Publications by authors named "Long Li"

1,129 Publications

  • Page 1 of 1

High-Quality-Factor AlON Transparent Ceramics for 5 GHz Wi-Fi Aesthetically Decorative Antennas.

ACS Appl Mater Interfaces 2021 Sep 24. Epub 2021 Sep 24.

Multifunctional Materials and Structures, Key Laboratory of the Ministry of Education, School of Electronic Science and Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.

Transparent material has been widely used in product design and has seen a large increase in its use. In this paper, a kind of aesthetically decorative 5 GHz Wi-Fi dielectric resonator antenna (DRA) of aluminum oxynitride (AlON) transparent ceramic has been designed. High-quality-factor AlON transparent dielectric ceramics were fabricated by presintering at 1780 °C and further cold isostatic pressing (CIP) under a 200 MPa argon atmosphere. For a 9.0 mm thick specimen, the in-line light transmittance reached 83%. Optimum dielectric constant (ε = 9.32), quality factor ( = 47 960) and temperature coefficient (TCF = -51.7 ppm/°C) was achieved in the AlON transparent ceramic by cold isostatic pressing. As a result, the proposed aesthetically decorative DRA can achieve an impedance bandwidth of 32% (4.48-6.19 GHz), a high radiation efficiency of 85%, and a low cross-polarization discrimination (XPD) of -30 dB. To achieve a broad bandwidth, the proposed antenna was excited in its dominant TE mode and higher-order TE mode. The proposed antenna is thus an excellent candidate for an indoor decoration Wi-Fi antenna.
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http://dx.doi.org/10.1021/acsami.1c12223DOI Listing
September 2021

EZH2 identifies the precursors of human natural killer cells with trained immunity.

Cancer Biol Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Immunology and Biotherapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

Objective: Trained immunity of natural killer (NK) cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation. However, the human NK cells responsible for the generation and maintenance of trained immunity are largely unknown. We hypothesized that heterogeneous human NK cells would respond differentially to stimulation with a combination of IL-12, IL-15, and IL-18, and that an NK cell subset might exist that is mainly responsible for the induction of trained immunity. On the basis of our hypothesis, we aimed to identify the subset from which cytokine-trained human NK cells originate and to explore possible regulatory targets for drug intervention.

Methods: Flow cytometry assays were performed to analyze the functions of cytokine-trained NK cells and examine cell division and protein expression in NK cell subsets. Single-cell RNA sequencing (scRNA-seq) plus TotalSeq™ technology was used to track the heterogeneity of NK cells during the induction of trained immunity.

Results: Traditional developmental markers for peripheral NK cells were unable to identify the precursors of human NK cells with trained immunity. Therefore, we used scRNA-seq plus TotalSeq™ technology to track the heterogeneity of NK cells during the induction of trained immunity and identified a unique cluster of CD57NKG2AEZH2IFNGMKI67IL12RIL15RIL18R NK cells. Enrichment and pseudotime trajectory analyses suggested that this cluster of NK cells contained the precursor of trained NK cells. We then used flow cytometry to further investigate the role of EZH2 in trained NK precursors and found that CD57NKG2AEZH2 NK cells had faster cell cycles and an enhanced trained phenotype, and EZH2 inhibition significantly impaired the induction of trained immunity in NK cells. These results suggested that EZH2 is a unique epigenetic marker of precursors of human NK cells with trained immunity.

Conclusions: Our work revealed human NK heterogeneity in the induction of trained immunity, identified the precursor subset for trained NK cells, and demonstrated the critical role of EZH2 in the induction of trained immunity in human NK cells.
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http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0791DOI Listing
September 2021

Rapid determination of trace Cu by an in-syringe membrane SPE and membrane solid-phase spectral technique.

Anal Methods 2021 Sep 23. Epub 2021 Sep 23.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

A new in-syringe membrane SPE and solid-phase visible spectral method was proposed for the rapid extraction and visible spectral determination of trace Cu. The chelation and membrane SPE can be accomplished in a syringe. The yellow Cu(DDTC) complex was separated using a polyethersulfone membrane from the sample solution. Then, the complex can be detected directly on the polyethersulfone membrane utilizing solid-phase visible absorbance spectra without elution. The proposed method simplified the experimental procedure and improved the sensitivity to the μg L level. Furthermore, this method is environmentally friendly since it avoids the use of organic solvents. After the investigation of the influence of different variables on the membrane SPE procedure, water and blood plasma were analyzed to validate the proposed method. A LOD of 0.04 μg L and recoveries of 96.0-103.7% confirmed that the present work can be applied for the determination of trace Cu in water and blood plasma samples.
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http://dx.doi.org/10.1039/d1ay01352aDOI Listing
September 2021

Toward Optimal Heat Transfer of 2D-3D Heterostructures van der Waals Binding Effects.

ACS Appl Mater Interfaces 2021 Sep 16. Epub 2021 Sep 16.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Two-dimensional (2D) materials and their heterogeneous integration have enabled promising electronic and photonic applications. However, significant thermal challenges arise due to numerous van der Waals (vdW) interfaces limiting the dissipation of heat generated in the device. In this work, we investigate the vdW binding effect on heat transport through a MoS-amorphous silica heterostructure. We show using atomistic simulations that the cross-plane thermal conductance starts to saturate with the increase of vdW binding energy, which is attributed to substrate-induced localized phonons. With these atomistic insights, we perform device-level heat transfer optimizations. Accordingly, we identify a regime, characterized by the coupling of in-plane and cross-plane heat transport mediated by vdW binding energy, where maximal heat dissipation in the device is achieved. These results elucidate fundamental heat transport through the vdW heterostructure and provide a pathway toward optimizing thermal management in 2D nanoscale devices.
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http://dx.doi.org/10.1021/acsami.1c08131DOI Listing
September 2021

Comparison between cystic biliary atresia and choledochal cyst: a clinical controlled study.

