Publications by authors named "Lluis Quintana-Murci"

100Publications

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19.

Authors:
Paul Bastard Lindsey B Rosen Qian Zhang Eleftherios Michailidis Hans-Heinrich Hoffmann Yu Zhang Karim Dorgham Quentin Philippot Jérémie Rosain Vivien Béziat Jérémy Manry Elana Shaw Liis Haljasmägi Pärt Peterson Lazaro Lorenzo Lucy Bizien Sophie Trouillet-Assant Kerry Dobbs Adriana Almeida de Jesus Alexandre Belot Anne Kallaste Emilie Catherinot Yacine Tandjaoui-Lambiotte Jeremie Le Pen Gaspard Kerner Benedetta Bigio Yoann Seeleuthner Rui Yang Alexandre Bolze András N Spaan Ottavia M Delmonte Michael S Abers Alessandro Aiuti Giorgio Casari Vito Lampasona Lorenzo Piemonti Fabio Ciceri Kaya Bilguvar Richard P Lifton Marc Vasse David M Smadja Mélanie Migaud Jérome Hadjadj Benjamin Terrier Darragh Duffy Lluis Quintana-Murci Diederik van de Beek Lucie Roussel Donald C Vinh Stuart G Tangye Filomeen Haerynck David Dalmau Javier Martinez-Picado Petter Brodin Michel C Nussenzweig Stéphanie Boisson-Dupuis Carlos Rodríguez-Gallego Guillaume Vogt Trine H Mogensen Andrew J Oler Jingwen Gu Peter D Burbelo Jeffrey Cohen Andrea Biondi Laura Rachele Bettini Mariella D'Angio Paolo Bonfanti Patrick Rossignol Julien Mayaux Frédéric Rieux-Laucat Eystein S Husebye Francesca Fusco Matilde Valeria Ursini Luisa Imberti Alessandra Sottini Simone Paghera Eugenia Quiros-Roldan Camillo Rossi Riccardo Castagnoli Daniela Montagna Amelia Licari Gian Luigi Marseglia Xavier Duval Jade Ghosn John S Tsang Raphaela Goldbach-Mansky Kai Kisand Michail S Lionakis Anne Puel Shen-Ying Zhang Steven M Holland Guy Gorochov Emmanuelle Jouanguy Charles M Rice Aurélie Cobat Luigi D Notarangelo Laurent Abel Helen C Su Jean-Laurent Casanova

Science 2020 Sep 24. Epub 2020 Sep 24.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.

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http://dx.doi.org/10.1126/science.abd4585DOI Listing
September 2020

Population variation in miRNAs and isomiRs and their impact on human immunity to infection.

Genome Biol 2020 Jul 30;21(1):187. Epub 2020 Jul 30.

Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, 75015, Paris, France.

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http://dx.doi.org/10.1186/s13059-020-02098-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391576PMC
July 2020

Evolutionary and population (epi)genetics of immunity to infection.

Hum Genet 2020 Jun 13;139(6-7):723-732. Epub 2020 Apr 13.

Unit of Human Evolutionary Genetics, CNRS UMR2000, Institut Pasteur, 75015, Paris, France.

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http://dx.doi.org/10.1007/s00439-020-02167-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285878PMC
June 2020

Functional consequences of archaic introgression and their impact on fitness.

Genome Biol 2020 01 2;21(1). Epub 2020 Jan 2.

Unit of Human Evolutionary Genetics, CNRS UMR2000, Institut Pasteur, 75015, Paris, France.

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http://dx.doi.org/10.1186/s13059-019-1920-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939326PMC
January 2020

Associations of autozygosity with a broad range of human phenotypes.

