Publications by authors named "Liu Ye"

1,075 Publications

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The efficacy and safety of rivaroxaban in coronary artery disease patients with heart failure and sinus rhythm: a systematic review and meta-analysis.

Eur J Clin Pharmacol 2021 Aug 3. Epub 2021 Aug 3.

Department of Pharmacy, the Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.

Purpose: To explore the efficacy and safety of rivaroxaban in patients with coronary artery disease (CAD), heart failure (HF) and sinus rhythm (SR).

Methods: Comprehensive literature searches were conducted using the PubMed, Cochrane Library, Embase, CNKI and Wanfang databases from inception to February 2021. Randomized controlled trials (RCTs) focusing on the efficacy and safety of new oral anticoagulant (NOAC) therapy in CAD and HF patients in SR were eligible. Statistical analyses were performed using R Programming Language.

Results: Three RCTs included 10,658 adult patients treated with antiplatelet drugs with or without rivaroxaban were ultimately analysed. The average follow-up period was 20.4-24 months. Rivaroxaban had a favourable point estimate in myocardial infarction (MI) and stroke (MI rivaroxaban group (3.83%, 203/5306) vs. APT group (4.52%, 214/4731), RR = 0.78, 95% CI 0.65-0.94, P < 0.01, I = 0%), (stroke: rivaroxaban group (1.60%, 85/5306) vs. APT group (2.52%, 119/4731), RR = 0.64, 95% CI 0.49-0.85, P < 0.01, I = 12%) compared with the placebo. Rivaroxaban was comparable to the placebo for all-cause death and major bleeding (all-cause death: rivaroxaban group (12.27%, 688/5606) vs. APT group (14.59%, 737/5052), RR = 0.73, 95% CI 0.49-1.06, P > 0.05, I = 87%), (major bleeding: rivaroxaban group (1.52%, 85/5586) vs. APT group (1.37%, 69/5043), RR = 1.18, 95% CI 0.86-1.62, P > 0.05, I = 0%).

Conclusions: In SR patients with CAD and HF, the rates of MI and stroke associated with rivaroxaban combined with APT were lower than those associated with APT alone, and the two treatments had similar rates of all-cause death and major bleeding.
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http://dx.doi.org/10.1007/s00228-021-03195-wDOI Listing
August 2021

Comparison of Genome-Wide DNA Methylation Profiles of Human Fetal Tissues Conceived by Fertilization and Natural Conception.

Front Cell Dev Biol 2021 14;9:694769. Epub 2021 Jul 14.

International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Assisted reproductive technology (ART) might induce adverse pregnancy outcomes and increase the risk of metabolic diseases in offspring' later life with unknown reasons. Here we evaluated the global methylation level and methylation profile of fetal tissue from elective terminations of pregnancy (ETP) after natural conception and multifetal pregnancy reduction (MFPR) after fertilization and embryo transfer (IVF-ET).

Results: Global methylation levels were comparable between the fetal tissue of ETP after natural conception group and MFPR after IVF-ET group. The methylation levels were lower in the hypermethylated regions of the MFPR group than in the ETP group, while the methylation levels were higher in the hypomethylated regions of the MFPR group. Heatmap visualization and hierarchical clustering of the candidate differentially methylated regions (DMRs) showed differences between the DMRs in the ETP and MFPR samples. We identified 196 differentially methylated regions that matched 164 genes between the ETP and MFPR groups. In the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, skeletal system morphogenesis and diabetes mellitus ranked first. Ingenuity Pathway Analysis (IPA) revealed 8 diseases and functional annotations associated with IVT-ET. In the MFPR group, the final validation showed lower methylation levels in gene bodies of bone morphogenetic protein 4 (BMP4), higher methylation levels in the 1st exon and 5'UTR of thyroid peroxidase (TPO), and higher methylation levels in TSS1500 and TSS200 of interleukin 1 beta (IL1B).

Conclusions: ART does not alter global DNA methylation level, but influences DNA methylation variation in specific regions of human fetus in the early stage of life. Further studies are warranted to clarify the potential role of DNA methylation alterations in the gene expression profile.
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http://dx.doi.org/10.3389/fcell.2021.694769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318003PMC
July 2021

Thermally induced variations in the nanostructure and reactivity of soot particles emitted from a diesel engine.

Chemosphere 2021 Jul 29;286(Pt 2):131712. Epub 2021 Jul 29.

Institute for Transport Studies, University of Leeds, Leeds, LS2 9JT, UK.

This work focuses on the thermally induced variation in the nanostructure, size of primary particles and oxidative reactivity of diesel soot and a commercial carbon black in an inert gas environment at temperatures ranging from 600 to 1000 °C. Soot nanostructure and size were characterized by high-resolution transmission electron microscopy (HRTEM) and X-ray diffraction (XRD). The soot reactivity was evaluated with respect to activation energy (E) and characteristic oxidation temperature, including peak temperature (T) and burnout temperature (T), using thermogravimetric analysis (TGA). The mass loss of diesel soot and carbon black rises when increasing the thermal treatment temperature, especially at 1000 °C, and a significant quantity of mass loss can be observed, which is primarily due to thermal fragmentation and the desorption of chemical species on soot surfaces. The HRTEM and XRD results all indicate that the thermally treated soot samples have more ordered nanostructure than the untreated samples. There is a reduction in the size of primary particles as thermal treatment temperature increases. The soot reactivity decreases after thermal treatment, as manifested by the elevation in E, T, and T values. Moreover, the oxidation reactivity of soot samples is closely associated with the fringe length, tortuosity, and fringe tortuosity. Compared to carbon black, diesel soot with a more disorder structure has a higher oxidative reactivity.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131712DOI Listing
July 2021

Emergence of Novel Recombinant Type 2 Porcine Reproductive and Respiratory Syndrome Viruses with high pathogenicity for piglets in China.

J Infect 2021 Jul 27. Epub 2021 Jul 27.

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal, Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2021.07.033DOI Listing
July 2021

Labour-saving construction of a target protein interaction network by selective culture and high-throughput sequencing.

