Lon-Fye Lye

Importance of polyphosphate in the life cycle.

Authors:

Kid Kohl Haroun Zangger Matteo Rossi Nathalie Isorce Lon-Fye Lye Katherine L Owens Stephen M Beverley Andreas Mayer Nicolas Fasel

Microb Cell 2018 Jun 22;5(8):371-384. Epub 2018 Jun 22.

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

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June 2018

parasites block the activation of the inflammasome by inhibiting maturation of IL-1β.

Authors:

Mary-Anne Hartley Remzi O Eren Matteo Rossi Florence Prevel Patrik Castiglioni Nathalie Isorce Chantal Desponds Lon-Fye Lye Stephen M Beverley Stefan K Drexler Nicolas Fasel

Microb Cell 2018 Jan 14;5(3):137-149. Epub 2018 Jan 14.

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

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January 2018

Spontaneous excision and facilitated recovery as a control for phenotypes arising from RNA interference and other dominant transgenes.

Authors:

Erin A Brettmann Lon-Fye Lye Stephen M Beverley

Mol Biochem Parasitol 2018 03 3;220:42-45. Epub 2018 Feb 3.

Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8230, St. Louis, MO 63110, United States. Electronic address:

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March 2018

Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite .

Proc Natl Acad Sci U S A 2018 01 28;115(3):E506-E515. Epub 2017 Dec 28.

Life Science Research Centre, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic;

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January 2018

Development of a semi-automated image-based high-throughput drug screening system.

Authors:

Remzi Onur Eren Dmitry Kopelyanskiy Dimitri Moreau Julien Bortoli Chapalay Marc Chambon Gerardo Turcatti Lon-Fye Lye Stephen M Beverley Nicolas Fasel

Front Biosci (Elite Ed) 2018 Jan 1;10:242-253. Epub 2018 Jan 1.

Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland,

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January 2018

Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response.

Authors:

Erin A Brettmann Jahangheer S Shaik Haroun Zangger Lon-Fye Lye F Matthew Kuhlmann Natalia S Akopyants Dayna M Oschwald Katherine L Owens Suzanne M Hickerson Catherine Ronet Nicolas Fasel Stephen M Beverley

Proc Natl Acad Sci U S A 2016 10 18;113(43):11998-12005. Epub 2016 Oct 18.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110;

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October 2016

Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence.

Authors:

Remzi Onur Eren Marta Reverte Matteo Rossi Mary-Anne Hartley Patrik Castiglioni Florence Prevel Ricardo Martin Chantal Desponds Lon-Fye Lye Stefan K Drexler Walter Reith Stephen M Beverley Catherine Ronet Nicolas Fasel

Cell Host Microbe 2016 Sep 1;20(3):318-328. Epub 2016 Sep 1.

Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland. Electronic address:

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September 2016

Low frequency of LRV1 in Leishmania braziliensis strains isolated from typical and atypical lesions in the State of Minas Gerais, Brazil.

Authors:

Diego H Macedo Armando Menezes-Neto Jeronimo M Rugani Ana C Rocha Soraia O Silva Maria N Melo Lon-Fye Lye Stephen M Beverley Célia M Gontijo Rodrigo P Soares

Mol Biochem Parasitol 2016 Nov - Dec;210(1-2):50-54. Epub 2016 Aug 18.

Centro de Pesquisas René Rachou/FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

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November 2017

A Novel Bunyavirus-Like Virus of Trypanosomatid Protist Parasites.

Authors:

Natalia S Akopyants Lon-Fye Lye Deborah E Dobson Julius Lukeš Stephen M Beverley

Genome Announc 2016 Aug 4;4(4). Epub 2016 Aug 4.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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August 2016

A Narnavirus-Like Element from the Trypanosomatid Protozoan Parasite Leptomonas seymouri.

Authors:

Lon-Fye Lye Natalia S Akopyants Deborah E Dobson Stephen M Beverley

Genome Announc 2016 Aug 4;4(4). Epub 2016 Aug 4.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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August 2016

A Narnavirus in the Trypanosomatid Protist Plant Pathogen Phytomonas serpens.