Authors:
David W Clark Yukinori Okada Kristjan H S Moore Dan Mason Nicola Pirastu Ilaria Gandin Hannele Mattsson Catriona L K Barnes Kuang Lin Jing Hua Zhao Patrick Deelen Rebecca Rohde Claudia Schurmann Xiuqing Guo Franco Giulianini Weihua Zhang Carolina Medina-Gomez Robert Karlsson Yanchun Bao Traci M Bartz Clemens Baumbach Ginevra Biino Matthew J Bixley Marco Brumat Jin-Fang Chai Tanguy Corre Diana L Cousminer Annelot M Dekker David A Eccles Kristel R van Eijk Christian Fuchsberger He Gao Marine Germain Scott D Gordon Hugoline G de Haan Sarah E Harris Edith Hofer Alicia Huerta-Chagoya Catherine Igartua Iris E Jansen Yucheng Jia Tim Kacprowski Torgny Karlsson Marcus E Kleber Shengchao Alfred Li Ruifang Li-Gao Anubha Mahajan Koichi Matsuda Karina Meidtner Weihua Meng May E Montasser Peter J van der Most Matthias Munz Teresa Nutile Teemu Palviainen Gauri Prasad Rashmi B Prasad Tallapragada Divya Sri Priyanka Federica Rizzi Erika Salvi Bishwa R Sapkota Daniel Shriner Line Skotte Melissa C Smart Albert Vernon Smith Ashley van der Spek Cassandra N Spracklen Rona J Strawbridge Salman M Tajuddin Stella Trompet Constance Turman Niek Verweij Clara Viberti Lihua Wang Helen R Warren Robyn E Wootton Lisa R Yanek Jie Yao Noha A Yousri Wei Zhao Adebowale A Adeyemo Saima Afaq Carlos Alberto Aguilar-Salinas Masato Akiyama Matthew L Albert Matthew A Allison Maris Alver Tin Aung Fereidoun Azizi Amy R Bentley Heiner Boeing Eric Boerwinkle Judith B Borja Gert J de Borst Erwin P Bottinger Linda Broer Harry Campbell Stephen Chanock Miao-Li Chee Guanjie Chen Yii-Der I Chen Zhengming Chen Yen-Feng Chiu Massimiliano Cocca Francis S Collins Maria Pina Concas Janie Corley Giovanni Cugliari Rob M van Dam Anna Damulina Maryam S Daneshpour Felix R Day Graciela E Delgado Klodian Dhana Alexander S F Doney Marcus Dörr Ayo P Doumatey Nduna Dzimiri S Sunna Ebenesersdóttir Joshua Elliott Paul Elliott Ralf Ewert Janine F Felix Krista Fischer Barry I Freedman Giorgia Girotto Anuj Goel Martin Gögele Mark O Goodarzi Mariaelisa Graff Einat Granot-Hershkovitz Francine Grodstein Simonetta Guarrera Daniel F Gudbjartsson Kamran Guity Bjarni Gunnarsson Yu Guo Saskia P Hagenaars Christopher A Haiman Avner Halevy Tamara B Harris Mehdi Hedayati David A van Heel Makoto Hirata Imo Höfer Chao Agnes Hsiung Jinyan Huang Yi-Jen Hung M Arfan Ikram Anuradha Jagadeesan Pekka Jousilahti Yoichiro Kamatani Masahiro Kanai Nicola D Kerrison Thorsten Kessler Kay-Tee Khaw Chiea Chuen Khor Dominique P V de Kleijn Woon-Puay Koh Ivana Kolcic Peter Kraft Bernhard K Krämer Zoltán Kutalik Johanna Kuusisto Claudia Langenberg Lenore J Launer Deborah A Lawlor I-Te Lee Wen-Jane Lee Markus M Lerch Liming Li Jianjun Liu Marie Loh Stephanie J London Stephanie Loomis Yingchang Lu Jian'an Luan Reedik Mägi Ani W Manichaikul Paolo Manunta Gísli Másson Nana Matoba Xue W Mei Christa Meisinger Thomas Meitinger Massimo Mezzavilla Lili Milani Iona Y Millwood Yukihide Momozawa Amy Moore Pierre-Emmanuel Morange Hortensia Moreno-Macías Trevor A Mori Alanna C Morrison Taulant Muka Yoshinori Murakami Alison D Murray Renée de Mutsert Josyf C Mychaleckyj Mike A Nalls Matthias Nauck Matt J Neville Ilja M Nolte Ken K Ong Lorena Orozco Sandosh Padmanabhan Gunnar Pálsson James S Pankow Cristian Pattaro Alison Pattie Ozren Polasek Neil Poulter Peter P Pramstaller Lluis Quintana-Murci Katri Räikkönen Sarju Ralhan Dabeeru C Rao Wouter van Rheenen Stephen S Rich Paul M Ridker Cornelius A Rietveld