Pediatr Surg Int 2021 Sep 15. Epub 2021 Sep 15.

Department of General Surgery, Capital Institute of Pediatrics, Beijing, China.

Purpose: It is difficult to distinguish cystic biliary atresia (CBA) from choledochal cyst (CC) before intraoperative cholangiography in neonates or young infants because of the similar ultrasonographic patterns and clinical manifestations. This study is to investigate the difference of clinical parameters between CBA and CC.

Methods: 96 patients with cyst at hepatic hilum whose ages were less than 120 days during the period from Jan'2013 to Nov'2015 were retrospectively studied, they were divided into CBA group and CC group by intraoperative cholangiography, there were 29 cases of CBA and 67 cases of CC. It was compared and analyzed on laboratory data, preoperative ultrasonographic features, intraoperative cholangiography and histopathological results between the two groups. Data were quoted as means ± standard deviation (SD) or median (range), Student's t test, non-parametric test and χ2 test were used as appropriate. P < 0.05 was considered as significant statistical difference.

Results: CBA group and CC group were comparable for the operative age (51.76 ± 23.99 days vs. 50.03 ± 26.38 days, P = 0.76), weight (4.60 ± 0.75 kg vs. 4.44 ± 1.03 kg, P = 0.46) and sex proportion (M/F: 9/20 vs. 20/47, P = 0.91). there were significant differences (CBA vs. CC) in ALT [59(3-375) vs. 30 (6-247) IU/L, P < 0.001], AST [140(30-694) vs. 44(18-410) IU/L, P < 0.001], T-Bil [190 (107-326) vs.87(5-310) μmol/L, P < 0.001], D-Bil [85 (31-174) vs.14(1-122) μmol/L, P < 0.001] and TBA [112 (23-269) vs.9(1-337) μmol/L, P < 0.001]. There was insignificant statistical difference in GGT [332(112-2154) vs. 226(21-1810) IU/L, P = 0.099] between CBA group and CC group. The cyst size in CBA group was obviously smaller than CC group (the maximum longitudinal diameter: 2.52 ± 1.16 cm vs. 4.71 ± 2.23 cm, P < 0.001; the maximum transverse diameter: 1.64 ± 0.75 cm vs. 3.41 ± 1.79 cm, P < 0.001). Significant differences presented in preoperative ultrasonographic features and histopathological results between the two groups.

Conclusion: CBA should be suspected if ultrasonography indicates small cyst with characteristic manifestations of BA and elevated laboratory data. GGT was an insensitive indicator in distinguishing CBA from CC. Cholangiography should be done for the suspected CBA patients as soon as possible to confirm the diagnosis and have surgical intervention timely.
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http://dx.doi.org/10.1007/s00383-021-05004-yDOI Listing
September 2021

CircRNA MFACR is upregulated in myocardial infarction and downregulates miR-125b to promote cardiomyocyte apoptosis induced by hypoxia.

J Cardiovasc Pharmacol 2021 Sep 13. Epub 2021 Sep 13.

Department of Cardiovascular Medicine, the Third People's Hospital, Baoji City, Shanxi Province, 721000, PR. China.

Abstract: Circular RNA (circRNA) MFACR promotes cardiomyocyte death that leads to myocardial infarction (MI). This study aimed to explore the role of MFACR in MI.RT-qPCRs were performed to measure the expression levels of MFACR and miR-125b in plasma samples from both MI patients (n = 61) and healthy controls (n = 61). MFACR or miR-125b was overexpressed in AC16 cells (cardiomyocytes) to explore the interaction between them. Methylation of miR-125b gene in cells with the overexpression of MFACR was detected by methylation-specific PCR. Cell apoptosis after transfections was detected by cell apoptosis assay. MI model was constructed to further demonstrate the effect of MFACR in vivo.We found that MFACR was upregulated in MI and inversely correlated with miR-125b. In AC16 cells, hypoxia treatment increased the expression levels of MFACR and decreased the expression levels of miR-125b. In AC16 cells, overexpression of MFACR decreased the expression levels of miR-125b and increased the methylation of miR-125b gene. Under hypoxia treatment, overexpression of MFACR increased AC16 cell apoptosis, and overexpression of miR-125b decreased cell apoptosis. In addition, overexpression of miR-125b reversed the effects of overexpression of MFACR on cell apoptosis both in vivo and in vitro.MFACR may increase the methylation of miR-125b gene to downregulate its expression, thereby promoting the apoptosis of cardiomyocytes in MI.
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http://dx.doi.org/10.1097/FJC.0000000000001123DOI Listing
September 2021

Efficient Mesh Interface Engineering: Insights from Bubble Dynamics in Electrocatalysis.

ACS Appl Mater Interfaces 2021 Sep 14. Epub 2021 Sep 14.

Key Laboratory of Semiconductor Materials Science, Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China.

Electrochemical catalysis offers great potential in energy and mass conversion in academy and industry. However, bubble dynamics and its influence on gas-evolving electrode systems remain ambiguous. Detailed information on the local transport process between different phases and the underlying mechanism are required for the full understanding of two-phase flow evolution and distribution. Here, we construct a three-electrode water splitting reaction system to study the bubble dynamics and system efficiency of titanium electrodes with different morphologies. The dynamics of a gas bubble at an electrode with a plate and 100-mesh, 150-mesh, and 300-mesh structures is systematically investigated with respect to applied voltage conditions. Parameters and underlying mechanisms that influence the two-phase flow evolution and electrochemical reaction performance are carefully discussed. Finally, the underlying dynamic force balance on the gas bubble is analyzed to illustrate the mechanism and experimental observations. Our study provides insights in gas-evolving electrocatalysis and offers opportunities for the design and fabrication of high-performance electrocatalytic reactors.
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http://dx.doi.org/10.1021/acsami.1c07637DOI Listing
September 2021

Manipulation of a Nonconductive Droplet in an Aqueous Fluid with AC Electric Fields: Droplet Dewetting, Oscillation, and Detachment.

