Lon Cardon

Lon Cardon

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Lon Cardon

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Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenet Genomics 2017 03;27(3):89-100

aGlaxoSmithKline Research and Development, Durham, North Carolina bGlaxoSmithKline Research and Development, King of Prussia, Pennsylvania cDepartment of Biostatistics and/or Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA dGlaxoSmithKline Research and Development, Sydney, New South Wales, Australia eSeoul National University fDNA Link Inc., Seoul, Korea gKyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1097/FPC.0000000000000260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287433PMC
March 2017

Precision medicine, genomics and drug discovery.

Hum Mol Genet 2016 Oct 18;25(R2):R166-R172. Epub 2016 Aug 18.

Venture Partner SV Life Sciences, Boston, MA, USA.

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http://dx.doi.org/10.1093/hmg/ddw246DOI Listing
October 2016

Trial watch: Impact of genetically supported target selection on R&D productivity.

Nat Rev Drug Discov 2016 Aug;15(9):596-597

GlaxoSmithKline, 709 Swedeland Rd, UW2230, King of Prussia, Pennsylvania 19406, USA.

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http://dx.doi.org/10.1038/nrd.2016.164DOI Listing
August 2016

Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of Pazopanib.

Clin Cancer Res 2015 Jan 19;21(2):365-72. Epub 2014 Nov 19.

Program in Personalized and Genomic Medicine, and Division of Endocrinology, Diabetes and Nutrition, School of Medicine, University of Maryland, Baltimore, Maryland. Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323272PMC
January 2015

Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury.

J Clin Oncol 2014 Aug 31;32(22):2296-303. Epub 2014 Mar 31.

Daniel J. Schaid and Shannon K. McDonnell, Mayo Clinic, Rochester, MN; Colin F. Spraggs and Charles J. Cox, GlaxoSmithKline Research and Development, Stevenage, Hertfordshire; Joan Curran, GlaxoSmithKline Research and Development, London, United Kingdom; Laura R. Parham, GlaxoSmithKline Research and Development, Research Triangle Park, NC; Bent Ejlertsen, Rigshospitalet, Copenhagen, Denmark; Dianne M. Finkelstein and Paul E. Goss, Massachusetts General Hospital, Boston, MA; and Erica Rappold and Lon R. Cardon, GlaxoSmithKline Research and Development, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2013.52.9867DOI Listing
August 2014

Reply to Rational drug repositioning by medical genetics.

Nat Biotechnol 2013 Dec;31(12):1082

Computational Biology Department, Quantitative Sciences, GlaxoSmithKline, Stevenage, UK.

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http://dx.doi.org/10.1038/nbt.2769DOI Listing
December 2013

Novelty in the target landscape of the pharmaceutical industry.

Nat Rev Drug Discov 2013 Aug;12(8):575-6

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http://dx.doi.org/10.1038/nrd4089DOI Listing
August 2013

Truncated robust distance for clinical laboratory safety data monitoring and assessment.

J Biopharm Stat 2012 ;22(6):1174-92

Quantitative Sciences, GlaxoSmithKline Pharmaceuticals R&D, Collegeville, Pennsylvania 19426, USA.

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http://dx.doi.org/10.1080/10543406.2011.580483DOI Listing
March 2013

HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer.

J Clin Oncol 2011 Feb 18;29(6):667-73. Epub 2011 Jan 18.

GlaxoSmithKline Research and Development, Genetics Division, Medicines Development Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NF, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2010.31.3197DOI Listing
February 2011

Basic statistical analysis in genetic case-control studies.

Nat Protoc 2011 Feb 3;6(2):121-33. Epub 2011 Feb 3.

Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/nprot.2010.182
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http://dx.doi.org/10.1038/nprot.2010.182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154648PMC
February 2011

Data quality control in genetic case-control association studies.

Nat Protoc 2010 Sep 26;5(9):1564-73. Epub 2010 Aug 26.

Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nprot.2010.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025522PMC
September 2010

Aspects of observing and claiming allele flips in association studies.

Genet Epidemiol 2010 Apr;34(3):266-74

Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.

