Publications by authors named "Liting Yang"

71 Publications

Effects of polysaccharides on the hydrodynamic parameters of sheet erosion on loessial slopes.

Environ Sci Pollut Res Int 2022 Jun 21. Epub 2022 Jun 21.

State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Northwest A&F University, Yangling, 712100, Shaanxi, China.

The variations in hydrodynamic parameters at different polysaccharides rates and the relationships between sheet erosion modulus and hydrodynamic parameters were analyzed to reveal the hydrodynamic mechanism of sheet erosion on loessial slopes. Artificially simulated rainfall experiments were carried out under three slope gradients (10°, 15°, and 20°), three rainfall intensities (1.0, 1.5, and 2.0 mm·min), and four dry-spreading rates of polysaccharides (0, 1, 3, and 5 g·m). The results showed that (1) four hydrodynamic parameters (flow velocity, shear stress, stream power, and unit stream power) all increased with both rainfall intensities and slope gradients at four rates of polysaccharides. (2) Polysaccharides could effectively reduce hydrodynamic parameters. In contrast to the bare slope, the average flow velocity, shear stress, stream power, and unit stream power diminished by 27.11~41.18%, 9.53~18.67%, 31.82~50.24%, and 27.11~41.18%, respectively. (3) Polysaccharides could effectively reduce the growth rate of the sheet erosion modulus with hydrodynamic parameters, and there were few differences among the different rates (1, 3, and 5 g·m). The increasing rates of the sheet erosion modulus with flow velocity, shear stress, stream power, and unit stream power were 14.0~65.7%, 14.8~33.9%, 7.8~23.7%, and 9.7~29.5%, respectively. (4) At different polysaccharides rates, the relationships between sheet erosion modulus and hydrodynamic parameters were all in logarithmic functions. Moreover, flow velocity (R ≥ 0.920) and stream power (R ≥ 0.876) were better hydrodynamic parameters than shear stress (R ≥ 0.598) or unit stream power (R ≥ 0.537). Polysaccharides decreased the hydrodynamic parameters and the response rates of sheet erosion to hydrodynamics.
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http://dx.doi.org/10.1007/s11356-022-21481-7DOI Listing
June 2022

Comprehensive Analysis of Endoplasmic Reticulum Stress in Intracranial Aneurysm.

Front Cell Neurosci 2022 6;16:865005. Epub 2022 Apr 6.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.

Background: Aberrant endoplasmic reticulum stress (ERS) plays an important role in multiple cardiovascular diseases. However, their implication in intracranial aneurysms (IAs) remains unclear. We designed this study to explore the general expression pattern and potential functions of ERS in IAs.

Methods: Five Gene Expression Omnibus (GEO) microarray datasets were used as the training cohorts, and 3 GEO RNA sequencing (RNA-seq) datasets were used as the validating cohorts. Differentially expressed genes (DEGs), functional enrichment, Lasso regression, logistic regression, ROC analysis, immune cell profiling, vascular smooth muscle cell (VSMC) phenotyping, weighted gene coexpression network analysis (WGCNA), and protein-protein interaction (PPI) analysis were applied to investigate the role of ERS in IA. Finally, we predicted the upstream transcription factor (TF)/miRNA and potential drugs targeting ERS.

Results: Significant DEGs were majorly associated with ERS, autophagy, and metabolism. Eight-gene ERS signature and IRE1 pathway were identified during the IA formation. WGCNA showed that ERS was highly associated with a VSMC synthesis phenotype. Next, ERS-VSMC-metabolism-autophagy PPI and ERS-TF-miRNA networks were constructed. Finally, we predicted 9 potential drugs targeting ERS in IAs.

Conclusion: ERS is involved in IA formation. Upstream and downstream regulatory networks for ERS were identified in IAs. Novel potential drugs targeting ERS were also proposed, which may delay IA formation and progress.
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http://dx.doi.org/10.3389/fncel.2022.865005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022475PMC
April 2022

The Role of m5C-Related lncRNAs in Predicting Overall Prognosis and Regulating the Lower Grade Glioma Microenvironment.

Front Oncol 2022 18;12:814742. Epub 2022 Mar 18.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.

