Publications by authors named "Lixin Wu"

192 Publications

Recent Progress of Near-Infrared Persistent Phosphors in Bio-related and Emerging Applications.

Chem Asian J 2021 Mar 18. Epub 2021 Mar 18.

State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.

Near-infrared persistent phosphors (NIR-PPs) are an emerging category of luminescent materials that can continuously emit NIR luminescence with super-long decay time of minutes, hours, or even days after the excitation ceases. Their unique excitation-free long-lasting afterglow, together with the NIR emission, has not only attracted wide research interests in the areas of photochemistry, photophysics, spectroscopy, and materials science, but also stimulated advanced applications in biosensing, bioimaging, biomedicine, and therapy in the past decade. Beyond these bio-related applications, the active research field triggers a number of novel applications recently. In this review, a brief outline of NIR-PPs including the luminescence mechanism, main material systems, and how they were applied into various fields was depicted. Particular emphasis was put on the emerging applications outside the field of biology. Future perspectives in this exploration research area were also presented. We hope this review can help researchers grab the latest information in the fast-growing field of NIR-PPs.
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http://dx.doi.org/10.1002/asia.202100108DOI Listing
March 2021

Constructing chiral polyoxometalate assemblies supramolecular approaches.

Dalton Trans 2021 Mar 18. Epub 2021 Mar 18.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

Polyoxometalates (POMs), as a typical class of discrete metal oxide clusters that are known in inorganic and structural chemistry since long, have displayed more and more interesting applications over recent years. However, in comparison to the chemical synthesis, the photochemical, electrochemical, and magnetic properties, the structural asymmetry, and relative characteristic investigations arising therefrom are far behind even if they are very important for functional materials, especially in solution systems. One of the main reasons is that it is hard to control and maintain a stable chiral state of POMs to carry out further corresponding performances. Aiming to overcome these disadvantages, the main concerns of this review are to discuss the generation of the chirality for discrete metal oxide clusters, chirality transfer via a supramolecular approach, chirality amplification in self-assemblies, and the related functional properties such as photochromism, catalysis, and bioactivities in solutions. Considering that some previous reviews dealt with chiral structures and packing architectures in the crystalline solids of POMs, this article only concentrates on the induced chirality and material properties in solution systems, which have been more active recently but no review article has been involved in this interesting area.
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http://dx.doi.org/10.1039/d1dt00182eDOI Listing
March 2021

Ocean fronts and eddies force atmospheric rivers and heavy precipitation in western North America.

Nat Commun 2021 02 24;12(1):1268. Epub 2021 Feb 24.

Department of Geological and Atmospheric Sciences, Iowa State University, Ames, IA, USA.

Atmospheric rivers (ARs) are responsible for over 90% of poleward water vapor transport in the mid-latitudes and can produce extreme precipitation when making landfall. However, weather and climate models still have difficulty simulating and predicting landfalling ARs and associated extreme precipitation, highlighting the need to better understand AR dynamics. Here, using high-resolution climate models and observations, we demonstrate that mesoscale sea-surface temperature (SST) anomalies along the Kuroshio Extension can exert a remote influence on landfalling ARs and related heavy precipitation along the west coast of North America. Inclusion of mesoscale SST forcing in the simulations results in approximately a 40% increase in landfalling ARs and up to a 30% increase in heavy precipitation in mountainous regions and this remote impact occurs on two-week time scales. The asymmetrical response of the atmosphere to warm vs. cold mesoscale SSTs over the eddy-rich Kuroshio Extension region is proposed as a forcing mechanism that results in a net increase of moisture flux above the planetary boundary layer, prompting AR genesis via enhancing moisture transport into extratropical cyclones in the presence of mesoscale SST forcing.
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http://dx.doi.org/10.1038/s41467-021-21504-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904778PMC
February 2021

Addendum: Butterfly effect and a self-modulating El Niño response to global warming.

Nature 2021 Mar;591(7849):E14-E15

NOAA/Pacific Marine Environmental Laboratory, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41586-021-03261-4DOI Listing
March 2021

Precise Topographic Model Assisted Slope Displacement Retrieval from Small Baseline Subsets Results: Case Study over a High and Steep Mining Slope.

Sensors (Basel) 2020 Nov 21;20(22). Epub 2020 Nov 21.

School of Geosciences and Info-Physics, Central South University, Changsha 410083, China.