Antonietta Robino Frank J A van Rooij Daniela Ruggiero Yasaman Saba Charumathi Sabanayagam Maria Sabater-Lleal Cinzia Felicita Sala Veikko Salomaa Kevin Sandow Helena Schmidt Laura J Scott William R Scott Bahareh Sedaghati-Khayat Bengt Sennblad Jessica van Setten Peter J Sever Wayne H-H Sheu Yuan Shi Smeeta Shrestha Sharvari Rahul Shukla Jon K Sigurdsson Timo Tonis Sikka Jai Rup Singh Blair H Smith Alena Stančáková Alice Stanton John M Starr Lilja Stefansdottir Leon Straker Patrick Sulem Gardar Sveinbjornsson Morris A Swertz Adele M Taylor Kent D Taylor Natalie Terzikhan Yih-Chung Tham Gudmar Thorleifsson Unnur Thorsteinsdottir Annika Tillander Russell P Tracy Teresa Tusié-Luna Ioanna Tzoulaki Simona Vaccargiu Jagadish Vangipurapu Jan H Veldink Veronique Vitart Uwe Völker Eero Vuoksimaa Salma M Wakil Melanie Waldenberger Gurpreet S Wander Ya Xing Wang Nicholas J Wareham Sarah Wild Chittaranjan S Yajnik Jian-Min Yuan Lingyao Zeng Liang Zhang Jie Zhou Najaf Amin Folkert W Asselbergs Stephan J L Bakker Diane M Becker Benjamin Lehne David A Bennett Leonard H van den Berg Sonja I Berndt Dwaipayan Bharadwaj Lawrence F Bielak Murielle Bochud Mike Boehnke Claude Bouchard Jonathan P Bradfield Jennifer A Brody Archie Campbell Shai Carmi Mark J Caulfield David Cesarini John C Chambers Giriraj Ratan Chandak Ching-Yu Cheng Marina Ciullo Marilyn Cornelis Daniele Cusi George Davey Smith Ian J Deary Rajkumar Dorajoo Cornelia M van Duijn David Ellinghaus Jeanette Erdmann Johan G Eriksson Evangelos Evangelou Michele K Evans Jessica D Faul Bjarke Feenstra Mary Feitosa Sylvain Foisy Andre Franke Yechiel Friedlander Paolo Gasparini Christian Gieger Clicerio Gonzalez Philippe Goyette Struan F A Grant Lyn R Griffiths Leif Groop Vilmundur Gudnason Ulf Gyllensten Hakon Hakonarson Anders Hamsten Pim van der Harst Chew-Kiat Heng Andrew A Hicks Hagit Hochner Heikki Huikuri Steven C Hunt Vincent W V Jaddoe Philip L De Jager Magnus Johannesson Åsa Johansson Jost B Jonas J Wouter Jukema Juhani Junttila Jaakko Kaprio Sharon L R Kardia Fredrik Karpe Meena Kumari Markku Laakso Sander W van der Laan Jari Lahti Matthias Laudes Rodney A Lea Wolfgang Lieb Thomas Lumley Nicholas G Martin Winfried März Giuseppe Matullo Mark I McCarthy Sarah E Medland Tony R Merriman Andres Metspalu Brian F Meyer Karen L Mohlke Grant W Montgomery Dennis Mook-Kanamori Patricia B Munroe Kari E North Dale R Nyholt Jeffery R O'connell Carole Ober Albertine J Oldehinkel Walter Palmas Colin Palmer Gerard G Pasterkamp Etienne Patin Craig E Pennell Louis Perusse Patricia A Peyser Mario Pirastu Tinca J C Polderman David J Porteous Danielle Posthuma Bruce M Psaty John D Rioux Fernando Rivadeneira Charles Rotimi Jerome I Rotter Igor Rudan Hester M Den Ruijter Dharambir K Sanghera Naveed Sattar Reinhold Schmidt Matthias B Schulze Heribert Schunkert Robert A Scott Alan R Shuldiner Xueling Sim Neil Small Jennifer A Smith Nona Sotoodehnia E-Shyong Tai Alexander Teumer Nicholas J Timpson Daniela Toniolo David-Alexandre Tregouet Tiinamaija Tuomi Peter Vollenweider Carol A Wang David R Weir John B Whitfield Cisca Wijmenga Tien-Yin Wong John Wright Jingyun Yang Lei Yu Babette S Zemel Alan B Zonderman Markus Perola Patrik K E Magnusson André G Uitterlinden Jaspal S Kooner Daniel I Chasman Ruth J F Loos Nora Franceschini Lude Franke Chris S Haley Caroline Hayward Robin G Walters John R B Perry Tōnu Esko Agnar Helgason Kari Stefansson Peter K Joshi Michiaki Kubo James F Wilson

