Publications by authors named "Long Hoang"

76 Publications

Fear-Related Reasons for Avoiding Sexual Intercourse in Early Pregnancy: A Cross-Sectional Study.

Sex Med 2021 Oct 7;9(6):100430. Epub 2021 Oct 7.

National Hospital of Obstetrics and Gynecology, Hanoi, Vietnam; Department of Obstetrics and Gynecology, Hanoi Medical University, Hanoi, Vietnam. Electronic address:

Introduction: Several studies have reported women's worry that sexual intercourse may harm the course of pregnancy. This worry might lead to avoidance of sexual intercourse during pregnancy.

Aim: To assess if fears about harming the pregnancy are associated with avoidance of sexual intercourse during pregnancy.

Methods: A cross-sectional study was conducted on 250 Vietnamese pregnant women in the first or second trimester who visited our hospital for antenatal care. We explored 5 types of fears including miscarriage/preterm labor, premature rupture of membranes, bleeding, infection, and injury to the fetus. Fears were measured by modified questions from the Reasons For Not Engaging in Sexual Activity During Pregnancy questionnaire. Using the total fear score, pregnant women were categorized into having low, moderate, and high fear.

Main Outcome Measure: Not having sexual intercourse during the past 4 weeks.

Results: 72 (28.8%) pregnant women had no sexual intercourse for the past 4 weeks. All types of fear were considered important among pregnant women; the more important fears were infection and injury to the fetus. In multivariable regression analysis, the prevalence of not having sexual intercourse was higher in both women who had moderate (adjusted prevalence ratio = 2.84, 95% CI 1.42-5.67) and high fear (adjusted prevalence ratio = 4.39, 95% CI 2.28-8.44).

Conclusion: Avoidance of sexual intercourse was common among Vietnamese pregnant women and was associated with the fears about harming the pregnancy. This can be a target in the health education programs for pregnancy couples. Thanh C. Phan, Long B. Hoang, Thanh K. Tran, et al. Fear-Related Reasons for Avoiding Sexual Intercourse in Early Pregnancy: A Cross-Sectional Study. Sex Med 2021;9:100430.
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http://dx.doi.org/10.1016/j.esxm.2021.100430DOI Listing
October 2021

Communicable disease pandemic: a simulation model based on community transmission and social distancing.

Soft comput 2021 Aug 31:1-11. Epub 2021 Aug 31.

Division of Computational Mathematics and Engineering, Institute for Computational Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Communicable disease pandemic is a severe disease outbreak all over the countries and continents. Swine Flu, HIV/AIDS, corona virus disease-19 (COVID-19), etc., are some of the global pandemics in the world. The major cause of becoming pandemic is community transmission and lack of social distancing. Recently, COVID-19 is such a largest outbreak all over the world. This disease is a communicable disease which is spreading fastly due to community transmission, where the affected people in the community affect the heathy people in the community. Government is taking precautions by imposing social distancing in the countries or state to control the impact of COVID-19. Social distancing can reduce the community transmission of COVID-19 by reducing the number of infected persons in an area. This is performed by staying at home and maintaining social distance with people. It reduces the density of people in an area by which it is difficult for the virus to spread from one person to other. In this work, the community transmission is presented using simulations. It shows how an infected person affects the healthy persons in an area. Simulations also show how social distancing can control the spread of COVID-19. The simulation is performed in GNU Octave programming platform by considering number of infected persons and number of healthy persons as parameters. Results show that using the social distancing the number of infected persons can be reduced and heathy persons can be increased. Therefore, from the analysis it is concluded that social distancing will be a better solution of prevention from community transmission.
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http://dx.doi.org/10.1007/s00500-021-06168-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406017PMC
August 2021

Effectiveness of continuous endotracheal cuff pressure control for the prevention of ventilator associated respiratory infections: an open-label randomised, controlled trial.

Clin Infect Dis 2021 Aug 22. Epub 2021 Aug 22.

Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.

Background: An endotracheal tube cuff pressure between 20-30 cmH2O is recommended to prevent ventilator-associated respiratory infection (VARI). We aimed to evaluate whether continuous cuff pressure control (CPC) was associated with reduced VARI incidence compared with intermittent CPC.

Methods: We conducted a multi-centre open-label randomised controlled trial in intensive care unit (ICU) patients within 24 hours of intubation in Vietnam. Patients were randomly assigned 1:1 to receive either continuous CPC using an automated electronic device or intermittent CPC using a manually hand-held manometer. The primary endpoint was the occurrence of VARI, evaluated by an independent reviewer blinded to the CPC allocation.

Results: We randomised 600 patients, 597 received the intervention or control and were included in the intention to treat analysis. Compared with intermittent CPC, continuous CPC did not reduce the proportion of patients with at least one episode of VARI [74/296 (25%) vs. 69/301 (23%); odds ratio (OR) 1.13; 95%CI 0.77-1.67]. There were no significant differences between continuous and intermittent CPC concerning the proportion of microbiologically confirmed VARI (OR 1.40; 95%CI 0.94- 2.10), the proportion of intubated days without antimicrobials [relative proportion (RP) 0.99; 95%CI 0.87-1.12], rate of ICU discharge [cause-specific hazard ratio (HR) 0.95; 95%CI 0.78-1.16], cost of ICU stay [difference in transformed mean (DTM) 0.02; 95%CI -0.05-0.08], cost of ICU antimicrobials (DTM 0.02; 95%CI -0.25-0.28), cost of hospital stay (DTM 0.02; 95%CI -0.04-0.08) and ICU mortality risk (OR 0.96; 95%CI 0.67-1.38).

Conclusions: Maintaining CPC through an automated electronic device did not reduce VARI incidence.

Clinical Trial Registration: NCT02966392.
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http://dx.doi.org/10.1093/cid/ciab724DOI Listing
August 2021

Defining the Role of Cellular Immune Signatures in Diagnostic Evaluation of Suspected Tuberculosis.

J Infect Dis 2021 Jul 31. Epub 2021 Jul 31.

