Publications by authors named "Livio Trusolino"

84Publications

Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer.

Int J Cancer 2020 Nov 13;147(10):2891-2901. Epub 2020 Aug 13.

Department of Physiology and Medical Physics and Centre Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1002/ijc.33226DOI Listing
November 2020

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga.

Trends Cancer 2019 12 6;5(12):779-788. Epub 2019 Nov 6.

Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy; Candiolo Cancer Institute - FPO IRCCS, 10060 Candiolo, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2019.10.006DOI Listing
December 2019

The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy.

Cancer Cell 2019 07;36(1):1-3

Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.001DOI Listing
July 2019

Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy.

Nat Rev Cancer 2018 06;18(6):341-358

Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.

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http://dx.doi.org/10.1038/s41568-018-0002-yDOI Listing
June 2018

Oncogenic MET as an Effective Therapeutic Target in Non-Small Cell Lung Cancer Resistant to EGFR Inhibitors: The Rise of the Phoenix.

Authors:
Livio Trusolino

Cancer Discov 2016 12;6(12):1306-1308

Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute IRCCS, and Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-16-1181DOI Listing
December 2016

Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody.

Cancer Res 2016 09 30;76(17):5019-29. Epub 2016 Jun 30.

Molecular Therapeutics and Exploratory Research Laboratories at Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Italy. Department of Oncology, University of Torino Medical School, Torino, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3107DOI Listing
September 2016

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

Nat Commun 2015 Sep 22;6:8305. Epub 2015 Sep 22.

Candiolo Cancer Institute - Fondazione Piemontese per l'Oncologia (FPO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Torino, 10060, Italy.

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http://dx.doi.org/10.1038/ncomms9305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595628PMC
September 2015

Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.

Clin Cancer Res 2015 Dec 21;21(24):5519-31. Epub 2015 Aug 21.

Department of Oncology, University of Turin Medical School, Turin, Italy. Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute-FPO IRCCS, Turin, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3066DOI Listing
December 2015

HER2 activating mutations are targets for colorectal cancer treatment.

Cancer Discov 2015 Aug;5(8):832-41

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri. Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527087PMC
August 2015

Stromal contribution to the colorectal cancer transcriptome.

Nat Genet 2015 Apr 23;47(4):312-9. Epub 2015 Feb 23.

1] Candiolo Cancer Institute, Fondazione Piemontese per l'Oncologia'Istituto di Ricovero e Cura a Carattere Scientifico (FRO-IRCCS), Candiolo, Italy. [2] Department of Oncology, University of Torino, Candiolo, Italy.

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http://dx.doi.org/10.1038/ng.3224DOI Listing
April 2015

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

Sci Transl Med 2015 Jan;7(272):272ra12

Department of Oncology, University of Torino Medical School, 10060 Candiolo, Torino, Italy. Translational Cancer Medicine, Candiolo Cancer Institute-Fondazione del Piemonte per l'Oncologia (FPO) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 10060 Candiolo, Torino, Italy. National Institute of Biostructures and Biosystems, 00136 Rome, Italy.

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http://dx.doi.org/10.1126/scitranslmed.3010445DOI Listing
January 2015

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models.

BMC Cancer 2014 Dec 5;14:918. Epub 2014 Dec 5.

University of Turin Medical School, Department of Oncology, IRCCS-Candiolo, Strada provinciale 142, Km 3,95, Candiolo, 10060 Turin, Italy.

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http://dx.doi.org/10.1186/1471-2407-14-918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289395PMC
December 2014

Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs.

Cancer Res 2014 Nov 12;74(22):6598-609. Epub 2014 Sep 12.

Department of Oncology, University of Torino Medical School, Candiolo, Torino, Italy. Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0761DOI Listing
November 2014

Inhibition of poly(ADP-ribosyl)ation in cancer: old and new paradigms revisited.

Biochim Biophys Acta 2014 Aug 12;1846(1):201-15. Epub 2014 Jul 12.

Department of Oncology, University of Torino Medical School, 10060 Candiolo, Torino, Italy; Laboratory of Molecular Pharmacology, Candiolo Cancer Institute, FPO IRCCS, 10060 Candiolo, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.07.004DOI Listing
August 2014

Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies.