Nat Commun 2019 10 31;10(1):4957. Epub 2019 Oct 31.

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/s41467-019-12283-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823371PMC
October 2019

A Call for Blood-In Human Immunology.

Immunity 2019 06;50(6):1335-1336

Human Evolutionary Genetics Unit, CNRS UMR 2000, Institut Pasteur, Paris 75015, France.

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http://dx.doi.org/10.1016/j.immuni.2019.05.012DOI Listing
June 2019

Impact and Evolutionary Determinants of Neanderthal Introgression on Transcriptional and Post-Transcriptional Regulation.

Am J Hum Genet 2019 06 30;104(6):1241-1250. Epub 2019 May 30.

Human Evolutionary Genetics Unit, Institut Pasteur, Centre National de la Recherche Scientifique, UMR 2000, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557732PMC
June 2019

Homozygosity for P1104A underlies tuberculosis in about 1% of patients in a cohort of European ancestry.

Proc Natl Acad Sci U S A 2019 05 8;116(21):10430-10434. Epub 2019 May 8.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, 75015 Paris, France.

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http://dx.doi.org/10.1073/pnas.1903561116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534977PMC
May 2019

Associations between usual diet and gut microbiota composition: results from the Milieu Intérieur cross-sectional study.

Am J Clin Nutr 2019 05;109(5):1472-1483

Sorbonne-Paris-Cité Research Center for Epidemiology and Statistics (CRESS), Nutritional Epidemiology Research Team (EREN) (INSERM U1153/INRA U1125/CNAM/Université Paris-XIII Nord), Bobigny, France.

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http://dx.doi.org/10.1093/ajcn/nqz029DOI Listing
May 2019

Defining the genetic and evolutionary architecture of alternative splicing in response to infection.

Nat Commun 2019 04 11;10(1):1671. Epub 2019 Apr 11.

Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR2000, 25-28 rue Dr Roux, Paris, 75015, France.

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http://dx.doi.org/10.1038/s41467-019-09689-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459842PMC
April 2019

Human Immunology through the Lens of Evolutionary Genetics.

Cell 2019 03;177(1):184-199

Unit of Human Evolutionary Genetics, CNRS UMR2000, Institut Pasteur, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.02.033DOI Listing
March 2019

Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria Exposure.