Langmuir 2021 Sep 14. Epub 2021 Sep 14.

Qian Xuesen Laboratory of Space Technology, China Academy of Space Technology, Beijing 100094, China.

Electrowetting (EW) is an effective method for droplet manipulation in microfluidics. In traditional EW, a conductive droplet is actuated, which spreads on a solid substrate. Recently, we considered an opposite phenomenon of droplet actuation in EW: inducing nonconductive droplet dewetting and detaching from the substrate. An oil/water system is used in which the oil droplet (nonconductive) is actuated on a flat substrate in surrounding water (conductive) by EW. In this work, alternating current (AC) electric fields are applied to EW, and the transient dynamics of droplet dewetting, oscillation, and detachment with the AC signals are investigated. The droplet is not in contact with electrodes, and it dances freely on the substrate. Experiments are performed in a wide range of voltages and AC frequencies. To demonstrate the droplet dynamics, we divide the full process of droplet manipulation into three distinguishable periods, that is, an initiating period, a steady oscillation period, and a detaching condition. Transient droplet dewetting is considered in the initiating period, and we obtain the distribution of the contact line friction factor. In steady oscillation, the oscillation resonance is verified from the oscillating amplitude of the contact line. Different periodical features are found for the droplet dancing at the resonance frequencies and departure from resonance. The droplet is detached at high voltages, and we provide a map for the detachable and nondetachable zones. The voltage is the dominant factor determining the droplet detachment; however, the AC frequency has notable influences on the critical voltage. The detachment is promoted when the AC frequency is within the region of the oscillation resonance (, 20 < < 75 Hz). In this region, the detaching process is not monotonic but instead, the droplet rebounds by several times before it is completely detached.
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http://dx.doi.org/10.1021/acs.langmuir.1c01934DOI Listing
September 2021

A chair-side plasma treatment system for rapidly enhancing the surface hydrophilicity of titanium dental implants in clinical operations.

J Oral Sci 2021 Sep 13. Epub 2021 Sep 13.

State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University.

Purpose: In order to promote osseointegration and shorten the healing time after dental implant operations, this study was conducted to develop a chair-side plasma treatment system in which Ti implants were used as a coaxial internal electrode to rapidly enhance their surface hydrophilicity.

Methods: Surface hydrophilicity was evaluated by measurement of the water contact angle and the defined wetting time. Changes in temperature and chemical composition were analyzed using infrared thermal imaging and X-ray photoelectron spectroscopy (XPS), respectively. The biocompatibility of the treated implants was examined in an animal experiment.

Results: A marked improvement of hydrophilicity was demonstrated by a decrease in the water contact angle of the treated implant to 0° and wetting of the whole surface within 3 s of water contact. The Ti implant hydrophilization mechanism was explained as a decrease in the degree of hydrocarbon contamination. The surface temperature of the treated implant was close to that of the human body, and good osseointegration was observed in the in vivo experiment.

Conclusion: The plasma treatment system developed here is a promising chair-side procedure for rapidly enhancing the surface hydrophilicity of Ti implants in clinical operations without any need to consider the degradation of hydrophilicity caused by long-term storage.
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http://dx.doi.org/10.2334/josnusd.21-0090DOI Listing
September 2021

Modified expression of TaCYP78A5 enhances grain weight with yield potential by accumulating auxin in wheat (Triticum aestivum L.).

Plant Biotechnol J 2021 Sep 12. Epub 2021 Sep 12.

College of Life Sciences, Northwest A & F University, Yangling, Shaanxi, China.

Increasing grain yield has always been the primary goal of crop breeding. KLUH/CYP78A5 has been shown to affect seed size in several plant species, but the relevant molecular mechanism is still unclear and there are no reports of this gene contributing to yield. Here, we demonstrate that modified expression of TaCYP78A5 can enhance wheat grain weight and grain yield per plant by accumulating auxin. TaCYP78A5 is highly expressed in maternal tissues, including ovary and seed coat during wheat development. The constitutive overexpression of TaCYP78A5 leads to significantly increased seed size and weight but not grain yield per plant due to the strengthening of apical dominance. However, localized overexpression of TaCYP78A5 in maternal integument enhances grain weight and grain yield per plant by 4.3%-18.8% and 9.6%-14.7%, respectively, in field trials. Transcriptome and hormone metabolome analyses reveal that TaCYP78A5 participates in auxin synthesis pathway and promotes auxin accumulation and cell wall remodelling in ovary. Phenotype investigation and cytological observation show that localized overexpression of TaCYP78A5 in ovary results in delayed flowering and prolonged proliferation of maternal integument cells, which promote grain enlargement. Moreover, naturally occurring variations in the promoter of TaCYP78A5-2A contribute to thousand-grain weight (TGW) and grain yield per plant of wheat;TaCYP78A5-2A haplotype Ap-HapII with higher activity is favourable for improving grain weight and grain yield per plant and has been positively selected in wheat breeding. Then, a functional marker of TaCYP78A5 haplotype Ap-HapII is developed for marker-assisted selection in wheat grain and yield improvement.
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http://dx.doi.org/10.1111/pbi.13704DOI Listing
September 2021

Correction to: Biomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering.

Tissue Eng Regen Med 2021 Oct;18(5):915

College of Materials and Metallurgy, Guizhou University, Guiyang, Guizhou, China.

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http://dx.doi.org/10.1007/s13770-021-00386-5DOI Listing
October 2021

Selective Extraction and Complexation Studies for Thorium(IV) with Bis-triamide Extractants: Synthesis, Solvent Extraction, EXAFS, and DFT.

Inorg Chem 2021 Sep 1;60(18):14212-14220. Epub 2021 Sep 1.

College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.