Due to the intrinsic side-looking geometry of synthetic aperture radar (SAR), time series interferometric SAR is only able to monitor displacements in line-of-sight (LOS) direction, which limits the accuracy of displacement measurement in landslide monitoring. This is because the LOS displacement is only a three dimensional projection of real displacement of a certain ground object. Targeting at this problem, a precise digital elevation model (DEM) assisted slope displacement retrieval method is proposed and applied to a case study over the high and steep slope of the Dagushan open pit mine. In the case study, the precise DEM generated by laser scanning is first used to minimize topographic residuals in small baseline subsets analysis. Then, the LOS displacements are converted to slope direction with assistance of the precise DEM. By comparing with ground measurements, relative root mean square errors (RMSE) of the estimated slope displacements reach approximately 12-13% for the ascending orbit, and 5.4-9.2% for the descending orbit in our study area. In order to validate the experimental results, comparison with microseism monitoring results is also conducted. Moreover, both results have found that the largest slope displacements occur on the slope part, with elevations varying from -138 m to -210 m, which corresponds to the landslide area. Moreover, there is a certain correlation with precipitation, as revealed by the displacement time series. The outcome of this article shows that rock mass structure, lithology, and precipitation are main factors affecting the stability of high and steep mining slopes.
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http://dx.doi.org/10.3390/s20226674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700281PMC
November 2020

Publisher Correction: Butterfly effect and a self-modulating El Niño response to global warming.

Nature 2020 Dec;588(7836):E3

NOAA/Pacific Marine Environmental Laboratory, Seattle, WA, USA.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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http://dx.doi.org/10.1038/s41586-020-2958-5DOI Listing
December 2020

Synthesis of High-Purity SiC Nanowires via Catalyst-Free Pyrolysis of SiO/Si and Sponge-Like Graphene Oxide.

ACS Omega 2020 Oct 23;5(39):25319-25325. Epub 2020 Sep 23.

Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350000, People's Republic of China.

The large-scale synthesis of high-purity SiC nanowires is a challenge. In this context, sponge-like graphene oxide (GO) was used as a carbon source as well as a reaction template for directly synthesizing SiC nanowires. GO was completely reacted with SiO to prepare high-purity 3C-SiC nanowires by thermal evaporation and carbothermal reduction without the use of any catalyst, rather than by epitaxy. Characterization was conducted using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and selected-area electron diffraction. The SiC nanowires had lengths of several tens of micrometers and a perfect single-crystalline structure with a bamboo-like morphology.
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http://dx.doi.org/10.1021/acsomega.0c03619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542835PMC
October 2020

Biocompatible Polymer Nanocomposites Integrating Magnetic Polyoxomolybdates for Enhanced MRI and On-Site Activated Photothermal Properties.

Macromol Rapid Commun 2020 Dec 30;41(24):e2000468. Epub 2020 Sep 30.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.

This work reports the ionic composition of a PEGylated and chemically crosslinked polyethyleneimine with a gadolinium-coordinated polyoxomolybdate cluster, K [Gd(P Mo O ) ], via electrostatic interaction. The prepared composites form nanoobjects with an average size of ≈27 nm at dried state and maintain structural stability in aqueous solution. While the biocompatibility on HeLa cells is demonstrated, the polymer-shielded multifunctional nanoplatform shows both the combined magnetic resonance imaging and redox-triggered photothermal conversion effect. As a contrast agent, the T -weighed relaxivity reaches up to 22.77 mm  s . The photothermal conversion of the prepared composites can be aroused by yielding a broad near infrared (NIR) adsorption through on-site reduction of the glutathione that is enriched in the tumor environment. The high efficiency ≈61.0% under the irradiation of 808 nm NIR laser illustrates a distinct treatment capability according to cell counting Kit-8 assay while the obvious inhibition for the growth of tumor cells is observed.
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http://dx.doi.org/10.1002/marc.202000468DOI Listing
December 2020

Projected Future Changes in Tropical Cyclones Using the CMIP6 HighResMIP Multimodel Ensemble.

Geophys Res Lett 2020 Jul 16;47(14):e2020GL088662. Epub 2020 Jul 16.

Qingdao National Laboratory for Marine Science (QNLM) Qingdao China.

Future changes in tropical cyclone properties are an important component of climate change impacts and risk for many tropical and midlatitude countries. In this study we assess the performance of a multimodel ensemble of climate models, at resolutions ranging from 250 to 25 km. We use a common experimental design including both atmosphere-only and coupled simulations run over the period 1950-2050, with two tracking algorithms applied uniformly across the models. There are overall improvements in tropical cyclone frequency, spatial distribution, and intensity in models at 25 km resolution, with several of them able to represent very intense storms. Projected tropical cyclone activity by 2050 generally declines in the South Indian Ocean, while changes in other ocean basins are more uncertain and sensitive to both tracking algorithm and imposed forcings. Coupled models with smaller biases suggest a slight increase in average TC 10 m wind speeds by 2050.
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http://dx.doi.org/10.1029/2020GL088662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507130PMC
July 2020

{VMoO[RC(CHO)]}: the first class of triol ligand covalently-decorated Keggin-type polyoxomolybdates.

Dalton Trans 2020 Oct 21;49(37):12950-12954. Epub 2020 Sep 21.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

Three trivacant polyoxomolybdates were constructed, presenting the first class of triol ligand covalently-decorated Keggin-type clusters through C-O-Mo bonds. The introduction of the organic component enhanced the stability of the cluster in the solid state with the leaving of active sites at the lacunary position.
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http://dx.doi.org/10.1039/d0dt02506bDOI Listing
October 2020

Effect of POSS-Modified Montmorillonite on Thermal, Mechanical, and Electrical Properties of Unsaturated Polyester Nanocomposites.