TB Research Centre, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Background: Diagnosis of paucibacillary tuberculosis (TB) including extrapulmonary TB is a significant challenge, particularly in high-income, low-incidence settings. Measurement of Mycobacterium tuberculosis (Mtb)-specific cellular immune signatures by flow cytometry discriminates active TB from latent TB infection (LTBI) in case-control studies; however, their diagnostic accuracy and clinical utility in routine clinical practice is unknown.

Methods: Using a nested case-control study design within a prospective multicenter cohort of patients presenting with suspected TB in England, we assessed diagnostic accuracy of signatures in 134 patients who tested interferon-gamma release assay (IGRA)-positive and had final diagnoses of TB or non-TB diseases with coincident LTBI. Cellular signatures were measured using flow cytometry.

Results: All signatures performed less well than previously reported. Only signatures incorporating measurement of phenotypic markers on functional Mtb-specific CD4 T cells discriminated active TB from non-TB diseases with LTBI. The signatures measuring HLA-DR+IFNγ + CD4 T cells and CD45RA-CCR7-CD127- IFNγ -IL-2-TNFα + CD4 T cells performed best with 95% positive predictive value (95% confidence interval, 90-97) in the clinically challenging subpopulation of IGRA-positive but acid-fast bacillus (AFB) smear-negative TB suspects.

Conclusions: Two cellular immune signatures could improve and accelerate diagnosis in the challenging group of patients who are IGRA-positive, AFB smear-negative, and have paucibacillary TB.
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http://dx.doi.org/10.1093/infdis/jiab311DOI Listing
July 2021

Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms.

J Multidiscip Healthc 2021 10;14:1395-1402. Epub 2021 Jun 10.

Internal Medicine Faculty, Hanoi Medical University, Hanoi, Vietnam.

Purpose: Using psychobiotics to modify the gut microbiome has been shown to improve the anxiety and depression situation of patients with chronic gastrointestinal (GI) symptoms. This study evaluated changes in depression, anxiety, GI symptomss and side effects when patients used a multispecies probiotics product.

Patients And Methods: A single-center uncontrolled trial was conducted in patients with chronic GI symptoms, anxiety and depression who used a multispecies probiotics product. The patients were screened for anxiety and depression symptoms using the Hospital Anxiety and Depression Scale (HADS). Those who had a component score of 8 or higher were given the multispecies probiotics product for 2 months and followed up after 1 and 2 months. All data are collected and managed in a case report form.

Results: Eighty-three patients were enrolled, with a mean age (SD) of 43.9 (12.3) years; 73.5% of the patients were female. Of these patients, 8 met the Rome IV criteria for irritable bowel syndrome. The HADS scores displayed significant improvement at follow-up. The mean (SD) total HADS scores were 20.0 (6.3), 7.2 (5.4), and 4.9 (5.1) at baseline, 1 month, and 2 months, respectively. Quality of life also improved significantly. A small proportion (<5%) of patients developed mild symptoms, including fullness, diarrhea, and sleep complaints.

Conclusion: After 2 months using the probiotic product, the symptoms of anxiety and depression improved significantly. Mild gastrointestinal or constitutional symptoms developed in some patients.
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http://dx.doi.org/10.2147/JMDH.S312316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203266PMC
June 2021

A Deep Learning Method for 3D Object Classification and Retrieval Using the Global Point Signature Plus and Deep Wide Residual Network.

Sensors (Basel) 2021 Apr 9;21(8). Epub 2021 Apr 9.

Department of IT Convergence and Application Engineering, Pukyong National University, Busan 48513, Korea.

A vital and challenging task in computer vision is 3D Object Classification and Retrieval, with many practical applications such as an intelligent robot, autonomous driving, multimedia contents processing and retrieval, and augmented/mixed reality. Various deep learning methods were introduced for solving classification and retrieval problems of 3D objects. Almost all view-based methods use many views to handle spatial loss, although they perform the best among current techniques such as View-based, Voxelization, and Point Cloud methods. Many views make network structure more complicated due to the parallel Convolutional Neural Network (CNN). We propose a novel method that combines a Global Point Signature Plus with a Deep Wide Residual Network, namely GPSP-DWRN, in this paper. Global Point Signature Plus (GPSPlus) is a novel descriptor because it can capture more shape information of the 3D object for a single view. First, an original 3D model was converted into a colored one by applying GPSPlus. Then, a 32 × 32 × 3 matrix stored the obtained 2D projection of this color 3D model. This matrix was the input data of a Deep Residual Network, which used a single CNN structure. We evaluated the GPSP-DWRN for a retrieval task using the Shapnetcore55 dataset, while using two well-known datasets-ModelNet10 and ModelNet40 for a classification task. Based on our experimental results, our framework performed better than the state-of-the-art methods.
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http://dx.doi.org/10.3390/s21082644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070544PMC
April 2021

Late Pleistocene-Holocene sedimentary evolution in the coastal zone of the Red River Delta.

Heliyon 2021 Jan 19;7(1):e05872. Epub 2021 Jan 19.

North Vietnam Geological Mapping Division, DGMV, Ai Mo, Gia Lam, Hanoi, Viet Nam.

The Red River Delta is considered one of the largest megadelta systems in Asia. The formation of this delta has been controlled by the continent-ocean interaction and sea-level fluctuation during the Cenozoic. In this study, we present a new sequence stratigraphic framework of the Red River Delta based on borehole lithofacies analysis and high resolution seismic data. The Late Pleistocene-Holocene sediments in the coastal zone of the Red River Delta were subdivided into three systems tracts: (1) the lowstand systems tract (LST) is characterized by a Late Pleistocene alluvial silty sand facies complex (arLSTQ ); (2) the transgressive systems tract (TST) is illustrated by the coastal marsh facies complex and the lagoonal greenish-gray clay facies of Early-Middle Holocene (amt, mtTSTQ ); and (3) the highstand systems tract (HST) is composed of the Middle-Late Holocene deltaic clayish silt facies complex (amhHSTQ ). The boundaries between these three systems tracts are not isochronous, namely: (1) The LST-HST boundary has been associated with the Würm 2 Glaciation, which occurred at ~40-18 Ka.; (2) The TST-LST boundary is identified by a transgressive erosion surface, whose age ranges from ~12-5 Ka.; and (3) the HST-TST boundary is an unconformity between the submarine deltaic facies complex and the Middle Holocene marine flooding plain.
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http://dx.doi.org/10.1016/j.heliyon.2020.e05872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820486PMC
January 2021

Evaluation of the dioxin-like toxicity in soil samples from Thua Thien Hue province using the AhR-CALUX bioassay - An update of Agent Orange contamination in Vietnam.

