Publications by authors named "Lois S Weisman"

58Publications

Insights into Lysosomal PI(3,5)P Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex.

Mol Cell 2020 11 23;80(4):736-743.e4. Epub 2020 Oct 23.

Department of Cell Biology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.10.003DOI Listing
November 2020

Cargo Release from Myosin V Requires the Convergence of Parallel Pathways that Phosphorylate and Ubiquitylate the Cargo Adaptor.

Curr Biol 2020 Nov 10;30(22):4399-4412.e7. Epub 2020 Sep 10.

Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA; Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2020.08.062DOI Listing
November 2020

The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation.

J Cell Sci 2019 02 28;132(5). Epub 2019 Feb 28.

Structure and Membrane Compartments, Institut Curie, Paris Sciences & Lettres Research University, Centre National de la Recherche Scientifique, UMR144, 75005 Paris, France

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http://dx.doi.org/10.1242/jcs.229500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432708PMC
February 2019

Vacuole-mediated selective regulation of TORC1-Sch9 signaling following oxidative stress.

Mol Biol Cell 2018 02 13;29(4):510-522. Epub 2017 Dec 13.

Department of Nanobiology, Graduate School of Advanced Integration Science

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http://dx.doi.org/10.1091/mbc.E17-09-0553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014174PMC
February 2018

Early protection to stress mediated by CDK-dependent PI3,5P signaling from the vacuole/lysosome.

J Cell Biol 2017 07 21;216(7):2075-2090. Epub 2017 Jun 21.

Life Sciences Institute, University of Michigan, Ann Arbor, MI

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http://dx.doi.org/10.1083/jcb.201611144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496620PMC
July 2017

Spatial regulation of organelle release from myosin V transport by p21-activated kinases.

J Cell Biol 2017 06 11;216(6):1557-1566. Epub 2017 May 11.

Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109

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http://dx.doi.org/10.1083/jcb.201607020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461012PMC
June 2017

PI5P and PI(3,5)P: Minor, but Essential Phosphoinositides.

Cell Struct Funct 2017 May 7;42(1):49-60. Epub 2017 Mar 7.

Life Sciences Institute, University of Michigan.

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http://dx.doi.org/10.1247/csf.17003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846621PMC
May 2017

Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

Tremor Other Hyperkinet Mov (N Y) 2017 15;7:428. Epub 2017 Feb 15.

Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Neurology Service, VAAAHS, University of Michigan, Ann Arbor, MI, USA; Udall Centre, University of Michigan, Ann Arbor, MI, USA; GRECC, VAAAHS, University of Michigan, Ann Arbor, MI, USA,; Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.7916/D8XD127WDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313633PMC
February 2017

Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.

Biochem Soc Trans 2016 Feb;44(1):177-84

Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A.

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http://dx.doi.org/10.1042/BST20150174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836390PMC
February 2016

The vacuole/lysosome is required for cell-cycle progression.

Elife 2015 Aug 31;4. Epub 2015 Aug 31.

Life Sciences Institute, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United States.

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http://dx.doi.org/10.7554/eLife.08160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586482PMC
August 2015

Close encounters of the lysosome-peroxisome kind.

Cell 2015 Apr;161(2):197-8

Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)00366-9.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741500366
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http://dx.doi.org/10.1016/j.cell.2015.03.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435959PMC
April 2015

Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression.

Proc Natl Acad Sci U S A 2014 Nov 29;111(45):E4896-905. Epub 2014 Oct 29.

Neuroscience Graduate Program, Molecular and Behavioral Neuroscience Institute, Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109

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http://dx.doi.org/10.1073/pnas.1411117111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234577PMC
November 2014

Release from myosin V via regulated recruitment of an E3 ubiquitin ligase controls organelle localization.

Dev Cell 2014 Mar;28(5):520-33

Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994899PMC
March 2014

The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPase.

Mol Biol Cell 2014 Apr 12;25(8):1251-62. Epub 2014 Feb 12.

Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13219 Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor MI 48109.

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http://dx.doi.org/10.1091/mbc.E13-10-0563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982991PMC
April 2014

Roles for PI(3,5)P2 in nutrient sensing through TORC1.

Mol Biol Cell 2014 Apr 29;25(7):1171-85. Epub 2014 Jan 29.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 Department of Molecular, Cellular, and Developmental Biology and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 Department of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 Department of Molecular Biology, University of Geneva, Geneva 1211, Switzerland Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109.

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http://dx.doi.org/10.1091/mbc.E14-01-0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967979PMC
April 2014

Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.

Proc Natl Acad Sci U S A 2013 Dec 9;110(52):21165-70. Epub 2013 Dec 9.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1311864110
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http://dx.doi.org/10.1073/pnas.1311864110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876232PMC
December 2013

Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.

Bioessays 2014 Jan 28;36(1):52-64. Epub 2013 Oct 28.

Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1002/bies.201300012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906640PMC
January 2014

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

Proc Natl Acad Sci U S A 2012 Oct 9;109(43):17472-7. Epub 2012 Oct 9.

Departments of Cell and Developmental Biology, Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1203106109
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http://dx.doi.org/10.1073/pnas.1203106109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491506PMC
October 2012

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P.

EMBO J 2012 Aug 27;31(16):3442-56. Epub 2012 Jul 27.

1] Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA [2] Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2012.200
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http://dx.doi.org/10.1038/emboj.2012.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419932PMC
August 2012

Overlap of cargo binding sites on myosin V coordinates the inheritance of diverse cargoes.

J Cell Biol 2012 Jul 2;198(1):69-85. Epub 2012 Jul 2.

Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1083/jcb.201201024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392941PMC
July 2012

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

Mol Biol Cell 2012 Aug 13;23(15):2955-62. Epub 2012 Jun 13.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1091/mbc.E11-12-1034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408421PMC
August 2012

Rab5 proteins regulate activation and localization of target of rapamycin complex 1.

J Biol Chem 2012 Jun 30;287(25):20913-21. Epub 2012 Apr 30.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M111.334060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375515PMC
June 2012

Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.

PLoS Genet 2011 Oct 20;7(10):e1002319. Epub 2011 Oct 20.

Human Inherited Neuropathies Unit, INSPE-Institute for Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1371/journal.pgen.1002319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197679PMC
October 2011

Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing.

Genetics 2010 Dec 5;186(4):1127-37. Epub 2010 Oct 5.

Department of Pathology, University of Michigan DNA Sequencing Core, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://www.genetics.org/cgi/doi/10.1534/genetics.110.123232
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http://dx.doi.org/10.1534/genetics.110.123232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998298PMC
December 2010

PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome.

Nat Commun 2010 Jul 13;1:38. Epub 2010 Jul 13.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 National Science Building (Kraus), 830 North University, Ann Arbor, Michigan 48109, USA.

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http://www.nature.com/doifinder/10.1038/ncomms1037
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http://dx.doi.org/10.1038/ncomms1037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928581PMC
July 2010

Myosin-driven peroxisome partitioning in S. cerevisiae.

J Cell Biol 2009 Aug 17;186(4):541-54. Epub 2009 Aug 17.

Department of Cell Biology and 2 Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G2H7, Canada.

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http://dx.doi.org/10.1083/jcb.200904050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733749PMC
August 2009

PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex.

Mol Biol Cell 2009 Mar 30;20(5):1312-23. Epub 2008 Dec 30.

Life Sciences Institute, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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http://dx.doi.org/10.1091/mbc.e08-09-0954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649272PMC
March 2009

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

EMBO J 2008 Dec 27;27(24):3221-34. Epub 2008 Nov 27.

Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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http://dx.doi.org/10.1038/emboj.2008.248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600653PMC
December 2008

The cyclin-dependent kinase Cdk1 directly regulates vacuole inheritance.

Dev Cell 2008 Sep;15(3):478-85

Department of Cell & Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.devcel.2008.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727752PMC
September 2008

Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion.

Mol Biol Cell 2008 Oct 23;19(10):4177-87. Epub 2008 Jul 23.

Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1091/mbc.e08-02-0220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555963PMC
October 2008

Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5.

Mol Biol Cell 2008 Jul 23;19(7):2718-28. Epub 2008 Apr 23.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1091/mbc.e08-01-0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441665PMC
July 2008

Pushing for answers: is myosin V directly involved in moving mitochondria?

J Cell Biol 2008 Apr;181(1):15-8

Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1083/jcb.200803064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287276PMC
April 2008

Palmitoylation plays a role in targeting Vac8p to specific membrane subdomains.

Traffic 2006 Oct;7(10):1378-87

Department of Cell & Developmental Biology, Life Sciences Institute, 210 Washtenaw Avenue, Room 6437, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2006.00472.xDOI Listing
October 2006

Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processes.

Traffic 2006 Oct 5;7(10):1368-77. Epub 2006 Jul 5.

Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.

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http://doi.wiley.com/10.1111/j.1600-0854.2006.00458.x
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http://dx.doi.org/10.1111/j.1600-0854.2006.00458.xDOI Listing
October 2006

Organelles on the move: insights from yeast vacuole inheritance.

Authors:
Lois S Weisman

Nat Rev Mol Cell Biol 2006 Apr;7(4):243-52

Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/nrm1892DOI Listing
April 2006

The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover.

J Cell Biol 2006 Feb 21;172(5):693-704. Epub 2006 Feb 21.

Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1083/jcb.200512105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063702PMC
February 2006

Structural basis for myosin V discrimination between distinct cargoes.

EMBO J 2006 Feb 26;25(4):693-700. Epub 2006 Jan 26.

Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383548PMC
February 2006

Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage.

J Cell Biol 2003 Dec;163(5):973-85

Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-2216, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200308071
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http://dx.doi.org/10.1083/jcb.200308071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1705953PMC
December 2003

Yeast vacuole inheritance and dynamics.

Authors:
Lois S Weisman

Annu Rev Genet 2003 ;37:435-60

Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1146/annurev.genet.37.050203.103207DOI Listing
February 2004

Identification of an organelle-specific myosin V receptor.

J Cell Biol 2003 Mar;160(6):887-97

Dept. of Biochemistry, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1083/jcb.200210139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173761PMC
March 2003

Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole.

Nature 2003 Mar 16;422(6927):87-92. Epub 2003 Feb 16.

Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1038/nature01453DOI Listing
March 2003

Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.

Mol Biol Cell 2002 Apr;13(4):1238-51

Department of Cellular and Molecular Medicine, University of California at San Diego, School of Medicine, La Jolla, CA 92093-0668, USA.

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http://dx.doi.org/10.1091/mbc.01-10-0498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC102265PMC
April 2002