Biotechnol J 2021 Jul 30:e2100204. Epub 2021 Jul 30.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, Key Laboratory of Landscaping, Ministry of Agriculture and Rural Affairs, College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.

Background: Yeast two-hybrid (Y2H) is a classic method of screening for protein-protein interactions. However, the operation process is labour intensive and time consuming, and there is a high possibility of false positives and false negatives.

Methods And Results: combined with wet lab operation and bioinformatics analysis, we developed a novel method of Y2H library screening using Chrysanthemum morifolium CmMPK3 as an example.

Conclusions And Implications: the protocol can not only greatly simplify the steps of traditional Y2H library screening but also identify as many interacting proteins as possible. Furthermore, this protocol is applicable to any species, even if no genomic information is available yet. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/biot.202100204DOI Listing
July 2021

Exploring Gut Microbiota in Patients with Colorectal Disease Based on 16S rRNA Gene Amplicon and Shallow Metagenomic Sequencing.

Front Mol Biosci 2021 9;8:703638. Epub 2021 Jul 9.

Key Laboratory of Advanced Drug Preparation Technologies, School of Pharmaceutical Sciences, Ministry of Education, Zhengzhou University, Zhengzhou, China.

The gastrointestinal tract, the largest human microbial reservoir, is highly dynamic. The gut microbes play essential roles in causing colorectal diseases. In the present study, we explored potential keystone taxa during the development of colorectal diseases in central China. Fecal samples of some patients were collected and were allocated to the adenoma (Group A), colorectal cancer (Group C), and hemorrhoid (Group H) groups. The 16S rRNA amplicon and shallow metagenomic sequencing (SMS) strategies were used to recover the gut microbiota. Microbial diversities obtained from 16S rRNA amplicon and SMS data were similar. Group C had the highest diversity, although no significant difference in diversity was observed among the groups. The most dominant phyla in the gut microbiota of patients with colorectal diseases were Bacteroidetes, Firmicutes, and Proteobacteria, accounting for >95% of microbes in the samples. The most abundant genera in the samples were , , and , and further species-level and network analyses identified certain potential keystone taxa in each group. Some of the dominant species, such as , , and , could be responsible for causing colorectal diseases. The SMS data recovered diverse antibiotic resistance genes of tetracycline, macrolide, and beta-lactam, which could be a result of antibiotic overuse. This study explored the gut microbiota of patients with three different types of colorectal diseases, and the microbial diversity results obtained from 16S rRNA amplicon sequencing and SMS data were found to be similar. However, the findings of this study are based on a limited sample size, which warrants further large-scale studies. The recovery of gut microbiota profiles in patients with colorectal diseases could be beneficial for future diagnosis and treatment with modulation of the gut microbiota. Moreover, SMS data can provide accurate species- and gene-level information, and it is economical. It can therefore be widely applied in future clinical metagenomic studies.
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http://dx.doi.org/10.3389/fmolb.2021.703638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299945PMC
July 2021

Dyadic effects of family resilience on post-traumatic stress symptoms among breast cancer patients and their primary family caregivers: A cross-sectional study.

Eur J Oncol Nurs 2021 Aug 1;53:101998. Epub 2021 Jul 1.

School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. Electronic address:

Purpose: The aims of this study were to verify actor and partner effects, by examining the effects of family resilience on post-traumatic stress symptoms (PTSS) among Chinese breast cancer patients and their primary family caregivers.

Methods: In this cross-sectional study, 104 breast cancer patients (age range 20-75, Mean = 47, Standard Deviation = 10), and their principal caregivers (n = 104), were recruited from a comprehensive cancer center of a public hospital in China. The patients and their caregivers self-reported sociodemographic, family resilience, and PTSS factors. The actor-partner interdependence model were adopted to examine whether the patients and caregivers' perceived family resilience could contribute to their own ("actor effect") and each other's ("partner effect") PTSS.

Results: There were significant correlations between patients' and caregivers' shortened Chinese version of Family Resilience Assessment Scale scores (r = 0.58, p < 0.01) and Post-traumatic Stress Disorder Checklist-Civilian Version scores (r = 0.69, p < 0.01). Caregivers' perceived family resilience was negatively related to their PTSS (actor effect), and the patients' PTSS (partner effect). However, the patients' perceived family resilience was not significantly related to their or the caregivers' PTSS.

Conclusions: The primary caregivers' perceived family resilience had both actor and partner effects on patient/caregiver PTSS within the first year of breast cancer diagnosis. Family-based interventions should be designed to enhance family resilience to decrease PTSS within families dealing with cancer patients. Supportive care should focus on the primary family caregivers within the first year of breast cancer diagnosis.
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http://dx.doi.org/10.1016/j.ejon.2021.101998DOI Listing
August 2021

The Effects of Altitude-related Hypoxia Exposure on the Multiscale Dynamics of Blood Pressure Fluctuation During Sleep: The Observation from a Pilot Study.

Nat Sci Sleep 2021 15;13:1147-1155. Epub 2021 Jul 15.

Hebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research, Harvard Medical School, Boston, MA, 02131, USA.

Purpose: The purpose exposure to hypoxia in high altitudes severely impairs the sleep quality and the related cardiovascular regulation, including the blood pressure (BP) regulation. BP regulation depends upon the continuous interaction of components over multiple temporal scales. As such, the dynamics of BP fluctuation are complex, and BP complexity has been linked to several pathological events. However, the effects of the exposure to hypoxia on BP complexity during sleep remain unknown.

Methods: Twenty-five younger men naïve to high-altitude sleep (apnea severity as assessed by hypoxia apnea index (AHI): normal=8; moderate=9; severe=8) completed one nocturnal sleep under each of the three altitudes: 0 (ie, baseline), 2000, and 4000 m. The sleep characteristics and oxygen saturation (ie, SpO) were assessed using polysomnography (PSG). The beat-to-beat BP fluctuation was recorded using a finger-blood-pressure sensor. Multiscale entropy (MSE) was used to characterize the complexity of systolic (SBP) and diastolic (DBP) BP fluctuations, and lower MSE reflected lower complexity.

