Loes Rutten-Jacobs

Loes Rutten-Jacobs

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Loes Rutten-Jacobs

Loes Rutten-Jacobs

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Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2019 Jul;51(7):1192-1193

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-019-0449-0DOI Listing
July 2019

Genetic variation in is associated with white matter hyperintensities (n = 11,226).

Neurology 2019 02 18;92(8):e749-e757. Epub 2019 Jan 18.

From the Department of Clinical Neurosciences, Stroke Research Group (M.T., D.J.T., I.D.C., D.M.L.F., A.O.O., L.R.-J., H.S.M.), University of Cambridge, UK; Department of Cerebrovascular Diseases (G.B.), Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan, Italy; Institute for Stroke and Dementia Research (M.D.), Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich; German Center for Neurodegenerative Diseases (DZNE) and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany; Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND) (R.L.), KU Leuven-University of Leuven; Department of Neurology (R.L.), University Hospitals Leuven; Laboratory of Neurobiology (R.L.), VIB Center for Brain and Disease Research, Leuven, Belgium; Center for Human Genetic Research (J.R.) and Division of Neurocritical Care and Emergency Neurology (J.R.) and J. Philip Kistler Stroke Research Center (J.R., N.S.R.), Department of Neurology, Massachusetts General Hospital, Boston; Nuffield Department of Clinical Neurosciences (Clinical Neurology), Stroke Prevention Research Unit (P.M.R.), University of Oxford; Centre for Clinical Brain Sciences and Institute for Genetics and Molecular Medicine (C.L.M.S.), University of Edinburgh, UK; Stroke Division, Florey Institute of Neuroscience and Mental Health (V.T.), University of Melbourne; and Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396967PMC
February 2019

Emerging insights from the genetics of cerebral small-vessel disease.

Ann N Y Acad Sci 2019 Jan 8. Epub 2019 Jan 8.

Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.13998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614021PMC
January 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

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http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Risk factors and mechanisms of stroke in young adults: The FUTURE study.

J Cereb Blood Flow Metab 2018 09 23;38(9):1631-1641. Epub 2017 May 23.

1 Department of Neurology, Center for Neuroscience, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

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http://journals.sagepub.com/doi/10.1177/0271678X17707138
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http://dx.doi.org/10.1177/0271678X17707138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120122PMC
September 2018

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis.

Stroke 2018 06 23;49(6):1325-1331. Epub 2018 Apr 23.

Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom (J.L., L.R.-J., H.S.M., M.T.)

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.117.020536
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http://dx.doi.org/10.1161/STROKEAHA.117.020536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976219PMC
June 2018

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.

Stroke 2018 06 11;49(6):1340-1347. Epub 2018 May 11.

From the Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom (L.C.A.R.-J., D.J.T., H.S.M., M.T.)

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http://dx.doi.org/10.1161/STROKEAHA.118.020811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976227PMC
June 2018

Increased Risk of Pregnancy Complications After Stroke: The FUTURE Study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation).

Stroke 2018 04 6;49(4):877-883. Epub 2018 Mar 6.

From the Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Center for Neuroscience (M.E.v.A., M.d.V., R.M.A., H.S., E.J.v.D., F.-E.d.L.) and Department of Cardiology (M.J.v.d.V.), Radboud University Nijmegen Medical Center, the Netherlands; Center for Neurology and Neurorehabilitation, State Hospital, Switzerland (N.A.M.M.M.); Department of Neurology, St. Elisabeth Hospital, the Netherlands (N.E.S.); Division of Woman and Baby, Birth Center, University Utrecht Medical Center, the Netherlands (R.d.H.); and German Center for Neurodegenerative Diseases (DZNE), Population Health Sciences, Bonn, Germany (L.C.A.R.-J.).

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http://dx.doi.org/10.1161/STROKEAHA.117.019904DOI Listing
April 2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2018 04 12;50(4):524-537. Epub 2018 Mar 12.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-018-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968830PMC
April 2018

Kidney Dysfunction Increases Mortality and Incident Events after Young Stroke: The FUTURE Study.