Glioma is the most lethal primary brain tumor with a poor prognosis and high recurrence rate. Enormous efforts have been made to find therapeutic targets for gliomas. In the current study, we identified m5C-related lncRNAs through Pearson correlation analysis by the criteria |R|>0.5 and p<0.001 in TCGA LGG and CGGA325 datasets. We then established an eight-lncRNA m5C-related prognostic signature (m5C LPS) through lasso cox regression analysis and multivariate analysis. The performance of the signature was confirmed in the CGGA325 dataset and evaluated in differential subgroups divided by relevant clinicopathological characteristics. Patients were then divided into high and low risk groups using risk scores calculated with the signature. Next, we performed GO, KEGG and gene set enrichment analysis (GSEA) and identified the m5C LPS to be related with glioma microenvironment, immune response, EMT, cell cycle, and hypoxia. Correlation of the risk groups with immune cell infiltration, somatic mutation, and CNVs was then explored. Responses to immuno- and chemotherapies in different risk groups were evaluated using submap and pRRophetic R packages respectively. The high-risk group was more sensitive to anti-CTLA4 therapy and to compounds including Temozolomide, Bleomycin, Cisplatin, Cyclopamine, A.443654 (Akt inhibitor), AZD6482 (PI3K inhibitor), GDC0941(PI3K inhibitor), and metformin. We present for the first time a m5C-related lncRNA signature for lower grade glioma patient prognosis and therapy response prediction with validated performance, providing a promising target for future research.
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http://dx.doi.org/10.3389/fonc.2022.814742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971304PMC
March 2022

Design of Photoactive Covalent Organic Frameworks as Heterogeneous Catalyst for Preparation of Thiophosphinates from Phosphine Oxides and Thiols.

Chemistry 2022 May 29;28(26):e202200600. Epub 2022 Mar 29.

Henan Key Laboratory of Functional Salt Materials, Center for Advanced Materials Research, Zhongyuan University of Technology, Henan, 450007, P. R. China.

Two new covalent organic frameworks (COFs) were synthesized from 4,4',4'',4'''-(pyrene-1,3,6,8-tetrayl)tetraaniline and 2,5-dimethoxyterephthalaldehyde (Py-DMTA-COF) or 2',5'-dimethoxy-[1,1':4',1''-terphenyl]-4,4''-dicarbaldehyde (Py-DMTPDA-COF) under solvothermal conditions. These two COFs were further facilely developed as efficient photocatalytic platforms for the synthesis of thiophosphinates. Py-DMTA-COF exhibited better photocatalytic activity, broad substrate applicability, and excellent recycling capacity for the preparation of thiophosphinates from P(O)H compounds and thiols compared to Py-DMTPDA-COF. This methodology was further extended to the seamless gram-scale production of target phosphorothioate derivatives. The results demonstrate that COFs can provide a robust platform for developing metal-free, base-free, highly efficient, and reusable heterogeneous photocatalysts for organic transformations.
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http://dx.doi.org/10.1002/chem.202200600DOI Listing
May 2022

Self-Assembly MXene-rGO/CoNi Film with Massive Continuous Heterointerfaces and Enhanced Magnetic Coupling for Superior Microwave Absorber.

Nanomicro Lett 2022 Mar 9;14(1):73. Epub 2022 Mar 9.

Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200438, People's Republic of China.

MXene, as a rising star of two-dimensional (2D) materials, has been widely applied in fields of microwave absorption and electromagnetic shielding to cope with the arrival of the 5G era. However, challenges arise due to the excessively high permittivity and the difficulty of surface modification of few-layered MXenes severely, which infect the microwave absorption performance. Herein, for the first time, a carefully designed and optimized electrostatic self-assembly strategy to fabricate magnetized MXene-rGO/CoNi film was reported. Inside the synthesized composite film, rGO nanosheets decorated with highly dispersed CoNi nanoparticles are interclacted into MXene layers, which effectively suppresses the originally self-restacked of MXene nanosheets, resulting in a reduction of high permittivity. In addition, owing to the strong magnetic coupling between the magnetic FeCo alloy nanoparticles on the rGO substrate, the entire MXene-rGO/CoNi film exhibits a strong magnetic loss capability. Moreover, the local dielectric polarized fields exist at the continuous hetero-interfaces between 2D MXene and rGO further improve the capacity of microwave loss. Hence, the synthesized composite film exhibits excellent microwave absorption property with a maximum reflection loss value of - 54.1 dB at 13.28 GHz. The electromagnetic synergy strategy is expected to guide future exploration of high-efficiency MXene-based microwave absorption materials.
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http://dx.doi.org/10.1007/s40820-022-00811-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907377PMC
March 2022

Atomic Short-Range Order in a Cation-Deficient Perovskite Anode for Fast-Charging and Long-Life Lithium-Ion Batteries.