Ecotoxicol Environ Saf 2021 Apr 26;212:111971. Epub 2021 Jan 26.

Analytical, Environmental and Geo-Chemistry laboratory (AMGC), Vrije Universiteit Brussel (University of Brussels), Pleinlaan 2, 1050 Brussels, Belgium.

In this study, an AhR-responsive reporter-gene cell-based bioassay CALUX was used to assess the biological potency of dioxins and dioxin-like PCBs (dl-PCBs) in top soil samples collected from a former airbase (A-So) and remote regions from urban and agricultural areas in Thua Thien Hue, Vietnam. In top soil collected from A-So airbase, Bioanalytical EQuivalent (BEQ) concentrations of up to 2700 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) per g dry weight (pg BEQ-TCDD g dw) were assessed. Interestingly, while BEQ values for dl-PCBs were found to be up to 13 pg BEQ-TCDD g dw, the dl-PCB activity was not detected in all the hotspot sample extracts. In contrasts, BEQ values for dioxin like compounds from remote regions were much lower and occasionally below the quantification limits of the method. The BEQ activities obtained in this study have a similar trend to the WHO-TEQ results for the samples collected in the A-So airbase. However, BEQ values were higher than those of TEQ, probably reflecting the presence of additional AhR ligands and/or possible non-additive interactions in the sample mixture. This study confirms that after more than 60 years, a strong residual pollution of PCDD/Fs remains on this former air base following the use and storage of Agent Orange during the Vietnam War, raising a health risk for populations exposed in this area because livestock animals graze there.
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http://dx.doi.org/10.1016/j.ecoenv.2021.111971DOI Listing
April 2021

Transcriptomic signatures for diagnosing tuberculosis in clinical practice: a prospective, multicentre cohort study.

Lancet Infect Dis 2021 03 25;21(3):366-375. Epub 2021 Jan 25.

Tuberculosis Research Centre, National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

Background: Blood transcriptomic signatures for diagnosis of tuberculosis have shown promise in case-control studies, but none have been prospectively designed or validated in adults presenting with the full clinical spectrum of suspected tuberculosis, including extrapulmonary tuberculosis and common differential diagnoses that clinically resemble tuberculosis. We aimed to evaluate the diagnostic accuracy of transcriptomic signatures in patients presenting with clinically suspected tuberculosis in routine practice.

Methods: The Validation of New Technologies for Diagnostic Evaluation of Tuberculosis (VANTDET) study was nested within a prospective, multicentre cohort study in secondary care in England (IDEA 11/H0722/8). Patients (aged ≥16 years) suspected of having tuberculosis in the routine clinical inpatient and outpatient setting were recruited at ten National Health Service hospitals in England for IDEA and were included in VANTDET if they provided consent for genomic analysis. Patients had whole blood taken for microarray analysis to measure abundance of transcripts and were followed up for 6-12 months to determine final diagnoses on the basis of predefined diagnostic criteria. The diagnostic accuracy of six signatures derived from the cohort and three previously published transcriptomic signatures with potentially high diagnostic performance were assessed by calculating area under the receiver-operating characteristic curves (AUC-ROCs), sensitivities, and specificities.

Findings: Between Nov 25, 2011, and Dec 31, 2013, 1162 participants were enrolled. 628 participants (aged ≥16 years) were included in the analysis, of whom 212 (34%) had culture-confirmed tuberculosis, 89 (14%) had highly probable tuberculosis, and 327 (52%) had tuberculosis excluded. The novel signature with highest performance for identifying all active tuberculosis gave an AUC-ROC of 0·87 (95% CI 0·81-0·92), sensitivity of 77% (66-87), and specificity of 84% (74-91). The best-performing published signature gave an AUC-ROC of 0·83 (0·80-0·86), sensitivity of 78% (73-83), and specificity of 76% (70-80). For detecting highly probable tuberculosis, the best novel signature yielded results of 0·86 (0·71-0·95), 77% (56-94%), and 77% (57-95%). None of the relevant cohort-derived or previously published signatures achieved the WHO-defined targets of paired sensitivity and specificity for a non-sputum-based diagnostic test.

Interpretation: In a clinically representative cohort in routine practice in a low-incidence setting, transcriptomic signatures did not have adequate accuracy for diagnosis of tuberculosis, including in patients with highly probable tuberculosis where the unmet need is greatest. These findings suggest that transcriptomic signatures have little clinical utility for diagnostic assessment of suspected tuberculosis.

Funding: National Institute for Health Research.
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http://dx.doi.org/10.1016/S1473-3099(20)30928-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907671PMC
March 2021

Future projections of flood dynamics in the Vietnamese Mekong Delta.

Sci Total Environ 2020 Nov 29;742:140596. Epub 2020 Jun 29.

GFZ German Research Center for Geosciences, Section Hydrology, Potsdam 14473, Germany.