Results: Compared to 0-m condition, SBP (=0.0003) and DBP (F=12.1, =0.0002) complexity, SpO (<0.0001) and REM ratio (<0.0090) were decreased, AHI was increased (=0.0004) in 2000-m and even more in 4000-m conditions. In addition, lower BP complexity was associated with greater AHI (r=-0.66~0.52, =0.0010), lower SpO (r=0.48~0.51, =0.0100~0.0200) and lower REM ratio (r=0.48~0.52, =0.0200). Participants with greater percent reduction in BP complexity between altitudes had greater percent reduction in REM ratio and SpO (r=0.38~0.45, =0.0090~0.0200), after adjustment for age, BMI, baseline apnea and altitude.

Conclusion: These results suggested that the characterization of BP complexity may provide novel insights into the underlying mechanisms through which the exposure to hypoxia affects cardiovascular health during sleep, as well as sleep quality. This BP complexity may serve as a novel marker to help the management of cardiovascular health and sleep quality in high-altitude living.
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http://dx.doi.org/10.2147/NSS.S319031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289331PMC
July 2021

Inhibition of TGF-β2-induced migration and epithelial-mesenchymal transition in ARPE-19 by sulforaphane.

Int J Ophthalmol 2021 18;14(7):973-980. Epub 2021 Jul 18.

Department of Ophthalmology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China.

Aim: To investigate the effects of sulforaphane (SFN) on transforming growth factor (TGF)-β2 stimulated migration and epithelial-mesenchymal transition (EMT) in ARPE-19 cells.

Methods: ARPE-19 cells were cultured in the presence or absence of SFN or TGF-β2. SFN toxicity was assessed by performing a lactate dehydrogenase assay (LDH) and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assays, and cell migration was evaluated by Transwell migration assay. Actin stress fiber formation in ARPE-19 cells was determined using immunofluorescence analysis. Immunoblotting analysis was used to determine fibronectin and α-smooth muscle actin expressions along with the degree of Smad and Akt phosphorylation.

Results: SFN inhibited ARPE-19 migration. Additionally, SFN attenuated TGF-β2-induced appearance of actin stress fibers as well as fibronectin and α-smooth muscle actin expressions in these cells. SFN also hindered the TGF-β2-stimulated phosphorylation of Smad2, Smad3, and Akt. SFN showed no cytotoxicity towards ARPE-19 cells.

Conclusion: SFN inhibits TGF-β2-stimulated migration and EMT in ARPE-19 cells, probably by preventing the establishment of actin stress fibers and Akt and Smad2/3 signaling.
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http://dx.doi.org/10.18240/ijo.2021.07.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243186PMC
July 2021

C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation.

J Neuroinflammation 2021 Jul 18;18(1):159. Epub 2021 Jul 18.

Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Yuzhong District, Chongqing, 400010, China.

Objective: C1qTNF-related protein 4 (CTRP4) acts in the hypothalamus to modulate food intake in diet-induced obese mice and has been shown to exert an anti-inflammatory effect on macrophages. Since high-fat diet-induced microglial activation and hypothalamic inflammation impair leptin signaling and increase food intake, we aimed to explore the potential connection between the anorexigenic effect of CTRP4 and the suppression of hypothalamic inflammation in mice with DIO.

Methods: Using an adenovirus-mediated hypothalamic CTRP4 overexpression model, we investigated the impact of CTRP4 on food intake and the hypothalamic leptin signaling pathway in diet-induced obese mice. Furthermore, central and plasma proinflammatory cytokines, including TNF-α and IL-6, were measured by Western blotting and ELISA. Changes in the hypothalamic NF-κB signaling cascade and microglial activation were also examined in vivo. In addition, NF-κB signaling and proinflammatory factors were investigated in BV-2 cells after CTRP4 intervention.

Results: We found that food intake was decreased, while leptin signaling was significantly improved in mice with DIO after CTRP4 overexpression. Central and peripheral TNF-α and IL-6 levels were reduced by central Ad-CTRP4 administration. Hypothalamic NF-κB signaling and microglial activation were also significantly suppressed in vivo. In addition, NF-κB signaling was inhibited in BV-2 cells following CTRP4 intervention, which was consistent with the decreased production of TNF-α and IL-6.

Conclusions: Our data indicate that CTRP4 reverses leptin resistance by inhibiting NF-κB-dependent microglial activation and hypothalamic inflammation.
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http://dx.doi.org/10.1186/s12974-021-02167-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286609PMC
July 2021

Experimental and computational study on the enantioseparation of four chiral fluoroquinolones by capillary electrophoresis with sulfated-β-cyclodextrin as chiral selector.

Chirality 2021 Jul 18. Epub 2021 Jul 18.

School of Pharmacy, Binzhou Medical University, Yantai, China.

In this work, enantioseparation of four chiral fluoroquinolones (FQs), namely, ofloxacin, gemifloxacin, lomefloxacin, and gatifloxacin, was achieved by capillary electrophoresis with sulfated-β-cyclodextrin (S-β-CD) as chiral selector. Factors affecting the enantiomeric resolution, such as the concentrations of S-β-CD, BGE pH conditions, and the buffer types and concentrations, were optimized and discussed. A BGE consisting of 30 g/L S-β-CD and 30-mM phosphate at pH 4.0 was found fit for enantiomeric resolution of ofloxacin and gemifloxacin, while the same BGE at pH 3.0 was suitable for enantioseparation of lomefloxacin and gatifloxacin. The pH-dependent experiments showed that separation resolutions of four FQs enantiomers were significantly affected by BGE pH, which was thought to be related with the varying electrostatic attraction between the enantiomers and chiral selector. To verify this speculation, molecular docking studies were used for further investigation of the enantiomeric recognition mechanism of S-β-CD. Molecular model indicated that hydrophobic effect and hydrogen bond were involved in host-guest inclusion, but the electrostatic attraction enhanced the chiral discrimination by increasing the difference in binding energy between individual enantiomers and S-β-CD. This work provided a further insight into the chiral recognition mechanisms of CD derivatives.
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http://dx.doi.org/10.1002/chir.23340DOI Listing
July 2021

Comparative analysis of non-exhaust airborne particles from electric and internal combustion engine vehicles.