Cerebrovasc Dis 2016 14;42(3-4):224-31. Epub 2016 May 14.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1159/000444683DOI Listing
November 2017

Nonlinear temporal dynamics of cerebral small vessel disease: The RUN DMC study.

Neurology 2017 Oct 6;89(15):1569-1577. Epub 2017 Sep 6.

From the Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroscience, Department of Neurology (E.M.C.v.L., I.W.M.v.U., M.I.B., V.L., E.C.M.K., H.M.v.d.H., A.M.T., E.J.v.D., C.J.M.K., F.-E.d.L.), and Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine (M.G., B.P.), Radboud University Medical Centre; Institute for Computing and Information Sciences (M.G.) and Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging (D.G.N.), Radboud University, Nijmegen, the Netherlands; Department of Clinical Neurosciences, Neurology Unit (L.C.A.R.-J.), University of Cambridge, UK; and Erwin L. Hahn Institute for Magnetic Resonance Imaging (D.G.N.), University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000004490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634663PMC
October 2017

Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke.

Stroke 2017 09 1;48(9):2405-2411. Epub 2017 Aug 1.

From the Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1161/STROKEAHA.117.017813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571884PMC
September 2017

New insights into mechanisms of small vessel disease stroke from genetics.

Clin Sci (Lond) 2017 Apr;131(7):515-531

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Box 83, R3 Neurosciences, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, U.K.

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http://dx.doi.org/10.1042/CS20160825DOI Listing
April 2017

Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study.

Neurol Genet 2017 Apr 15;3(2):e142. Epub 2017 Mar 15.

Department of Medical and Molecular Genetics (M.T., C.M.L.), King's College London, Guy's Hospital; Stroke Research Group (M.T., L.R.-J., H.S.M.), Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus; and SGDP Centre (C.C., H.P., G.B., S.N., C.M.L.), Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

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http://dx.doi.org/10.1212/NXG.0000000000000142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354108PMC
April 2017

The very long-term risk and predictors of recurrent ischaemic events after a stroke at a young age: The FUTURE study.

Eur Stroke J 2016 Dec 14;1(4):337-345. Epub 2016 Oct 14.

Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1177/2396987316673440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301250PMC
December 2016

Remote Lower White Matter Integrity Increases the Risk of Long-Term Cognitive Impairment After Ischemic Stroke in Young Adults.

Stroke 2016 10 13;47(10):2517-25. Epub 2016 Sep 13.

From the Departments of Neurology (P.S., A.M.T., R.M.A., S.F., N.A.M.M., H.C.S., E.J.v.D., F.-E.d.L.) and Medical Psychology (R.P.C.K.), Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands; Department of Clinical Neurosciences, University of Cambridge, United Kingdom (L.C.A.R.-J.); and Department of Neurology, Medisch Spectrum Twente, Enschede, The Netherlands (L.D.A.D.).

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http://stroke.ahajournals.org/content/early/2016/09/13/STROK
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http://dx.doi.org/10.1161/STROKEAHA.116.014356DOI Listing
October 2016

Accelerated development of cerebral small vessel disease in young stroke patients.

Neurology 2016 Sep 12;87(12):1212-9. Epub 2016 Aug 12.

From Donders Institute for Brain, Cognition and Behaviour, Department of Neurology (R.M.A., S.M.A.v.d.B., I.W.M.v.U., L.C.A.R.-J., N.A.M.M., P.S., H.C.S., E.J.v.D., F.-E.d.L.), and Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine (M.G., B.P.), Radboudumc; Institute for Computing and Information Sciences (M.G.), Radboud University, Nijmegen, the Netherlands; and Department of Clinical Neurosciences, Neurology Unit (L.C.A.R.-J.), University of Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035980PMC
http://dx.doi.org/10.1212/WNL.0000000000003123DOI Listing
September 2016

Women have a poorer very long-term functional outcome after stroke among adults aged 18-50 years: the FUTURE study.