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http://doi.wiley.com/10.1002/gepi.20458
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http://dx.doi.org/10.1002/gepi.20458DOI Listing
April 2010

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Authors:
Marcin Imielinski Robert N Baldassano Anne Griffiths Richard K Russell Vito Annese Marla Dubinsky Subra Kugathasan Jonathan P Bradfield Thomas D Walters Patrick Sleiman Cecilia E Kim Aleixo Muise Kai Wang Joseph T Glessner Shehzad Saeed Haitao Zhang Edward C Frackelton Cuiping Hou James H Flory George Otieno Rosetta M Chiavacci Robert Grundmeier Massimo Castro Anna Latiano Bruno Dallapiccola Joanne Stempak Debra J Abrams Kent Taylor Dermot McGovern Gary Silber Iwona Wrobel Antonio Quiros Jeffrey C Barrett Sarah Hansoul Dan L Nicolae Judy H Cho Richard H Duerr John D Rioux Steven R Brant Mark S Silverberg Kent D Taylor M Michael Barmuda Alain Bitton Themistocles Dassopoulos Lisa Wu Datta Todd Green Anne M Griffiths Emily O Kistner Michael T Murtha Miguel D Regueiro Jerome I Rotter L Philip Schumm A Hillary Steinhart Stephen R Targan Ramnik J Xavier Cécile Libioulle Cynthia Sandor Mark Lathrop Jacques Belaiche Olivier Dewit Ivo Gut Simon Heath Debby Laukens Myriam Mni Paul Rutgeerts André Van Gossum Diana Zelenika Denis Franchimont J P Hugot Martine de Vos Severine Vermeire Edouard Louis Lon R Cardon Carl A Anderson Hazel Drummond Elaine Nimmo Tariq Ahmad Natalie J Prescott Clive M Onnie Sheila A Fisher Jonathan Marchini Jilur Ghori Suzannah Bumpstead Rhian Gwillam Mark Tremelling Panos Delukas John Mansfield Derek Jewell Jack Satsangi Christopher G Mathew Miles Parkes Michel Georges Mark J Daly Melvin B Heyman George D Ferry Barbara Kirschner Jessica Lee Jonah Essers Richard Grand Michael Stephens Arie Levine David Piccoli John Van Limbergen Salvatore Cucchiara Dimitri S Monos Stephen L Guthery Lee Denson David C Wilson Straun F A Grant Mark Daly Mark S Silverberg Jack Satsangi Hakon Hakonarson

Nat Genet 2009 Dec 15;41(12):1335-40. Epub 2009 Nov 15.

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267927PMC
December 2009

GLIDERS--a web-based search engine for genome-wide linkage disequilibrium between HapMap SNPs.

BMC Bioinformatics 2009 Oct 31;10:367. Epub 2009 Oct 31.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/1471-2105-10-367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777181PMC
October 2009

Marker selection for genetic case-control association studies.

Nat Protoc 2009 23;4(5):743-52. Epub 2009 Apr 23.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nprot.2009.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025519PMC
June 2009

Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

Am J Hum Genet 2008 Jul 26;83(1):112-9. Epub 2008 Jun 26.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN Oxford, UK.

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http://dx.doi.org/10.1016/j.ajhg.2008.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443836PMC
July 2008

To what extent do scans of non-synonymous SNPs complement denser genome-wide association studies?

Eur J Hum Genet 2008 Jun 16;16(6):718-23. Epub 2008 Jan 16.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/5202011
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http://dx.doi.org/10.1038/sj.ejhg.5202011DOI Listing
June 2008

Singleton SNPs in the human genome and implications for genome-wide association studies.

Eur J Hum Genet 2008 Apr 16;16(4):506-15. Epub 2008 Jan 16.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://bioinfo.ut.ee/JC/2007-2008/Reedik_Magi.pdf
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http://www.nature.com/doifinder/10.1038/sj.ejhg.5201987
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http://dx.doi.org/10.1038/sj.ejhg.5201987DOI Listing
April 2008

Designing candidate gene and genome-wide case-control association studies.

Nat Protoc 2007 ;2(10):2492-501

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nprot.2007.366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180089PMC
January 2008

Fine mapping versus replication in whole-genome association studies.