The annual flood pulse of the Mekong River is crucial to sustain agriculture production, nutrition, and the livelihood of millions of people living in the Vietnamese part of the Mekong Delta (VMD). However, climate change impacts on precipitation, temperature and sea-level combined with land subsidence, upstream hydropower development, and water infrastructures (i.e. high-dykes construction) are altering the hydrological regime of the VMD. This study investigates future changes in flood hazard and agricultural production caused by these different scales of human-induced stresses. A quasi- two-dimensional (quasi-2D) hydrodynamic model was used to simulate eight scenarios representing the individual and compound impacts of these drivers for a baseline (1971-2000) and future (2036-2065) period. The scenarios map the most likely future pathway of climate change (RCP 4.5) combined with the best available Mekong upstream hydropower development, and land subsidence scenarios as well as the current delta development plan. We found that sea-level rise and land subsidence would cause the highest changes in flood hazard and damage to rice crop, followed by hydropower and climate change impacts. Expansion of high-dyke areas in two northernmost delta provinces (An Giang and Dong Thap) would have the smallest impact. The combination of all modelled drivers is projected to increase delta inundation extent by 20%, accompanied with prolonging submergence of 1-2 months, and 2-3 times increase in annual flood damage to rice crops in the flood-prone areas of the VMD. These findings of likely increasing risk of tidal induced flood hazard and damage call for well-planned adaptation and mitigation measures, both structural and non-structural.
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http://dx.doi.org/10.1016/j.scitotenv.2020.140596DOI Listing
November 2020

Optimal control of a fractional order model for granular SEIR epidemic with uncertainty.

Commun Nonlinear Sci Numer Simul 2020 Sep 30;88:105312. Epub 2020 Apr 30.

Department of Mathematics, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran.

In this study, we present a general formulation for the optimal control problem to a class of fuzzy fractional differential systems relating to SIR and SEIR epidemic models. In particular, we investigate these epidemic models in the uncertain environment of fuzzy numbers with the rate of change expressed by granular Caputo fuzzy fractional derivatives of order  ∈ (0, 1]. Firstly, the existence and uniqueness of solution to the abstract fractional differential systems with fuzzy parameters and initial data are proved. Next, the optimal control problem for this fractional system is proposed and a necessary condition for the optimality is obtained. Finally, some examples of the fractional SIR and SEIR models are presented and tested with real data extracted from COVID-19 pandemic in Italy and South Korea.
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http://dx.doi.org/10.1016/j.cnsns.2020.105312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338880PMC
September 2020

ITFDS: Channel-Aware Integrated Time and Frequency-Based Downlink LTE Scheduling in MANET.

Sensors (Basel) 2020 Jun 16;20(12). Epub 2020 Jun 16.

Department of Computer Science and Engineering, GIET University, Gunupur 765022, India.

One of the crucial problems in Industry 4.0 is how to strengthen the performance of mobile communication within mobile ad-hoc networks (MANETs) and mobile computational grids (MCGs). In communication, Industry 4.0 needs dynamic network connectivity with higher amounts of speed and bandwidth. In order to support multiple users for video calling or conferencing with high-speed transmission rates and low packet loss, 4G technology was introduced by the 3G Partnership Program (3GPP). 4G LTE is a type of 4G technology in which LTE stands for Long Term Evolution, followed to achieve 4G speeds. 4G LTE supports multiple users for downlink with higher-order modulation up to 64 quadrature amplitude modulation (QAM). With wide coverage, high reliability and large capacity, LTE networks are widely used in Industry 4.0. However, there are many kinds of equipment with different quality of service (QoS) requirements. In the existing LTE scheduling methods, the scheduler in frequency domain packet scheduling exploits the spatial, frequency, and multi-user diversity to achieve larger MIMO for the required QoS level. On the contrary, time-frequency LTE scheduling pays attention to temporal and utility fairness. It is desirable to have a new solution that combines both the time and frequency domains for real-time applications with fairness among users. In this paper, we propose a channel-aware Integrated Time and Frequency-based Downlink LTE Scheduling (ITFDS) algorithm, which is suitable for both real-time and non-real-time applications. Firstly, it calculates the channel capacity and quality using the channel quality indicator (CQI). Additionally, data broadcasting is maintained by using the dynamic class-based establishment (DCE). In the time domain, we calculate the queue length before transmitting the next packets. In the frequency domain, we use the largest weight delay first (LWDF) scheduling algorithm to allocate resources to all users. All the allocations would be taken placed in the same transmission time interval (TTI). The new method is compared against the largest weighted delay first (LWDF), proportional fair (PF), maximum throughput (MT), and exponential/proportional fair (EXP/PF) methods. Experimental results show that the performance improves by around 12% compared with those other algorithms.
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http://dx.doi.org/10.3390/s20123394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348730PMC
June 2020

Economic burden of venous thromboembolism in surgical patients: A propensity score analysis from the national claims database in Vietnam.

PLoS One 2020 9;15(4):e0231411. Epub 2020 Apr 9.

Department of Scientific Research and International Cooperation, Hanoi Medical University Hospital, Hanoi, Vietnam.

Background: Venous thromboembolism (VTE) associated with surgery can cause serious comorbidities or death and imposes a substantial economic burden to society. The study examined VTE cases after surgery to determined how this condition imposed an economic burden on patients based on the national health insurance reimbursement database. Methods: This retrospective analysis adopted the public payer's perspective. The direct medical cost was estimated using data from the national claims database of Vietnam from Jan 1, 2017 to Sep 31, 2018. Adult patients who underwent surgeries were recruited for the study. Patients with a diagnostic code of up to 90 days after surgery were considered VTE cases with the outcome measure being the surgery-related costs within 90 days.

Results: The 90-day cost of VTE patients was found to be US$2,939. The rate of readmission increased by 5.4 times, the rate of outpatient visits increased by 1.8 times and total costs over 90 days in patients with VTE undergoing surgery increased by 2.2 times. Estimation using propensity score matching method showed that an increase of US$1,019 in the 90-day cost of VTE patients.

Conclusion: The VTE-related costs can be used to assess the potential economic benefit and cost-savings from prevention efforts.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231411PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145013PMC
July 2020

Hypertension in a mountainous province of Vietnam: prevalence and risk factors.

Heliyon 2020 Feb 8;6(2):e03383. Epub 2020 Feb 8.

Department of Human and Animal Physiology, Faculty of Biology, Hanoi National University of Education, Hanoi, Viet Nam.

