Long Cai

Long Cai

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Publisher Correction: In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription.

Nat Biotechnol 2020 Feb;38(2):245

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

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http://dx.doi.org/10.1038/s41587-020-0432-4DOI Listing
February 2020

Inhibition of EZH2 Attenuates Sorafenib Resistance by Targeting NOTCH1 Activation-Dependent Liver Cancer Stem Cells via NOTCH1-Related MicroRNAs in Hepatocellular Carcinoma.

Transl Oncol 2020 Feb 21;13(3):100741. Epub 2020 Feb 21.

Central Laboratory, Zhejiang Chinese Medicine and Western Medicine Integrated Hospital (Hangzhou Red Cross Hospital), 208 Huancheng Dong Road, Hangzhou 310003, Zhejiang Province, People's Republic of China.

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http://dx.doi.org/10.1016/j.tranon.2020.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036423PMC
February 2020

In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription.

Nat Biotechnol 2020 01 18;38(1):66-75. Epub 2019 Nov 18.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

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http://dx.doi.org/10.1038/s41587-019-0299-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954335PMC
January 2020

Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior.

Cell 2019 Oct;179(3):713-728.e17

Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA, USA; Howard Hughes Medical Institute; Tianqiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.09.020DOI Listing
October 2019

Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.

Cell Syst 2019 Oct 16;9(4):321-337.e9. Epub 2019 Oct 16.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932747PMC
October 2019

Putrescine mitigates intestinal atrophy through suppressing inflammatory response in weanling piglets.

J Anim Sci Biotechnol 2019 10;10:69. Epub 2019 Sep 10.

1Key Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Feed Research Institute, Chinese Academy of Agricultural Sciences, No. 12 Zhongguancun South St., Haidian district, Beijing, 100081 China.

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http://dx.doi.org/10.1186/s40104-019-0379-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734277PMC
September 2019

Sandpaper as template for a robust superhydrophobic surface with self-cleaning and anti-snow/icing performances.

J Colloid Interface Sci 2019 Jul 15;548:224-232. Epub 2019 Apr 15.

Key Laboratory for Anisotropy and Texture of Materials, Ministry of Education, Northeastern University, Shenyang 110819, China. Electronic address:

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http://dx.doi.org/10.1016/j.jcis.2019.04.040DOI Listing
July 2019

Preparation of Cellulose Films from Sustainable CO/DBU/DMSO System.

Polymers (Basel) 2019 Jun 4;11(6). Epub 2019 Jun 4.

Department of Polymer Materials & Engineering, College of Materials & Metallurgy, Guizhou University, West Campus, Huaxi District, Guiyang 550025, China.

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http://dx.doi.org/10.3390/polym11060994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631611PMC
June 2019

Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH.

Nature 2019 04 25;568(7751):235-239. Epub 2019 Mar 25.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

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http://dx.doi.org/10.1038/s41586-019-1049-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544023PMC
April 2019

The adult human testis transcriptional cell atlas.

Cell Res 2018 12 12;28(12):1141-1157. Epub 2018 Oct 12.

Department of Oncological Sciences and Huntsman Cancer Institute, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.

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http://www.nature.com/articles/s41422-018-0099-2
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http://dx.doi.org/10.1038/s41422-018-0099-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274646PMC
December 2018

Identification of spatially associated subpopulations by combining scRNAseq and sequential fluorescence in situ hybridization data.

Nat Biotechnol 2018 Oct 29. Epub 2018 Oct 29.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://www.nature.com/doifinder/10.1038/nbt.4260
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http://dx.doi.org/10.1038/nbt.4260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488461PMC
October 2018

Characterization of pseudoparticles paired with hemagglutinin and neuraminidase from highly pathogenic H5N1 influenza and avian influenza A (H7N9) viruses.

Virus Res 2018 07 31;253:20-27. Epub 2018 May 31.

Central Laboratory, Hang Zhou Red Cross Hospital, Hangzhou city, Zhejiang Prov, 310003, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01681702183008
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http://dx.doi.org/10.1016/j.virusres.2018.05.024DOI Listing
July 2018

Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH.

Cell 2018 07 7;174(2):363-376.e16. Epub 2018 Jun 7.