J Neurol 2016 Jun 2;263(6):1099-105. Epub 2016 Apr 2.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00415-016-8042-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893376PMC
June 2016

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke.

Stroke 2016 05 12;47(5):1174-9. Epub 2016 Apr 12.

From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (M.T., L.C.A.R.-J., H.S.M.); Department of Medical and Molecular Genetics, King's College London, London, United Kingdom (M.T.); Laboratory of Neurobiology, Vesalius Research Center, VIB, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease, University of Leuven, Leuven, Belgium (V.T.); Department of Neurology, Austin Health and Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia (V.T.); School of Medicine and Public Health (E.G.H.) and Centre for Clinical Epidemiology and Biostatistics, Hunter Medical Research Institute and School of Medicine and Public Health (C.L.), University of Newcastle, Newcastle, NSW, Australia; Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia (E.G.H.); School of Life Science, University of Lincoln, Lincoln, United Kingdom (S.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany (R.M., M.D.); Department of Cerebrovascular Disease, IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (G.B.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (C.S.); Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, Oxford, United Kingdom (P.M.R.); and Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839546PMC
May 2016

Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.

Stroke 2016 Mar 2;47(3):646-51. Epub 2016 Feb 2.

From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (L.C.A.R.-J., M.T., H.S.M.); Department of Medical & Molecular Genetics, King's College London, London, UK (M.T.); Stroke and Dementia Research Centre, Department of Clinical Neuroscience, St George's University of London, London, UK (P.A.-S.); KULeuven Department of Experimental Neurology and Leuven Research Institute for Neuroscience and Disease, University of Leuven, and Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium and Department of Neurology, Austin Health and Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia (V.T.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, UK (P.M.R.); Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano, Italy (G.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University Munich and Munich Cluster of Systems Neurology, SyNergy, Munich, Germany (M.D.); Department of Neurology, Mayo Clinic, Jacksonville (J.M.); School of Nursing and Midwifery (J.M.) and Hunter Medical Research Institute (J.M., C.L.), University of Newcastle, NSW, Australia; Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston (N.S.R., J.R.); Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK (A.H.); and School of Life Science, University of Lincoln, Lincoln, UK (S.B.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760380PMC
March 2016

Structural network efficiency predicts conversion to dementia.

Neurology 2016 Mar 17;86(12):1112-9. Epub 2016 Feb 17.

From the Departments of Neurology (A.M.T., I.W.M.v.U., H.v.d.H., E.v.D., F.-E.d.L.), Geriatrics (J.A.H.R.C., R.P.C.K.), and Medical Psychology (R.P.C.K.), Radboudumc, and Centre for Cognitive Neuroimaging, Radboud University Nijmegen (A.M.T., D.G.N.), Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands; Department of Clinical Neurosciences, Neurology Unit (L.C.A.R.-J., A.L., H.S.M.), University of Cambridge, UK; Department of Neurology (A.v.N.), Amphia ziekenhuis Breda; Department of Neurology (K.d.L.), HagaZiekenhuis Den Haag, the Netherlands; Erwin L. Hahn Institute for Magnetic Resonance Imaging (D.G.N.), University of Duisburg-Essen, Essen, Germany; and MIRA Institute for Biomedical Technology and Technical Medicine (D.G.N.), University of Twente, Enschede, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000002502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820137PMC
March 2016

Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex.

Stroke 2015 Nov 6;46(11):3042-7. Epub 2015 Oct 6.

From the Stroke Research Group, Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (M.T., L.C.A.R.-J., S.B., H.S.M.); School of Medicine and Public Health (E.G.H.) School of Nursing and Midwifery (J.M.M.), University of Newcastle, Callaghan, Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton Heights, Newcastle, Australia (E.G.H., C.L.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Centre for Clinical Brain Sciences and Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom (P.M.R.); Hunter Medical Research Institute, New Lambton Heights, Newcastle, Australia (J.M.M.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Adelaide, South Australia, Australia (S.A.K.); Department of Cerebrovascular Disease, IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (G.B.); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.); Department of Neurology, John Hunter Hospital, New Lambton Heights, Newcastle, Australia (C.L.); Department of Medical and Molecular Genetics, King's College London, London, United Kingdom (C.M.L.); and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom (C.M.L.).