Polymers (Basel) 2020 Sep 7;12(9). Epub 2020 Sep 7.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.

Montmorillonite (MMT) displays excellent cohesion with an unsaturated polyester (UP) matrix to generate a material which exhibits an extensive range of commercial applications. The organic modification of MMT using polyhedral oligomeric silsesquioxanes (POSS) and the effect of POSS-MMT on the thermal, mechanical, and electrical properties of UP are reported here. Transmission electron microscopy (TEM) images were used to characterize the modification of MMT using POSS. Modified MMT (POSS-MMT) was incorporated, at different wt.% (0.5, 1, 3, 5), into UP via in-situ polymerization. The presence of POSS-MMT enhanced the characteristic properties of UP as a consequence of good dispersion in the polymer matrix. Scanning electron microscopy (SEM) images support effective POSS-MMT dispersion leading to tensile strength enhancement of a UP/POSS-MMT nanocomposite (3 wt.% POSS-MMT) by 54.7% as compared to that for unmodified UP. TGA displays a 35 °C improvement of thermal stability (10% mass loss) at 5% POSS-MMT incorporation, while the electrical conductivity is improved by 10 S/m (3 wt.% POSS-MMT) in comparison to that for unmodified UP. The conventional obstacle of UP associated with shrinkage weight loss during curing seems to be moderated with POSS-MMT incorporation (3%) resulting in a 27.8% reduction in shrinkage weight loss. These fabricated nanocomposites expand the versatility of UP as a high-performance material owing to enhancements of properties.
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http://dx.doi.org/10.3390/polym12092031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564685PMC
September 2020

Butterfly effect and a self-modulating El Niño response to global warming.

Nature 2020 09 2;585(7823):68-73. Epub 2020 Sep 2.

NOAA/Pacific Marine Environmental Laboratory, Seattle, WA, USA.

El Niño and La Niña, collectively referred to as the El Niño-Southern Oscillation (ENSO), are not only highly consequential but also strongly nonlinear. For example, the maximum warm anomalies of El Niño, which occur in the equatorial eastern Pacific Ocean, are larger than the maximum cold anomalies of La Niña, which are centred in the equatorial central Pacific Ocean. The associated atmospheric nonlinear thermal damping cools the equatorial Pacific during El Niño but warms it during La Niña. Under greenhouse warming, climate models project an increase in the frequency of strong El Niño and La Niña events, but the change differs vastly across models, which is partially attributed to internal variability. Here we show that like a butterfly effect, an infinitesimal random perturbation to identical initial conditions induces vastly different initial ENSO variability, which systematically affects its response to greenhouse warming a century later. In experiments with higher initial variability, a greater cumulative oceanic heat loss from ENSO thermal damping reduces stratification of the upper equatorial Pacific Ocean, leading to a smaller increase in ENSO variability under subsquent greenhouse warming. This self-modulating mechanism operates in two large ensembles generated using two different models, each commencing from identical initial conditions but with a butterfly perturbation; it also operates in a large ensemble generated with another model commencing from different initial conditions and across climate models participating in the Coupled Model Intercomparison Project. Thus, if the greenhouse-warming-induced increase in ENSO variability is initially suppressed by internal variability, future ENSO variability is likely to be enhanced, and vice versa. This self-modulation linking ENSO variability across time presents a different perspective for understanding the dynamics of ENSO variability on multiple timescales in a changing climate.
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http://dx.doi.org/10.1038/s41586-020-2641-xDOI Listing
September 2020

High-Performance Cyanate Ester Resins with Interpenetration Networks for 3D Printing.

ACS Appl Mater Interfaces 2020 Aug 11;12(34):38682-38689. Epub 2020 Aug 11.

Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350000, Fujian, China.

As the 3D printing technology is getting more and more popular and useful, demands for materials for 3D printing have increased significantly. Cyanate ester (CE) resin possesses the characteristics of high heat distortion temperature and high glass transition temperature, outstanding mechanical properties, low dielectric constant, and excellent water uptake. However, CE resin has not been widely used in 3D printing of UV curing because it is difficult for photopolymerizable groups to graft onto the chains of CE resin. On the other hand, the glass transition temperature () of the homopolymer of the tris(2-hydroxyethyl)isocyanurate triacrylate (THEICTA) outclasses that of other acrylates. Although THEICTA is particularly advantageous to prepare a UV-curing prepolymer with high glass transition temperature, it also cannot be directly used for fabricating heat-resistant 3D-printed parts because it is solid and adding diluents will reduce the thermal stability of printed objects. This study is unique in producing 3D-printed materials, in which the THEICTA tactfully dissolves in low viscosity (about 100 mPa·s under 25 °C) bisphenol E cyanate (BECy) without sacrificing two kinds of bulk material properties. In the process of 3D printing, the carbon-carbon double bonds from THEICTA are cured by radical polymerization. Postprinting thermal treatment transforms three cyanate groups to a triazine ring structure. Additionally, the two kinds of structures are interpenetrating. The high-performance 3D-printing material has potential in fields ranging from space flight and aviation to the automotive and electronic industry.
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http://dx.doi.org/10.1021/acsami.0c10909DOI Listing
August 2020

Enhancement of Neural Stem Cell Proliferation in Rats with Spinal Cord Injury by a Combination of Repetitive Transcranial Magnetic Stimulation (rTMS) and Human Umbilical Cord Blood Mesenchymal Stem Cells (hUCB-MSCs).