J Hazard Mater 2021 Jul 10;420:126626. Epub 2021 Jul 10.

Brembo S.p.A., Via Europa 2, 24020 Stezzano (BG), Italy.

This paper evaluates the effect of the electrification of the small, medium, and large internal combustion engine (ICE) passenger cars on the levels of total particulate matter (PM). The total mean PM and PM emission factors (EFs) on urban, rural, and motorway roads are in the range of 26.13 - 39.57 mg km veh and 13.39 - 18.44 mg km veh, respectively, from small to large ICE passenger cars. Correspondingly, the total mean PM and PM non-exhaust EFs on urban, rural, and motorway roads range from 27.76 to 43.43 mg km veh and 13.17 -19.24 mg km veh from equivalent small to large electric vehicles (EVs) without regenerative braking. These results show that the total non-exhaust PM from the equivalent EVs may exceed all PM from ICE passenger cars, including exhaust particle emissions, which are dependent mainly on the extent of regenerative braking, followed by passenger car type and road type. PM EFs for equivalent EVs without regenerative braking on urban, rural, and motorway roads are all higher than those from ICE cars. As for PM, most of the equivalent EVs require different extents of regenerative braking to reduce brake emissions to be in line with all particle emissions from relative ICE cars.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126626DOI Listing
July 2021

A modified percutaneous atrial balloon septoplasty for difficult transseptal puncture.

Medicine (Baltimore) 2021 Jul;100(28):e26525

Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Abstract: Catheter ablation of atrial fibrillation sometimes encounters difficulty in passing the interatrial septum. This study reports a modified percutaneous atrial balloon septoplasty with short balloon to gain access to left atrium (LA) during challenging transseptal puncture (TSP).We retrospectively analyzed 20 patients (61.75 ± 7.31 years, 45% male) who received modified percutaneous atrial balloon septoplasty from August 2015 to October 2018. Soft-headed balance middle weight (BMW) guidewire was inserted into left superior pulmonary vein (LSPV) and short non-compliant balloon (15 mm in length and 4.0 or 5.0 mm in diameter) was used for atrial balloon septoplasty (ABS). Interatrial septum was located with inflated balloon and contrast "Hitting Wall" sign. All patients were followed-up for iatrogenic atrial septal defect (iASD) and other related complications.ABS and LA access were performed successfully without complications in all 20 patients. Time needed for ABS was correlated to the number of prior TSP (P = .007). During the 6-month follow-up, no remaining iASD was found by echocardiography.For atrial fibrillation patients with difficulty in passing the interatrial septum, this modified percutaneous ABS might be an alternative strategy which is safe to obtain transseptal access without short or long term complications.
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http://dx.doi.org/10.1097/MD.0000000000026525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284759PMC
July 2021

Cooperative Catalysis of Ru(III)-Porphyrin in CO -Involved Synthesis of Oxazolidinones.

Chem Asian J 2021 Jul 13. Epub 2021 Jul 13.

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P. R. China.

CO -transformations into high value-added products have become a fascinating area in green chemistry. Herein, a Ru(III)-porphyrin catalyst (RuCl  ⋅ 3H O-H TPP) was found highly efficient in the three-component reaction of CO , aliphatic amines and dichloroethane (or its derivative) for synthesis of oxazolidinones in the yields of 71∼91%. It was indicated by means of the control experiments and UV-vis spectra that CO was stoichiometrically activated by the involved aliphatic amine substrates to form a stable carbamate salt while 1,2-dichloroethane (or its derivative) was independently activated by the involved Ru(III)-porphyrin catalyst. The combination of CO -activation by aliphatic amines with 1,2-dichloroethane activation by Ru(III)-porphyrin catalyst cooperatively contributed to this successful transformation.
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http://dx.doi.org/10.1002/asia.202100533DOI Listing
July 2021

Validation of the Chinese Version of the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults.

J Sex Med 2021 Jul 8. Epub 2021 Jul 8.

Vanke School of Public Health, Tsinghua University, Beijing, China. Electronic address:

Background: The number of individuals with potential gender dysphoria (GD) being referred to specialized gender identity clinics or programs is increasing internationally; these cases are initially screened using the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults (GIDYQ-AA).

Aim: The current study aimed to assess the psychometric properties of the GIDYQ-AA in a sample of adolescents and young adults from China.

Methods: A cross-sectional study was conducted in October 2020. Sociodemographic information of the participants was first collected. Participants then completed the GIDYQ-AA, the Generalized Anxiety Disorder-7 scale, the Patient Health Questionnaire-9, and a suicidal ideation assessment. A total of 2,533 participants with a mean age of 19.30 (SD = 1.19) years were recruited. Of the participants, 841 (33.2%) were cis men, 1,589 (62.7%) were cis women, 66 (2.6%) self-identified as transgender, 17 (0.7%) self-identified as non-binary, and 20 (0.8%) self-identified as gender queer.

Results: The GIDYQ-AA had high internal consistency with a Cronbach's alpha = 0.89. Exploratory factor analysis showed that the GIDYQ-AA had a four-factor structure in China. The GIDYQ-AA was significantly correlated with anxiety symptoms (r = -0.32, P < .01), depressive symptoms (r = -0.33, P < .01), and suicidal ideation (r = -0.20, P < .01).

Clinical Translation: The Chinese version of GIDYQ-AA is a useful measurement with high practical value, which could promote the assessment and research of GD across China or among Chinese migrants in other countries.

Strengths And Limitations: This is the first study assessing the psychometric properties of the GIDYQ-AA in Chinese adolescents and young adults. The convergent and divergent validity of the GIDYQ-AA were not examined due to the unavailability of data. Also, the sample did not have an equal distribution of male to males and female to females.

Conclusion: The Chinese version of GIDYQ-AA is a useful measure, which could promote both the assessment and research of GD in the Chinese population. Wang Y, Feng Y, Su D, et al. Validation of the Chinese Version of the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults. J Sex Med 2021;XX:XXX-XXX.
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http://dx.doi.org/10.1016/j.jsxm.2021.05.007DOI Listing
July 2021

Dual species dynamic transcripts reveal the interaction mechanisms between Chrysanthemum morifolium and Alternaria alternata.