J Mol Med (Berl) 2014 Jul 10;92(7):709-22. Epub 2014 May 10.

Department of Oncology, University of Torino Medical School, 10060, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1007/s00109-014-1161-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055851PMC
July 2014

The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells.

Int J Cancer 2014 Nov 15;135(10):2305-16. Epub 2014 Apr 15.

ECMO, Experimental Clinical Molecular Oncology, Candiolo Cancer Institute-FPO, IRCCS, Candiolo (Torino), Italy.

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http://dx.doi.org/10.1002/ijc.28879DOI Listing
November 2014

NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells.

Cancer Res 2014 Apr 13;74(7):2106-18. Epub 2014 Feb 13.

Authors' Affiliations: Department of Surgery, Oncology and Gastroenterology, University of Padova; Istituto Oncologico Veneto IRCCS, Padova; IRCC, Institute for Cancer Research and Treatment, Candiolo; Department of Oncology, University of Torino School of Medicine, Torino, Italy; OncoMed Pharmaceuticals Inc., Redwood City, California; and Centre de Génétique et de Physiologie Moléculaire et Cellulaire, Université Claude Bernard Lyon 1, Villeurbanne, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2022DOI Listing
April 2014

MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.

Cancer Res 2014 Mar 21;74(6):1857-69. Epub 2014 Jan 21.

Authors' Affiliations: Institute for Cancer Research at Candiolo (IRCC), Center for Experimental Clinical Molecular Oncology; Department of Oncology, University of Torino, Candiolo, Torino, Italy; Aveo Oncology Inc., Cambridge, Massachusetts; and Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2340-TDOI Listing
March 2014

An 'in-cell trial' to assess the efficacy of a monovalent anti-MET antibody as monotherapy and in association with standard cytotoxics.

Mol Oncol 2014 Mar 18;8(2):378-88. Epub 2013 Dec 18.

IRCC - Institute for Cancer Research at Candiolo, Center for Experimental Clinical Molecular Oncology, 10060 Candiolo, Italy; Department of Oncology, University of Torino School of Medicine, 10060 Candiolo, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528555PMC
March 2014

From bench to bedside: does preclinical practice in translational oncology need some rebuilding?

J Natl Cancer Inst 2013 Oct 19;105(19):1426-7. Epub 2013 Sep 19.

Affiliations of authors: Department of Oncology, University of Torino Medical School (AB, LT); Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment (AB, LT), Candiolo, Torino, Italy.

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http://dx.doi.org/10.1093/jnci/djt253DOI Listing
October 2013

Animal research: Temper Italy's strict lab-animal law.

Nature 2013 Sep;501(7465):33

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http://dx.doi.org/10.1038/501033dDOI Listing
September 2013

Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies: six degrees of separation.

Cancer Discov 2012 Oct;2(10):876-80

Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment, and Department of Oncological Sciences, University of Torino School of Medicine, Candiolo (Torino), Italy.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-12-0400DOI Listing
October 2012

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils.

EMBO Mol Med 2011 Nov 23;3(11):623-36. Epub 2011 Sep 23.

Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo (Torino), Italy.

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http://dx.doi.org/10.1002/emmm.201100176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377106PMC
November 2011

A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors.

Int J Cancer 2012 Mar 30;130(6):1357-66. Epub 2011 May 30.

Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1002/ijc.26137DOI Listing
March 2012

Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis.

Cancer Res 2011 Apr 12;71(8):3132-41. Epub 2011 Apr 12.

Exploratory Research Laboratory, Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Turin, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2662DOI Listing
April 2011

MET signalling: principles and functions in development, organ regeneration and cancer.

Nat Rev Mol Cell Biol 2010 Dec;11(12):834-48

Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo, Torino, Italy.

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http://dx.doi.org/10.1038/nrm3012DOI Listing
December 2010

The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth.

J Biol Chem 2010 Dec 11;285(50):38756-64. Epub 2010 Oct 11.

Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, 10060 Candiolo, Torino, Italy.

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http://dx.doi.org/10.1074/jbc.M110.145417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998140PMC
December 2010

The Met oncogene and basal-like breast cancer: another culprit to watch out for?

