Lloyd J Old

Lloyd J Old

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Lloyd J Old

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The human cell surfaceome of breast tumors.

Biomed Res Int 2013 9;2013:976816. Epub 2013 Sep 9.

Ludwig Institute for Cancer Research, São Paulo 01308-050, SP, Brazil ; Center for Applied Toxinology, Butantan Institute, São Paulo 05503-900, SP, Brazil.

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http://dx.doi.org/10.1155/2013/976816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781997PMC
June 2014

Nonclassical antigen-processing pathways are required for MHC class II-restricted direct tumor recognition by NY-ESO-1-specific CD4(+) T cells.

Cancer Immunol Res 2014 Apr 17;2(4):341-50. Epub 2013 Dec 17.

Authors' Affiliations: Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.

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http://cancerimmunolres.aacrjournals.org/cgi/doi/10.1158/232
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http://dx.doi.org/10.1158/2326-6066.CIR-13-0138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004114PMC
April 2014

Prostate cancer progression correlates with increased humoral immune response to a human endogenous retrovirus GAG protein.

Clin Cancer Res 2013 Nov 30;19(22):6112-25. Epub 2013 Sep 30.

Authors' Affiliations: Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center; Departments of Surgery, Medicine, Pathology, Biostatistics, and Immunology, Memorial Sloan-Kettering Cancer Center; NYU Langone Medical Center, New York; Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; RIKEN Bioresource Center, Tsukuba, Ibaraki, Japan; and Klinik für Onkologie und Hämatologie, Krankenhaus Nordwest, Frankfurt, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3580DOI Listing
November 2013

MAGE-A3 is highly expressed in a subset of colorectal cancer patients.

Cancer Immun 2012 28;12:16. Epub 2012 Dec 28.

Division of Colon and Rectal Surgery, Department of Surgery, St Luke's-Roosevelt Hospital Center, New York, NY 10019, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554221PMC
July 2013

A Pilot Study of Anti-CTLA4 Antibody Ipilimumab in Patients with Synovial Sarcoma.

Sarcoma 2013 27;2013:168145. Epub 2013 Feb 27.

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA ; Departments of Medicine, Pediatrics, and Orthopaedics, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, P.O. Box 1208, New York, NY 10029-6574, USA.

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http://dx.doi.org/10.1155/2013/168145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608267PMC
April 2013

Spontaneous antibody, and CD4 and CD8 T-cell responses against XAGE-1b (GAGED2a) in non-small cell lung cancer patients.

Int J Cancer 2012 Sep 3;131(5):E649-58. Epub 2012 Jan 3.

Department of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Japan.

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http://doi.wiley.com/10.1002/ijc.27359
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http://dx.doi.org/10.1002/ijc.27359DOI Listing
September 2012

Intracellular tumor-associated antigens represent effective targets for passive immunotherapy.

Cancer Res 2012 Apr 8;72(7):1672-82. Epub 2012 Feb 8.

Department of Cancer Vaccine, Cellular and Molecular Immunology, and Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3072DOI Listing
April 2012

Heat shock protein 90-mediated peptide-selective presentation of cytosolic tumor antigen for direct recognition of tumors by CD4(+) T cells.

J Immunol 2012 Apr 16;188(8):3851-8. Epub 2012 Mar 16.

Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.4049/jimmunol.1103269DOI Listing
April 2012

Antibody therapy of cancer.

Nat Rev Cancer 2012 Mar 22;12(4):278-87. Epub 2012 Mar 22.

Ludwig Institute for Cancer Research; University of Melbourne; and Centre for PET, Austin Hospital, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1038/nrc3236DOI Listing
March 2012

Split T cell tolerance against a self/tumor antigen: spontaneous CD4+ but not CD8+ T cell responses against p53 in cancer patients and healthy donors.

PLoS One 2011 12;6(8):e23651. Epub 2011 Aug 12.

Ludwig Institute for Cancer Research Ltd., New York Branch at Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023651PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155555PMC
February 2012

Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma.

Hum Reprod 2011 Dec 20;26(12):3232-43. Epub 2011 Oct 20.

Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1093/humrep/der330DOI Listing
December 2011

Trypanosoma cruzi as an effective cancer antigen delivery vector.

Proc Natl Acad Sci U S A 2011 Dec 23;108(49):19695-700. Epub 2011 Nov 23.

Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, Minas Gerais, Brazil.