Med Sci Monit 2020 Aug 20;26:e924445. Epub 2020 Aug 20.

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).

BACKGROUND This study was designed to explore the combined effects of repetitive transcranial magnetic stimulation (rTMS) and human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) transplantation on neural stem cell proliferation in rats with spinal cord injury (SCI). MATERIAL AND METHODS SCI was induced in 90 rats by laminectomy at T10. Fifteen rats each were treated with 0.5 Hz rTMS or 10 Hz rTMS or underwent hUCB-MSC transplantation; 15 each were treated with 0.5 Hz rTMS+hUCB-MSCs or 10 Hz rTMS+hUCB-MSCs; and 15 were untreated (control group). The Basso, Beattie, and Bresnahan (BBB) scores and motor evoked potentials (MEPs) were measured, and all rats underwent biotin dextran-amine (BDA) tracing of the corticospinal tract (CST). The levels of expression of neural stem cell proliferation related proteins, including BrdU, nestin, Tuj1, Ng2+ and GFAP, were measured, and the levels of bFGF and EGF determined by Western blotting. RESULTS BBB scores and MEPs were increased after rTMS and hUCB-MSC transplantation, while histologically determined SCI-induced neuron apoptosis was attenuated. The numbers of BDA-positive fibers and Brdu-, nestin- and Tuj1-positive cells were markedly increased and the numbers of Ng2+- and GFAP-positive cells were markedly decreased following treatment with rTMS alone or rTMS plus hUCB-MSC transplantation. The levels of expression of bFGF and EGF were significantly upregulated following rTMS treatment and hUCB-MSC transplantation. Higher performance was observed after combined treatment with rTMS and hUCB-MSC transplantation than after either alone. CONCLUSIONS The combination of rTMS treatment and hUCB-MSC transplantation could attenuate SCI-induced neural stem cell apoptosis and motor dysfunction in rats.
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http://dx.doi.org/10.12659/MSM.924445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453755PMC
August 2020

Recent advances of polyoxometalates in multi-functional imaging and photothermal therapy.

J Mater Chem B 2020 09;8(36):8189-8206

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.

Polyoxometalates (POMs) as a kind of molecular metal-oxide cluster with precise chemical composition and architecture have been demonstrated to show potential in multidisciplinary materials. Accompanied by their bioactivities, POM clusters have also been shown to be capable of sensing diseases and allowing synergistic therapy based on their redox and near infrared absorption. In parallel with metal nanoparticles and organic materials, these inorganic clusters have also displayed unique photothermal imaging and therapeutic properties over recent years. In this review, we outlined the main achievements of POMs in the fields of bio-detecting probes and the photothermal effect. Fluorescence detection, magnetic resonance, computed tomography, and photothermal property-supported photoacoustic imaging acting as a multifunction platform that integrates photothermal therapy (PTT) were discussed at the same time. The comparison of nanocomposites to POMs alone in imaging-guided PTT, multi-modal imaging, and the combination of PTT with controlled chemotherapy and gas therapy were described in detail. The advantages and possible drawbacks of POMs as well as perspectives in related areas were analyzed, which ascertained such clusters to be a type of promising agent in biomedical applications.
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http://dx.doi.org/10.1039/d0tb01375gDOI Listing
September 2020

Heteropoly acid-driven assembly of glutathione into redox-responsive underwater adhesive.

Chem Commun (Camb) 2020 Sep 18;56(75):11034-11037. Epub 2020 Aug 18.

State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Qianjin Avenue 2699, Changchun 130012, China.

Dynamic adhesives were fabricated based on the ionic co-assembly of glutathione and heteropoly acids (HPAs). The underwater attachment and detachment of the adhesives were achieved based on the redox properties of glutathione. We demonstrated that the formation of disulfide bonds of glutathione plays a pivotal role in the formation of robust 3D network structures as well as the improvement of cohesion.
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http://dx.doi.org/10.1039/d0cc03746jDOI Listing
September 2020

CAR T-cell therapy for triple-negative breast cancer: Where we are.

Cancer Lett 2020 10 12;491:121-131. Epub 2020 Aug 12.