Division of Biology and Biological Engineering, Caltech, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046268PMC
July 2018

Equitable access to global health internships: a documentary short.

Lancet Glob Health 2018 02;6(2):e145

Stitching Health Action International, Netherlands.

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http://dx.doi.org/10.1016/S2214-109X(17)30499-0DOI Listing
February 2018

Profiling the transcriptome with RNA SPOTs.

Nat Methods 2017 Dec 13;14(12):1153-1155. Epub 2017 Nov 13.

Division of Biology and Biological Engineering, Caltech, Pasadena, CA, USA.

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http://dx.doi.org/10.1038/nmeth.4500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819366PMC
December 2017

Identification of a neural crest stem cell niche by Spatial Genomic Analysis.

Nat Commun 2017 11 28;8(1):1830. Epub 2017 Nov 28.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

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http://dx.doi.org/10.1038/s41467-017-01561-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705662PMC
November 2017

Simultaneous identification and quantification of the common compounds of Viscum coloratum and its corresponding host plants by ultra-high performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry and triple quadrupole mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Sep 18;1061-1062:176-184. Epub 2017 Jul 18.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2017.07.028DOI Listing
September 2017

Multiplexed Dynamic Imaging of Genomic Loci by Combined CRISPR Imaging and DNA Sequential FISH.

Biophys J 2017 May 17;112(9):1773-1776. Epub 2017 Apr 17.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425380PMC
May 2017

seqFISH Accurately Detects Transcripts in Single Cells and Reveals Robust Spatial Organization in the Hippocampus.

Neuron 2017 May;94(4):752-758.e1

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.05.008DOI Listing
May 2017

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore.

Cell Chem Biol 2017 Mar 2;24(3):415-425. Epub 2017 Mar 2.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA; Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456173003
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http://dx.doi.org/10.1016/j.chembiol.2017.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357175PMC
March 2017

Synthetic recording and in situ readout of lineage information in single cells.

Nature 2017 01 21;541(7635):107-111. Epub 2016 Nov 21.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/nature20777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487260PMC
January 2017

In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus.

Neuron 2016 Oct;92(2):342-357

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273163070
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087994PMC
http://dx.doi.org/10.1016/j.neuron.2016.10.001DOI Listing
October 2016

Dense transcript profiling in single cells by image correlation decoding.

Nat Methods 2016 08 6;13(8):657-60. Epub 2016 Jun 6.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.

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http://dx.doi.org/10.1038/nmeth.3895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965285PMC
August 2016

Single-molecule RNA detection at depth by hybridization chain reaction and tissue hydrogel embedding and clearing.

Development 2016 08 24;143(15):2862-7. Epub 2016 Jun 24.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA

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http://dx.doi.org/10.1242/dev.138560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004914PMC
August 2016

Noncommutative Biology: Sequential Regulation of Complex Networks.

PLoS Comput Biol 2016 08 25;12(8):e1005089. Epub 2016 Aug 25.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999240PMC
August 2016

Combinatorial gene regulation by modulation of relative pulse timing.

Nature 2015 Nov 14;527(7576):54-8. Epub 2015 Oct 14.

Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

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http://authors.library.caltech.edu/59247/3/nature15710-s1.pd
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http://www.nature.com/doifinder/10.1038/nature15710
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http://dx.doi.org/10.1038/nature15710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870307PMC
November 2015

Efficacy and safety of first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer: a meta-analysis.

Chin Med J (Engl) 2014 ;127(3):538-46

Department of Laparoscopic Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Email:

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January 2015

Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 and liver X receptor α gene and risk of polycystic ovary syndrome in a Chinese Han population.

Cell Biochem Biophys 2014 Nov;70(2):1421-6

Department of gynaecology and obstetrics, Hangzhou Red Cross Hospital, Hangzhou, 310003, Zhejiang Province, China.

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http://dx.doi.org/10.1007/s12013-014-0075-5DOI Listing
November 2014

NADPH oxidase-dependent formation of reactive oxygen species contributes to transforming growth factor β1-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells, and the role of astragalus intervention.

