Publications by authors named "Lloyd Paul Aiello"

100Publications

Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study.

Ophthalmology 2020 Sep 14. Epub 2020 Sep 14.

Department of Ophthalmology, Harvard Medical School and Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ophtha.2020.09.014DOI Listing
September 2020

Retinal Vascular Caliber Association with Nonperfusion and Diabetic Retinopathy Severity Depends on Vascular Caliber Measurement Location.

Ophthalmol Retina 2020 Sep 11. Epub 2020 Sep 11.

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Teleophthalmology and Image Reading Center, Philippine Eye Research Institute, National Institutes of Health, University of the Philippines, Manila, Philippines. Electronic address:

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http://dx.doi.org/10.1016/j.oret.2020.09.003DOI Listing
September 2020

Diabetic retinopathy and ultrawide field imaging.

Semin Ophthalmol 2020 Jan 13;35(1):56-65. Epub 2020 Mar 13.

Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.

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http://dx.doi.org/10.1080/08820538.2020.1729818DOI Listing
January 2020

Long-Term Effect on HbA1c in Poorly Controlled Diabetic Patients Following Nonmydriatic Retinal Image Review at the Time of Endocrinology Visit.

Telemed J E Health 2020 Oct 14;26(10):1265-1270. Epub 2020 Jan 14.

Department of Ophthalmology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1089/tmj.2019.0239DOI Listing
October 2020

One-Time Intravitreal Injection of KVD001, a Plasma Kallikrein Inhibitor, in Patients with Central-Involved Diabetic Macular Edema and Reduced Vision: An Open-Label Phase 1B Study.

Ophthalmol Retina 2019 12 26;3(12):1107-1109. Epub 2019 Jul 26.

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.oret.2019.07.006DOI Listing
December 2019

Ultrawide field scanning laser ophthalmoscopy imaging of lipemia retinalis.

Acta Ophthalmol 2018 Aug 3;96(5):e643-e646. Epub 2017 Aug 3.

Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.

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http://dx.doi.org/10.1111/aos.13525DOI Listing
August 2018

Hemorrhage and/or Microaneurysm Severity and Count in Ultrawide Field Images and Early Treatment Diabetic Retinopathy Study Photography.

Ophthalmology 2017 07 20;124(7):970-976. Epub 2017 Mar 20.

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ophtha.2017.02.012DOI Listing
July 2017

Computational fluid dynamics assisted characterization of parafoveal hemodynamics in normal and diabetic eyes using adaptive optics scanning laser ophthalmoscopy.

Biomed Opt Express 2016 Dec 4;7(12):4958-4973. Epub 2016 Nov 4.

Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1364/BOE.7.004958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175544PMC
December 2016

Macula Society Collaborative Retrospective Study of Ocriplasmin for Symptomatic Vitreomacular Adhesion.

Ophthalmol Retina 2017 Sep - Oct;1(5):413-420. Epub 2017 Apr 25.

Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

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http://dx.doi.org/10.1016/j.oret.2016.10.018DOI Listing
April 2017

Clinical Components of Telemedicine Programs for Diabetic Retinopathy.

Curr Diab Rep 2016 12;16(12):129

Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11892-016-0813-8DOI Listing
December 2016

Operational Components of Telemedicine Programs for Diabetic Retinopathy.

Curr Diab Rep 2016 12;16(12):128

Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11892-016-0814-7DOI Listing
December 2016

Presence and Risk Factors for Glaucoma in Patients with Diabetes.

Curr Diab Rep 2016 12;16(12):124

Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11892-016-0815-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310929PMC
December 2016

Report From the NEI/FDA Diabetic Retinopathy Clinical Trial Design and Endpoints Workshop.

Invest Ophthalmol Vis Sci 2016 10;57(13):5127-5142

National Eye Institute, Bethesda, Maryland, United States.

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http://dx.doi.org/10.1167/iovs.16-20356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016432PMC
October 2016

Anti-Vascular Endothelial Growth Factor Agents in the Treatment of Retinal Disease: From Bench to Bedside.