BMC Genomics 2021 Jul 9;22(1):523. Epub 2021 Jul 9.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, Key Laboratory of Landscaping, Ministry of Agriculture and Rural Affairs, Key Laboratory of Biology of Ornamental Plants in East China, College of Horticulture, National Forestry and Grassland Administration, Nanjing Agricultural University, 210095, Nanjing, China.

Background: Chrysanthemum (Chrysanthemum morifolium) black spot disease caused by Alternaria alternata is one of the plant's most destructive diseases. Dual RNA-seq was performed to simultaneously assess their transcriptomes to analyze the potential interaction mechanism between the two species, i.e., host and pathogen.

Results: C. morifolium and A. alternata were subjected to dual RNA-seq at 1, 12, and 24 h after inoculation, and differential expression genes (DEGs) in both species were identified. This analysis confirmed 153,532 DEGs in chrysanthemum and 14,932 DEGs in A. alternata, which were involved in plant-fungal interactions and phytohormone signaling. Fungal DEGs such as toxin synthesis related enzyme and cell wall degrading enzyme genes played important roles during chrysanthemum infection. Moreover, a series of key genes highly correlated with the early, middle, or late infection stage were identified, together with the regulatory network of key genes annotated in the Plant Resistance Genes database (PRGdb) or Pathogen-Host Interactions database (PHI-base). Highly correlated genes were identified at the late infection stage, expanding our understanding of the interplay between C. morifolium and A. alternata. Additionally, six DEGs each from chrysanthemum and A. alternata were selected for quantitative real-time PCR (qRT-PCR) assays to validate the RNA-seq output.

Conclusions: Collectively, data obtained in this study enriches the resources available for research into the interactions that exist between chrysanthemum and A. alternata, thereby providing a theoretical basis for the development of new chrysanthemum cultivars with resistance to pathogen.
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http://dx.doi.org/10.1186/s12864-021-07709-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268330PMC
July 2021

Synthesis of Nonalternating Polyketones Using Cationic Diphosphazane Monoxide-Palladium Complexes.

J Am Chem Soc 2021 Jul 8;143(28):10743-10750. Epub 2021 Jul 8.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.

Copolymerization of olefin with carbon monoxide has received considerable interest from both academia and industry, and the introduction of polar carbonyl group renders the resultant polyketones with excellent mechanical strength, crystallinity, photodegradability, hydrophilicity, surface, and barrier properties. However, most of the reported polyketones are difficult to be processed because of limited solubility in common solvents and high melting temperature ( ∼ 260 °C) resulting from the strictly alternative structure. Nonalternating copolymerization of ethylene with CO is a very promising method to circumvent the problem of processability of traditional perfectly alternating polyketone. In the contribution, the palladium coordinated diphosphazane monoxide substituted by strong electron-donating groups is discovered to be highly reactive for producing nonalternating polyketones, and up to 24.2% extra ethylene incorporation has lowered values to 147 and 165 °C and further improved thermal stability ( ∼ 339 °C) of the resultant materials. Our data demonstrates that cationic palladium complexes can also exhibit excellent reactivity and an unprecedented nonalternating degree in this copolymerization.
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http://dx.doi.org/10.1021/jacs.1c04964DOI Listing
July 2021

FGF, Mechanism of Action, Role in Parkinson's Disease, and Therapeutics.

Front Pharmacol 2021 21;12:675725. Epub 2021 Jun 21.

College of Pharmacy, Zunyi Medical University, Zunyi, China.

Parkinson's disease (PD) is a neurodegenerative disease associated with severe disability and adverse effects on life quality. In PD, motor dysfunction can occur, such as quiescence, muscle stiffness, and postural instability. PD is also associated with autonomic nervous dysfunction, sleep disorders, psychiatric symptoms, and other non-motor symptoms. Degeneration of dopaminergic neurons in the substantia nigra compact (SNPC), Lewy body, and neuroinflammation are the main pathological features of PD. The death or dysfunction of dopaminergic neurons in the dense part of the substantia nigra leads to dopamine deficiency in the basal ganglia and motor dysfunction. The formation of the Lewy body is associated with the misfolding of α-synuclein, which becomes insoluble and abnormally aggregated. Astrocytes and microglia mainly cause neuroinflammation, and the activation of a variety of pro-inflammatory transcription factors and regulatory proteins leads to the degeneration of dopaminergic neurons. At present, PD is mainly treated with drugs that increase dopamine concentration or directly stimulate dopamine receptors. Fibroblast growth factor (FGF) is a family of cellular signaling proteins strongly associated with neurodegenerative diseases such as PD. FGF and its receptor (FGFR) play an essential role in the development and maintenance of the nervous system as well as in neuroinflammation and have been shown to improve the survival rate of dopaminergic neurons. This paper summarized the mechanism of FGF and its receptors in the pathological process of PD and related signaling pathways, involving the development and protection of dopaminergic neurons in SNPC, α-synuclein aggregation, mitochondrial dysfunction, and neuroinflammation. It provides a reference for developing drugs to slow down or prevent the potential of PD.
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http://dx.doi.org/10.3389/fphar.2021.675725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255968PMC
June 2021

Fabrication of gelatin-based printable inks with improved stiffness as well as antibacterial and UV-shielding properties.

Int J Biol Macromol 2021 Jul 3;186:396-404. Epub 2021 Jul 3.

PLA Key Laboratory of Trauma and Surgical Infections, Research Institute of General Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing 210009, China. Electronic address:

Gelatin-based inks have a broad range of applications in bioprinting for tissue engineering and regenerative medicine due to their biocompatibility, ease of modification, degradability, and rapid gelation induced by low temperature. However, gelatin-derived inks prepared through low-temperature treatment have poor mechanical properties that limit their applications. To solve this problem, we designed polyacrylamide/gelatin/silver nanoparticle (PAAm-GelatinAgNPs) ink to improve gelatin-based hydrogels. The ink is based on double networks, in which the physically cross-linked gelatin as the first network and covalently cross-linked PAAm as the second network. It was found that the presence of PAAm increased the tensile and compression strength of the gelatin-based ink. Moreover, silver nanoparticles endowed the antibacterial properties to the gelatin-based ink and were able to shield the UV irradiation and damages to rat skin. In addition, this ink showed the shear thinning property; Consequently it succeeded in printing complex 3D scaffolds such as the cube, five-pointed star, flower, and university logo of "SEU". In summary, this ink presents a new strategy for the modification of gelatin and offers new potential applications for customized therapy of antimicrobial and anti-UV damage to tissues.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.06.193DOI Listing
July 2021

MRI radiomic features-based machine learning approach to classify ischemic stroke onset time.