Chin J Integr Med 2014 Sep 22;20(9):667-74. Epub 2012 Oct 22.

Department of Nephrology, Zhejiang Provincial Hospital of Integrated Chinese and Western Medicine, Hangzhou, 310003, China.

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http://link.springer.com/10.1007/s11655-012-1176-x
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http://dx.doi.org/10.1007/s11655-012-1176-xDOI Listing
September 2014

Pulsatile dynamics in the yeast proteome.

Curr Biol 2014 Sep 11;24(18):2189-2194. Epub 2014 Sep 11.

Howard Hughes Medical Institute, Division of Biology and Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.07.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203654PMC
September 2014

Single-cell phenotyping within transparent intact tissue through whole-body clearing.

Cell 2014 Aug 31;158(4):945-958. Epub 2014 Jul 31.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153367PMC
August 2014

Dynamic heterogeneity and DNA methylation in embryonic stem cells.

Mol Cell 2014 Jul;55(2):319-31

Howard Hughes Medical Institute and Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140056
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http://dx.doi.org/10.1016/j.molcel.2014.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104113PMC
July 2014

Single-cell in situ RNA profiling by sequential hybridization.

Nat Methods 2014 Apr;11(4):360-1

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.

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http://www.nature.com/articles/nmeth.2892
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http://dx.doi.org/10.1038/nmeth.2892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085791PMC
April 2014

Effect of Wenhua Juanbi recipe on proliferation and apoptosis of synoviocytes in rats with collagen-inducing arthritis.

Chin J Integr Med 2013 Jun 29;19(6):453-8. Epub 2011 Jun 29.

Department of Arthropathy, Zhejiang Provincial Hospital of Integrated Traditional and Western Medicine, Hangzhou, China.

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http://dx.doi.org/10.1007/s11655-011-0753-8DOI Listing
June 2013

Turning single cells into microarrays by super-resolution barcoding.

Authors:
Long Cai

Brief Funct Genomics 2013 Mar 22;12(2):75-80. Epub 2012 Nov 22.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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https://academic.oup.com/bfg/article-lookup/doi/10.1093/bfgp
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http://dx.doi.org/10.1093/bfgp/els054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609437PMC
March 2013

Single-cell systems biology by super-resolution imaging and combinatorial labeling.

Nat Methods 2012 Jun 3;9(7):743-8. Epub 2012 Jun 3.

Program in Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, California, USA.

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http://dx.doi.org/10.1038/nmeth.2069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418883PMC
June 2012

The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients.

Clin Rheumatol 2010 Nov 19;29(11):1251-8. Epub 2010 Jun 19.

Division of Rheumatology, Immunology and Nephrology, Zhejiang Traditional Chinese Medicine and Western Medicine Hospital, 208 Huancheng East Road, Hangzhou, 310003, People's Republic of China.

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http://link.springer.com/10.1007/s10067-010-1510-7
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http://dx.doi.org/10.1007/s10067-010-1510-7DOI Listing
November 2010

A stochastic single-molecule event triggers phenotype switching of a bacterial cell.

Science 2008 Oct;322(5900):442-6

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1161427
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http://dx.doi.org/10.1126/science.1161427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819113PMC
October 2008

Frequency-modulated nuclear localization bursts coordinate gene regulation.

Nature 2008 Sep;455(7212):485-90

Howard Hughes Medical Institute, Division of Biology and Department of Applied Physics, California Institute of Technology, M/C 114-96, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/nature07292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695983PMC
September 2008

Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4(+)Foxp3(+) Regulatory Cells.

Int J Biomed Sci 2008 Mar;4(1):52-7

Division of Rheumatology, Immunology and Nephrology, Zhejiang Traditional Chinese Medicine and Western Medicine Hospital, Hangzhou, P.R. China;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614670PMC
March 2008

Linking stochastic dynamics to population distribution: an analytical framework of gene expression.

Phys Rev Lett 2006 Oct 19;97(16):168302. Epub 2006 Oct 19.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1103/PhysRevLett.97.168302DOI Listing
October 2006

Stochastic protein expression in individual cells at the single molecule level.

Nature 2006 Mar;440(7082):358-62

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature04599DOI Listing
March 2006