Background: Hypertension (HTN) significantly contributes to global disease burden, and its prevalence varies amongst different countries and regions. This work is aimed to characterize the hypertensive prevalence and identify risk factors for HTN among the residents in five locations (four communes and one town) of Moc Chau district (Son La province, Vietnam).

Methods: A cross-sectional study with a cross-sectional methodology was done in selected places from August 2018 to December 2018. We interviewed 197 participants aged equal to or more than 18 years old and measured their blood pressure (BP). Univariate and multivariate logistic regression were applied.

Results: The overall HTN prevalence of 30.0% was recorded. The differences of HTN prevalence rates were seen by several characters including age groups (p <0.001), accompanying disease (p <0.001) and alcohol drinking (p <0.05). Factors independently associated with hypertension were age (ORs: 3.1 [1.1-9.1]; 6.1 [1.7-22.3]), much salty consumption (OR: 2.6 [1.1-6.6]), alcohol use (OR: 3.1 [1.2-8.1]), HTN familial history (OR: 4.2 [1.3-13.3]) and at least one suffering disease (OR: 5.2 [2.1-12.7]).

Conclusions: Thus, this study highlighted the high overall HTN prevalence in the Vietnam Northwestern region. Significant differences of HTN rate were observed among several characteristics such as age groups, accompanying disease and alcohol drinking. Age group, much salty consumption, alcohol use, hypertension familial history and at least one suffering disease were risk factors for HTN in study group.
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http://dx.doi.org/10.1016/j.heliyon.2020.e03383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015972PMC
February 2020

Interstitial Lymphatic Embolization with Balloon Assistance for Treatment of Chyluria.

J Vasc Interv Radiol 2020 03 29;31(3):523-526. Epub 2020 Jan 29.

Department of Respiratory Medicine, Hanoi French Hospital, 1 Phuong Mai St., Dong Da District, 10000 Hanoi, Vietnam.

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http://dx.doi.org/10.1016/j.jvir.2019.09.025DOI Listing
March 2020

Multi-residue analytical method for trace detection of new-generation pesticides in vegetables using gas chromatography-tandem mass spectrometry.

J Environ Sci Health B 2020 27;55(5):417-428. Epub 2019 Dec 27.

Institute of Chemistry, Analytical Chemistry, Karl Franzens Univeristy, Graz, Austria.

A GC-MS/MS method with low solvent consumption and easy operation was developed to simultaneously determine ten new-generation pesticides, namely fenobucarb, acetochlor, pretilachlor, fipronil, trifloxystrobin, fluazifop-p-butyl, isoprothiolane, tebuconazole, cypermethrin and difenoconazole in leafy vegetables. Influences from ultrasonic sample extraction and the clean-up steps to reduce matrix effects were investigated. Under suitable conditions, good linearity (deviation of back calculated concentration from true concentration lower than 20%) was achieved for all studied pesticides; the method detection limits (MDLs) ranged from 1.4 to 3.6 ng g wet weight. For mustard green and green onion the method yielded good recoveries at two spiking levels (20 and 100 ng g) ranging from 80% to 111% ( = 5). The repeatability, expressed as relative standard deviation (RSD), was lower than 11% ( = 5). The method was successfully used to quantify pesticide residues in 207 vegetable samples (green onions, mustard greens, and lettuce) collected in Thua Thien Hue and Quang Binh Provinces, Central Vietnam. The insecticide cypermethrin was found at critical levels in 98% of the vegetable samples. Green onions had high pesticide residues with a significant number of samples containing pesticides at concentrations exceeding the maximum residue levels (MRLs).
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http://dx.doi.org/10.1080/03601234.2019.1707585DOI Listing
July 2020

Diversity and Distribution of Rice Blast ( Cavara) Races in Vietnam.

Plant Dis 2020 Feb 16;104(2):381-387. Epub 2019 Dec 16.

Tropical Agricultural Research Front, Japan International Research Center for Agricultural Sciences, Maezato, Ishigaki, Okinawa 907-0002, Japan.

A total of 239 isolates of blast ( Cavara) collected from northern and central Vietnam showed a wide variation in pathogenicity based on the reaction patterns to 25 differential varieties (DVs) harboring 23 resistance genes and susceptible cultivar Lijiangxintuanheigu (LTH). The frequencies of isolates virulent toward DVs for , , , , , , (t), (t), , , and were low, but they were high for DVs for , , , , , (t), , , , (t), (t), and (t). Isolates were classified into three cluster groups Ia, Ib, and II based on reaction patterns to DVs and LTH. The frequencies of isolates virulent toward 11 DVs for , , , , , (t), (t), , , , and in cluster II and DV for were higher and lower than those of Ia and Ib, respectively. The frequencies to DVs for , , (t), and were different between clusters Ia and Ib. Clusters Ia and Ib were distributed with similar frequencies in the northeast, north central, and south central coast regions, but the frequencies among three cluster groups in the Red River Delta and northwest regions were different. This means that the blast races in these two regions were different from the others. Overall, the blast isolates were categorized into 153 races. Among them, 26 were selected as a set of standard differential blast isolates for characterizing 23 resistance genes and developing a differential system in Vietnam.
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http://dx.doi.org/10.1094/PDIS-05-19-1008-REDOI Listing
February 2020

Metabolomic, transcriptomic and genetic integrative analysis reveals important roles of adenosine diphosphate in haemostasis and platelet activation in non-small-cell lung cancer.

Mol Oncol 2019 11 30;13(11):2406-2421. Epub 2019 Sep 30.

National Heart and Lung Institute, Faculty of Medicine, Imperial College London, UK.

