Publications by authors named "Ljubica Caldovic"

38Publications

The Urine Microbiome of Healthy Men and Women Differs by Urine Collection Method.

Int Neurourol J 2020 Mar 31;24(1):41-51. Epub 2020 Mar 31.

Division of Urology, Children's National Medical Center, George Washington University School of Medicine, Washington DC, USA.

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http://dx.doi.org/10.5213/inj.1938244.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136448PMC
March 2020

A single intravesical instillation of Lactobacillus rhamnosus GG is safe in children and adults with neuropathic bladder: A phase Ia clinical trial.

J Spinal Cord Med 2019 May 17:1-8. Epub 2019 May 17.

g Paralysis Rehabilitation and Recovery Program, Spinal Cord Injury Research, MedStar National Rehabilitation Hospital , Washington , DC , USA.

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http://dx.doi.org/10.1080/10790268.2019.1616456DOI Listing
May 2019

Sources and Fates of Carbamyl Phosphate: A Labile Energy-Rich Molecule with Multiple Facets.

Biology (Basel) 2018 Jun 12;7(2). Epub 2018 Jun 12.

Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC 20010, USA.

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http://dx.doi.org/10.3390/biology7020034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022934PMC
June 2018

Disease-causing mutations in the promoter and enhancer of the ornithine transcarbamylase gene.

Hum Mutat 2018 04 16;39(4):527-536. Epub 2018 Jan 16.

Center for Genetic Medicine Research, Children's National Health System, Washington, District of Columbia.

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http://dx.doi.org/10.1002/humu.23394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388160PMC
April 2018

Corrigendum to "GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease" [Mol. Genet. Metab. 111 (2014) 393-398].

Mol Genet Metab 2016 11;119(3):293

Department of Neurology, Children's National Medical Center, Washington, DC, USA; Department of Pediatrics, Children's National Medical Center, Washington, DC, USA; Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2016.06.011DOI Listing
November 2016

Genotype-Phenotype Correlations in Ornithine Transcarbamylase Deficiency: A Mutation Update.

J Genet Genomics 2015 May 19;42(5):181-94. Epub 2015 May 19.

Department of Integrative Systems Biology, Center for Genetic Medicine Research, Children's National Health System, Washington DC 20010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2015.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565140PMC
May 2015

Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase.

PLoS One 2014 22;9(1):e85597. Epub 2014 Jan 22.

Department of Biological Sciences, Rowan University, Glassboro, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085597PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899043PMC
December 2014

GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease.

Mol Genet Metab 2014 03 16;111(3):393-398. Epub 2013 Dec 16.

Department of Neurology, Children's National Medical Center, Washington, DC, USA; Department of Pediatrics, Children's National Medical Center, Washington, DC, USA; Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2013.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183365PMC
March 2014

A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase.

Mol Genet Metab 2012 Jun 17;106(2):160-8. Epub 2012 Mar 17.

Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA.

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http://dx.doi.org/10.1016/j.ymgme.2012.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356441PMC
June 2012

Transcriptional regulation of N-acetylglutamate synthase.

PLoS One 2012 27;7(2):e29527. Epub 2012 Feb 27.

Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029527PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287996PMC
August 2012

N-carbamylglutamate enhancement of ureagenesis leads to discovery of a novel deleterious mutation in a newly defined enhancer of the NAGS gene and to effective therapy.

Hum Mutat 2011 Oct 9;32(10):1153-60. Epub 2011 Sep 9.

Research Center for Genetic Medicine, Children's National Medical Center, The George Washington University, Washington, DC, USA.

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http://dx.doi.org/10.1002/humu.21553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976964PMC
October 2011

Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase.

J Biol Chem 2011 Jun 3;286(25):22055-68. Epub 2011 May 3.

Division of Child Development, Rehabilitation Medicine, and Metabolic Disease, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.209023
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http://dx.doi.org/10.1074/jbc.M110.209023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121350PMC
June 2011

N-acetylglutamate synthase deficiency: an insight into the genetics, epidemiology, pathophysiology, and treatment.

Appl Clin Genet 2011 24;4:127-35. Epub 2011 Aug 24.

Center for Genetic Medicine Research, Children's Research institute, Children's National Medical Center, Washington DC, USA.

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http://dx.doi.org/10.2147/TACG.S12702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681184PMC
June 2013

N-acetylglutamate synthase: structure, function and defects.

Mol Genet Metab 2010 26;100 Suppl 1:S13-9. Epub 2010 Feb 26.

The Children's Research Institute, Children's National Medical Center, The George Washington University, Washington, DC 20010, USA.

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http://dx.doi.org/10.1016/j.ymgme.2010.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876818PMC
July 2010

Mechanism of allosteric inhibition of N-acetyl-L-glutamate synthase by L-arginine.

J Biol Chem 2009 Feb 18;284(8):4873-80. Epub 2008 Dec 18.

Research Center for Genetic Medicine, Children's National Medical Center, The George Washington University, Washington, D. C. 20010, USA.