Am J Hum Genet 2007 Nov 19;81(5):995-1005. Epub 2007 Sep 19.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1086/521952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265650PMC
November 2007

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Authors:
Paul R Burton David G Clayton Lon R Cardon Nick Craddock Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem H Ouwehand Nilesh J Samani John A Todd Peter Donnelly Jeffrey C Barrett Dan Davison Doug Easton David M Evans Hin-Tak Leung Jonathan L Marchini Andrew P Morris Chris C A Spencer Martin D Tobin Antony P Attwood James P Boorman Barbara Cant Ursula Everson Judith M Hussey Jennifer D Jolley Alexandra S Knight Kerstin Koch Elizabeth Meech Sarah Nutland Christopher V Prowse Helen E Stevens Niall C Taylor Graham R Walters Neil M Walker Nicholas A Watkins Thilo Winzer Richard W Jones Wendy L McArdle Susan M Ring David P Strachan Marcus Pembrey Gerome Breen David St Clair Sian Caesar Katharine Gordon-Smith Lisa Jones Christine Fraser Elaine K Green Detelina Grozeva Marian L Hamshere Peter A Holmans Ian R Jones George Kirov Valentina Moskivina Ivan Nikolov Michael C O'Donovan Michael J Owen David A Collier Amanda Elkin Anne Farmer Richard Williamson Peter McGuffin Allan H Young I Nicol Ferrier Stephen G Ball Anthony J Balmforth Jennifer H Barrett Timothy D Bishop Mark M Iles Azhar Maqbool Nadira Yuldasheva Alistair S Hall Peter S Braund Richard J Dixon Massimo Mangino Suzanne Stevens John R Thompson Francesca Bredin Mark Tremelling Miles Parkes Hazel Drummond Charles W Lees Elaine R Nimmo Jack Satsangi Sheila A Fisher Alastair Forbes Cathryn M Lewis Clive M Onnie Natalie J Prescott Jeremy Sanderson Christopher G Matthew Jamie Barbour M Khalid Mohiuddin Catherine E Todhunter John C Mansfield Tariq Ahmad Fraser R Cummings Derek P Jewell John Webster Morris J Brown Mark G Lathrop John Connell Anna Dominiczak Carolina A Braga Marcano Beverley Burke Richard Dobson Johannie Gungadoo Kate L Lee Patricia B Munroe Stephen J Newhouse Abiodun Onipinla Chris Wallace Mingzhan Xue Mark Caulfield Martin Farrall Anne Barton Ian N Bruce Hannah Donovan Steve Eyre Paul D Gilbert Samantha L Hilder Anne M Hinks Sally L John Catherine Potter Alan J Silman Deborah P M Symmons Wendy Thomson Jane Worthington David B Dunger Barry Widmer Timothy M Frayling Rachel M Freathy Hana Lango John R B Perry Beverley M Shields Michael N Weedon Andrew T Hattersley Graham A Hitman Mark Walker Kate S Elliott Christopher J Groves Cecilia M Lindgren Nigel W Rayner Nicolas J Timpson Eleftheria Zeggini Melanie Newport Giorgio Sirugo Emily Lyons Fredrik Vannberg Adrian V S Hill Linda A Bradbury Claire Farrar Jennifer J Pointon Paul Wordsworth Matthew A Brown Jayne A Franklyn Joanne M Heward Matthew J Simmonds Stephen C L Gough Sheila Seal Michael R Stratton Nazneen Rahman Maria Ban An Goris Stephen J Sawcer Alastair Compston David Conway Muminatou Jallow Melanie Newport Giorgio Sirugo Kirk A Rockett Suzannah J Bumpstead Amy Chaney Kate Downes Mohammed J R Ghori Rhian Gwilliam Sarah E Hunt Michael Inouye Andrew Keniry Emma King Ralph McGinnis Simon Potter Rathi Ravindrarajah Pamela Whittaker Claire Widden David Withers Niall J Cardin Dan Davison Teresa Ferreira Joanne Pereira-Gale Ingeleif B Hallgrimsdo'ttir Bryan N Howie Zhan Su Yik Ying Teo Damjan Vukcevic David Bentley Matthew A Brown Alastair Compston Martin Farrall Alistair S Hall Andrew T Hattersley Adrian V S Hill Miles Parkes Marcus Pembrey Michael R Stratton Sarah L Mitchell Paul R Newby Oliver J Brand Jackie Carr-Smith Simon H S Pearce R McGinnis A Keniry P Deloukas John D Reveille Xiaodong Zhou Anne-Marie Sims Alison Dowling Jacqueline Taylor Tracy Doan John C Davis Laurie Savage Michael M Ward Thomas L Learch Michael H Weisman Mathew Brown

Nat Genet 2007 Nov 21;39(11):1329-37. Epub 2007 Oct 21.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ng.2007.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680141PMC
November 2007

A second generation human haplotype map of over 3.1 million SNPs.