J Neurol 2021 Jul 4. Epub 2021 Jul 4.

Department of Vascular Neurosurgery, New Era Stroke Care and Research Institute, The PLA Rocket Force Characteristic Medical Center, Beijing, 100088, China.

Purpose: We aimed to investigate the ability of MRI radiomics features-based machine learning (ML) models to classify the time since stroke onset (TSS), which could aid in stroke assessment and treatment options.

Methods: This study involved 84 patients with acute ischemic stroke due to anterior circulation artery occlusion (51 in the training cohort and 33 in the independent test cohort). Region of infarct segmentation was manually outlined by 3D-slicer software. Image processing including registration, normalization and radiomics features calculation were done in R (version 3.6.1). A total of 4312 radiomic features from each image sequence were captured and used in six ML models to estimate stroke onset time for binary classification (≤ 4.5 h). Receiver-operating characteristic curve (ROC) and other parameters were calculated to evaluate the performance of the models in both training and test cohorts.

Results: Twelve radiomics and six clinic features were selected to construct the ML models for TSS classification. The deep learning model-based DWI/ADC radiomic features performed the best for binary TSS classification in the independent test cohort, with an AUC of 0.754, accuracy of 0.788, sensitivity of 0.952, specificity of 0.500, positive predictive value of 0.769, and negative predictive value of 0.857, respectively. Furthermore, adding clinical information did not improve the performance of the DWI/ADC-based deep learning model. The TSS prediction models can be visited at: http://123.57.65.199:3838/deeptss/ .

Conclusions: A unique deep learning model based on DWI/ADC radiomic features was constructed for TSS classification, which could aid in decision making for thrombolysis in patients with unknown stroke onset.
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http://dx.doi.org/10.1007/s00415-021-10638-yDOI Listing
July 2021

Enzymatic Machinery of Ubiquitin and Ubiquitin-Like Modification Systems in Chondrocyte Homeostasis and Osteoarthritis.

Curr Rheumatol Rep 2021 Jul 3;23(8):62. Epub 2021 Jul 3.

Department of Cell Biology, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA.

Purpose Of Review: To date, a vast amount of information regarding ubiquitination (Ub) and ubiquitylation-like (Ubl) modification-related mechanisms has been reported in the context of skeletal cell homeostasis and diseases. In this review, we mainly focus on recent findings regarding the contribution of enzymatic machinery that directly adds or removes Ub and Ubl modifications from protein targets in chondrocyte homeostasis and osteoarthritis (OA) development.

Recent Findings: Mechanisms that promote homeostasis of articular chondrocytes are crucial for maintaining the integrity of articular joints to prevent osteoarthritis development. Articular chondrocytes are postmitotic cells that continuously produce and remodel cartilage matrix. In addition, the long lifespan of chondrocytes makes them susceptible to accumulating cellular damage. Ub and the evolutionarily conserved Ubl modifications, such as SUMOylation, ATGylation, and UFMylation, play important roles in promoting chondrocyte homeostasis, including regulating cell signaling and protein stability, resolving cellular stresses and inflammation, and maintaining differentiation and survival of chondrocytes. Uncovering new components/functions of Ub/Ubl modification machinery may provide novel drug targets to treat OA.
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http://dx.doi.org/10.1007/s11926-021-01022-wDOI Listing
July 2021

Triple Combination Therapy With PD-1/PD-L1, BRAF, and MEK Inhibitor for Stage III-IV Melanoma: A Systematic Review and Meta-Analysis.

Front Oncol 2021 14;11:693655. Epub 2021 Jun 14.

Department of Oncology, The Second People's Hospital of Dongying, Dongying, China.

Triple combination of anti-PD-1/PD-L1 immunotherapy and anti-BRAF plus anti-MEK targeted therapy is a promising antitumor strategy and is increasingly being used in clinical trials. To evaluate the safety and efficacy of triple combination of PD-1/PD-L1, BRAF, and MEK inhibition in patients diagnosed with stage III-IV melanoma, we performed a systematic review and meta-analysis of randomized controlled trials (RCTs). The PubMed, EMBASE, and Cochrane Library were searched for all studies published from inception to January 2021. The progression free survival (PFS), overall survival (OS), overall response rate (ORR), and risk of adverse events (AEs) were extracted by two independent investigators and pooled hazard ratio (HR) or risk ratio (RR) with 95% CI were determined using the random-effects model for data synthesis. Overall, five randomized controlled trials encompassing 1,266 patients with stage III-IV melanoma were selected. Triple combination therapy significantly improved PFS (HR = 0.71; 95% CI = 0.59 to 0.86; P = 0.0005) and 2-year OS (RR = 1.12; 95% CI = 1.03 to 1.23; P = 0.01), but had no impact on ORR (RR = 1.09; 95% CI = 0.91 to 1.30; P = 0.37) when compared with controlled treatment group. In addition, triple combination therapy was associated with increased risks of hypothyroidism, arthralgia, myalgia, ALT increased, AST increased, asthenia, and pyrexia compared with control group. Triple combination therapy of PD-1/PD-L1, BRAF, and MEK inhibition achieved better survival benefits but had higher incidence of some adverse events over two-drug combination or monotherapy. Further randomized controlled clinical trials are needed to verify our results.

Systematic Review Registration: PROSPERO 2021 CRD42021235845 Available from https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021235845.
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http://dx.doi.org/10.3389/fonc.2021.693655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236832PMC
June 2021

Revealing Microbiome Structure and Assembly Process in Three Rhizocompartments of Under Continuous Monoculture Regimes.