Am J Hum Genet 2019 03 28;104(3):553-561. Epub 2019 Feb 28.

Human Evolutionary Genetics Unit, Institut Pasteur, UMR 2000 Centre National de la Recherche Scientifique, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297193005
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http://dx.doi.org/10.1016/j.ajhg.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407493PMC
March 2019

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant.

Sci Immunol 2018 12;3(30)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.

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http://immunology.sciencemag.org/lookup/doi/10.1126/sciimmun
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http://dx.doi.org/10.1126/sciimmunol.aau8714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341984PMC
December 2018

Editorial overview: The history, geography and adaptation of human genes: A tribute to L. Luca Cavalli-Sforza.

Curr Opin Genet Dev 2018 12;53:iii-v

Unit of Human Evolutionary Genetics, Institut Pasteur and CNRS UMR2000, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2018.11.004DOI Listing
December 2018

The demographic and adaptive history of central African hunter-gatherers and farmers.

Curr Opin Genet Dev 2018 12 10;53:90-97. Epub 2018 Aug 10.

Unit of Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), UMR2000, 75015 Paris, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, 75015 Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X183006
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http://dx.doi.org/10.1016/j.gde.2018.07.008DOI Listing
December 2018

Host and viral genetic diversity can help explain mortality during the 1918-21 influenza pandemic in the Pacific region.

Lancet Infect Dis 2018 08;18(8):833-834

Unit of Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1016/S1473-3099(18)30408-0DOI Listing
August 2018

miR-222 isoforms are differentially regulated by type-I interferon.

RNA 2018 03 20;24(3):332-341. Epub 2017 Dec 20.

Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1261/rna.064550.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824353PMC
March 2018

The Genetic Legacy of the Indian Ocean Slave Trade: Recent Admixture and Post-admixture Selection in the Makranis of Pakistan.

Am J Hum Genet 2017 Dec 9;101(6):977-984. Epub 2017 Nov 9.

Unit of Human Evolutionary Genetics, Department of Genomes & Genetics, Institut Pasteur, Paris 75015, France; Centre National de la Recherche Scientifique URA3012, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812914PMC
December 2017

Living in an adaptive world: Genomic dissection of the genus and its immune response.

J Exp Med 2017 04 28;214(4):877-894. Epub 2017 Mar 28.

Human Evolutionary Genetics Unit, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France

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http://dx.doi.org/10.1084/jem.20161942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379985PMC
April 2017

[Innate immunity and human diseases: from archaic introgression to natural selection].

Med Sci (Paris) 2016 Dec 3;32(12):1079-1086. Epub 2017 Jan 3.

Institut Pasteur, Unité de Génétique Évolutive humaine, Département Génomes et Génétique, 25, rue du Docteur Roux, 75015 Paris, France ; Centre national de la recherche scientifique, URA3012, 75015 Paris, France ; Université Pierre et Marie Curie, cellule Pasteur UPMC, 25, rue du Docteur Roux, 75015 Paris, France.

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http://dx.doi.org/10.1051/medsci/20163212011DOI Listing
December 2016

Understanding rare and common diseases in the context of human evolution.

Genome Biol 2016 11 7;17(1):225. Epub 2016 Nov 7.

Human Evolutionary Genetics Unit, Department of Genomes & Genetics, Institut Pasteur, Paris, 75015, France.

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http://dx.doi.org/10.1186/s13059-016-1093-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098287PMC
November 2016

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations.

Cell 2016 Oct;167(3):643-656.e17

Human Evolutionary Genetics Unit, Institut Pasteur, Paris 75015, France; CNRS, URA3012, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075285PMC
October 2016

Might Interspecific Interactions between Pathogens Drive Host Evolution? The Case of Plasmodium Species and Duffy-Negativity in Human Populations.

Trends Parasitol 2017 01 17;33(1):21-29. Epub 2016 Oct 17.

CNRS, MIVEGEC (UMR CNRS/IRD/UM), 911 Ave. Agropolis, BP 64501, FR-34394 Montpellier cedex 5 France.