Three octyl-extended bis-triamide extractants (-) were designed and synthesized for the selective solvent extraction of Th(IV) over U(VI) in a kerosene-HNO system. and exhibited good extraction property and selectivity toward Th(IV) over U(VI) and reached extraction equilibrium within 10 min. In a wide range of a HNO concentration from 0.1 to 3.0 M, the separation factor of Th(IV) over U(VI) (SF) of and ranged from 12.1 ± 1.6 to 123.0 ± 20.2 and 15.2 ± 2.4 to 88.1 ± 14.9, respectively. Slope analysis indicated that Th(IV) was extracted as different species under different HNO concentrations, in which the slopes were 2.08 ± 0.20, 1.61 ± 0.03, and 1.54 ± 0.03 for and 2.37 ± 0.22, 2.07 ± 0.17, and 1.76 ± 0.18 for under 0.1, 1.0, and 3.0 M HNO, respectively. A continuous variation method (Job plot) illustrated a 1.5:1 ligand/thorium (L/Th) ratio in a methanol phase, indicating that / and Th(IV) could form mixed 1:1 and 2:1 L/Th extracted complexes. Extended X-ray absorption fine structure (EXAFS) and density functional theory (DFT) calculations revealed that the extracted complexes of and with Th during the extraction process at 0.1 M HNO were [2L1·Th·3(NO)] and [2L2·Th·3(NO)].
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http://dx.doi.org/10.1021/acs.inorgchem.1c01660DOI Listing
September 2021

Plasmon Coupling in DNA-Assembled Silver Nanoclusters.

J Am Chem Soc 2021 Sep 31;143(36):14573-14580. Epub 2021 Aug 31.

The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.

Quantum-size metal clusters with multiple delocalized electrons could support collective plasmon excitation, and thus, theoretically, coupling of plasmons in the few-atom limit might exist between assembled metal clusters, while currently few experimental observations about this phenomenon have been reported. Here we examined the optical absorption of DNA-templated Ag nanoclusters (DNA-AgNCs) assembled through DNA hybridization and found their absorption peaks were sensitive to the assembled distances, which share common characteristics with classical plasmon coupling. Dipolar charge distribution, multiple transition contributed optical absorption, and strongly enhanced electric field simulated by time-dependent density functional theory (TDDFT) indicated the origin of the absorption of individual DNA-AgNCs is a plasmon. The consistency of the peak-shifting trend between experimental and simulation results for assembled DNA-AgNCs suggested the possible presence of plasmon coupling. Our data imply the possibility for quantum-size structures to support plasmon coupling and also show that DNA-AgNCs possess the potential to be promising materials for construction of plasmon-coupling devices with ultrasmall size, site-specific and stoichiometric binding abilities, and biocompatibility.
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http://dx.doi.org/10.1021/jacs.1c04949DOI Listing
September 2021

Effects of the Laplace pressure on the cells during cytokinesis.

iScience 2021 Sep 4;24(9):102945. Epub 2021 Aug 4.

State Key Laboratory of Nonlinear Mechanics and Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China.

The Laplace pressure is one of the most fundamental regulators that determine cell shape and function, and thus has been receiving widespread attention. Here, we systemically investigate the effect of the Laplace pressure on the shape and function of the cells during cytokinesis. We find that the Laplace pressure during cytokinesis can directly control the distribution and size of cell blebbing and adjust the symmetry of cell division by virtue of changing the characteristics of cell blebbing. Further, we demonstrate that the Laplace pressure changes the structural uniformity of cell boundary to regulate the symmetry of cell division. Our findings provide further insights as to the important role of the Laplace pressure in regulating the symmetry of cell division during cytokinesis.
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http://dx.doi.org/10.1016/j.isci.2021.102945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377492PMC
September 2021

Association Analysis Revealed That Genes Are Linked to Plant Growth Related Traits in Multiple Environment.

Front Plant Sci 2021 11;12:641087. Epub 2021 Aug 11.

National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.

Abscisic acid (ABA), one of phytohormones, plays an important regulatory role in plant growth and development. ABA receptor (pyrabactin resistance 1-like 4) was previously detected to be involved in plant response to a variety of stresses. overexpression could enhance wheat () drought resistance. In order to further investigate TaPYL4's role in regulating development of other major agronomic traits in wheat, genes of , , and were cloned from wheat, respectively. Polymorphism analysis on sequences revealed that encoding regions of the three genes were highly conserved, without any SNP (single nucleotide polymorphism) presence. However, nine SNPs and four SNPs were identified in the promoter regions of and , respectively. Functional molecular markers were developed based on these polymorphisms, which were then used to scan a natural population of 323 common wheat accessions for correlation analysis between genotype and the target phenotypic traits. Both and markers were significantly correlated with plant growth-related traits under multiple environments (well-watered, drought and heat stress treatments). The additive effects of and were verified by the combinational haplotype (-AB1∼-AB4) effects determined from field data. -acting elements were analyzed in the promoters of and , showing that a TGA-element bound by ARFs (auxin response factors) existed only in -2A-1 of . Gene expression assays indicated that was constitutively expressed in various tissues, with higher expression in -2A-1 genotypes than in -2A-2 materials. Notably, TaARF4 could act as transcription activator in -2A-1 materials, but not in -2A-2 genotypes. Analysis of geographic distribution and temporal frequency of haplotypes indicated that -AB1 was positively selected in wheat breeding in China. Therefore, and could be a valuable target gene in wheat genetic improvement to develop the ideal plant architecture.
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http://dx.doi.org/10.3389/fpls.2021.641087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387097PMC
August 2021

Hemodynamic Versus Anatomic Assessment of Symptomatic Atherosclerotic Middle Cerebral Artery Stenosis: the Relationship Between Pressure Wire Translesional Gradient and Angiographic Lesion Geometry.