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http://dx.doi.org/10.1073/pnas.1110030108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241774PMC
December 2011

Defining the critical hurdles in cancer immunotherapy.

Authors:
Bernard A Fox Dolores J Schendel Lisa H Butterfield Steinar Aamdal James P Allison Paolo Antonio Ascierto Michael B Atkins Jirina Bartunkova Lothar Bergmann Neil Berinstein Cristina C Bonorino Ernest Borden Jonathan L Bramson Cedrik M Britten Xuetao Cao William E Carson Alfred E Chang Dainius Characiejus A Raja Choudhury George Coukos Tanja de Gruijl Robert O Dillman Harry Dolstra Glenn Dranoff Lindy G Durrant James H Finke Jerome Galon Jared A Gollob Cécile Gouttefangeas Fabio Grizzi Michele Guida Leif Håkansson Kristen Hege Ronald B Herberman F Stephen Hodi Axel Hoos Christoph Huber Patrick Hwu Kohzoh Imai Elizabeth M Jaffee Sylvia Janetzki Carl H June Pawel Kalinski Howard L Kaufman Koji Kawakami Yutaka Kawakami Ulrich Keilholtz Samir N Khleif Rolf Kiessling Beatrix Kotlan Guido Kroemer Rejean Lapointe Hyam I Levitsky Michael T Lotze Cristina Maccalli Michele Maio Jens-Peter Marschner Michael J Mastrangelo Giuseppe Masucci Ignacio Melero Cornelius Melief William J Murphy Brad Nelson Andrea Nicolini Michael I Nishimura Kunle Odunsi Pamela S Ohashi Jill O'Donnell-Tormey Lloyd J Old Christian Ottensmeier Michael Papamichail Giorgio Parmiani Graham Pawelec Enrico Proietti Shukui Qin Robert Rees Antoni Ribas Ruggero Ridolfi Gerd Ritter Licia Rivoltini Pedro J Romero Mohamed L Salem Rik J Scheper Barbara Seliger Padmanee Sharma Hiroshi Shiku Harpreet Singh-Jasuja Wenru Song Per Thor Straten Hideaki Tahara Zhigang Tian Sjoerd H van Der Burg Paul von Hoegen Ena Wang Marij Jp Welters Hauke Winter Tara Withington Jedd D Wolchok Weihua Xiao Laurence Zitvogel Heinz Zwierzina Francesco M Marincola Thomas F Gajewski Jon M Wigginton Mary L Disis

J Transl Med 2011 Dec 14;9:214. Epub 2011 Dec 14.

Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA.

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http://dx.doi.org/10.1186/1479-5876-9-214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338100PMC
December 2011

Expression and purification of cGMP grade NY-ESO-1 for clinical trials.

Biotechnol Prog 2011 Mar-Apr;27(2):435-41. Epub 2011 Mar 1.

Graduate Field of Microbiology, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1002/btpr.552DOI Listing
September 2011

A proteomic analysis of the Pichia pastoris secretome in methanol-induced cultures.

Appl Microbiol Biotechnol 2011 Apr 9;90(1):235-47. Epub 2011 Feb 9.

Field of Microbiology (317 Stocking Hall), Cornell University, Ithaca, NY 14853, USA.

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http://link.springer.com/content/pdf/10.1007/s00253-011-3118
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http://link.springer.com/10.1007/s00253-011-3118-5
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http://dx.doi.org/10.1007/s00253-011-3118-5DOI Listing
April 2011

Correlation of in vivo and in vitro measures of carbonic anhydrase IX antigen expression in renal masses using antibody 124I-cG250.

J Nucl Med 2011 Apr 18;52(4):535-40. Epub 2011 Mar 18.

Division of Nuclear Medicine and Clinical Molecular Imaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.2967/jnumed.110.083295DOI Listing
April 2011

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.

Science 2011 Mar;331(6024):1565-70

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/science.1203486DOI Listing
March 2011

Multiple cancer/testis antigens are preferentially expressed in hormone-receptor negative and high-grade breast cancers.

PLoS One 2011 Mar 18;6(3):e17876. Epub 2011 Mar 18.

Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017876PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060908PMC
March 2011

Efficient in vivo priming by vaccination with recombinant NY-ESO-1 protein and CpG in antigen naive prostate cancer patients.

Clin Cancer Res 2011 Feb 16;17(4):861-70. Epub 2010 Dec 16.