Front Microbiol 2021 14;12:677654. Epub 2021 Jun 14.

Fujian Provincial Key Laboratory of Agroecological Processing and Safety Monitoring, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.

The complex composition and interaction of root-associated microbes are critical to plant health and performance. In this study, we presented a detailed characterization of three rhizocompartment (rhizosphere, rhizoplane, and root) microbiomes of under different years of consecutive monoculture by deep sequencing in order to determine keystone microorganisms co-occurrence network analysis. The network analysis showed that multiple consecutive monoculture (MCM, represented 5Y and 10Y) soils generated some distinct beneficial bacterial taxa such as , , , , and . For fungi, substituted for in occupying an important position in different rhizocompartments under monoculture. Quantitative PCR analysis confirmed a significant increase in , , and spp. The results of the inoculation assay showed that addition of beneficial bacteria 74 and 75 significantly increased the root length and fresh weight of Furthermore, three types of phytosterones, as the main allochemicals, were identified both in the rhizosphere soil and in culture medium under sterile conditions by LC-MS/MS. When looking at interactions, it was found that phytosterones displayed a positive interaction with dominant beneficial species ( 4 and 75) and had a negative effect on the presence of the pathogenic fungi and . Overall, this study demonstrated that consecutive monoculture of can alter the bacterial and fungal community by secreting root exudates, leading to recruitment of beneficial microbes and replacement of plant-specific pathogenic fungi with plant beneficial fungi.
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http://dx.doi.org/10.3389/fmicb.2021.677654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236951PMC
June 2021

NSC23766 and Ehop016 suppress herpes simplex virus-1 replication by inhibiting Rac1 activity.

Biol Pharm Bull 2021 Jun 23. Epub 2021 Jun 23.

Center for Public Health Research, Medical School of Nanjing University.

Herpes simplex virus-1 (HSV-1) infection of the eyes leads to herpes simplex virus keratitis (HSK), the main cause of infectious blindness in the world. As the current therapeutics for HSV-1 infection are rather limited and prolonged use of acyclovir (ACV)/ganciclovir (GCV) and in immunocompromised patients lead to the rise of drug resistant mutants, it underlines the urgent need for new antiviral agents with distinct mechanisms. Our study attempted to establish ras-related C3 botulinum toxin substrate 1 (Rac1) as a new therapeutic target for HSV-1 infection by using Rac1-specific inhibitors to evaluate the in vitro inhibition of virus growth. Our results showed that increased Rac1 activity facilitated HSV-1 replication and inhibition of Rac1 activity by NSC23766 and Ehop016 significantly reduced HSV-1 replication. Thus, we identified NSC23766 and Ehop016 as possessing potent anti-HSV-1 activities by suppressing the Rac1 activity, suggesting that Rac1 is a potential target for treating HSV-1-related diseases.
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http://dx.doi.org/10.1248/bpb.b21-00054DOI Listing
June 2021

Influence of hyperocclusion on the remodeling of gingival tissues.

Int Immunopharmacol 2021 Jun 19;98:107885. Epub 2021 Jun 19.

Department of Stomatology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao 266003, Shandong, China. Electronic address:

Objective: The purpose of this study was to observe the effect of hyperocclusion on the remodeling of gingival tissues and detect the related signaling pathways.

Design: Hyperocclusion models were established by tooth extraction in mice. The mice were sacrificed at 3, 7, 14, 28, or 56 days after the surgery, and the left mandibular first molars with gingival tissues were isolated and examinations were focused on the gingival tissues. Apoptotic cells were examined using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) technology. Proliferating cells, p65, inflammatory cytokines, and β-catenin were detected using immunohistochemical methods.

Results: A series of apoptosis and proliferation responses were triggered in stressed gingival tissues. It was observed that the levels of p65, proinflammatory factors including interleukin-1β and tumor necrosis factor-α in extraction group were higher compared with those from mice with intact dentition, and peaked on days 14, 14 and 7 respectively. The expression of β-catenin was increased under hyperocclusion situations, peaked on day 14, and declined to the initial levels over time.

Conclusions: The results of this study suggest that hyperocclusion causes remodeling of the gingival tissues by activating a series of adaptive responses. Both nuclear factor kappa B and Wnt/β-catenin signaling pathways may be responsible for those adaptive responses though the exact mechanism is not clear.
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http://dx.doi.org/10.1016/j.intimp.2021.107885DOI Listing
June 2021

Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.

Toxicology 2021 06 19;458:152838. Epub 2021 Jun 19.

Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

N,N-dimethylformamide (DMF) is an organic compound widely used in industrial production processes as a solvent with a low evaporation rate. Excessive exposure to DMF may lead to liver damage. Oxidative stress has been reported as one of the main causes of DMF-induced hepatotoxicity. Several doses of DMF (0, 1, 5, and 10 mM) were used to treat HL-7702 cells for a relatively long period to simulate the actual exposure pattern in occupational settings, and oxidative stress was induced. Previous studies illustrated that circular RNA (circRNA) plays a vital role in sustaining hepatocyte physiological function. To explore whether aberrant circRNA expression is involved in DMF-induced excessive ROS generation and hepatotoxicity, high-throughput transcriptional sequencing was performed to identify the altered circRNA expression profiles in HL-7702 liver cells after treatment with 0, 75, or 150 mM DMF for 48 h. We found that levels of induced oxidative stress were similar to those in the long-term exposure model. Among the altered circRNAs, one circRNA (hsa_circ_0005915) was significantly upregulated after DMF exposure, and it affected DMF-mediated oxidative stress in HL-7702 cells. Further experiments revealed that hsa_circ_0005915 downregulated the expression of nuclear factor erythoid-2-related factor 2 (NRF2) at the post-transcriptional level via promoting the ubiquitination and degradation of NRF2, which led to the increase of ROS accumulation. Further investigation demonstrated that the expression levels of NRF2-regulated antioxidative genes-heme oxygenase 1 (HO1) and NAD(P)H quinone dehydrogenase 1 (NQO1)-indeed declined after the overexpression of hsa_circ_0005915. In vivo study also indicated that DMF exposure can upregulate the expression of mmu_circ_0007941 (homologous circRNA of hsa_circ_0005915) and downregulated Nrf2 and Ho1 proteins. In summary, our results revealed that hsa_circ_0005915 plays an important role in promoting DMF-induced oxidative stress by inhibiting the transcriptional activity of the NRF2/ARE axis, which provides a potential molecular mechanism of DMF-mediated hepatotoxicity.
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http://dx.doi.org/10.1016/j.tox.2021.152838DOI Listing
June 2021

Characterization and phylogenetic analysis of the complete chloroplast genome sequence of (Asteraceae), a rare and endangered wild plant species in China.