Breast Cancer Res 2010 23;12(4):208. Epub 2010 Aug 23.

Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo, Torino, Italy.

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http://dx.doi.org/10.1186/bcr2617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949647PMC
March 2011

Inhibition of Src impairs the growth of met-addicted gastric tumors.

Clin Cancer Res 2010 Aug 13;16(15):3933-43. Epub 2010 Jul 13.

Division of Molecular Oncology and Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Torino Medical School, Strada Provinciale 142, Candiolo, Turin, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0106DOI Listing
August 2010

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition.

Mol Cancer 2010 May 26;9:121. Epub 2010 May 26.

Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo (Torino), Italy.

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http://dx.doi.org/10.1186/1476-4598-9-121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892452PMC
May 2010

Only a subset of Met-activated pathways are required to sustain oncogene addiction.

Sci Signal 2009 ;2(102):er11

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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http://dx.doi.org/10.1126/scisignal.2102er11DOI Listing
March 2011

Only a subset of Met-activated pathways are required to sustain oncogene addiction.

Sci Signal 2009 Dec 8;2(100):ra80. Epub 2009 Dec 8.

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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http://dx.doi.org/10.1126/scisignal.2000643DOI Listing
December 2009

The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis.

Mol Biol Cell 2009 Jan 12;20(2):642-57. Epub 2008 Nov 12.

Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.

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http://dx.doi.org/10.1091/mbc.e08-03-0321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626568PMC
January 2009

Drug development of MET inhibitors: targeting oncogene addiction and expedience.

Nat Rev Drug Discov 2008 Jun;7(6):504-16

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Turin School of Medicine, Candiolo, Turin 10060, Italy.

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http://dx.doi.org/10.1038/nrd2530DOI Listing
June 2008

The Met tyrosine kinase receptor in development and cancer.

Cancer Metastasis Rev 2008 Mar;27(1):85-94

Division of Molecular Oncology, University of Turin Medical School, 10060, Candiolo (Torino), Italy.

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http://dx.doi.org/10.1007/s10555-007-9107-6DOI Listing
March 2008

Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth.

J Cell Biol 2006 Dec 11;175(6):993-1003. Epub 2006 Dec 11.

Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200605114
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http://dx.doi.org/10.1083/jcb.200605114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064708PMC
December 2006

Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.

Cancer Res 2005 Dec;65(23):10674-9

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino School of Medicine, Candiolo (Torino), Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2827DOI Listing
December 2005

Cancer: the matrix is now in control.

Nat Med 2005 Nov;11(11):1156-9

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http://dx.doi.org/10.1038/nm1105-1156DOI Listing
November 2005

Negative feedback regulation of Met-dependent invasive growth by Notch.

Mol Cell Biol 2005 May;25(10):3982-96

Institute for Cancer Research and Treatment, University of Turin School of Medicine, Division of Molecular Oncology, IV Floor, Str. Prov. 142, Km. 3,95, 10060 Candiolo, Torino, Italy.

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http://dx.doi.org/10.1128/MCB.25.10.3982-3996.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087707PMC
May 2005

Interactions between growth factor receptors and adhesion molecules: breaking the rules.

Curr Opin Cell Biol 2003 Oct;15(5):565-71

Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142, 10060 Candiolo (Torino), Italy.

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http://dx.doi.org/10.1016/s0955-0674(03)00096-6DOI Listing
October 2003

Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma.

FASEB J 2003 Jun 22;17(9):1162-4. Epub 2003 Apr 22.

Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment (IRCC), Strada Provinciale 142, Km 3.95, 10060 Candiolo (To), Italy.

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http://dx.doi.org/10.1096/fj.02-0576fjeDOI Listing
June 2003

Scatter-factor and semaphorin receptors: cell signalling for invasive growth.

Nat Rev Cancer 2002 Apr;2(4):289-300

Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy.

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http://dx.doi.org/10.1038/nrc779DOI Listing
April 2002

Invasive growth: from development to metastasis.

J Clin Invest 2002 Apr;109(7):857-62

Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo (Torino), Italy.

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http://dx.doi.org/10.1172/JCI15392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150936PMC
April 2002