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http://dx.doi.org/10.1016/j.pt.2016.09.010DOI Listing
January 2017

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.

Cell Rep 2016 09 25;16(10):2777-2791. Epub 2016 Aug 25.

Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, Paris 75015, France; INSERM U1223, Paris 75015, France; Center for Translational Research, Institut Pasteur, Paris 75015, France; Department of Cancer Immunology, Genentech Inc., San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.011DOI Listing
September 2016

Genetic and epigenetic variation of human populations: An adaptive tale.

C R Biol 2016 Jul-Aug;339(7-8):278-83. Epub 2016 May 13.

Unit of Human Evolutionary Genetics, CNRS URA3012, Institut Pasteur, 25-28, rue du Docteur-Roux, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.crvi.2016.04.005DOI Listing
February 2017

The human gene damage index as a gene-level approach to prioritizing exome variants.

Proc Natl Acad Sci U S A 2015 Nov 19;112(44):13615-20. Epub 2015 Oct 19.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U.1163, Necker Hospital for Sick Children, 75015 Paris, France; Paris Descartes University, Imagine Institute, 75015 Paris, France; Howard Hughes Medical Institute, New York, NY 10065; Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France

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http://dx.doi.org/10.1073/pnas.1518646112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640721PMC
November 2015

bacterial infection drives the expression dynamics of microRNAs and their isomiRs.

PLoS Genet 2015 Mar 20;11(3):e1005064. Epub 2015 Mar 20.

Institut Pasteur, Unit of Human Evolutionary Genetics, Paris, France; Centre National de la Recherche Scientifique, Paris, France.

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http://dx.doi.org/10.1371/journal.pgen.1005064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368565PMC
March 2015

Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping.

Clin Immunol 2015 Apr 6;157(2):261-76. Epub 2015 Jan 6.

Center for Human Immunology, Institut Pasteur, Paris, France; Laboratory of Immunoregulation, Department of Immunology, Institut Pasteur, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2014.12.008DOI Listing
April 2015

The Milieu Intérieur study - an integrative approach for study of human immunological variance.

Clin Immunol 2015 Apr 3;157(2):277-93. Epub 2015 Jan 3.

Center for Human Immunology, Institut Pasteur, Paris, France; Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, Paris, France; INSERM U818, France; INSERM UMS20, France. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2014.12.004DOI Listing
April 2015

Editorial Overview: immunogenetics and transplantation: bringing evolution and genomics to human immunology.

Curr Opin Immunol 2014 Oct 17;30:v-vii. Epub 2014 Sep 17.

Unit of Human Evolutionary Genetics, Institut Pasteur and CNRS URA3012, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2014.09.003DOI Listing
October 2014

Preserving immune diversity through ancient inheritance and admixture.

Curr Opin Immunol 2014 Oct 3;30:79-84. Epub 2014 Sep 3.

Unit of Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France; CNRS URA3012, 75015 Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09527915140010
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http://dx.doi.org/10.1016/j.coi.2014.08.002DOI Listing
October 2014

The Red Queen's long race: human adaptation to pathogen pressure.

Curr Opin Genet Dev 2014 Dec 24;29:31-8. Epub 2014 Aug 24.

Unit of Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, Paris 75015, France; CNRS URA3012, Paris 75015, France. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2014.07.004DOI Listing
December 2014

Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.

Proc Natl Acad Sci U S A 2014 09 18;111(35):E3596-603. Epub 2014 Aug 18.

Sainte-Justine Hospital Research Centre, Montreal, QC, Canada H3T 1C5; Institute of Ecology and Evolution, University of Bern, 3012 Bern, Switzerland;

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http://dx.doi.org/10.1073/pnas.1402875111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156716PMC
September 2014

Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets.

Mol Biol Evol 2014 Jul 1;31(7):1850-68. Epub 2014 Apr 1.