Adv Mater 2022 Apr 16;34(17):e2200914. Epub 2022 Mar 16.

Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200438, P. R. China.

Perovskite-type oxides are widely used for energy conversion and storage, but their rate-inhibiting phase transition and large volume change hinder the applications of most perovskite-type oxides for high-rate electrochemical energy storage. Here, it is shown that a cation-deficient perovskite CeNb O (CNO) can store a sufficient amount of lithium at a high charge/discharge rate, even when the sizes of the synthesized particles are on the order of micrometers. At 60 C (15 A g ), corresponding to a 1 min charge, the CNO anode delivers over 52.8% of its capacity. In addition, the CNO anode material exhibits 96.6% capacity retention after 2000 charge-discharge cycles at 50 C (12.5 A g ), indicating exceptional long-term cycling stability at high rates. The excellent cycling performance is attributed to the formation of atomic short-range order, which significantly prevents local and long-range structural rearrangements, stabilizing the host structure and being responsible for the small volume evolution. Moreover, the extremely high rate capacity can be explained by the intrinsically large interstitial sites in multiple directions, intercalation pseudocapacitance, atomic short-range order, and cation-vacancy-enhanced 3D-conduction networks for lithium ions. These structural characteristics and mechanisms can be used to design advanced perovskite electrode materials for fast-charging and long-life lithium-ion batteries.
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http://dx.doi.org/10.1002/adma.202200914DOI Listing
April 2022

Construction of Co-MoS/Pd Nanosheets on Polypyrrole-Derived Nitrogen-Doped Carbon Microtubes as Multifunctional Catalysts with Enhanced Catalytic Performance.

Inorg Chem 2022 Jan 13;61(1):542-553. Epub 2021 Dec 13.

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.

The structural design of multiple functional components could integrate synergistic effects to enhance the catalytic performance of MoS-based composites for catalytic applications. Herein, one-dimensional (1D) Co-MoS/[email protected] composites were designed to prepare Co-doped MoS/Pd nanosheets (NSs) on N-doped carbon microtubes (NCMTs) from tubular polypyrrole (PPy) as multifunctional catalysts. The Co-MoS/[email protected] composites integrated the synergistic effects of Co-doping, a 1D tubular structure, and noble-metal Pd decoration. Thus, a higher catalytic activity was observed in 4-nitrophenol (4-NP) reduction and peroxidase-like catalysis than other components, such as MoS, [email protected], and [email protected] Remarkably, the results indicated that the dissolution, diffusion, and redistribution led to the dissolution of [email protected] cores and generation of Co-doped MoS NSs. Benefiting from the synergistic effect from these components, Co-MoS/[email protected] were considered as a facile colorimetric sensing platform for detecting tannic acid. Moreover, outstanding performance was realized in the reduction of 4-NP with the composites. Thus, we provide a simple synthetic strategy for simultaneously integrating electronic engineering and structural advantages to develop an efficient MoS-based multifunctional catalyst.
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http://dx.doi.org/10.1021/acs.inorgchem.1c03228DOI Listing
January 2022

Controllable Domain Walls in Two-Dimensional Ferromagnetic Material FeGeTe Based on the Spin-Transfer Torque Effect.

ACS Nano 2021 Dec 13;15(12):19513-19521. Epub 2021 Dec 13.

Laboratory of Advanced Materials, Department of Materials Science and Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, China.