Lung cancer is the leading cause of cancer-related deaths in the world. The most prevalent subtype, accounting for 85% of cases, is non-small-cell lung cancer (NSCLC). Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are the most common subtypes. Despite recent advances in treatment, the low 5-year survival rate of NSCLC patients (approximately 13%) reflects the lack of early diagnostic biomarkers and incomplete understanding of the underlying disease mechanisms. We hypothesized that integration of metabolomic, transcriptomic and genetic profiles of tumours and matched normal tissues could help to identify important factors and potential therapeutic targets that contribute to tumorigenesis. We integrated omics profiles in tumours and matched adjacent normal tissues of patients with LUSC (N = 20) and LUAD (N = 17) using multiple system biology approaches. We confirmed the presence of previously described metabolic pathways in NSCLC, particularly those mediating the Warburg effect. In addition, through our combined omics analyses we found that metabolites and genes that contribute to haemostasis, angiogenesis, platelet activation and cell proliferation were predominant in both subtypes of NSCLC. The important roles of adenosine diphosphate in promoting cancer metastasis through platelet activation and angiogenesis suggest this metabolite could be a potential therapeutic target.
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http://dx.doi.org/10.1002/1878-0261.12568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822241PMC
November 2019

Linear quadratic regulator problem governed by granular neutrosophic fractional differential equations.

ISA Trans 2020 Feb 5;97:296-316. Epub 2019 Aug 5.

Department of Mathematics, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran. Electronic address:

Quadratic cost functions estimation in the linear optimal control systems governed by differential equations (DEs) or partial differential equations (PDEs) has a well-established discipline in mathematics with many interfaces to science and engineering. During its development, the impact of uncertain phenomena to objective function and the complexity of the systems to be controlled have also increased significantly. Many engineering problems like magnetohydromechanical, electromagnetical and signal analysis for the transmission and propagation of electrical signals under uncertain environment can be dealt with. In this paper, we study the optimal control problem with operating a fractional DEs and PDEs at minimum quadratic objective function in the framework of neutrosophic environment and granular computing. However, there has been no studies appeared on the neutrosophic calculus of fractional order. Hence, we will introduce some derivatives of fractional order, including the neutrosophic Riemann-Liouville fractional derivatives and neutrosophic Caputo fractional derivatives. Next, we propose a new setting of two important problems in engineering. In the first problem, we investigate the numerical and exact solutions of some neutrosophic fractional DEs and neutrosophic telegraph PDEs. In the second problem, we study the optimality conditions together with the simulation of states of a linear quadratic optimal control problem governed by neutrosophic fractional DEs and PDEs. Some key applications to DC motor model and one-link robot manipulator model are investigated to prove the effectiveness and correctness of the proposed method.
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http://dx.doi.org/10.1016/j.isatra.2019.08.006DOI Listing
February 2020

Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza.

Eur Respir J 2019 10 24;54(4). Epub 2019 Oct 24.

National Heart and Lung Institute, Imperial College London, St Mary's Campus, London, UK

Background: Patients with asthma are at risk of hospitalisation with influenza, but the reasons for this predisposition are unknown.

Study Setting: A prospective observational study of adults with PCR-confirmed influenza in 11 UK hospitals, measuring nasal, nasopharyngeal and systemic immune mediators and whole-blood gene expression.

Results: Of 133 admissions, 40 (30%) had previous asthma; these were more often female (70% 38.7%, OR 3.69, 95% CI 1.67-8.18; p=0.0012), required less mechanical ventilation (15% 37.6%, Chi-squared 6.78; p=0.0338) and had shorter hospital stays (mean 8.3 15.3 days, p=0.0333) than those without. In patients without asthma, severe outcomes were more frequent in those given corticosteroids (OR 2.63, 95% CI 1.02-6.96; p=0.0466) or presenting >4 days after disease onset (OR 5.49, 95% CI 2.28-14.03; p=0.0002). Influenza vaccination in at-risk groups (including asthma) were lower than intended by national policy and the early use of antiviral medications were less than optimal. Mucosal immune responses were equivalent between groups. Those with asthma had higher serum interferon (IFN)-α, but lower serum tumour necrosis factor, interleukin (IL)-5, IL-6, CXCL8, CXCL9, IL-10, IL-17 and CCL2 levels (all p<0.05); both groups had similar serum IL-13, total IgE, periostin and blood eosinophil gene expression levels. Asthma diagnosis was unrelated to viral load, IFN-α, IFN-γ, IL-5 or IL-13 levels.

Conclusions: Asthma is common in those hospitalised with influenza, but may not represent classical type 2-driven disease. Those admitted with influenza tend to be female with mild serum inflammatory responses, increased serum IFN-α levels and good clinical outcomes.
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http://dx.doi.org/10.1183/13993003.00949-2019DOI Listing
October 2019

A New Approach for Construction of Geodemographic Segmentation Model and Prediction Analysis.

Comput Intell Neurosci 2019 13;2019:9252837. Epub 2019 May 13.

Digital Contents Research Institute, Sejong University, Seoul 143-747, Republic of Korea.

Customer retention is invariably the top priority of all consumer businesses, and certainly it is one of the most critical challenges as well. Identifying and gaining insights into the most probable cause of churn can save from five to ten times in terms of cost for the company compared with finding new customers. Therefore, this study introduces a full-fledged geodemographic segmentation model, assessing it, testing it, and deriving insights from it. A bank dataset consisting 11,000 instances, which consists of 10,000 instances for training and 10,000 instances for testing, with 14 attributes, has been used, and the likelihood of a person staying with the bank or leaving the bank is computed with the help of logistic regression. Base on the proposed model, insights are drawn and recommendations are provided. Stepwise logistic regression methods, namely, backward elimination method, forward selection method, and bidirectional model are constructed and contrasted to choose the best among them. Future forecasting of the models has been done by using cumulative accuracy profile (CAP) curve analysis.
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http://dx.doi.org/10.1155/2019/9252837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545749PMC
December 2019

Endoscopic carpal tunnel release surgery: a case study in Vietnam.

J Orthop Surg Res 2019 May 24;14(1):149. Epub 2019 May 24.

VietDuc University Hospital, 40 Tràng Thi, Hàng Bông, Hoàn Kiếm, Hanoi, 10000, Vietnam.

Background: This study aims at investigating the outcome and electrophysiologic recovery of 150 carpal tunnel syndrome hands after single-portal endoscopic surgery.