Department of Anesthesiology, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518038, China. Electronic address:

Triple-negative breast cancer (TNBC) is the most complex and challenging breast cancer subtype to treat, and chemotherapy remains the standard of care. Clinically, TNBC has a relatively high rate of recurrence and poor prognosis, which leads to a significant effort to discover novel strategies to treat patients with these tumors. Currently, chimeric antigen receptor (CAR) T cell-based immunotherapy redirects the patient's immune system directly to recognize and eradicate tumor-associated antigens (TAAs) expressing tumor cells being explored as a treatment for TNBC. A steadily increasing research in CAR T-cell therapy targeting different TAAs in TNBC has reported. In this review, we introduce the CAR technology and summarize the potential TAAs, available CARs, the antitumor activity, and the related toxicity of CARs currently under investigation for TNBC. We also highlight the potential strategies to prevent/reduce potential "on target, off tumor" toxicity induced by CAR T-cell therapy. This review will help to explore proper targets to expand further the CAR T-cell therapy for TNBCs in the clinic.
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http://dx.doi.org/10.1016/j.canlet.2020.07.044DOI Listing
October 2020

Maintenance of mid-latitude oceanic fronts by mesoscale eddies.

Sci Adv 2020 Jul 31;6(31):eaba7880. Epub 2020 Jul 31.

Key Laboratory of Physical Oceanography and Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, China.

Oceanic fronts associated with strong western boundary current extensions vent a vast amount of heat into the atmosphere, anchoring mid-latitude storm tracks and facilitating ocean carbon sequestration. However, it remains unclear how the surface heat reservoir is replenished by ocean processes to sustain the atmospheric heat uptake. Using high-resolution climate simulations, we find that the vertical heat transport by ocean mesoscale eddies acts as an important heat supplier to the surface ocean in frontal regions. This vertical eddy heat transport is not accounted for by the prevailing inviscid and adiabatic ocean dynamical theories such as baroclinic instability and frontogenesis but is tightly related to the atmospheric forcing. Strong surface cooling associated with intense winds in winter promotes turbulent mixing in the mixed layer, destructing the vertical shear of mesoscale eddies. The restoring of vertical shear induces an ageostrophic secondary circulation transporting heat from the subsurface to surface ocean.
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http://dx.doi.org/10.1126/sciadv.aba7880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399485PMC
July 2020

Recent advances on porous interfaces for biomedical applications.

Soft Matter 2020 Aug;16(31):7231-7245

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.

Porous structures on solid surfaces prepared artificially through the water droplet template method have the features of easy operation, low cost and self-removal of templates, and thus are widely applied in the fields of medicine, biomedicine, adsorption, catalysis, and separation, optical and electronic materials. Due to their tunable dimensions, abundant selection of materials, mechanical stability, high porosity, and enlarged pore surface, the formed porous interfaces show specific significance in bio-related systems. In this study, recent achievements related to applications of porous interfaces and a focus into biological and medical-related systems are summarized. The discussion involves the preparation of porous interfaces, and porous interface-induced cell behaviors including culture, growth, proliferation, adhesion, and differentiation of cells. The inhibitory effect of bacteria and separated features of microorganisms supported by porous interfaces, the immobilization of biomolecules related to proteins, DNA and enzymes, and the controllable drug delivery are also discussed. The summary of recent advances pointed out in the study, are suggestive of insights for motivating unique potential applications including their extension to porous interfaces in biomedical materials.
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http://dx.doi.org/10.1039/d0sm00997kDOI Listing
August 2020

Nanocomposites of ionic copolymer integrating Gd-containing polyoxometalate as a multiple platform for enhanced MRI and pH-response chemotherapy.

J Mater Chem B 2020 08;8(30):6390-6401

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.

This article describes the fabrication of nanosized paramagnetic drug carriers via the assembly of a pH-responsive hydrophilic block copolymer poly(polyethylene glycol methyl ether methacrylate)-b-poly(methacrylic acid-co-trimethyl ammonium bromide propyl methacrylate) (PPMT) and polyoxometalate K13[Gd(β2-SiW11O39)2] (GdSiW11) through electrostatic interaction. Owing to the hydrophilicity, large molecular weight, and high content of the GdSiW11 cluster bearing in the nanocomposites, the organic-inorganic nanocomposite exhibited an impressive longitudinal relaxivity as a contrast agent for magnetic resonance imaging (MRI). The surplus negative charges from the polyoxometalate cluster in the polymer nanocomposites facilitated the capture of the anti-tumor drug doxorubicin (DOX). The DOX-loaded nanocomposites were stable under the physiological environment, whereas a responsive release of DOX was achieved at pH values similar to the tumor microenvironment due to the regulation of the polyoxometalate and carboxyl groups. The DOX-loaded PPMT2-GdSiW11 nanocomposites were observed to enrich effectively at tumor sites through MRI after intravenous injection. Furthermore, the DOX-loaded composites manifested enhanced in vivo anti-tumor therapeutic efficacy and sustainable circulation time of more than 5 h, which were favourable for imaging measurement. With the advantages of the designed composite system, the present experiments propose a strategy for developing a new multiple imaging-drug delivery-local therapy platform for synergistic diagnosis and therapy.
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http://dx.doi.org/10.1039/d0tb00782jDOI Listing
August 2020

FGD5-AS1 facilitates glioblastoma progression by activation of Wnt/β-catenin signaling via regulating miR-129-5p/HNRNPK axis.