II. Medizinische Klinik, Hämatologie - Onkologie, Krankenhaus Nordwest, Frankfurt, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1811DOI Listing
February 2011

Antibody-targeted NY-ESO-1 to mannose receptor or DEC-205 in vitro elicits dual human CD8+ and CD4+ T cell responses with broad antigen specificity.

J Immunol 2011 Jan 13;186(2):1218-27. Epub 2010 Dec 13.

Ludwig Institute for Cancer Research, Ltd., New York Branch, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.4049/jimmunol.1000808DOI Listing
January 2011

Assessment of vaccine-induced CD4 T cell responses to the 119-143 immunodominant region of the tumor-specific antigen NY-ESO-1 using DRB1*0101 tetramers.

Clin Cancer Res 2010 Sep 29;16(18):4607-15. Epub 2010 Jul 29.

Institut National de Santé et de Recherche Médicale, Unité 892, CLCC René Gauducheau, Saint Herblain, France.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-10-1485DOI Listing
September 2010

Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells.

J Immunol 2010 Sep 23;185(6):3768-76. Epub 2010 Aug 23.

Department of Cancer Vaccine, Mie University Graduate School of Medicine, Mie, Japan.

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http://dx.doi.org/10.4049/jimmunol.0903649DOI Listing
September 2010

Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.

Clin Cancer Res 2010 May 11;16(10):2781-91. Epub 2010 May 11.

Department of Cancer Vaccine, Mie University Graduate School of Medicine, Mie, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-3243DOI Listing
May 2010

Improved secretion of the cancer-testis antigen SSX2 in Pichia pastoris by deletion of its nuclear localization signal.

Appl Microbiol Biotechnol 2010 Mar 14;86(1):243-53. Epub 2009 Oct 14.

Field of Microbiology, Cornell University, 317 Stocking Hall, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1007/s00253-009-2275-2DOI Listing
March 2010

Seromic profiling of ovarian and pancreatic cancer.

Proc Natl Acad Sci U S A 2010 Mar 1;107(11):5088-93. Epub 2010 Mar 1.

Ludwig Institute for Cancer Research Ltd, Memorial-Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0914213107
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http://dx.doi.org/10.1073/pnas.0914213107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841879PMC
March 2010

Characterization of preexisting MAGE-A3-specific CD4+ T cells in cancer patients and healthy individuals and their activation by protein vaccination.

J Immunol 2009 Oct 4;183(7):4800-8. Epub 2009 Sep 4.

Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.4049/jimmunol.0900903DOI Listing
October 2009

Immune responses detected in urothelial carcinoma patients after vaccination with NY-ESO-1 protein plus BCG and GM-CSF.

J Immunother 2008 Nov-Dec;31(9):849-57

Department of Genitourinary Medical Oncology, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.

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http://dx.doi.org/10.1097/CJI.0b013e3181891574DOI Listing
July 2009

Vaccination with recombinant NY-ESO-1 protein elicits immunodominant HLA-DR52b-restricted CD4+ T cell responses with a conserved T cell receptor repertoire.

Clin Cancer Res 2009 Jul 16;15(13):4467-74. Epub 2009 Jun 16.

Institut National de la Santé et de la Recherche Médicale, CLCC René Gauducheau, Boulevard Jacques Monod, Saint Herblain, France.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-0582DOI Listing
July 2009

Deep depletion of abundant serum proteins reveals low-abundant proteins as potential biomarkers for human ovarian cancer.

Proteomics Clin Appl 2009 Jul;3(7):853-861

Systems Biology Division, Zhejiang-California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, P. R. China.

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http://doi.wiley.com/10.1002/prca.200800141
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http://dx.doi.org/10.1002/prca.200800141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886282PMC
July 2009

Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer.

Int J Cancer 2009 Jun;124(12):2893-8

Departments of Pathology and Surgery, Weill Cornell Medical College, New York, NY 10065, USA.

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http://doi.wiley.com/10.1002/ijc.24296
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http://dx.doi.org/10.1002/ijc.24296DOI Listing
June 2009

Autoantibodies against cancer antigens.

Methods Mol Biol 2009 ;520:11-9

Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-60327-811-9_2DOI Listing
May 2009

Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells.

J Immunother 2009 Feb-Mar;32(2):101-8

Institut National de la Santé et de la Recherche Médicale, CLCC René Gauducheau, Saint Herblain section signFaculty of Medicine, University of Nantes, Nantes, France.