Authors:
Kelly A Frazer Dennis G Ballinger David R Cox David A Hinds Laura L Stuve Richard A Gibbs John W Belmont Andrew Boudreau Paul Hardenbol Suzanne M Leal Shiran Pasternak David A Wheeler Thomas D Willis Fuli Yu Huanming Yang Changqing Zeng Yang Gao Haoran Hu Weitao Hu Chaohua Li Wei Lin Siqi Liu Hao Pan Xiaoli Tang Jian Wang Wei Wang Jun Yu Bo Zhang Qingrun Zhang Hongbin Zhao Hui Zhao Jun Zhou Stacey B Gabriel Rachel Barry Brendan Blumenstiel Amy Camargo Matthew Defelice Maura Faggart Mary Goyette Supriya Gupta Jamie Moore Huy Nguyen Robert C Onofrio Melissa Parkin Jessica Roy Erich Stahl Ellen Winchester Liuda Ziaugra David Altshuler Yan Shen Zhijian Yao Wei Huang Xun Chu Yungang He Li Jin Yangfan Liu Yayun Shen Weiwei Sun Haifeng Wang Yi Wang Ying Wang Xiaoyan Xiong Liang Xu Mary M Y Waye Stephen K W Tsui Hong Xue J Tze-Fei Wong Luana M Galver Jian-Bing Fan Kevin Gunderson Sarah S Murray Arnold R Oliphant Mark S Chee Alexandre Montpetit Fanny Chagnon Vincent Ferretti Martin Leboeuf Jean-François Olivier Michael S Phillips Stéphanie Roumy Clémentine Sallée Andrei Verner Thomas J Hudson Pui-Yan Kwok Dongmei Cai Daniel C Koboldt Raymond D Miller Ludmila Pawlikowska Patricia Taillon-Miller Ming Xiao Lap-Chee Tsui William Mak You Qiang Song Paul K H Tam Yusuke Nakamura Takahisa Kawaguchi Takuya Kitamoto Takashi Morizono Atsushi Nagashima Yozo Ohnishi Akihiro Sekine Toshihiro Tanaka Tatsuhiko Tsunoda Panos Deloukas Christine P Bird Marcos Delgado Emmanouil T Dermitzakis Rhian Gwilliam Sarah Hunt Jonathan Morrison Don Powell Barbara E Stranger Pamela Whittaker David R Bentley Mark J Daly Paul I W de Bakker Jeff Barrett Yves R Chretien Julian Maller Steve McCarroll Nick Patterson Itsik Pe'er Alkes Price Shaun Purcell Daniel J Richter Pardis Sabeti Richa Saxena Stephen F Schaffner Pak C Sham Patrick Varilly David Altshuler Lincoln D Stein Lalitha Krishnan Albert Vernon Smith Marcela K Tello-Ruiz Gudmundur A Thorisson Aravinda Chakravarti Peter E Chen David J Cutler Carl S Kashuk Shin Lin Gonçalo R Abecasis Weihua Guan Yun Li Heather M Munro Zhaohui Steve Qin Daryl J Thomas Gilean McVean Adam Auton Leonardo Bottolo Niall Cardin Susana Eyheramendy Colin Freeman Jonathan Marchini Simon Myers Chris Spencer Matthew Stephens Peter Donnelly Lon R Cardon Geraldine Clarke David M Evans Andrew P Morris Bruce S Weir Tatsuhiko Tsunoda James C Mullikin Stephen T Sherry Michael Feolo Andrew Skol Houcan Zhang Changqing Zeng Hui Zhao Ichiro Matsuda Yoshimitsu Fukushima Darryl R Macer Eiko Suda Charles N Rotimi Clement A Adebamowo Ike Ajayi Toyin Aniagwu Patricia A Marshall Chibuzor Nkwodimmah Charmaine D M Royal Mark F Leppert Missy Dixon Andy Peiffer Renzong Qiu Alastair Kent Kazuto Kato Norio Niikawa Isaac F Adewole Bartha M Knoppers Morris W Foster Ellen Wright Clayton Jessica Watkin Richard A Gibbs John W Belmont Donna Muzny Lynne Nazareth Erica Sodergren George M Weinstock David A Wheeler Imtaz Yakub Stacey B Gabriel Robert C Onofrio Daniel J Richter Liuda Ziaugra Bruce W Birren Mark J Daly David Altshuler Richard K Wilson Lucinda L Fulton Jane Rogers John Burton Nigel P Carter Christopher M Clee Mark Griffiths Matthew C Jones Kirsten McLay Robert W Plumb Mark T Ross Sarah K Sims David L Willey Zhu Chen Hua Han Le Kang Martin Godbout John C Wallenburg Paul L'Archevêque Guy Bellemare Koji Saeki Hongguang Wang Daochang An Hongbo Fu Qing Li Zhen Wang Renwu Wang Arthur L Holden Lisa D Brooks Jean E McEwen Mark S Guyer Vivian Ota Wang Jane L Peterson Michael Shi Jack Spiegel Lawrence M Sung Lynn F Zacharia Francis S Collins Karen Kennedy Ruth Jamieson John Stewart