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http://dx.doi.org/10.1161/STROKEAHA.115.009816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617282PMC
November 2015

Post-stroke fatigue and its association with poor functional outcome after stroke in young adults.

J Neurol Neurosurg Psychiatry 2015 Oct 31;86(10):1120-6. Epub 2014 Oct 31.

Department of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2014-308784DOI Listing
October 2015

Cognitive performance and poor long-term functional outcome after young stroke.

Neurology 2015 Sep 5;85(9):776-82. Epub 2015 Aug 5.

From the Department of Neurology, Centre for Neuroscience (N.E.S., P.S., R.M.A., N.A.M.M., L.C.A.R.-J., H.C.S., E.J.v.D., R.P.C.K., F.-E.d.L.), and Centre for Cognition (R.P.C.K.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center; the Department of Neurology (N.E.S., P.L.M.d.K.), Elisabeth Hospital Tilburg, the Netherlands; the Department of Clinical Neurosciences (L.C.A.R.-J.), Neurology Unit, University of Cambridge, UK; and the Department of Neurology (L.D.A.D.), Medisch Spectrum Twente, the Netherlands.

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http://www.neurology.org/content/85/9/776.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000188
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http://dx.doi.org/10.1212/WNL.0000000000001882DOI Listing
September 2015

Poststroke Epilepsy Is Associated With a High Mortality After a Stroke at Young Age: Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation Study.

Stroke 2015 Aug 2;46(8):2309-11. Epub 2015 Jul 2.

From the Department of Neurology and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands (R.M.A., L.C.A.R.-J., N.A.M.M., H.C.S., E.J.v.D., F.-E.d.L.); Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (L.C.A.R.-J.); and Department of Neurolog, Medisch Spectrum Twente, Enschede, The Netherlands (L.D.A.D.).

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August 2015

Ipsilateral hippocampal atrophy is associated with long-term memory dysfunction after ischemic stroke in young adults.

Hum Brain Mapp 2015 Jul 10;36(7):2432-42. Epub 2015 Mar 10.

Centre for Neuroscience and Centre for Cognition, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/hbm.22782DOI Listing
July 2015

Common NOTCH3 Variants and Cerebral Small-Vessel Disease.

Stroke 2015 Jun 7;46(6):1482-7. Epub 2015 May 7.

From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (L.C.A.R.-J., M.T., S.B., H.S.M.); Stroke and Dementia Research Center, Department of Clinical Neuroscience, St George's University of London, London, United Kingdom (P.A.-S.); Department of Experimental Neurology, KULeuven and Leuven Research Institute for Neuroscience and Disease, University of Leuven, Leuven, Belgium (V.T.); Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium (V.T.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (C.S.); Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, Oxford, United Kingdom (P.M.R.); Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano, Italy (G.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich, Germany (M.D.); Department of Neurology, Mayo Clinic, Jacksonville, FL (J.M.); Center for Clinical Epidemiology and Biostatistics, Department of Neurology, Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia (C.L.); Department of Neurology, Center for Human Genetic Research and Massachusetts General Hospital, Boston (N.S.R., J.R.); and Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom (A.H.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442025PMC
June 2015

Cardiovascular disease is the main cause of long-term excess mortality after ischemic stroke in young adults.

Hypertension 2015 Mar 26;65(3):670-5. Epub 2015 Jan 26.

From the Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, The Netherlands (L.C.A.R.-J., R.M.A., N.A.M.M., H.C.S., E.J.v.D., F.-E.d.L.); Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (L.C.A.R.-J.); and Department of Neurology, Medisch Spectrum Twente, Enschede, The Netherlands (L.D.D.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04895DOI Listing
March 2015

Letter by Rutten-Jacobs and de Leeuw regarding article, "long-term mortality after first-ever and recurrent stroke in young adults".