Ophthalmology 2016 Oct;123(10S):S78-S88

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

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http://dx.doi.org/10.1016/j.ophtha.2016.04.056DOI Listing
October 2016

Plasma Kallikrein Mediates Vascular Endothelial Growth Factor-Induced Retinal Dysfunction and Thickening.

Invest Ophthalmol Vis Sci 2016 05;57(6):2390-9

Joslin Diabetes Center, Boston, Massachusetts, United States 5Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1167/iovs.15-18272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857835PMC
May 2016

Identification of Diabetic Retinopathy and Ungradable Image Rate with Ultrawide Field Imaging in a National Teleophthalmology Program.

Ophthalmology 2016 06 2;123(6):1360-7. Epub 2016 Mar 2.

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ophtha.2016.01.043DOI Listing
June 2016

Comparison of Nondiabetic Retinal Findings Identified With Nonmydriatic Fundus Photography vs Ultrawide Field Imaging in an Ocular Telehealth Program.

JAMA Ophthalmol 2016 Mar;134(3):330-4

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts2Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaophthalmol.2015.5605DOI Listing
March 2016

The Future of Ultrawide Field Imaging for Diabetic Retinopathy: Pondering the Retinal Periphery.

JAMA Ophthalmol 2016 Mar;134(3):247-8

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts2Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaophthalmol.2015.5384DOI Listing
March 2016

Proteomic Analysis of Embryonic and Young Human Vitreous.

Invest Ophthalmol Vis Sci 2015 Nov;56(12):7036-42

VMR Institute for Vitreous Macula Retina, Huntington Beach, California, United States 2Doheny Eye Institute, Los Angeles, California, United States.

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http://dx.doi.org/10.1167/iovs.15-16809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110202PMC
November 2015

Diabetic Retinopathy Severity and Peripheral Lesions Are Associated with Nonperfusion on Ultrawide Field Angiography.

Ophthalmology 2015 Dec 6;122(12):2465-72. Epub 2015 Sep 6.

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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https://linkinghub.elsevier.com/retrieve/pii/S01616420150077
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http://dx.doi.org/10.1016/j.ophtha.2015.07.034DOI Listing
December 2015

Reply: To PMID 24830822.

Retina 2015 Jul;35(7):e37-8

Beetham Eye Institute, Joslin Diabetes Center, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/IAE.0000000000000640DOI Listing
July 2015

Real-Time Ultrawide Field Image Evaluation of Retinopathy in a Diabetes Telemedicine Program.

Diabetes Care 2015 Sep 1;38(9):1643-9. Epub 2015 Jun 1.

Beetham Eye Institute, Joslin Diabetes Center, Boston, MA Department of Ophthalmology, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.2337/dc15-0161DOI Listing
September 2015

Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema.

Diabetes 2015 Oct 15;64(10):3588-99. Epub 2015 May 15.

Joslin Diabetes Center, Harvard Medical School, Boston, MA Department of Medicine, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db15-0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587649PMC
October 2015

Telemedicine and eye examinations for diabetic retinopathy: a time to maximize real-world outcomes.

JAMA Ophthalmol 2015 May;133(5):525-6

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts2Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaophthalmol.2015.0333DOI Listing
May 2015

Peripheral Lesions Identified on Ultrawide Field Imaging Predict Increased Risk of Diabetic Retinopathy Progression over 4 Years.

Ophthalmology 2015 May 19;122(5):949-56. Epub 2015 Feb 19.

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ophtha.2015.01.008DOI Listing
May 2015

Automated retinal image analysis for diabetic retinopathy in telemedicine.

Curr Diab Rep 2015 Mar;15(3):14

Department of Ophthalmology, Harvard Medical School and Beetham Eye Institute, Joslin Diabetes Center, One Joslin Place, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s11892-015-0577-6DOI Listing
March 2015

Neural Retinal Disorganization as a Robust Marker of Visual Acuity in Current and Resolved Diabetic Macular Edema.

Diabetes 2015 Jul 29;64(7):2560-70. Epub 2015 Jan 29.