Authors:

Natalia S Akopyants Lon-Fye Lye Deborah E Dobson Julius Lukeš Stephen M Beverley

Genome Announc 2016 Jul 28;4(4). Epub 2016 Jul 28.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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July 2016

Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia.

Authors:

Vanessa Adaui Lon-Fye Lye Natalia S Akopyants Mirko Zimic Alejandro Llanos-Cuentas Lineth Garcia Ilse Maes Simonne De Doncker Deborah E Dobson Jorge Arevalo Jean-Claude Dujardin Stephen M Beverley

J Infect Dis 2016 Jan 29;213(1):112-21. Epub 2015 Jun 29.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri.

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January 2016

Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response.

Authors:

Haroun Zangger Asrat Hailu Chantal Desponds Lon-Fye Lye Natalia S Akopyants Deborah E Dobson Catherine Ronet Hashim Ghalib Stephen M Beverley Nicolas Fasel

PLoS Negl Trop Dis 2014 Apr 24;8(4):e2836. Epub 2014 Apr 24.

Department of Biochemistry, University of Lausanne, Epalinges, Vaud, Switzerland.

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April 2014

The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway.

Authors:

Vanessa D Atayde Huafang Shi Joseph B Franklin Nicholas Carriero Timothy Notton Lon-Fye Lye Katherine Owens Stephen M Beverley Christian Tschudi Elisabetta Ullu

Mol Microbiol 2013 Feb 26;87(3):580-93. Epub 2012 Dec 26.

Departments of Internal Medicine, Yale University, New Haven, CT 06536, USA.

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February 2013

'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana.

Authors:

Xiuhong Feng Dayana Rodriguez-Contreras Tamsen Polley Lon-Fye Lye David Scott Richard J S Burchmore Stephen M Beverley Scott M Landfear

Mol Microbiol 2013 Jan 10;87(2):412-29. Epub 2012 Dec 10.

Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR 97239, USA.

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January 2013

Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.

Authors:

Annette Ives Catherine Ronet Florence Prevel Giulia Ruzzante Silvia Fuertes-Marraco Frederic Schutz Haroun Zangger Melanie Revaz-Breton Lon-Fye Lye Suzanne M Hickerson Stephen M Beverley Hans Acha-Orbea Pascal Launois Nicolas Fasel Slavica Masina

Science 2011 Feb;331(6018):775-8

Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.

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February 2011

Retention and loss of RNA interference pathways in trypanosomatid protozoans.

Authors:

Lon-Fye Lye Katherine Owens Huafang Shi Silvane M F Murta Ana Carolina Vieira Salvatore J Turco Christian Tschudi Elisabetta Ullu Stephen M Beverley

PLoS Pathog 2010 Oct 28;6(10):e1001161. Epub 2010 Oct 28.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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October 2010

Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major.

Authors:

Lon-Fye Lye Song Ok Kang Joshua D Nosanchuk Arturo Casadevall Stephen M Beverley

Mol Biochem Parasitol 2011 Jan 29;175(1):58-67. Epub 2010 Sep 29.

Department of Molecular Microbiology, Box 8230, Washington University Medicine School, 600 S. Euclid Ave., St. Louis, MO 63110, USA.

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January 2011

Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms.

Authors:

Valeria Naponelli Alexandre Noiriel Michael J Ziemak Stephen M Beverley Lon-Fye Lye Andrew M Plume José Ramon Botella Karen Loizeau Stéphane Ravanel Fabrice Rébeillé Valérie de Crécy-Lagard Andrew D Hanson

Plant Physiol 2008 Apr 1;146(4):1515-27. Epub 2008 Feb 1.

Department of Horticultural Sciences , University of Florida, Gainesville, Florida 32611, USA.

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April 2008

Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies.

Authors:

Gerald F Späth Lon-Fye Lye Hiroaki Segawa Salvatore J Turco Stephen M Beverley

Infect Immun 2004 Jun;72(6):3622-7

Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110, USA.

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June 2004

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