Stroke 2014 Dec 16;45(12):e301. Epub 2014 Oct 16.

Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Radboud University Medical Center, Nijmegen, the Netherlands.

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December 2014

Clinical characteristics and outcome of intracerebral hemorrhage in young adults.

J Neurol 2014 Nov 20;261(11):2143-9. Epub 2014 Aug 20.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands,

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http://dx.doi.org/10.1007/s00415-014-7469-6DOI Listing
November 2014

Long-term increased risk of unemployment after young stroke: a long-term follow-up study.

Neurology 2014 Sep 15;83(13):1132-8. Epub 2014 Aug 15.

From the Department of Neurology, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, the Netherlands. L.C.A.R.-J. is currently with the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1212/WNL.0000000000000817DOI Listing
September 2014

Subjective cognitive failures after stroke in young adults: prevalent but not related to cognitive impairment.

J Neurol 2014 Jul 17;261(7):1300-8. Epub 2014 Apr 17.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands,

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http://link.springer.com/10.1007/s00415-014-7346-3
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http://dx.doi.org/10.1007/s00415-014-7346-3DOI Listing
July 2014

Ischaemic stroke in young adults: risk factors and long-term consequences.

Nat Rev Neurol 2014 Jun 29;10(6):315-25. Epub 2014 Apr 29.

Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, PO Box 9101, 6500 HB, Nijmegen, Netherlands.

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http://dx.doi.org/10.1038/nrneurol.2014.72DOI Listing
June 2014

Poor long-term functional outcome after stroke among adults aged 18 to 50 years: Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation (FUTURE) study.

Stroke 2014 Apr 27;45(4):1157-60. Epub 2014 Feb 27.

From the Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Center for Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands (N.E.S., R.M.A., N.A.M.M., L.C.A.R.-J., H.C.S., E.J.v.D., F.-E.d.L.); Department of Neurology, Elisabeth Hospital Tilburg, Tilburg, The Netherlands (N.E.S., P.L.M.d.K.); and Department of Neurology, Medisch Spectrum Twente, Enschede, The Netherlands (L.D.A.D.).

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http://dx.doi.org/10.1161/STROKEAHA.113.004411DOI Listing
April 2014

Epilepsy after TIA or stroke in young patients impairs long-term functional outcome: the FUTURE Study.

Neurology 2013 Nov 30;81(22):1907-13. Epub 2013 Oct 30.

From the Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1212/01.wnl.0000436619.25532.f3DOI Listing
November 2013

Long-term risk of recurrent vascular events after young stroke: The FUTURE study.

Ann Neurol 2013 Oct 3;74(4):592-601. Epub 2013 Jul 3.

Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Center, Nijmegen.

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http://dx.doi.org/10.1002/ana.23953DOI Listing
October 2013

Post-stroke epilepsy in young adults: a long-term follow-up study.

PLoS One 2013 4;8(2):e55498. Epub 2013 Feb 4.

Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563638PMC
July 2013

Long-term cognitive impairment after first-ever ischemic stroke in young adults.

Stroke 2013 Jun 7;44(6):1621-8. Epub 2013 May 7.

Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour. PO Box 9101, 6500 HB Nijmegen, the Netherlands.

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http://dx.doi.org/10.1161/STROKEAHA.111.000792DOI Listing
June 2013

Long-term mortality after stroke among adults aged 18 to 50 years.

JAMA 2013 Mar;309(11):1136-44

Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1001/jama.2013.842DOI Listing
March 2013

White Matter Lesions Are Not Related to β-Amyloid Deposition in an Autopsy-Based Study.

Curr Gerontol Geriatr Res 2011 8;2011:826862. Epub 2011 Dec 8.

Department of Neurology, Donders Centre for Neuroscience, Medical Centre, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1155/2011/826862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235440PMC
August 2012