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https://insights.ovid.com/crossref?an=00002371-200902000-000
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http://dx.doi.org/10.1097/CJI.0b013e318195b59eDOI Listing
April 2009

Factors affecting endotoxin removal from recombinant therapeutic proteins by anion exchange chromatography.

Protein Expr Purif 2009 Mar 22;64(1):76-81. Epub 2008 Oct 22.

Graduate Field of Chemical Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1016/j.pep.2008.10.006DOI Listing
March 2009

NY-ESO-1 DNA vaccine induces T-cell responses that are suppressed by regulatory T cells.

Clin Cancer Res 2009 Mar 10;15(6):2130-9. Epub 2009 Mar 10.

Ludwig Institute for Cancer Research, New York Branch, Memorial Sloan-Kettering Cancer Center, New York, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806520PMC
March 2009

Genome-wide analysis of cancer/testis gene expression.

Proc Natl Acad Sci U S A 2008 Dec 16;105(51):20422-7. Epub 2008 Dec 16.

Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, SPH2, 4th Floor, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0810777105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603434PMC
December 2008

Identification of the HERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity.

Cancer Immun 2008 Nov 13;8:15. Epub 2008 Nov 13.

Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935773PMC
November 2008

Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient.

Cancer Immunol Immunother 2008 Oct 1;57(10):1429-37. Epub 2008 Mar 1.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

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http://dx.doi.org/10.1007/s00262-008-0478-5DOI Listing
October 2008

Inducing efficient cross-priming using antigen-coated yeast particles.

J Immunother 2008 Sep;31(7):607-19

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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https://insights.ovid.com/crossref?an=00002371-200809000-000
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http://dx.doi.org/10.1097/CJI.0b013e318181c87fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820298PMC
September 2008

Recognition of naturally processed and ovarian cancer reactive CD8+ T cell epitopes within a promiscuous HLA class II T-helper region of NY-ESO-1.

Cancer Immunol Immunother 2008 Aug 6;57(8):1185-95. Epub 2008 Feb 6.

Department of Gynecologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1007/s00262-008-0450-4DOI Listing
August 2008

A33 antigen displays persistent surface expression.

Cancer Immunol Immunother 2008 Jul;57(7):1017-27

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.

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http://dx.doi.org/10.1007/s00262-007-0433-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836164PMC
July 2008

Antibody therapy in renal cell carcinoma.

World J Urol 2008 Apr 1;26(2):141-6. Epub 2008 Feb 1.

267 Experimental Urology, University Medical Center St Radboud, Geert Grooteplein 26-28, 6525 GA Nijmegen, The Netherlands.

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http://link.springer.com/10.1007/s00345-008-0236-5
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http://dx.doi.org/10.1007/s00345-008-0236-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2295251PMC
April 2008

Cancer-testis (CT) antigen expression in medulloblastoma.

Cancer Immun 2008 Apr 22;8. Epub 2008 Apr 22.

Department of Neurology, School of Medicine, University of São Paulo, Av Dr Arnaldo, 455, room 4110, São Paulo, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935780PMC
April 2008

Humoral immune responses in patients vaccinated with 1-146 HER2 protein complexed with cholesteryl pullulan nanogel.

Cancer Sci 2008 Mar 15;99(3):601-7. Epub 2007 Dec 15.

Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2007.00705.xDOI Listing
March 2008

Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs.

Clin Immunol 2008 Mar 31;126(3):291-302. Epub 2007 Dec 31.

Ludwig Institute Clinical Trial Center, Division of Medical Oncology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.clim.2007.11.008DOI Listing
March 2008

Cancer vaccines: an overview.

Authors:
Lloyd J Old

Cancer Immun 2008 Mar 12;8 Suppl 1. Epub 2008 Mar 12.

Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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March 2008

Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming.

Proc Natl Acad Sci U S A 2008 Feb 23;105(5):1650-5. Epub 2008 Jan 23.

Department of Oncology/Hematology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1073/pnas.0707140104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234199PMC
February 2008

Immunization with a recombinant MAGE-A3 protein after high-dose therapy for myeloma.

J Immunother 2007 Nov-Dec;30(8):847-54

Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.1097/CJI.0b013e318158fcffDOI Listing
January 2008

CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer.

Clin Cancer Res 2007 Dec;13(23):6947-58

Department of Pathology, The Center for Cell and Gene Therapy, Baylor Colleg of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0842DOI Listing
December 2007