Life Sci 2020 Sep 22;256:117998. Epub 2020 Jun 22.

Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:

Aims: Accumulating evidence elucidates the biological significance of long non-coding RNA (lncRNAs) in tumorigenesis and development. FGD5 antisense RNA 1 (FGD5-AS1) was previously revealed as an oncogene in several types of malignancies. However, the roles of FGD5-AS1 in glioblastoma (GBM) and its potential molecular mechanisms remain unclear.

Materials And Methods: The expression of FGD5-AS1, miR-129-5p, and heterogeneous nuclear ribonucleoprotein K (HNRNPK) mRNA were measured by qRT-PCR. Cell proliferation, invasion and apoptosis were determined by MTT, colony formation, transwell and flow cytometry assays. The protein levels of Ki-67, HNRNPK and Wnt signaling-associated genes were examined by western blot assay. The possible action mechanism of FGD5-AS1 was detected by bioinformatic tools, luciferase reporter, RIP and TOP/FOP Flash reporter assays. A nude mouse xenograft model was built to analyze the function of FGD5-AS1 in vivo.

Key Findings: FGD5-AS1 expression was increased in GBM tumor tissues and cells. Knockdown of FGD5-AS1 inhibited cell proliferation and invasion in vitro, and slowed tumor growth in vivo. Mechanistically, FGD5-AS1 served as a sponge of miR-129-5p to relieve its suppression on HNRNPK. Moreover, down-regulation of HNRNPK repressed cell proliferation and invasion, while enhanced apoptosis. Additionally, si-FGD5-AS1-mediated suppression of cell proliferation and invasion was obviously reversed by the decrease of miR-129-5p or restoration of HNRNPK. Furthermore, FGD5-AS1 promoted cell growth and invasion by stimulating Wnt/β-catenin signaling via regulation of miR-129-5p/HNRNPK.

Significance: FGD5-AS1 promoted GBM progression at least partly by regulating miR-129-5p/HNRNPK to activate Wnt/β-catenin signaling, suggesting the potential of FGD5-AS1 as a candidate target to improve GBM therapy.
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http://dx.doi.org/10.1016/j.lfs.2020.117998DOI Listing
September 2020

Two-Dimensional Supramolecular Ionic Frameworks for Precise Membrane Separation of Small Nanoparticles.

ACS Appl Mater Interfaces 2020 Jul 9;12(27):30761-30769. Epub 2020 Jun 9.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

Supramolecular frameworks driven by intermolecular interactions represent a new type of porous materials differing from those driven by covalent or coordination bonding. The intermolecular interaction-induced flexible assembly structures display unique advantages in material processing, structure stimuli response, and recycling. In this work, a two-dimensional (2D) supramolecular ionic framework (SIF) was constructed through the initial ionic interaction between the host cation and polyoxometalate polyanion and then the host-guest inclusion of the formed host ionic complex with a four-arm porphyrin guest molecule following a [2+4] type reaction. Several prepared framework monolayers bearing an orthometric grid structure constituted a nanosheet-like assembly with flexibility and exhibited processability, which provided feasibility for the further preparation of separation membranes via a simple suction procedure of their dispersed suspensions in mixed solvents. The nanofiltration based on the uniform square pores under a slightly reduced pressure successfully achieved precise separation of several types of nanoparticles and molecular clusters in wide distribution at a cutting off value as small as 2.2 nm. These results also implied the potential of the present strategy for more separations at a molecular level and very fine nanoscale.
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http://dx.doi.org/10.1021/acsami.0c05947DOI Listing
July 2020

Improvement in hourly PM estimations for the Beijing-Tianjin-Hebei region by introducing an aerosol modeling product from MASINGAR.

Environ Pollut 2020 Sep 29;264:114691. Epub 2020 Apr 29.

School of Geosciences and Info-Physics, Central South University, Changsha, 410083, China.

This study improves traditional PM estimation models by combining an hourly aerosol optical depth from the Advanced Himawari Imager onboard Himawari-8 with a newly introduced predictor to estimate hourly PM concentrations in the Beijing-Tianjin-Hebei (BTH) region from November 1, 2018 to October 31, 2019. The new predictor is an hourly PM forecasting product from the Model of Aerosol Species IN the Global AtmospheRe (MASINGAR). Comparative experiments were conducted by utilizing three extensively used regression models, namely, multiple linear regression (MLR), geographically weighted regression (GWR), and linear mixed effects (LME). A ten-fold cross validation (CV) demonstrated that the MASINGAR product significantly improved the performances of these models. The introduced product increased the model's determination coefficients (from 0.316 to 0.379 for MLR, from 0.393 to 0.445 for GWR, and from 0.718 to 0.765 for LME), decreased their root mean square errors (from 38.2 μg/m to 36.4 μg/m for MLR, from 36.0 μg/m to 34.4 μg/m for GWR, and from 24.5 μg/m to 22.4 μg/m for LME) and mean absolute errors (from 25.2 μg/m to 23.3 μg/m for MLR, from 23.5 μg/m to 21.8 μg/m for GWR, and from 15.2 μg/m to 13.7 μg/m for LME). Then, a well-trained LME model was utilized to estimate the spatial distributions of hourly PM concentrations. Highly polluted localities were clustered in the central and southern areas of the BTH region, and the least polluted area was in northwestern Hebei. Seasonal PM levels averaged from the hourly estimations exhibited the highest concentrations (55.4 ± 56.8 μg/m) in the winter and lowest concentrations (25.1 ± 18.2 μg/m) in the summer. MAIN FINDING: Introducing the PM products from MASINGAR can significantly improve the performance of traditional models for surface PM estimations by 7-20%.
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http://dx.doi.org/10.1016/j.envpol.2020.114691DOI Listing
September 2020