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http://dx.doi.org/10.1074/jbc.M805348200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643497PMC
February 2009

Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods.

BMC Biochem 2008 Sep 18;9:24. Epub 2008 Sep 18.

Research Center for Genetic Medicine, Children's National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA.

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http://dx.doi.org/10.1186/1471-2091-9-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566978PMC
September 2008

The crystal structure of N-acetyl-L-glutamate synthase from Neisseria gonorrhoeae provides insights into mechanisms of catalysis and regulation.

J Biol Chem 2008 Mar 9;283(11):7176-84. Epub 2008 Jan 9.

Children's Research Institute, Children's National Medical Center, The George Washington University, Washington, DC 20010, USA.

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http://dx.doi.org/10.1074/jbc.M707678200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099063PMC
March 2008

A novel bifunctional N-acetylglutamate synthase-kinase from Xanthomonas campestris that is closely related to mammalian N-acetylglutamate synthase.

BMC Biochem 2007 Apr 10;8. Epub 2007 Apr 10.

Children's Research Institute, Children's National Medical Center, The George Washington University, Washington, DC 20010, USA.

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http://dx.doi.org/10.1186/1471-2091-8-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865377PMC
April 2007

Mutations and polymorphisms in the human N-acetylglutamate synthase (NAGS) gene.

Hum Mutat 2007 Aug;28(8):754-9

Children's Research Institute, Children's National Medical Center, George Washington University, Washington, DC 20010, USA.

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http://dx.doi.org/10.1002/humu.20518DOI Listing
August 2007

Expression, crystallization and preliminary crystallographic studies of a novel bifunctional N-acetylglutamate synthase/kinase from Xanthomonas campestris homologous to vertebrate N-acetylglutamate synthase.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Dec 30;62(Pt 12):1218-22. Epub 2006 Nov 30.

Children's National Medical Center, The George Washington University, 111 Michigan Avenue, Washington, DC 20010, USA.

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http://dx.doi.org/10.1107/S1744309106044101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225375PMC
December 2006

Biochemical properties of recombinant human and mouse N-acetylglutamate synthase.

Mol Genet Metab 2006 Mar;87(3):226-32

Children's Research Institute, Children's National Medical Center, The George Washington University, Washington, DC 20010, USA.

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http://dx.doi.org/10.1016/j.ymgme.2005.10.003DOI Listing
March 2006

Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria.

J Biol Chem 2005 Apr 24;280(15):14366-9. Epub 2005 Feb 24.

Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.

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http://dx.doi.org/10.1074/jbc.C500005200DOI Listing
April 2005

Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles.

Hum Mutat 2005 Mar;25(3):293-8

Children's Research Institute, Children's National Medical Center, The George Washington University, Washington, DC 20010, USA.

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http://dx.doi.org/10.1002/humu.20146DOI Listing
March 2005

Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate.

J Pediatr 2004 Oct;145(4):552-4

Children's Research Institute, Children's National Medical Center, The George Washington University, Washington, DC 20010, USA.

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http://dx.doi.org/10.1016/j.jpeds.2004.06.047DOI Listing
October 2004

Mammalian N-acetylglutamate synthase.

Mol Genet Metab 2004 Apr;81 Suppl 1:S4-11

Children's Research Institute, Children's National Medical Center, The George Washington University, 111 Michigan Ave NW, Washington, DC 20010, USA.

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http://dx.doi.org/10.1016/j.ymgme.2003.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031861PMC
April 2004

N-acetylglutamate and its changing role through evolution.

Biochem J 2003 Jun;372(Pt 2):279-90

Children's Research Institute, Children's National Medical Center, the George Washington University, 111 Michigan Ave NW, Washington, DC 20010, USA.

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http://dx.doi.org/10.1042/BJ20030002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223426PMC
June 2003

Null mutations in the N-acetylglutamate synthase gene associated with acute neonatal disease and hyperammonemia.

Hum Genet 2003 Apr 20;112(4):364-8. Epub 2003 Feb 20.

Children's Research Institute, Children's National Medical Center, The George Washington University, 111 Michigan Avenue NW, Washington, DC 20010, USA.

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http://dx.doi.org/10.1007/s00439-003-0909-5DOI Listing
April 2003

Cloning and expression of the human N-acetylglutamate synthase gene.

Biochem Biophys Res Commun 2002 Dec;299(4):581-6

Children's Research Institute, Children's National Medical Center, The George Washington University, 111 Michigan Ave NW, Washington, DC 20010, USA.

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http://dx.doi.org/10.1016/s0006-291x(02)02696-7DOI Listing
December 2002

Identification, cloning and expression of the mouse N-acetylglutamate synthase gene.

Biochem J 2002 Jun;364(Pt 3):825-31

Children's Research Institute, Children's National Medical Center, George Washington University, 111 Michigan Ave NW, Washington, DC 20010, USA.

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http://dx.doi.org/10.1042/BJ20020161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222632PMC
June 2002