Nature 2007 Oct;449(7164):851-61

The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA.

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https://www.genome.gov/Pages/Newsroom/CurrentNewsReleases/In
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http://www.nature.com/doifinder/10.1038/nature06258
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http://dx.doi.org/10.1038/nature06258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689609PMC
October 2007

Genome-wide detection and characterization of positive selection in human populations.

Authors:
Pardis C Sabeti Patrick Varilly Ben Fry Jason Lohmueller Elizabeth Hostetter Chris Cotsapas Xiaohui Xie Elizabeth H Byrne Steven A McCarroll Rachelle Gaudet Stephen F Schaffner Eric S Lander Kelly A Frazer Dennis G Ballinger David R Cox David A Hinds Laura L Stuve Richard A Gibbs John W Belmont Andrew Boudreau Paul Hardenbol Suzanne M Leal Shiran Pasternak David A Wheeler Thomas D Willis Fuli Yu Huanming Yang Changqing Zeng Yang Gao Haoran Hu Weitao Hu Chaohua Li Wei Lin Siqi Liu Hao Pan Xiaoli Tang Jian Wang Wei Wang Jun Yu Bo Zhang Qingrun Zhang Hongbin Zhao Hui Zhao Jun Zhou Stacey B Gabriel Rachel Barry Brendan Blumenstiel Amy Camargo Matthew Defelice Maura Faggart Mary Goyette Supriya Gupta Jamie Moore Huy Nguyen Robert C Onofrio Melissa Parkin Jessica Roy Erich Stahl Ellen Winchester Liuda Ziaugra David Altshuler Yan Shen Zhijian Yao Wei Huang Xun Chu Yungang He Li Jin Yangfan Liu Yayun Shen Weiwei Sun Haifeng Wang Yi Wang Ying Wang Xiaoyan Xiong Liang Xu Mary M Y Waye Stephen K W Tsui Hong Xue J Tze-Fei Wong Luana M Galver Jian-Bing Fan Kevin Gunderson Sarah S Murray Arnold R Oliphant Mark S Chee Alexandre Montpetit Fanny Chagnon Vincent Ferretti Martin Leboeuf Jean-François Olivier Michael S Phillips Stéphanie Roumy Clémentine Sallée Andrei Verner Thomas J Hudson Pui-Yan Kwok Dongmei Cai Daniel C Koboldt Raymond D Miller Ludmila Pawlikowska Patricia Taillon-Miller Ming Xiao Lap-Chee Tsui William Mak You Qiang Song Paul K H Tam Yusuke Nakamura Takahisa Kawaguchi Takuya Kitamoto Takashi Morizono Atsushi Nagashima Yozo Ohnishi Akihiro Sekine Toshihiro Tanaka Tatsuhiko Tsunoda Panos Deloukas Christine P Bird Marcos Delgado Emmanouil T Dermitzakis Rhian Gwilliam Sarah Hunt Jonathan Morrison Don Powell Barbara E Stranger Pamela Whittaker David R Bentley Mark J Daly Paul I W de Bakker Jeff Barrett Yves R Chretien Julian Maller Steve McCarroll Nick Patterson Itsik Pe'er Alkes Price Shaun Purcell Daniel J Richter Pardis Sabeti Richa Saxena Stephen F Schaffner Pak C Sham Patrick Varilly David Altshuler Lincoln D Stein Lalitha Krishnan Albert Vernon Smith Marcela K Tello-Ruiz Gudmundur A Thorisson Aravinda Chakravarti Peter E Chen David J Cutler Carl S Kashuk Shin Lin Gonçalo R Abecasis Weihua Guan Yun Li Heather M Munro Zhaohui Steve Qin Daryl J Thomas Gilean McVean Adam Auton Leonardo Bottolo Niall Cardin Susana Eyheramendy Colin Freeman Jonathan Marchini Simon Myers Chris Spencer Matthew Stephens Peter Donnelly Lon R Cardon Geraldine Clarke David M Evans Andrew P Morris Bruce S Weir Tatsuhiko Tsunoda Todd A Johnson James C Mullikin Stephen T Sherry Michael Feolo Andrew Skol Houcan Zhang Changqing Zeng Hui Zhao Ichiro Matsuda Yoshimitsu Fukushima Darryl R Macer Eiko Suda Charles N Rotimi Clement A Adebamowo Ike Ajayi Toyin Aniagwu Patricia A Marshall Chibuzor Nkwodimmah Charmaine D M Royal Mark F Leppert Missy Dixon Andy Peiffer Renzong Qiu Alastair Kent Kazuto Kato Norio Niikawa Isaac F Adewole Bartha M Knoppers Morris W Foster Ellen Wright Clayton Jessica Watkin Richard A Gibbs John W Belmont Donna Muzny Lynne Nazareth Erica Sodergren George M Weinstock David A Wheeler Imtaz Yakub Stacey B Gabriel Robert C Onofrio Daniel J Richter Liuda Ziaugra Bruce W Birren Mark J Daly David Altshuler Richard K Wilson Lucinda L Fulton Jane Rogers John Burton Nigel P Carter Christopher M Clee Mark Griffiths Matthew C Jones Kirsten McLay Robert W Plumb Mark T Ross Sarah K Sims David L Willey Zhu Chen Hua Han Le Kang Martin Godbout John C Wallenburg Paul L'Archevêque Guy Bellemare Koji Saeki Hongguang Wang Daochang An Hongbo Fu Qing Li Zhen Wang Renwu Wang Arthur L Holden Lisa D Brooks Jean E McEwen Mark S Guyer Vivian Ota Wang Jane L Peterson Michael Shi Jack Spiegel Lawrence M Sung Lynn F Zacharia Francis S Collins Karen Kennedy Ruth Jamieson John Stewart