Self-Inclusion and Dissociation of a Bridging β-Cyclodextrin Triplet.

ACS Omega 2020 Apr 31;5(14):8127-8136. Epub 2020 Mar 31.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

To understand the self-inclusion and the dissociation in a branched β-cyclodextrin (CD) system, we designed and synthesized a β-CD trimer in which each CD group is connected to one of bridging arms of a planar triphenylbenzene core through a CuAAC click reaction. Only one rather than two or all of the three host CDs was demonstrated to be in a self-including state in water, while no self-inclusion was observed to occur in dimethylsulfoxide (DMSO) via the characterization of H and NOESY NMR spectra. The configuration structures of the CD groups in the self-included state were evaluated, and the dissociation to free state in water was investigated under various conditions like heating, increased acidity, and discharging versus the addition of competitive guests. While raised temperature and increased acidity did not break the self-inclusion, two adamantane guest molecules were found to show capability in driving the equilibrium to get back to free state against the self-inclusion. The inclusion process of the added guests was believed to involve in the dissociation of the self-inclusion and the occupation of the guests in CD cavity. The results of host-guest interaction study indicated that the stable combination of guests was favorable for blocking the structural overturning of glucose toward trapping the bridging group into the cavity.
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http://dx.doi.org/10.1021/acsomega.0c00363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161068PMC
April 2020

Novel Unsaturated Polyester Nanocomposites via Hybrid 3D POSS-Modified Graphene Oxide Reinforcement: Electro-Technical Application Perspective.

Nanomaterials (Basel) 2020 Feb 3;10(2). Epub 2020 Feb 3.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.

The latest trends in technologies has shifted the focus to developing innovative methods for comprehensive property enhancement of the polymer composites with facile and undemanding experimental techniques. This work reports an elementary technique to fabricate high-performance unsaturated polyester-based nanocomposites. It focuses on the interactive effect of polyhedral oligomeric silsesquioxanes (POSS)-functionalized graphene oxide (GO) within the unsaturated polymermatrix. The hybrid framework of POSS-functionalized graphene oxide has been configured via peptide bonding between the aminopropyl isobutyl POSS and graphene oxide. The synergistic effect of POSS and graphene oxide paved the way for a mechanism to inculcate a hybrid framework within the unsaturated polyester (UP) via in situ polymerization to develop UP/GO-POSS nanocomposites. The surface-appended POSS within the graphene oxide boosted its dispersion in the UP matrix, furnishing an enhancement in tensile strength of the UP/GO-POSS composites by 61.9%, thermal decomposition temperature (10% mass loss) by 69.8 °C and electrical conductivity by 10 S/m, in contrast to pure UP. In particular, the homogenous influence of the POSS-modified GO could be vindicated in the surging of the limiting oxygen index (%) in the as-prepared nanocomposites. The inclusive property amelioration vindicates the use of fabricated nanocomposites as high-performance nanomaterials in electrotechnical applications.
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http://dx.doi.org/10.3390/nano10020260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075121PMC
February 2020

A Novel Approach to Enhance Mechanical and Thermal Properties of SLA 3D Printed Structure by Incorporation of Metal-Metal Oxide Nanoparticles.

Nanomaterials (Basel) 2020 Jan 27;10(2). Epub 2020 Jan 27.

CAS Key Laboratory of Design and Assembly of Functional Nanostructure, and Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.

Silver (Ag) ornamented TiO semiconducting nanoparticles were synthesized through the sol-gel process to be utilized as nanofillers with photo resin to enhance the mechanical and thermal properties of stereolithography 3D printed objects. The as-prepared Ag-TiO nanoparticles (Ag-TNP) were typified and qualified by XRD, XPS, Raman, and FESEM; TEM analysis dissected the morphologies. The enhancement in the tensile and flexural strengths of SLR/Ag-TNP nanocomposites was noted as 60.8% and 71.8%, respectively, at the loading content of 1.0% / Ag-TNP within the SLR (stereolithography resin) matrix. Similarly, the thermal conductivity and thermal stability were observed as higher for SLR/Ag-TNP nanocomposites, equated to neat SLR. The nanoindentation investigation shows an excerpt hike in reduced modulus and hardness by the inclusion of Ag-TNP. The resulted thermal analysis discloses that the introduction of Ag-TNP can appreciably augment the glass transition temperature (T), and residual char yield of SLR nanocomposites remarkably. Hence, the significant incorporation of as-prepared Ag-TNP can act as effective nanofillers to enhance the thermal and mechanical properties of photo resin.
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http://dx.doi.org/10.3390/nano10020217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074857PMC
January 2020

Geoacoustic inversion using ray-based blind deconvolution of shipping sources.