Recently, two-dimensional magnetic material has attracted attention worldwide due to its potential application in magnetic memory devices. The previous concept of domain walls driven by current pulses is a disordered motion. Further investigation of the mechanism is urgently lacking. Here, FeGeTe, a typical high-Curie temperature () two-dimensional magnetic material, is chosen to explore the magnetic domain dynamics by Lorentz transmission electron microscopy experiments. It has been found that the stripe domain could be driven, compressed, and expanded by the pulses with a critical current density. Revealed by micromagnetic simulations, all the domain walls cannot move synchronously due to the competition between demagnetization energy and spin-transfer torque effect. In consideration of the reflection of high-frequency pulses, the disordered motion could be well explained together. The multiple stable states of the magnetic structure due to the weak exchange interaction in a two-dimensional magnet provides complex dynamic processes. Based on plenty of experiments, a cluster of domain walls could be more steady and move more synchronously under the drive of pulse current. The complication of domain wall motions presents a challenge in race track memory devices and two-dimensional magnetic material will be a better choice for application research.
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http://dx.doi.org/10.1021/acsnano.1c06361DOI Listing
December 2021

Effects of antibiotics and heavy metals on denitrification in shallow eutrophic lakes.

Chemosphere 2022 Mar 17;291(Pt 2):132948. Epub 2021 Nov 17.

Center for Environment and Health in Water Source Area of South-to-North Water Diversion, School of Public Health, Hubei University of Medicine, Shiyan, 442000, PR China. Electronic address:

Antibiotic and heavy metal residues in shallow lakes caused by aquaculture and human activities such as sewage discharge have attracted much attention and public concern. However, mechanisms by which these environmental pollutants affect the microorganism-mediated biogeochemical cycle are unknown. This study focused on the effects of antibiotics, heavy metal, and antibiotic resistance genes (ARGs) on denitrification in shallow lakes. The results showed that antibiotics and metal elements had inhibitory effects on denitrification, whereas AGRs exhibited stimulating effects. Specifically, the enrofloxacin concentration showed a significant negative correlation with the copy number of denitrifying bacteria, whereas the copy number of the ARGs sulI, sulII, and tetG showed significant positive correlations. In addition, tetG was closely related to the community structure of nirS-type denitrifiers, and nirS-type denitrifiers were significantly correlated with the potential denitrification rate (PDR). Furthermore, the ARGs sulI, sulII, and tetG were positively correlated with PDR (P < 0.05). By contrast, the metal elements arsenic, manganese, cobalt, and antimony were negatively correlated with the copy number of denitrifying bacteria. Arsenic was significantly correlated with the community composition of nirK-type denitrifiers, but nirK-type denitrifiers did not show a significant correlation with the PDR. This work extends our understanding of the effects of antibiotics and heavy metals on denitrification, but further studies are needed to determine the interaction effects of pollutants.
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http://dx.doi.org/10.1016/j.chemosphere.2021.132948DOI Listing
March 2022

Long non-coding RNAs are involved in alternative splicing and promote cancer progression.

Br J Cancer 2022 05 8;126(8):1113-1124. Epub 2021 Nov 8.

NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Alternative splicing (AS) is a key process in which precursor RNAs produce different mature RNAs, and the disorder of AS is a key factor in promoting cancer development. Compared with coding RNA, studies on the functions of long non-coding RNAs (lncRNAs) are far from enough. In fact, lncRNA is an important participant and regulator in the process of AS. On the one hand, lncRNAs regulate cancer progression as AS products of precursor messenger RNA (mRNA), but on the other hand, precursor lncRNA generates cancer-related abnormal splicing variants through AS. In addition, lncRNAs directly or indirectly regulate the AS events of downstream target genes, thus affecting the occurrence and development of cancer. Here, we reviewed how lncRNAs regulate AS and influence oncogenesis in different ways.
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http://dx.doi.org/10.1038/s41416-021-01600-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023592PMC
May 2022

De Novo Fabrication of Large-Area and Self-Standing Covalent Organic Framework Films for Efficient Separation.

ACS Appl Mater Interfaces 2021 Sep 14;13(37):44806-44813. Epub 2021 Sep 14.

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, State Key Laboratory of Silicon Materials, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.

Covalent organic frameworks (COFs) have aroused extensive attention from various fields owing to their numerous advantages, including permanent porosity, high crystallinity, strong robustness, and well-ordered channels. However, the poor processability of the crystallite powder has greatly impeded their further utilization in many advanced devices and frontier areas. In this work, we fabricate a series of COF films using an interfacial polymerization strategy at a liquid-liquid interface under ambient conditions. The as-synthesized freestanding films are continuous, flexible, and defect-free and have large areas of up to 4 × 6 cm. In addition, the pore sizes of these COF films can be well controlled based on the principle of reticular chemistry. These films exhibit high chemical stability even in acidic and basic aqueous solutions. More significantly, the highly robust COF films can serve as a nanofiltration membrane for efficient separation of pollutant molecules with different dimensions. These films show high selectivity for the separation of mixed molecule feed and excellent recyclability without a significant loss in the rejection rate.
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http://dx.doi.org/10.1021/acsami.1c14420DOI Listing
September 2021

Ligand-Directed Conformational Control over Porphyrinic Zirconium Metal-Organic Frameworks for Size-Selective Catalysis.