Nature 2007 Oct;449(7164):913-8

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA.

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https://www.genome.gov/Pages/Newsroom/CurrentNewsReleases/Le
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http://www.nature.com/doifinder/10.1038/nature06250
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http://dx.doi.org/10.1038/nature06250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687721PMC
October 2007

Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype.

Inflamm Bowel Dis 2007 Sep;13(9):1063-8

Wellcome Trust Centre for Human Genetics, University of Oxford, and Gastroenterology Unit, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK.

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http://dx.doi.org/10.1002/ibd.20180DOI Listing
September 2007

Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene.

Inflamm Bowel Dis 2007 Aug;13(8):941-6

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1002/ibd.20162DOI Listing
August 2007

Genetics. Delivering new disease genes.

Authors:
Lon R Cardon

Science 2006 Dec;314(5804):1403-5

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1126/science.1136668DOI Listing
December 2006

Functional epistasis on a common MHC haplotype associated with multiple sclerosis.

Nature 2006 Oct 27;443(7111):574-7. Epub 2006 Sep 27.

Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, 8200 N, Aarhus, Denmark.

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http://dx.doi.org/10.1038/nature05133DOI Listing
October 2006

TUCAN (CARD8) genetic variants and inflammatory bowel disease.

Gastroenterology 2006 Oct 5;131(4):1190-6. Epub 2006 Aug 5.

Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK.

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http://dx.doi.org/10.1053/j.gastro.2006.08.008DOI Listing
October 2006

Two-stage two-locus models in genome-wide association.

PLoS Genet 2006 Sep;2(9):e157

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.0020157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570380PMC
September 2006

Genome-wide association: a promising start to a long race.

Trends Genet 2006 Jul 19;22(7):350-4. Epub 2006 May 19.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1016/j.tig.2006.05.001DOI Listing
July 2006

Evaluating coverage of genome-wide association studies.

Nat Genet 2006 Jun 21;38(6):659-62. Epub 2006 May 21.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/ng1801DOI Listing
June 2006

The portability of tagSNPs across populations: a worldwide survey.

Genome Res 2006 Mar 8;16(3):323-30. Epub 2006 Feb 8.

Unitat de Biologia Evolutiva, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1101/gr.4138406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1415211PMC
March 2006

Disentangling linkage disequilibrium and linkage from dense single-nucleotide polymorphism trio data.