Beetham Eye Institute, Joslin Diabetes Center, Boston, MA Department of Ophthalmology, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.2337/db14-0782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477364PMC
July 2015

Disorganization of the retinal inner layers as a predictor of visual acuity in eyes with center-involved diabetic macular edema.

JAMA Ophthalmol 2014 Nov;132(11):1309-16

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts2Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaophthalmol.2014.2350DOI Listing
November 2014

Collaborative retrospective macula society study of photodynamic therapy for chronic central serous chorioretinopathy.

Ophthalmology 2014 May 16;121(5):1073-8. Epub 2014 Jan 16.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.ophtha.2013.11.040DOI Listing
May 2014

Peripheral lesions identified by mydriatic ultrawide field imaging: distribution and potential impact on diabetic retinopathy severity.

Ophthalmology 2013 Dec 15;120(12):2587-2595. Epub 2013 Jun 15.

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ophtha.2013.05.004DOI Listing
December 2013

Ultra-wide field retinal imaging in detection, classification, and management of diabetic retinopathy.

Semin Ophthalmol 2012 Sep-Nov;27(5-6):221-7

Beetham Eye Institute and Eye Research Section, Joslin Diabetes Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.3109/08820538.2012.708812DOI Listing
February 2013

Comparison of low-light nonmydriatic digital imaging with 35-mm ETDRS seven-standard field stereo color fundus photographs and clinical examination.

Telemed J E Health 2012 Sep 24;18(7):492-9. Epub 2012 Jul 24.

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1089/tmj.2011.0232DOI Listing
September 2012

Antiangiogenic therapy for ischemic retinopathies.

Cold Spring Harb Perspect Med 2012 Jun;2(6):a006411

Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA

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http://perspectivesinmedicine.cshlp.org/content/early/2012/0
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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a006411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367538PMC
June 2012

Nonmydriatic ultrawide field retinal imaging compared with dilated standard 7-field 35-mm photography and retinal specialist examination for evaluation of diabetic retinopathy.

Am J Ophthalmol 2012 Sep 23;154(3):549-559.e2. Epub 2012 May 23.

Beetham Eye Institute, Joslin Diabetes Center, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.ajo.2012.03.019DOI Listing
September 2012

Automated Retinal Imaging System (ARIS) compared with ETDRS protocol color stereoscopic retinal photography to assess level of diabetic retinopathy.

Diabetes Technol Ther 2012 Jun 2;14(6):515-22. Epub 2012 Mar 2.

Beetham Eye Institute, Joslin Diabetes Center, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.liebertpub.com/doi/10.1089/dia.2011.0270
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http://dx.doi.org/10.1089/dia.2011.0270DOI Listing
June 2012

Evaluation of visual acuity measurements after autorefraction vs manual refraction in eyes with and without diabetic macular edema.

Arch Ophthalmol 2012 Apr 12;130(4):470-9. Epub 2011 Dec 12.

Beetham Eye Institute and Research Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1001/archophthalmol.2011.377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489033PMC
April 2012

Vitreous levels of soluble vascular endothelial growth factor receptor (VEGFR)-1 in eyes with vitreoretinal diseases.

Br J Ophthalmol 2011 Dec 30;95(12):1745-8. Epub 2011 Jun 30.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1136/bjophthalmol-2011-300139DOI Listing
December 2011

Nonmydriatic retinal image review at time of endocrinology visit results in short-term HbA1c reduction in poorly controlled patients with diabetic retinopathy.

Telemed J E Health 2011 Jul-Aug;17(6):415-9. Epub 2011 Jun 15.

Department of Ophthalmology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1089/tmj.2010.0180DOI Listing
December 2011

Comparison of film and digital fundus photographs in eyes of individuals with diabetes mellitus.

Invest Ophthalmol Vis Sci 2011 Aug 3;52(9):6168-73. Epub 2011 Aug 3.

Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1167/iovs.11-7321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176025PMC
August 2011

Telemedicine and diabetic retinopathy: moving beyond retinal screening.