Methods: Patients with the cross-sectional area of the median nerve being 13-15 mm on ultrasound or abnormal sensory nerve conduction velocity on EMG are assigned to endoscopic surgery that cuts the decompressing transverse ligament to avoid the emergence of severe symptoms, such as muscular atrophy and loss of hand function.

Results: Single-portal endoscopic release is a safe and efficacious option for carpal tunnel release. The findings demonstrate encouraging results.

Conclusion: The endoscopic carpal tunnel release with the placement of a MicroAire system is a safe and effective method for treating carpal tunnel syndrome.
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http://dx.doi.org/10.1186/s13018-019-1192-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533663PMC
May 2019

HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease.

Hum Immunol 2019 Sep 20;80(9):731-738. Epub 2019 May 20.

Department of Pathology, HLA Laboratory, Penn State Hershey Medical Center, Hershey, PA, USA.

Kawasaki disease (KD) is a pediatric vasculitis caused by an unknown trigger in genetically susceptible children. The incidence varies widely across genetically diverse populations. Several associations with HLA Class I alleles have been reported in single cohort studies. Using a genetic approach, from the nine single nucleotide variants (SNVs) associated with KD susceptibility in children of European descent, we identified SNVs near the HLA-C (rs6906846) and HLA-B genes (rs2254556) whose association was replicated in a Japanese descent cohort (rs6906846 p = 0.01, rs2254556 p = 0.005). The risk allele (A at rs6906846) was also associated with HLA-C*07:02 and HLA-C*04:01 in both US multi-ethnic and Japanese cohorts and HLA-C*12:02 only in the Japanese cohort. The risk A-allele was associated with eight non-conservative amino acid substitutions (amino acid positions); Asp or Ser (9), Arg (14), Ala (49), Ala (73), Ala (90), Arg (97), Phe or Ser (99), and Phe or Ser (116) in the HLA-C peptide binding groove that binds peptides for presentation to cytotoxic T cells (CTL). This raises the possibility of increased affinity to a "KD peptide" that contributes to the vasculitis of KD in genetically susceptible children.
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http://dx.doi.org/10.1016/j.humimm.2019.04.020DOI Listing
September 2019

Extensive Ethnic Variation and Linkage Disequilibrium at the Locus: Different Genetic Associations Revealed in Kawasaki Disease.

Front Immunol 2019 21;10:185. Epub 2019 Mar 21.

Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

The human Fc-gamma receptors (FcγRs) link adaptive and innate immunity by binding immunoglobulin G (IgG). All human low-affinity FcγRs are encoded by the locus containing functional single nucleotide polymorphisms (SNPs) and gene copy number variants. This locus is notoriously difficult to genotype and high-throughput methods commonly used focus on only a few SNPs. We performed multiplex ligation-dependent probe amplification for all relevant genetic variations at the locus in >4,000 individuals to define linkage disequilibrium (LD) and allele frequencies in different populations. Strong LD and extensive ethnic variation in allele frequencies was found across the locus. LD was strongest for the -ORF haplotype (rs759550223+rs76277413), which leads to expression of FcγRIIc. In Europeans, the -ORF haplotype showed strong LD with, among others, rs201218628 (-Q27W, = 0.63). LD between these two variants was weaker ( = 0.17) in Africans, whereas the -ORF haplotype was nearly absent in Asians (minor allele frequency <0.005%). The -ORF haplotype and rs1801274 (-H131R) were in weak LD ( = 0.08) in Europeans. We evaluated the importance of ethnic variation and LD in Kawasaki Disease (KD), an acute vasculitis in children with increased incidence in Asians. An association of rs1801274 with KD was previously shown in ethnically diverse genome-wide association studies. Now, we show in 1,028 European KD patients that the -ORF haplotype, although nearly absent in Asians, was more strongly associated with susceptibility to KD than rs1801274 in Europeans. Our data illustrate the importance of interpreting findings of association studies concerning the locus with knowledge of LD and ethnic variation.
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http://dx.doi.org/10.3389/fimmu.2019.00185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437109PMC
January 2020

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Nat Immunol 2019 Mar;20(3):373

Respiratory Infection Section, National Heart and Lung Institute, Imperial College London, London, UK.

In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE project 602525. The error has been corrected in the HTML and PDF version of the article.
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http://dx.doi.org/10.1038/s41590-019-0328-yDOI Listing
March 2019

C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting - a cost benefit analysis.

Antimicrob Resist Infect Control 2018 4;7:119. Epub 2018 Oct 4.

1Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Aim: We assess the cost-benefit implications of C-reactive protein (CRP) testing in reducing antibiotic prescription for acute respiratory infection in Viet Nam by comparing the incremental costs of CRP testing with the economic costs of antimicrobial resistance averted due to lower antibiotic prescribing.

Findings: Patients in the CRP group and the controls incurred similar costs in managing their illness, excluding the costs of the quantitative CRP tests, provided free of charge in the trial context. Assuming a unit cost of $1 per test, the incremental cost of CRP testing was $0.93 per patient. Based on a previous modelling analysis, the 20 percentage point reduction in prescribing observed in the trial implies a societal benefit of $0.82 per patient. With the low levels of adherence to the test results observed in the trial, CRP testing would not be cost-beneficial. The sensitivity analyses showed, however, that with higher adherence to test results their use would be cost-beneficial.
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http://dx.doi.org/10.1186/s13756-018-0414-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172744PMC
September 2019

The Mekong's future flows under multiple drivers: How climate change, hydropower developments and irrigation expansions drive hydrological changes.

Sci Total Environ 2019 Feb 17;649:601-609. Epub 2018 Aug 17.

Water Systems and Global Change Group, Wageningen University, P.O. Box 47, 6700 AA Wageningen, the Netherlands.