Front Neurol 2021 11;12:671778. Epub 2021 Aug 11.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Intracranial cerebral atherosclerosis (ICAS) is a leading etiology of ischemic stroke. The diagnosis and assessment of intracranial stenosis are shifting from anatomic to hemodynamic for better risk stratification. However, the relationships between lesion geometry and translesional pressure gradient have not been clearly elucidated. Patients with symptomatic unifocal M1 middle cerebral artery (M1-MCA) stenosis were consecutively recruited. The translesional pressure gradient was measured with a pressure wire and was recorded as both mean distal/proximal pressure ratios (Pd/Pa) and translesional pressure difference (Pa-Pd). Lesion geometry measured on angiography was recorded as diameter stenosis, minimal lumen diameter, and lesion length. The correlations between pressure-derived and angiography-derived indices were then analyzed. Forty-three patients were analyzed. A negative correlation was found between Pd/Pa and diameter stenosis ( = -0.371; = 0.014) and between Pa - Pd and minimal lumen diameter ( = -0.507; = 0.001). A positive correlation was found between Pd/Pa and minimal lumen diameter ( = 0.411; = 0.006) and between Pa - Pd and diameter stenosis ( = 0.466; = 0.002). In a highly selected ICAS subgroup, geometric indices derived from angiography correlate significantly with translesional pressure gradient indices. However, the correlation strength is weak-to-moderate, which implies that anatomic assessment could only partly reflect hemodynamic status. Translesional pressure gradient measured by pressure wire may serve as a more predictive marker of ICAS severity. More factors need to be identified in further studies.
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http://dx.doi.org/10.3389/fneur.2021.671778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385769PMC
August 2021

Adsorption and catalytic degradation of organic contaminants by biochar: Overlooked role of biochar's particle size.

J Hazard Mater 2021 Aug 17;422:126928. Epub 2021 Aug 17.

College of Environmental Science and Engineering, Hunan University, Changsha, Hunan 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, Hunan 410082, China.

Biochar (BC) is considered as a promising adsorbent and/or catalyst for the removal of organic contaminants. However, the relationship between the particle size of BC and its adsorption/catalysis performance is largely unclear. We therefore investigated the influence of particle size on the performance of BC pyrolyzed at 300-900 °C in trichloroethylene (TCE) adsorption and persulfate (PS) activation for sulfamethazine (SMT) degradation. The results showed that high-temperature pyrolyzed BC (BC900) presented superior adsorption capacity for TCE and excellent catalytic activity for PS activation to degrade SMT. Compared to 150-250 µm, 75-150 µm and pristine BC900, 0-75 µm BC900 showed the highest TCE adsorption efficiency, which increased by 19.5-62.3%. Similarly, SMT removal by BC900/PS systems also increased from 24.2% to 98.3% with decreasing BC particle size. However, the catalytic activity of BC after grinding was not significantly improved as expected, indicating the properties of biochar was not only controlled by size effect. Characterization measurements proved that small-sized BC tended to have larger specific surface area, more micropores, higher conductivity, rich graphitic domains and surface redox-active functional groups, thus resulting in an enhanced adsorption and catalytic ability of BC.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126928DOI Listing
August 2021

Genome-Wide Analysis and Expression Profiling of the Phospholipase D Gene Family in .

Biology (Basel) 2021 Aug 2;10(8). Epub 2021 Aug 2.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling 712100, China.

Phospholipase D (PLD) is the most important phospholipid hydrolase in plants, which can hydrolyze phospholipids into phosphatidic acid (PA) and choline. When plants encounter low temperature, drought and high salt stress, phospholipase D and its products play an important role in regulating plant growth and development and coping with stress. In this study, 16 members of StPLD gene family were identified in potato genome, which were distributed in α, β, δ, and ζ subfamilies, and their expression patterns under salt, high temperature, drought, and ABA stress were detected by qRT-PCR method. Gene expression analysis showed that the expression of StPLD genes in potato was upregulated and downregulated to varying degrees under the four stresses, indicating that the PLD gene family is involved in the interaction of potato plant hormones and abiotic stress signals. Chromosome distribution showed that StPLD gene was unevenly distributed on 8 chromosomes, and only one pair of tandem repeat genes was found. All StPLD promoters contain hormone and stress-related cis-regulatory elements to respond to different stresses. Structural analysis showed that StPLD genes in the same subgroup had a similar exon-intron structure. Our study provides a valuable reference for further research of the function and structure of PLD gene.
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http://dx.doi.org/10.3390/biology10080741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389595PMC
August 2021

Pan-Cancer Analysis of Prognostic and Immune Infiltrates for CXCs.

Cancers (Basel) 2021 Aug 18;13(16). Epub 2021 Aug 18.

Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Background: CXCs are important genes that regulate inflammation and tumor metastasis. However, the expression level, prognosis value, and immune infiltration of CXCs in cancers are not clear.

Methods: Multiple online datasets were used to analyze the expression, prognosis, and immune regulation of CXCs in this study. Network analysis of the Amadis database and GEO dataset was used to analyze the regulation of intestinal flora on the expression of CXCs. A mouse model was used to verify the fact that intestinal bacterial dysregulation can affect the expression of CXCs.

Results: In the three cancers, multiple datasets verified the fact that the mRNA expression of this family was significantly different; the mRNA levels of CXCL3, 8, 9, 10, 14, and 17 were significantly correlated with the prognosis of three cancers. CXCs were correlated with six types of immuno-infiltrating cells in three cancers. Immunohistochemistry of clinical samples confirmed that the expression of CXCL8 and 10 was higher in three cancer tissues. Animal experiments have shown that intestinal flora dysregulation can affect CXCL8 and 10 expressions.

Conclusion: Our results further elucidate the function of CXCs in cancers and provide new insights into the prognosis and immune infiltration of breast, colon, and pancreatic cancers, and they suggest that intestinal flora may influence disease progression through CXCs.
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http://dx.doi.org/10.3390/cancers13164153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392715PMC
August 2021

Instance-Level Relative Saliency Ranking with Graph Reasoning.