Institut Pasteur, Human Evolutionary Genetics, Department of Genomes and Genetics, Paris, FranceCentre National de la Recherche Scientifique, URA3012, Paris, France

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http://dx.doi.org/10.1093/molbev/msu118DOI Listing
July 2014

HGCS: an online tool for prioritizing disease-causing gene variants by biological distance.

BMC Genomics 2014 Apr 3;15:256. Epub 2014 Apr 3.

St, Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1186/1471-2164-15-256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051124PMC
April 2014

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

Immunity 2014 Mar;40(3):436-50

Center for Human Immunology, Institut Pasteur, 75015 Paris, France; INSERM U818, 75015 Paris, France; Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 75015 Paris, France; INSERM UMS20, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.03.002DOI Listing
March 2014

Immunology taught by human genetics.

Cold Spring Harb Symp Quant Biol 2013 3;78:157-72. Epub 2013 Oct 3.

Unit of Human Evolutionary Genetics, Pasteur Institute, Paris 75015, France CNRS URA 3012, Paris 75015, France.

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http://dx.doi.org/10.1101/sqb.2013.78.019968DOI Listing
March 2015

Human genetic data reveal contrasting demographic patterns between sedentary and nomadic populations that predate the emergence of farming.

Mol Biol Evol 2013 Dec 24;30(12):2629-44. Epub 2013 Sep 24.

Laboratoire Eco-Anthropologie et Ethnobiologie, UMR 7206, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique, Université Paris 7 Diderot, Paris, France.

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http://dx.doi.org/10.1093/molbev/mst156DOI Listing
December 2013

The impact of natural selection on health and disease: uses of the population genetics approach in humans.

Evol Appl 2013 Jun 21;6(4):596-607. Epub 2013 Jan 21.

Institut Pasteur, Unit of Human Evolutionary Genetics 75015, Paris, France ; Centre National de la Recherche Scientifique, URA 3012 75015, Paris, France ; Centre National de la Recherche Scientifique, UMR 5174, Evolution et Diversité Biologique 31062, Toulouse, France ; Université de Toulouse 31062, Toulouse, France.

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http://dx.doi.org/10.1111/eva.12045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684741PMC
June 2013

Evidence for polygenic adaptation to pathogens in the human genome.

Mol Biol Evol 2013 Jul 26;30(7):1544-58. Epub 2013 Apr 26.

Computational and Molecular Population Genetics Lab, Institute of Ecology and Evolution, University of Berne, Berne, Switzerland.

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http://dx.doi.org/10.1093/molbev/mst080DOI Listing
July 2013

The genetics of innate immunity sensors and human disease.

Int Rev Immunol 2013 Apr;32(2):157-208

Institut Pasteur, Unit of Human Evolutionary Genetics, Paris, France.

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http://dx.doi.org/10.3109/08830185.2013.777064DOI Listing
April 2013

The human gene connectome as a map of short cuts for morbid allele discovery.

Proc Natl Acad Sci U S A 2013 Apr 18;110(14):5558-63. Epub 2013 Mar 18.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1218167110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619280PMC
April 2013

Population genetic tools for dissecting innate immunity in humans.

Nat Rev Immunol 2013 Apr 8;13(4):280-93. Epub 2013 Mar 8.

Institut Pasteur, Unit of Human Evolutionary Genetics, Paris, France.

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http://dx.doi.org/10.1038/nri3421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015519PMC
April 2013

[Population genetics and human immunity: the interferon paradigm].

Med Sci (Paris) 2012 Dec 21;28(12):1095-101. Epub 2012 Dec 21.

Institut Pasteur, département génomes et génétique, unité génétique évolutive humaine, 25, rue du Docteur Roux, 75015 Paris, France - CNRS URA3012, 75015 Paris, France.

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http://dx.doi.org/10.1051/medsci/20122812020DOI Listing
December 2012

A genome-wide perspective of human diversity and its implications in infectious disease.