Mitochondrial DNA B Resour 2021 Jun 7;6(7):1934-1936. Epub 2021 Jun 7.

College of Life Sciences, Taizhou University, Jiaojiang, China.

(Asteraceae) is a rare wild plant species narrowly distributed in Zhejiang province, China. In our present study, we assembled its complete chloroplast genome using high-throughput sequencing data. The results indicated that the whole chloroplast genome of was 153,396 bp in length. Its large single copy, small single copy, and inverted region sequences were 84,575 bp, 18,451 bp, and 25,185 bp. The chloroplast genome was composed of 134 genes, including 87 protein-coding genes, 37 tRNA genes, eight rRNA genes, and two pseudogenes. Phylogenetic analysis results showed that was grouped with , with 100% bootstrap support.
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http://dx.doi.org/10.1080/23802359.2021.1936671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189106PMC
June 2021

Legacy and alternative plasticizers in surface sediment of black-odorous urban rivers across China: Occurrence, spatial distribution, and ecological risk assessment.

Chemosphere 2021 Jun 14;283:131206. Epub 2021 Jun 14.

State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China; Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China; CAS Center for Excellence in Deep Earth Science, Guangzhou, 510640, PR China.

In this study, surface sediment samples from 173 black-odorous urban rivers in 74 cities of China were investigated regarding the occurrence, spatial distribution, and ecological risk of legacy phthalates (LPs) and alternative plasticizers (APs). The total concentrations of ΣLPs and ΣAPs ranged from 0.0035 to 522 μg/g dw (median: 33 μg/g dw; mean: 60 μg/g dw) and from 0.0015 to 16 μg/g dw (median: 16 μg/g dw; mean: 2.2 μg/g dw), respectively. Di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DnBP), and di-iso-butyl phthalate (DiBP) were the dominant LPs, and di-iso-decyl phthalate and di-iso-nonylcyclohexane-1,2-dicarboxylate were the dominant APs. The concentrations and compositions of the LPs and APs varied among different sites and regions, implying location-specific use or production of LPs and APs. The pollutant concentrations in southern and central China were higher than those in northern China. Among the seven regions, Northwest China had the lowest concentrations of LPs and APs. This could be related to industry development level, municipal facilities, and population density. Total organic carbon (TOC) was significantly and positively correlated with the pollutant concentrations, implying that TOC could be an important influencing factor for the distribution of LPs and APs in sediments. The risk quotients of DiBP and DnBP in almost all sediment samples were above 1, indicating the high ecological risks to aquatic organisms. Nevertheless, DEHP, di-methyl phthalate, di-ethyl phthalate, and di-n-octyl phthalate showed low or moderate ecological risks for most sampling sites.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131206DOI Listing
June 2021

Photoinduced Reversible Semicrystalline-to-Amorphous State Transitions of Stereoregular Azopolyesters.

Angew Chem Int Ed Engl 2021 Aug 12;60(33):17898-17903. Epub 2021 Jul 12.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian, 116024, China.

We report the synthesis of isotactic azobenzene-based polyesters (azopolyesters) with main-chain chirality via highly enantioselective resolution copolymerization of racemic azobenzene-containing epoxides with cyclic anhydrides. All polyesters with trans-azobenzene moieties were found to be semicrystalline materials with melting temperatures of 153-231 °C, while the corresponding isotactic cis-azopolyesters were amorphous. The azobenzene groups in the copolymers exhibited reversible trans-to-cis and cis-to-trans photoisomerization upon irradiation with light. This demonstrates that the crystallinity of isotactic azopolyesters can be manipulated via photoinduced reversible isomerization. In addition, mixing isotactic trans-polyesters with different enantiomeric configurations in a 1:1 mass ratio afforded crystalline stereocomplexes for which the crystalline behavior differed significantly from those of the component enantiomer. Also, photoinduced reversible transitions between semicrystalline and amorphous states were observed in various stereocomplexes of isotactic trans-azopolyesters, similar to the isotactic azopolyesters themselves.
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http://dx.doi.org/10.1002/anie.202104750DOI Listing
August 2021

Ni-Foam-Structured Ni-AlO Ensemble as an Efficient Catalyst for Gas-Phase Acetone Hydrogenation to Isopropanol.

ACS Appl Mater Interfaces 2021 Jun 13;13(24):28334-28347. Epub 2021 Jun 13.

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

The free-standing Ni-AlO ensemble derived from NiAl-layered double hydroxides (NiAl-LDHs) grown onto a Ni-foam has been developed for the exothermic gas-phase acetone hydrogenation to isopropanol. This approach works effectively and efficiently to achieve a unique combination of high activity/selectivity and enhanced heat/mass transfer stemmed from the Ni-foam. The outstanding catalyst is obtained by direct reduction of the un-calcined NiAl-LDH/Ni-foam, with a high turnover frequency of 0.90 s, being capable of converting 90.8% acetone into isopropanol with almost 100% selectivity under stoichiometric H/acetone molar ratio, atmospheric pressure at 80 °C, and a WHSV of 10 h. The catalyst derivation using the un-calcined NiAl-LDH/Ni-foam enables the Ni nanoparticles to be intertwined with AlO to form a large Ni-AlO interface, without interruption of impurities such as irreducible NiO (in the case of calcined NiAl-LDH/Ni-foam samples), which markedly improves the strong acetone adsorption next to the Ni hydrogenation sites, thereby leading to a dramatic improvement of catalyst activity.
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http://dx.doi.org/10.1021/acsami.1c07084DOI Listing
June 2021
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