IEEE Trans Pattern Anal Mach Intell 2021 Aug 26;PP. Epub 2021 Aug 26.

Conventional salient object detection models cannot differentiate the importance of different salient objects. Two works have proposed to detect saliency ranking by assigning different degrees of saliency to different objects. However, one of these models cannot differentiate object instances and the other focuses more on sequential attention shift order inference. In this paper, we investigate a practical problem setting which requires to simultaneously segment salient instances and infer their relative saliency rank order. We present a novel unified model as the first end-to-end solution, where an improved Mask R-CNN is first used to segment salient instances and a saliency ranking branch is then added to infer the relative saliency. For relative saliency ranking, we build a novel graph reasoning module by combining four graphs to incorporate the instance interaction relation, local contrast, global contrast, and a high-level semantic prior, respectively. A novel loss function is proposed to effectively train the saliency ranking branch. Besides, a new dataset and an evaluation metric are proposed for this task, aiming at pushing forward this field of research. Finally, experimental results demonstrate that our proposed model is more effective than previous methods. We show an example of its practical usage on adaptive image retargeting.
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http://dx.doi.org/10.1109/TPAMI.2021.3107872DOI Listing
August 2021

Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells.

Cell Discov 2021 Aug 24;7(1):73. Epub 2021 Aug 24.

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.

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http://dx.doi.org/10.1038/s41421-021-00310-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384103PMC
August 2021

Surgical approach and functional outcome of redo pull-through for postoperative complications in Hirschsprung's disease.

Pediatr Surg Int 2021 Oct 20;37(10):1401-1407. Epub 2021 Aug 20.

Department of General Surgery, Capital Institute of Pediatrics, Beijing, China.

Aim: To review our surgical experience and outcome of redo pull-through for various postoperative complications of Hirschsprung's disease.

Methods: A retrospective study was performed on children who underwent redo pull-through from 2016 to 2019. Operative methods and functional outcomes were compared between those with anastomotic complications (stricture and fistula, n = 12) and patients without anastomotic complications (n = 24) such as residual aganglionosis/transition zone, twisted pull-through and tight soave cuff.

Result: 36 Patients (29 male and 7 female) were included with median age 6 (0.1-54) months at primary and 36 (9-144) months at redo pull-through. A transanal rectal mucosectomy and partial internal anal sphincterectomy (TRM-PIAS) pull-through with laparoscopic (n = 10, 27.8%) or laparotomy (n = 26, 72.2%) assisted techniques were performed for all patients during redo procedure. Patients with anastomotic complications had lower incidence of successful laparoscopic pull-through (0%), higher postoperative complications (25%) after redo surgery, but similar functional outcomes compared to those without anastomotic complications (41.6% underwent laparoscopic surgery, 4.2% complications). Patients with partial colectomy had significantly less soiling (36.4%) and enterocolitis (0%) compared to those with subtotal/total colectomy (79.2% soiling and 58.3% enterocolitis).

Conclusion: TRM-PIAS with/without laparoscopic-assisted redo pull-through was effective in treating various complications after primary pull-through. The functional outcome is strongly associated with the length of residual colon after redo pull-though.
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http://dx.doi.org/10.1007/s00383-021-04965-4DOI Listing
October 2021

Time course of histopathological changes after bleomycin sclerotherapy in rabbit gallbladders as a model for simple hepatic cysts.

Biomed Rep 2021 Sep 19;15(3):75. Epub 2021 Jul 19.

Department of Pathology, Liwan Central Hospital of Guangzhou City, Guangzhou, Guangdong 510507, P.R. China.

Bleomycin sclerotherapy is used in the treatment of cystic lesions; however, the histopathological changes are undefined. Present animal models of cystic diseases are not adequate for the study of sclerotherapy of hepatic cysts, primarily because the established cysts in these models are too small in size. The aim of the present study was to establish a new animal model of simple hepatic cysts, and assess the histopathological changes after bleomycin sclerotherapy. Rabbit gallbladder, with ligaturing of the cholecystic duct whilst preserving cholecystic vessels, was used as a model for simple hepatic cysts. Bleomycin (2 mg dissolved in 1 ml saline) was injected into the aspirated gallbladder, gallbladder tissue was harvested (after 1, 7, 14, 28, 42, 56 and 84 days) and histopathological changes were evaluated (n=4 per group). Additionally, control rabbit gallbladders were injected with 1 ml saline and sampled after 14 days (n=4). Histopathological changes were evaluated using hematoxylin-eosin and Masson's trichrome staining, and immunohistochemistry for CD20-, CD43- and CD68-positive cells was performed. The integrated optical density (IOD) of immunohistochemical staining and average positive stained area percentage (APSAP) of collagen were quantitatively analyzed. The results revealed gallbladders in the control group had regular epithelial cells with no visible inflammation or fibrosis. In the experimental group, epithelial cells were swollen and necrotic on the first day, and were replaced gradually by single-layer flat cells from day 56. Inflammatory infiltration was found in the submucosa, and the IOD of T cells, B cells and macrophages were highest on day 1, and these parameters declined gradually, eventually disappearing. The APSAP of collagen was highest on day 7, and gradually declined thereafter. The results suggest that histopathological changes after bleomycin sclerotherapy of a simple hepatic cyst model were characterized by sequential epithelial destruction, inflammatory cell infiltration, collagen proliferation and epithelial partial regeneration.
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http://dx.doi.org/10.3892/br.2021.1451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330001PMC
September 2021

Integrating bioinformatics with pharmacological evaluation for illustrating the action mechanism of herbal formula Jiao'e mixture in suppressing lung carcinoma.

J Ethnopharmacol 2021 Aug 13;281:114513. Epub 2021 Aug 13.