J Am Chem Soc 2021 08 2;143(31):12129-12137. Epub 2021 Aug 2.

Department of Chemistry, Texas A&M University, College Station, Texas 77843-3255, United States.

Zirconium-based metal-organic frameworks (Zr-MOFs) have aroused enormous interest owing to their superior stability, flexible structures, and intriguing functions. Precise control over their crystalline structures, including topological structures, porosity, composition, and conformation, constitutes an important challenge to realize the tailor-made functionalization. In this work, we developed a new Zr-MOF (PCN-625) with a topological net, which is similar to that of the well-known PCN-222 and NU-1000. However, the significant difference lies in the conformation of porphyrin rings, which are vertical to the pore surfaces rather than in parallel. The resulting PCN-625 exhibits two types of one-dimensional channels with concrete diameters of 2.03 and 0.43 nm. Furthermore, the vertical porphyrins together with shrunken pore sizes could limit the accessibility of substrates to active centers in the framework. On the basis of the structural characteristics, PCN-625(Fe) can be utilized as an efficient heterogeneous catalyst for the size-selective [4 + 2] hetero-Diels-Alder cycloaddition reaction. Due to its high chemical stability, this catalyst can be repeatedly used over six times. This work demonstrates that Zr-MOFs can serve as tailor-made scaffolds with enhanced flexibility for target-oriented functions.
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http://dx.doi.org/10.1021/jacs.1c03960DOI Listing
August 2021

3D Seed-Germination-Like MXene with In Situ Growing CNTs/Ni Heterojunction for Enhanced Microwave Absorption via Polarization and Magnetization.

Nanomicro Lett 2021 Jul 19;13(1):157. Epub 2021 Jul 19.

Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200438, People's Republic of China.

Highlights: Benefiting from the possible "seed-germination" effect, the "seeds" Ni grow into "buds" Ni nanoparticles and "stem" carbon nanotubes (CNTs) from the enlarged "soil" of MXene skeleton. Compared with the traditional magnetic agglomeration, the MXene-CNTs/Ni hybrids exhibit the highly spatial dispersed magnetic architecture. 3D MXene-CNTs/Ni composites hold excellent microwave absorption performance (-56.4 dB at only 2.4 mm). TiCT MXene is widely regarded as a potential microwave absorber due to its dielectric multi-layered structure. However, missing magnetic loss capability of pure MXene leads to the unmatched electromagnetic parameters and unsatisfied impedance matching condition. Herein, with the inspiration from dielectric-magnetic synergy, this obstruction is solved by fabricating magnetic CNTs/Ni hetero-structure decorated MXene substrate via a facile in situ induced growth method. Ni ions are successfully attached on the surface and interlamination of each MXene unit by intensive electrostatic adsorption. Benefiting from the possible "seed-germination" effect, the "seeds" Ni grow into "buds" Ni nanoparticles and "stem" carbon nanotubes (CNTs) from the enlarged "soil" of MXene skeleton. Due to the improved impedance matching condition, the MXene-CNTs/Ni hybrid holds a superior microwave absorption performance of - 56.4 dB at only 2.4 mm thickness. Such a distinctive 3D architecture endows the hybrids: (i) a large-scale 3D magnetic coupling network in each dielectric unit that leading to the enhanced magnetic loss capability, (ii) a massive multi-heterojunction interface structure that resulting in the reinforced polarization loss capability, confirmed by the off-axis electron holography. These outstanding results provide novel ideas for developing magnetic MXene-based absorbers.
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http://dx.doi.org/10.1007/s40820-021-00680-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289940PMC
July 2021

Estrogen Protects Vasomotor Functions in Rats During Catecholamine Stress.

Front Cardiovasc Med 2021 16;8:679240. Epub 2021 Jun 16.

Department of Physiology, Xuzhou Medical University, Xuzhou, China.