The river flow regime and water resources are highly important for economic growths, flood security, and ecosystem dynamics in the Mekong basin - an important transboundary river basin in South East Asia. The river flow, although remains relatively unregulated, is expected to be increasingly perturbed by climate change and rapidly accelerating socioeconomic developments. Current understanding about hydrological changes under the combined impacts of these drivers, however, remains limited. This study presents projected hydrological changes caused by multiple drivers, namely climate change, large-scale hydropower developments, and irrigated land expansions by 2050s. We found that the future flow regime is highly susceptible to all considered drivers, shown by substantial changes in both annual and seasonal flow distribution. While hydropower developments exhibit limited impacts on annual total flows, climate change and irrigation expansions cause changes of +15% and -3% in annual flows, respectively. However, hydropower developments show the largest seasonal impacts characterized by higher dry season flows (up to +70%) and lower wet season flows (-15%). These strong seasonal impacts tend to outplay those of the other drivers, resulting in the overall hydrological change pattern of strong increases of the dry season flow (up to +160%); flow reduction in the first half of the wet season (up to -25%); and slight flow increase in the second half of the wet season (up to 40%). Furthermore, the cumulative impacts of all drivers cause substantial flow reductions during the early wet season (up to -25% in July), posing challenges for crop production and saltwater intrusion in the downstream Mekong Delta. Substantial flow changes and their consequences require careful considerations of future development activities, as well as timely adaptation to future changes.
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http://dx.doi.org/10.1016/j.scitotenv.2018.08.160DOI Listing
February 2019

Chemical weathering in central Vietnam from clay mineralogy and major-element geochemistry of sedimentary rocks and river sediments.

Heliyon 2018 Jul 25;4(7):e00710. Epub 2018 Jul 25.

Department of Marine Geology, Hanoi University of Mining and Geology, Vietnam.

Clay mineralogy and major-element geochemistry of Miocene sedimentary rock and modern river sediment samples collected from the Ba River basin in central Vietnam are used to evaluate the chemical weathering processes during the Miocene and the present time. The results show that Miocene andesitic sedimentary rocks consist of high smectite (average 72%) with moderate kaolinite (24%), while Miocene felsic sedimentary rocks display abundant kaolinite (65%) with moderate smectite (25%). In comparison, modern river sediments are characterized by moderate smectite (43%) and kaolinite (37%). The typical distribution of clay minerals in the Ba River basin can be resulted from abundant occurrence of felsic intrusive rocks and volcanic rocks along with weak tectonic uplift and the tropical East Asian monsoon climate during the Miocene and in the present time. Despite their different clay mineralogical compositions, major elements of these Miocene sedimentary rocks and modern river sediments display stronger depletion of Ca, Na and Mg than of K and Si during the chemical weathering. The chemical index of alteration (CIA) combined with kaolinite/illite ratio demonstrated moderate chemical weathering during the Miocene and in the present time in central Vietnam, demonstrating similar tectonic activity and climatic conditions occurred during these two periods.
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http://dx.doi.org/10.1016/j.heliyon.2018.e00710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074724PMC
July 2018

Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature.

JAMA Pediatr 2018 10 1;172(10):e182293. Epub 2018 Oct 1.

Section of Paediatrics, Imperial College London, London, United Kingdom.

Importance: To date, there is no diagnostic test for Kawasaki disease (KD). Diagnosis is based on clinical features shared with other febrile conditions, frequently resulting in delayed or missed treatment and an increased risk of coronary artery aneurysms.

Objective: To identify a whole-blood gene expression signature that distinguishes children with KD in the first week of illness from other febrile conditions.

Design, Setting, And Participants: The case-control study comprised a discovery group that included a training and test set and a validation group of children with KD or comparator febrile illness. The setting was pediatric centers in the United Kingdom, Spain, the Netherlands, and the United States. The training and test discovery group comprised 404 children with infectious and inflammatory conditions (78 KD, 84 other inflammatory diseases, and 242 bacterial or viral infections) and 55 healthy controls. The independent validation group comprised 102 patients with KD, including 72 in the first 7 days of illness, and 130 febrile controls. The study dates were March 1, 2009, to November 14, 2013, and data analysis took place from January 1, 2015, to December 31, 2017.

Main Outcomes And Measures: Whole-blood gene expression was evaluated using microarrays, and minimal transcript sets distinguishing KD were identified using a novel variable selection method (parallel regularized regression model search). The ability of transcript signatures (implemented as disease risk scores) to discriminate KD cases from controls was assessed by area under the curve (AUC), sensitivity, and specificity at the optimal cut point according to the Youden index.

Results: Among 404 patients in the discovery set, there were 78 with KD (median age, 27 months; 55.1% male) and 326 febrile controls (median age, 37 months; 56.4% male). Among 202 patients in the validation set, there were 72 with KD (median age, 34 months; 62.5% male) and 130 febrile controls (median age, 17 months; 56.9% male). A 13-transcript signature identified in the discovery training set distinguished KD from other infectious and inflammatory conditions in the discovery test set, with AUC of 96.2% (95% CI, 92.5%-99.9%), sensitivity of 81.7% (95% CI, 60.0%-94.8%), and specificity of 92.1% (95% CI, 84.0%-97.0%). In the validation set, the signature distinguished KD from febrile controls, with AUC of 94.6% (95% CI, 91.3%-98.0%), sensitivity of 85.9% (95% CI, 76.8%-92.6%), and specificity of 89.1% (95% CI, 83.0%-93.7%). The signature was applied to clinically defined categories of definite, highly probable, and possible KD, resulting in AUCs of 98.1% (95% CI, 94.5%-100%), 96.3% (95% CI, 93.3%-99.4%), and 70.0% (95% CI, 53.4%-86.6%), respectively, mirroring certainty of clinical diagnosis.

Conclusions And Relevance: In this study, a 13-transcript blood gene expression signature distinguished KD from other febrile conditions. Diagnostic accuracy increased with certainty of clinical diagnosis. A test incorporating the 13-transcript disease risk score may enable earlier diagnosis and treatment of KD and reduce inappropriate treatment in those with other diagnoses.
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http://dx.doi.org/10.1001/jamapediatrics.2018.2293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233768PMC
October 2018
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