Arch Ophthalmol 2011 Feb;129(2):236-42

Department of Ophthalmology, Harvard Medical School and Beetham Eye Institute, Joslin Diabetes Center, 1 Joslin Pl., Boston, MA 02215, USA.

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http://dx.doi.org/10.1001/archophthalmol.2010.365DOI Listing
February 2011

Vitreous proteomics and diabetic retinopathy.

Semin Ophthalmol 2010 Sep-Nov;25(5-6):289-94

Joslin Diabetes Center, Boston, MA, USA.

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http://dx.doi.org/10.3109/08820538.2010.518912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996366PMC
April 2011

Effect of systemic medications on onset and progression of diabetic retinopathy.

Nat Rev Endocrinol 2010 Sep 27;6(9):494-508. Epub 2010 Jul 27.

Beetham Eye Institute, Joslin Diabetes Center, Department of Ophthalmology, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/nrendo.2010.122DOI Listing
September 2010

Histopathology of neovascular tissue from eyes with proliferative diabetic retinopathy after intravitreal bevacizumab injection.

Am J Ophthalmol 2010 Aug 9;150(2):223-229.e1. Epub 2010 Jun 9.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.ajo.2010.03.016DOI Listing
August 2010

Ruboxistaurin mesilate hydrate for diabetic retinopathy.

Drugs Today (Barc) 2009 Apr;45(4):269-74

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL, USA.

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http://dx.doi.org/10.1358/dot.2009.45.4.1354195DOI Listing
April 2009

Role of steroids in the management of diabetic macular edema and proliferative diabetic retinopathy.

Semin Ophthalmol 2009 Mar-Apr;24(2):93-9

Beetham Eye Institute and Section of Eye Research, Joslin Diabetes Center and Department of Ophthalmology, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1080/08820530902800355DOI Listing
May 2009

Effects of dilation on electronic-ETDRS visual acuity in diabetic patients.

Invest Ophthalmol Vis Sci 2009 Apr 20;50(4):1580-4. Epub 2008 Oct 20.

Beetham Eye Institute and Eye Research Section, Joslin Diabetes Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1167/iovs.08-2426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762194PMC
April 2009

Targeting intraocular neovascularization and edema--one drop at a time.

N Engl J Med 2008 Aug;359(9):967-9

Beetham Eye Institute and Section of Eye Research, Joslin Diabetes Center, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcibr0804551DOI Listing
August 2008

Can OCT serve as a surrogate for visual acuity in eyes with DME?

Curr Diab Rep 2008 Aug;8(4):255-6

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http://dx.doi.org/10.1007/s11892-008-0045-7DOI Listing
August 2008

Rosiglitazone and delayed onset of proliferative diabetic retinopathy.

Arch Ophthalmol 2008 Jun;126(6):793-9

Harvard Medical School, USA.

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http://dx.doi.org/10.1001/archopht.126.6.793DOI Listing
June 2008

Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy.

J Proteome Res 2008 Jun 24;7(6):2516-25. Epub 2008 Apr 24.

Research Division, Beetham Eye Institute, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.

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http://pubs.acs.org/doi/abs/10.1021/pr800112g
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http://dx.doi.org/10.1021/pr800112gDOI Listing
June 2008

Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation.

Nat Med 2007 Feb 28;13(2):181-8. Epub 2007 Jan 28.

Research Division, Joslin Diabetes Center, One Joslin Place, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nm1534DOI Listing
February 2007

Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy.

Ophthalmology 2006 Dec 20;113(12):2221-30. Epub 2006 Sep 20.

Beetham Eye Institute, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.ophtha.2006.07.032DOI Listing
December 2006

Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics.

Invest Ophthalmol Vis Sci 2006 Jun;47(6):2701-8

Section of Eye Research and Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1167/iovs.05-0071DOI Listing
June 2006

Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema.

Invest Ophthalmol Vis Sci 2005 Oct;46(10):3855-8

Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1167/iovs.05-0096DOI Listing
October 2005

Angiogenic pathways in diabetic retinopathy.

N Engl J Med 2005 Aug;353(8):839-41

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http://dx.doi.org/10.1056/NEJMe058142DOI Listing
August 2005