The incidence of dysfunctional vasomotor diseases has mostly occurred in postmenopausal women but not in premenopausal women. Hence, this study sought to investigate the impact of estrogen deficiency during catecholamine stress on vasomotor function. Also, attempts were made to utilize estrogen replacement therapy to mitigate the adverse effects (pathological remodeling) of stress on the aortic vessels to preserve vasomotor functions. To do this, female Sprague-Dawley (SD) rats were ovariectomized (OVX) along with sham operations (Sham). Day 14 after OVX operation, 17-estradiol (E) was subcutaneously implanted (OVX+E). Day 35 after operation, stress was induced by isoproterenol (ISO) subcutaneous injections. Clinically relevant blood pressure indexes (systolic, diastolic, and mean atrial blood pressures) were assessed in the rats. Aortic vascular ring tensions were assessed to ascertain the impact of E on their vasomotor function. Aortic vascular rings (AVRs) from OVX+ISO exhibited a significant increase in contractility in response to phenylephrine than AVRs isolated from Sham+ISO rats. Also, sera levels of nitric oxide (NO) and endothelin-1 (ET-1) and the expression of p-eNOS/eNOS from vascular tissues were ascertained. We demonstrate that, during stress, E prevented excessive weight gain and OVX rats had higher blood pressures than those in the Sham group. Further, we showed that E decreases ET-1 expressions during stress while upregulating NO expressions via enhancing eNOS activities to facilitate vasomotor functions. Finally, histological assessment revealed the E treatments during stress preserved vasomotor functions by preventing excessive intima-media thickening and collagen depositions in the aortic vascular walls.
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http://dx.doi.org/10.3389/fcvm.2021.679240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241912PMC
June 2021

Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc.

Signal Transduct Target Ther 2021 06 25;6(1):240. Epub 2021 Jun 25.

NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Actin filament associated protein 1 antisense RNA 1 (named AFAP1-AS1) is a long non-coding RNA and overexpressed in many cancers. This study aimed to identify the role and mechanism of AFAP1-AS1 in lung cancer. The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization. The migration and invasion abilities of AFAP1-AS1 were investigated in lung cancer cells. To uncover the molecular mechanism about AFAP1-AS1 function in lung cancer, we screened proteins that interact with AFAP1-AS1 by RNA pull down and the mass spectrometry analyses. AFAP1-AS1 was highly expressed in lung cancer clinical tissues and its expression was positively correlated with lung cancer patients' poor prognosis. In vivo experiments confirmed that AFAP1-AS1 could promote lung cancer metastasis. AFAP1-AS1 promoted lung cancer cells migration and invasion through interacting with Smad nuclear interacting protein 1 (named SNIP1), which inhibited ubiquitination and degradation of c-Myc protein. Upregulation of c-Myc molecule in turn promoted the expression of ZEB1, ZEB2, and SNAIL gene, which ultimately enhanced epithelial to mesenchymal transition (EMT) and lung cancer metastasis. Understanding the molecular mechanism by which AFAP1-AS1 promotes lung cancer's migration and invasion may provide novel therapeutic targets for lung cancer patients' early diagnosis and therapy.
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http://dx.doi.org/10.1038/s41392-021-00562-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225811PMC
June 2021

Controllable Compositions and Structures of [email protected]@C-Ni Hybrids with a Silica Layer as a Mineral Redox Buffer.

Inorg Chem 2021 Jun 27;60(12):8880-8889. Epub 2021 May 27.

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.

Mineral redox buffer is a vital concept in geology that can be applied to modulate hybrid compositions and generate nanostructures with expected morphology. Here, combining a dual coating of an inorganic silica and organic resorcinol-formaldehyde-Ni (RF-Ni) layer on α-FeO spindles with a subsequent calcination process, core-shell [email protected]@C-Ni composites with multicompositional structures were fabricated as efficient catalysts for 4-nitrophenol (4-NP) reduction. Notably, the silica layer as a redox buffer between hematite cores and the RF-Ni shell played a crucial role in modulating the compositions and structures of the [email protected]@C-Ni. Without the silica layer, FeO-Ni/C composites with Ni nanoparticles trapped into the FeO cores were generated. Moreover, a significant impact of the calcination temperature on morphologies and compositions of the [email protected]@C-Ni catalysts along with their catalytic performances has been verified. As a result, the catalyst annealed at 500 °C exhibited a high magnetic property and optimized morphology with high-density small nickel nanoparticles (∼11.6 nm), showing remarkably enhanced catalytic activity compared to the FeO-Ni/C composites and excellent recyclability with a high conservation of about 92%. Furthermore, this synthetic strategy shows significant potential to modulate the nanostructures and phases of other multivalent metal oxide nanocomposites.
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http://dx.doi.org/10.1021/acs.inorgchem.1c00778DOI Listing
June 2021

AFAP1-AS1: a rising star among oncogenic long non-coding RNAs.