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 71000, Xi'an, China. Electronic address:

Ethnopharmacological Relevance: Lung carcinoma (LC) is not only a kind of disease that seriously threatens human life but also an intractable problem in modern medicine. Jiao'e Mixture (JEM) is an innovative Chinese medicine formula with Chinese patent, which is composed of two herbal extracts with a specific ratio-zedoary turmeric oil and medicinal Zanthoxylum bungeanum Maxim(Z. bungeanum Maxim) seeds oil (ZMSO). Zedoary turmeric oil is extracted from dried rhizomes of Curcuma wenyujin Y.H.Chen et C. Ling, which has been reported have an anti-cancer effects. Medicinal ZMSO is a by-product of Z. bungeanum Maxim, refined from kernel shell separation, modern cold soaking and refining technology; JEM is used to treat Lung carcinoma (LC) patients in folk for many years. However, its therapeutic mechanisms for treating LC have not been fully explored.

Aim Of The Study: The purpose of this study was to explore the therapeutic mechanisms of JEM for treating LC.

Materials And Methods: The action mechanism of JEM in LC treatment was analysed by comprehensive network pharmacology approach combined with experimental validation (in vivo and in vitro).

Results: Seventeen active compounds and 457 related targets were collected from the HERB, TCMSP, and Swiss Target Prediction platforms. Nine hundred and thirty-eight LC related targets were obtained from Gene Cards and OMIM databases. Finally, 140 overlapping targets were obtained, which representing the target of JEM in LC treatment. The pathway analysis showed that PI3K-AKT could be a potential pathway for JEM in LC treatment. In vivo results presented that JEM had a good effect in inhibiting the growth of LC tumour cells with high efficacy and low toxicity. In vitro experiments validated that JEM had inhibited LC cells' proliferation, migration and invasion, and had induced cell apoptosis mainly via PI3K/Akt signalling pathways.

Conclusion: The anti-LC activity of JEM might via regulating the PI3K-AKT signalling pathways.This study may provide further evidence for the potential use of JEM in LC treatment.
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http://dx.doi.org/10.1016/j.jep.2021.114513DOI Listing
August 2021

Belowground facilitation and trait matching: two or three to tango?

Trends Plant Sci 2021 Aug 13. Epub 2021 Aug 13.

Key Laboratory of Plant-Soil Interactions, Ministry of Education, Beijing Key Laboratory of Biodiversity and Organic Farming, College of Resources and Environmental Sciences, China Agricultural University, 2 Yuan Ming Yuan West Road, Beijing 100193, PR China. Electronic address:

High biodiversity increases ecosystem functions; however, belowground facilitation remains poorly understood in this context. Here, we explore mechanisms that operate via 'giving-receiving feedbacks' for belowground facilitation. These include direct effects via root exudates, signals, and root trait plasticity, and indirect biotic facilitation via the effects of root exudates on soil biota and feedback from biota to plants. We then highlight that these two- or three-way mechanisms must affect biodiversity-ecosystem function relationships via specific combinations of matching traits. To tango requires a powerful affinity and harmony between well-matched partners, and such matches link belowground facilitation to the effect of biodiversity on function. Such matching underpins applications in intercropping, forestry, and pasture systems, in which diversity contributes to greater productivity and sustainability.
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http://dx.doi.org/10.1016/j.tplants.2021.07.014DOI Listing
August 2021

Invisibility Cloak Technology of Anti-Infrared Detection Materials Prepared Using CoGaZnSe Multilayer Nanofilms.

ACS Appl Mater Interfaces 2021 Aug 16;13(33):40145-40154. Epub 2021 Aug 16.

College of Science, Xi'an University of Architecture and Technology, Xi'an 710055, China.

The development of infrared stealth clothing technology and materials has been widely studied. However, the research of near-infrared stealth clothing still faces some challenges including complex preparation processes, narrow spectral ranges, and poor antidetection efficiency. To solve these questions, a CoGaZnSe multilayer film used for anti-near-infrared detection is designed and prepared by pulse laser deposition (PLD) at different pressures from 2 to 12 Pa. Microstructures of the film can transform from amorphous to crystal at different Ar atmospheres demonstrated by X-ray diffraction, Raman spectroscopy, and theoretical calculations. The films with different transmittances from 10 to 95% are combined with multilayer films for reducing the infrared reflection, which results in the lowest energy loss per unit thickness of 1.01 × 10 dB/cm. The light propagation in the multilayer is calculated by finite-difference time domain, revealing the regular sinusoidal propagation and absorption in multilayers. The multilayer films are coated on the surface of common clothing materials and tested using an infrared detector in the range of 400-6000 nm. The results prove that the quantum efficiency of infrared detection can be effectively reduced by CoGaZnSe multilayer films, especially for wool (83% in the range of 400-1800 nm and 86% in the range of 2000-6000 nm). Finally, a physical model is established to discover the mechanism of the antireflection and infrared effect and a theory of anti-infrared radiation. This research provides a new idea and method supporting the stealth technology and materials, which improves the efficiency of anti-infrared detection and makes it feasible to be applied in military, detection, and stealth technology.
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http://dx.doi.org/10.1021/acsami.1c11649DOI Listing
August 2021

Perfluorinated compounds disrupted osmoregulation in Oryzias melastigma during acclimation to hypoosmotic environment.

Ecotoxicol Environ Saf 2021 Oct 10;223:112613. Epub 2021 Aug 10.

Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, PR China. Electronic address:

Perfluorinated compounds (PFCs) are a type of ubiquitous contaminants spreading in the estuarine and coastal areas. Anadromous fish should deal with hypoosmotic challenge with PFCs stress during their migration from seawater to estuaries. However, few studies have been carried out to investigate the adverse impact of PFCs on fish osmoregulation and the underlying mechanism. In this study, Oryzias melastigma, an euryhaline fish model, were exposed to four representative PFC congeners including perfluorobutane sulfonate (PFBS), perfluorooctane sulfonates (PFOS), perfluorooctanoic acid (PFOA), and perfluorododecanoic acid (PFDoA) separately under both seawater and freshwater conditions. Histopathological changes in gills, ion homeostasis, Na/K-ATPase (NKA) activity, as well as the expression of related genes was detected upon exposure. Results showed that PFCs induced morphological changes in gills, disturbed the levels of major ions (Na, Ca, Mg), and inhibited the NKA activity. Transcriptome analysis in fish gills during the acclimation to freshwater revealed that PFCs influenced the osmoregulation mainly by interfering with the endocrine system, signal transduction, as well as cellular community and motility. Validation with qRT-PCR confirmed that the mRNA expressions of osmoregulatory genes encoding hormones and receptors, as well as ion transmembrane transporters were disturbed by PFCs. Longer chain homolog (PFOS) showed a greater impact on osmoregulation than the shorter chain homolog (PFBS). Within the same carbon chain, sulfonic congener (PFOS) induced more serious injury to gills than carboxylic congener (PFOA). The interaction between PFCs and salinity varied in different adverse outcome. These results help to further understand the mechanism of how PFCs influence osmoregulation and elicit the need to assess the ecological risk of PFCs and other pollutants on anadromous migration.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112613DOI Listing
October 2021

Defect and Doping Engineered Penta-graphene for Catalysis of Hydrogen Evolution Reaction.

Nanoscale Res Lett 2021 Aug 13;16(1):130. Epub 2021 Aug 13.

School of Science, Xi'an University of Architecture and Technology, Xi'an, 710055, China.

Water electrolysis is a sustainable and clean method to produce hydrogen fuel via hydrogen evolution reaction (HER). Using stable, effective and low-cost electrocatalysts for HER to substitute expensive noble metals is highly desired. In this paper, by using first-principles calculation, we designed a defect and N-, S-, P-doped penta-graphene (PG) as a two-dimensional (2D) electrocatalyst for HER, and its stability, electronic properties and catalytic performance were investigated. The Gibbs free energy (ΔG), which is the best descriptor for the HER, is calculated and optimized, the calculation results show that the ΔG can be 0 eV with C2 vacancies and P doping at C1 active sites, which should be the optimal performance for a HER catalyst. Moreover, we reveal that the larger charge transfer from PG to H, the closer ΔG is to zero according to the calculation of the electron charge density differences and Bader charges analysis. Ulteriorly, we demonstrated that the HER performance prefers the Volmer-Heyrovsky mechanism in this study.
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http://dx.doi.org/10.1186/s11671-021-03590-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363696PMC
August 2021

Macrocalcification of intracranial vertebral artery may be related to in-stent restenosis: lessons learned from optical coherence tomography.

J Neurointerv Surg 2021 Aug 10. Epub 2021 Aug 10.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China

Background: Calcification has been proven to be a marker of atherosclerosis and is related to an increased risk of ischemic stroke. Additionally, calcification was reported to be prevalent in patients with stenotic lesions of the intracranial vertebral artery. Thus, reliable imaging facilities for evaluating plaque calcification have remarkable significance in guiding stenting and predicting patient outcomes. Optical coherence tomography (OCT) has a unique advantage in its ability to detect calcium and to achieve three-dimensional volumetric calcium characterization.

Methods: From March 2017 to September 2018, seven cases of calcified lesions with intracranial vertebral artery stenosis were investigated using OCT, before and after the placement of an Apollo balloon-mounted stent. Transcranial color-coded duplex sonography was performed to identify restenosis with a mean follow-up time of 13.3 months in this case series.

Results: All calcified lesions were evaluated quantitatively and qualitatively using OCT. Among all cases, five had macrocalcifications and two had spotty calcifications. Severe in-stent restenosis was observed in two cases, both with macrocalcifications.

Conclusions: This study suggests a potential relationship between macrocalcifications and the risk of in-stent restenosis of the intracranial vertebral artery. These preliminary findings obtained from a limited sample should be verified by prospective large-scale studies.
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http://dx.doi.org/10.1136/neurintsurg-2021-017913DOI Listing
August 2021

Search for ABO Type Ferroelectric Perovskites with Targeted Multi-Properties by Machine Learning Strategies.

J Chem Inf Model 2021 Aug 10. Epub 2021 Aug 10.

Materials Genome Institute, Shanghai University, and Shanghai Materials Genome Institute, Shanghai 200444, China.

Ferroelectric perovskites are one of the most promising functional materials due to the pyroelectric and piezoelectric effect. In the practical applications of ferroelectric perovskites, it is often necessary to meet the requirements of multiple properties. In this work, a multiproperties machine learning strategy was proposed to accelerate the discovery and design of new ferroelectric ABO-type perovskites. First, a classification model was constructed with data collected from publications to distinguish ferroelectric and nonferroelectric perovskites. The classification accuracies of LOOCV and the test set are 87.29% and 86.21%, respectively. Then, two machine learning strategies, Machine-Learning Workflow and SISSO, were used to construct the regression models to predict the specific surface area (SSA), band gap (), Curie temperature (), and dielectric loss (tan δ) of ABO-type perovskites. The correlation coefficients of LOOCV in the optimal models for SSA, , and are 0.935, 0.891, and 0.971, respectively, while the correlation coefficient of the predicted and experimental values of the SISSO model for tan δ prediction could reach 0.913. On the basis of the models, 20 ABO ferroelectric perovskites with three different application prospects were screened out with the required properties, which could be explained by the patterns between the important descriptors and the properties by using SHAP. Furthermore, the constructed models were developed into web servers for the researchers to accelerate the rational design and discovery of ABO ferroelectric perovskites with desired multiple properties.
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http://dx.doi.org/10.1021/acs.jcim.1c00566DOI Listing
August 2021
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