J Acoust Soc Am 2020 Jan;147(1):285

School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

The ray-based blind deconvolution algorithm can provide an estimate of the channel impulse responses (CIRs) between a shipping source of opportunity and the elements of a receiving array by estimating the unknown phase of this random source through wideband beamforming along a well-resolved ray path. However, due to the shallow effective depth (typically <10 m) and low frequency content (typically less than a few kHz) associated with shipping sources, the interfering direct and surface arriving pair and subsequent bottom and surface-bottom arrival pair cannot always be resolved in the CIR arrival-time structure. Nevertheless, this study demonstrates that the bottom reflection loss can be inferred from the ratio of the magnitude spectra of these two arrival pairs if a frequency-dependent correction (which can be purely data based) is applied to correct for the dipole source effect. The feasibility of the proposed approach is demonstrated to invert for the geoacoustic parameters of a soft-layer covering the ocean floor using a nonlinear least-square algorithm.
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http://dx.doi.org/10.1121/10.0000605DOI Listing
January 2020

Processing supramolecular framework for free interconvertible liquid separation.

Nat Commun 2020 Jan 22;11(1):425. Epub 2020 Jan 22.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, P. R. China.

Nanoporous structures constructed by small molecular components exhibited vigorous materials potentials. While maintianing uniform porosity and functional properties, more applicable processing methods for the solid powders need to be considered and the improvement of binding interactions represents a preferable approach for structural flexibility. Here, by combining ionic interaction and host-guest inclusion, we constructed flexible supramolecular frameworks composing of inorganic polyanionic clusters, cationic organic hosts, and a bridging guest. The formed layer framework structure assemblies grew into nano-fibers and then supramolecular gels, donating highly convenient processability to porous materials. A simple spin-coating generated a new type of liquid separation membranes which showed structural stability for many liquids. The surface properties can be facilely modulated via filling a joystick liquid and then a hydrophilic/hydrophobic liquid into the porous frameworks, providing in-situ consecutive switchings for cutting liquids. This strategy extends the potential of flexible supramolecular frameworks for responsive materials in the laboratory and in industry.
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http://dx.doi.org/10.1038/s41467-019-14227-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976700PMC
January 2020

Light-powered and transient peptide two-dimensional assembly driven by trans-to-cis isomerization of azobenzene side chains.

Chem Commun (Camb) 2020 Feb 17;56(12):1867-1870. Epub 2020 Jan 17.

State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Qianjin Avenue 2699, Changchun 130012, China.

Transient nanosheets were fabricated based on the ionic self-assembly of anionic polyoxometalates and cationic peptides appended with azobenzene side chains. The two-dimensional (2D) nanostructures are initiated through ultraviolet (UV) light-actuated trans-to-cis isomerization of azobenzene moieties.
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http://dx.doi.org/10.1039/c9cc09448bDOI Listing
February 2020

3D Printing Mechanically Robust and Transparent Polyurethane Elastomers for Stretchable Electronic Sensors.

ACS Appl Mater Interfaces 2020 Feb 23;12(5):6479-6488. Epub 2020 Jan 23.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials , Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Fuzhou 350002 , People's Republic of China.

Advanced stretchable electronic sensors with a complex structure place higher requirements on the mechanical properties and manufacturing process of the stretchable substrate materials. Herein, three kinds of polyurethane acrylate oligomers were synthesized successfully and mixed with a commercial acrylate monomer (isobornyl acrylate) to prepare photocurable resins with a low viscosity for a digital light processing three-dimensional (3D) printer without custom equipment. Results showed that the resin containing poly(tetrahydrofuran) units (PPTMGA-40) exhibited optimal mechanical properties and shape recoverability. The tensile strength and elongation at break of PPTMGA-40 were 15.7 MPa and 414.3%, respectively. The unprecedented fatigue resistance of PPTMGA-40 allowed it to withstand 100 compression cycles at 80% strain without fracture. The transmittance of PPTMGA-40 reached 89.4% at 550 nm, showing high transparency. An ionic hydrogel was coated on the surface of 3D-printed structures to fabricate stretchable sensors, and their conductivity, transparency, and mechanical performance were characterized. A robust piezoresistive strain sensor with a high strength (∼6 MPa) and a wearable finger guard sensor were fabricated, demonstrating that this hydrogel-elastomer system can meet the requirements of applications for advanced stretchable electronic sensors and expand the usage scope.
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http://dx.doi.org/10.1021/acsami.9b20631DOI Listing
February 2020