Sci China Life Sci 2021 Oct 13;64(10):1602-1611. Epub 2021 May 13.

NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education of China, Cancer Research Institute, Central South University, Changsha, 410078, China.

Long non-coding RNAs (lncRNAs) have become a hotspot in biomedical research. This interest reflects their extensive involvement in the regulation of the expression of other genes, and their influence on the occurrence and development of a variety of human diseases. Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1) is a recently discovered oncogenic lncRNA. It is highly expressed in a variety of solid tumors, and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs, or by the direct binding to other proteins. Ultimately, AFAP1-AS1 promotes proliferation, chemotherapy resistance, and resistance to apoptosis, maintains stemness, and enhances invasion and migration of tumor cells. This paper summarizes the research concerning AFAP1-AS1 in malignant tumors, including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors. We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research. AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules.
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http://dx.doi.org/10.1007/s11427-020-1874-6DOI Listing
October 2021

Effects of electrolyzed water treatment on pesticide removal and texture quality in fresh-cut cabbage, broccoli, and color pepper.

Food Chem 2021 Aug 1;353:129408. Epub 2021 Mar 1.

Hebei Key Laboratory of Quality & Safety Analysis-Testing for Agro-Products and Food, Hebei North University, 11 Diamond South Road, Zhangjiakou 075000, China.

The effects of alkaline and acidic electrolyzed water (AlEW, AcEW) treatment on the removal of pesticides (phorate, chlorpyrifos, lambda-cyhalothrin, cyfluthrin, procymidone, and chlorothalonil) and texture quality of fresh-cut cabbage, broccoli, and color pepper were investigated. AlEW efficiently removed pesticides from color pepper, whereas AcEW was the optimal treatment for pesticide removal from cabbage and broccoli. AcEW resulted in greater losses of pyrethroid and organophosphates than fungicides, while AlEW was superior for removing fungicides. The best pesticide removal from cabbage (72.28%-91.04%) was achieved by continuous oscillation treatment, while intermittent oscillation for 20 min achieved optimal results for broccoli and color pepper (72.28%-90.11% and 72.24%-88.12%, respectively). No significant deterioration in texture was detected in samples treated with electrolyzed water for 5-25 min. The results suggest that electrolyzed water treatment is effective for removing organophosphate, pyrethroid, and fungicide residues from fresh-cut vegetables while not negatively affecting their texture quality.
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http://dx.doi.org/10.1016/j.foodchem.2021.129408DOI Listing
August 2021

The Influence of NDRG1 Single Nucleotide Polymorphisms on Glioma Risk and Prognosis in Chinese Han Population.

Cell Mol Neurobiol 2022 Aug 12;42(6):1949-1964. Epub 2021 Mar 12.

Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082, Shaanxi, China.

Glioma is a highly fatal malignant tumor with a high recurrence rate, poor clinical treatment effect, and prognosis. We aimed to determine the association between single nucleotide polymorphisms (SNPs) of NDRG1 and glioma risk and prognosis in the Chinese Han population. 5 candidate SNPs were genotyped by Agena MassARRAY in 558 cases and 503 controls; logistic regression was used to analyze the relationship between SNPs and glioma risk. We used multi-factor dimensionality reduction to analyze the interaction of 'SNP-SNP'; the prognosis analysis was performed by log-rank test, Kaplan-Meier analysis, and Cox regression model. Our results showed that the polymorphisms of rs3808599 was associated with the reduction of glioma risk in all participants (OR 0.41, p = 0.024) and the participants ≤ 40 years old (OR 0.30, p = 0.020). rs3802251 may reduce glioma risk in all participants (OR 0.79, p = 0.008), the male participants (OR 0.68, p = 0.033), and astrocytoma patients (OR 0.81, p = 0.023). rs3779941 was associated with poor glioma prognosis in all participants (HR = 2.59, p = 0.039) or astrocytoma patients (HR = 2.63, p = 0.038). We also found that the key factors for glioma prognosis may include surgical operation, radiotherapy, and chemotherapy. This study is the first to find that NDRG1 gene polymorphisms may have a certain association with glioma risk or prognosis in the Chinese Han population.
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http://dx.doi.org/10.1007/s10571-021-01075-6DOI Listing
August 2022

Compressible and flexible [email protected]/C microwave absorption foam with strong dielectric polarization from 2D semiconductor intermediate sandwich structure.

