenovirus with pIX-EGFP for vector detection.

Mol Imaging 2004 Apr;3(2):105-16

University of Alabama, Birmingham, USA.

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http://dx.doi.org/10.1162/1535350041464874DOI Listing
April 2004