Genetics 2005 Dec 22;171(4):2085-95. Epub 2005 Aug 22.

Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1534/genetics.105.047431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456135PMC
December 2005

An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets.

Nat Genet 2005 Dec 30;37(12):1320-2. Epub 2005 Oct 30.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng1670DOI Listing
December 2005

Will the real disease gene please stand up?

BMC Genet 2005 Dec 30;6 Suppl 1:S66. Epub 2005 Dec 30.

Epidemiology Unit, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866716PMC
December 2005

Measures of human population structure show heterogeneity among genomic regions.

Genome Res 2005 Nov;15(11):1468-76

Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695-7566, USA.

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http://dx.doi.org/10.1101/gr.4398405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310634PMC
November 2005

Shaking the tree: mapping complex disease genes with linkage disequilibrium.

Lancet 2005 Oct;366(9492):1223-34

Western Australian Institute for Medical Research and University of Western Australia Centre for Medical Research, University of Western Australia.

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http://dx.doi.org/10.1016/S0140-6736(05)67485-5DOI Listing
October 2005

A comparison of tagging methods and their tagging space.

Hum Mol Genet 2005 Sep 15;14(18):2757-67. Epub 2005 Aug 15.

Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

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http://dx.doi.org/10.1093/hmg/ddi309DOI Listing
September 2005

Replication publication.

PLoS Biol 2005 Sep 13;3(9):e327. Epub 2005 Sep 13.

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http://dx.doi.org/10.1371/journal.pbio.0030327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201309PMC
September 2005

Prospects and pitfalls in whole genome association studies.

Philos Trans R Soc Lond B Biol Sci 2005 Aug;360(1460):1589-95

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1098/rstb.2005.1689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569530PMC
August 2005

A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations.

Am J Hum Genet 2005 Apr 17;76(4):681-7. Epub 2005 Feb 17.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1086/429274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199305PMC
April 2005

Genome-wide strategies for detecting multiple loci that influence complex diseases.

Nat Genet 2005 Apr 27;37(4):413-7. Epub 2005 Mar 27.

Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.

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http://www.nature.com/articles/ng1537
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http://dx.doi.org/10.1038/ng1537DOI Listing
April 2005

Multivariate genetic analysis of chronic pelvic pain and associated phenotypes.

Behav Genet 2005 Mar;35(2):177-88

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1007/s10519-004-1017-6DOI Listing
March 2005

How useful is the fine-scale mapping of complex trait linkage peaks? Evaluating the impact of additional microsatellite genotyping on the posterior probability of linkage.

Genet Epidemiol 2005 Jan;28(1):1-10

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/gepi.20023DOI Listing
January 2005

Genotype prediction using a dense map of SNPs.

Genet Epidemiol 2004 Dec;27(4):375-84

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1002/gepi.20045DOI Listing
December 2004

GOLDsurfer: three dimensional display of linkage disequilibrium.

Bioinformatics 2004 Nov 16;20(17):3241-3. Epub 2004 Jun 16.

Department of Organic Chemistry, Umeä University, Sweden.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/bth341DOI Listing
November 2004

Efficiency and consistency of haplotype tagging of dense SNP maps in multiple samples.

Hum Mol Genet 2004 Nov 14;13(21):2557-65. Epub 2004 Sep 14.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1093/hmg/ddh294DOI Listing
November 2004

Guidelines for genotyping in genomewide linkage studies: single-nucleotide-polymorphism maps versus microsatellite maps.

Am J Hum Genet 2004 Oct 13;75(4):687-92. Epub 2004 Aug 13.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1086/424696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182056PMC
October 2004

Linkage disequilibrium in young genetically isolated Dutch population.

Eur J Hum Genet 2004 Jul;12(7):527-34

Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/sj.ejhg.5201188DOI Listing
July 2004

Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes.

Am J Hum Genet 2004 Jul 13;75(1):35-43. Epub 2004 May 13.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1086/422174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182006PMC
July 2004

The effects of human population structure on large genetic association studies.

Nat Genet 2004 May 28;36(5):512-7. Epub 2004 Mar 28.

Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.

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http://dx.doi.org/10.1038/ng1337DOI Listing
May 2004

Familial aggregation of endometriosis in a large pedigree of rhesus macaques.

Hum Reprod 2004 Feb;19(2):448-55

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1093/humrep/deh052DOI Listing
February 2004