Cold Spring Harb Perspect Med 2013 Jan 1;3(1):a012450. Epub 2013 Jan 1.

Institut Pasteur, Unit of Human Evolutionary Genetics, Department of Genomes and Genetics, F-75015 Paris, France.

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http://dx.doi.org/10.1101/cshperspect.a012450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530038PMC
January 2013

The evolutionary landscape of cytosolic microbial sensors in humans.

Am J Hum Genet 2012 Jul 28;91(1):27-37. Epub 2012 Jun 28.

Institut Pasteur, Unit of Human Evolutionary Genetics, Paris, France.

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http://dx.doi.org/10.1016/j.ajhg.2012.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397270PMC
July 2012

Evidence of pre-Roman tribal genetic structure in Basques from uniparentally inherited markers.

Mol Biol Evol 2012 Sep 12;29(9):2211-22. Epub 2012 Mar 12.

Departament de Ciències de la Salut i de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1093/molbev/mss091DOI Listing
September 2012

Genetics. Gene losses in the human genome.

Science 2012 Feb;335(6070):806-7

Institut Pasteur, Unit of Human Evolutionary Genetics, CNRS URA3012, Paris, France.

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http://dx.doi.org/10.1126/science.1219299DOI Listing
February 2012

Evolutionary genetic dissection of human interferons.

J Exp Med 2011 Dec 12;208(13):2747-59. Epub 2011 Dec 12.

Unit of Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, F-75015 Paris, France.

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http://dx.doi.org/10.1084/jem.20111680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244034PMC
December 2011

Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection.

Hum Immunol 2012 Feb 23;73(2):196-200. Epub 2011 Oct 23.

Unit of Human Evolutionary Genetics, Institut Pasteur, F-75015 Paris, France.

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http://dx.doi.org/10.1016/j.humimm.2011.10.014DOI Listing
February 2012

The selective footprints of viral pressures at the human RIG-I-like receptor family.

Hum Mol Genet 2011 Nov 24;20(22):4462-74. Epub 2011 Aug 24.

Unit of Human Evolutionary Genetics, URA3012, Institut Pasteur, 25-28 Rue du Dr Roux, F-75015 Paris, France.

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http://dx.doi.org/10.1093/hmg/ddr377DOI Listing
November 2011

Lactase persistence in central Asia: phenotype, genotype, and evolution.

Hum Biol 2011 Jun;83(3):379-92

Eco-anthropology and Ethnobiology Unit, Muséum National d'Histoire Naturelle, Université Paris Diderot, France.

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http://dx.doi.org/10.3378/027.083.0304DOI Listing
June 2011

Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.

Mol Biol Evol 2011 Nov 9;28(11):3087-97. Epub 2011 Jun 9.

Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1093/molbev/msr137DOI Listing
November 2011

Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.

Hum Mutat 2011 Jun;32(6):643-52

Institut Pasteur, Human Evolutionary Genetics, Department of Genomes and Genetics, Paris, France.

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http://dx.doi.org/10.1002/humu.21486DOI Listing
June 2011

HTLV-2B strains, similar to those found in several Amerindian tribes, are endemic in central African Bakola Pygmies.

J Infect Dis 2011 May;203(9):1316-23

Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Institut National de la Santéet de la Recherche Médicale, Paris, France.

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http://dx.doi.org/10.1093/infdis/jir031DOI Listing
May 2011

Evolutionary genetics evidence of an essential, nonredundant role of the IFN-γ pathway in protective immunity.

Hum Mutat 2011 Jun 29;32(6):633-42. Epub 2011 Mar 29.

Institut Pasteur, Human Evolutionary Genetics, Department of Genomes and Genetics, Paris, France.

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http://dx.doi.org/10.1002/humu.21484DOI Listing
June 2011

Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics.

Annu Rev Immunol 2011 ;29:447-91

St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1146/annurev-immunol-030409-101335DOI Listing
June 2011