Nanoscale 2021 Mar;13(9):5115-5124

Laboratory of Advanced Materials, Department of Materials Science and Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, P. R. China.

Structural engineering represents a major trend in the field of two-dimensional (2D) materials regarding microscopic interfacial electric/dielectric properties and macroscopic device strategies. 2D molybdenum disulfide (MoS2) with semiconductive features and lamellar architecture has been widely applied in the microwave absorption (MA) field. However, due to its limitations of weak dielectric loss capacity and poor intrinsic mechanical property, MoS2-based MA devices are a considerable design challenge for practical applications with the peculiarities of light weight, high absorption performance, flexibility, and compressibility. Herein, 2D MoS2 was riveted on carbonized melamine foam (CMF) templated from a commercial foam skeleton, which was cladded with the conductive polymer polypyrrole (PPy). The as-prepared [email protected]/CMF was integrated to simultaneously achieve an excellent MA performance including a maximum reflection loss (RL) value of -45.40 dB and a wide absorption bandwidth of 3.8 GHz, together with mechanical practicability including a high compression ratio of over 45.6% in volume and a bending angle of over 43.2°. This excellent MA performance is attributed to the synergetic effect from its sandwiched multi-layered skeleton, consisting of a conductive/semiconductive/conductive ternary conductive network, and multiple polarizations from the 2D MoS2 interlayer. Our strategy sheds novel insight into the construction of advanced carbon-supported composites and 2D materials for use in devices, which can be further extended to energy storage and conversion applications.
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http://dx.doi.org/10.1039/d0nr08794gDOI Listing
March 2021

Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk.

Cancer Cell Int 2021 Jan 4;21(1). Epub 2021 Jan 4.

The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, #229 North TaiBai Road, Xi'an, 710069, Shaanxi, China.

Background: Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk.

Methods: Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis.

Results: The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR 1.46, 95% CI 1.04-2.06, p = 0.028; OR 8.43, 95% CI 1.05-67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls.

Conclusion: The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.
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http://dx.doi.org/10.1186/s12935-020-01646-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784262PMC
January 2021

Differentiated mineral nutrient management in two bamboo species under elevated CO environment.

J Environ Manage 2021 Feb 5;279:111600. Epub 2020 Nov 5.

Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou, 311400, Zhejiang, China. Electronic address:

Mineral nutrients play a critical role in maintaining plant growth, but are vulnerable to climate change, such as elevated atmospheric carbon dioxide (CO) concentrations. Previous studies reported that impact of elevated CO concentrations on plant growth vary among plant species, which may affect differential mineral nutrient cycling among plant species. However, little is known about how increasing CO concentrations affect mineral nutrient uptake and allocation in bamboo species. Using open top chambers (OTCs), we investigated the effects of elevated CO concentrations on three key mineral nutrients (iron (Fe), calcium (Ca), and magnesium (Mg)) in two mature bamboo species (Phyllostachys edulis and Oligostachyum lubricum). Results showed increased leaf and root biomass under elevated CO concentrations (P. edulis: 30.24% and 10.94%; O. lubricum: 24.47% and 13.84%, respectively). Conversely, elevated CO concentrations had negligible effects on the biomass of other bamboo organs (e.g., branches and culms). To a certain extent, elevated CO concentrations also caused nutrient variation among the various organs of these two species. For Ph. edulis, elevated CO concentrations increased mineral content (Fe, Ca, and Mg) in and allocation to leaves while it decreased Fe and Mg allocation to roots. By contrast, elevated CO concentrations only increased mineral content in and allocation to O. lubricum leaves and decreased Mg to its roots. Results confirmed that elevated CO concentrations resulted in differential mineral nutrient uptake and allocation response between these two species. Understanding such differences is critical to the sustainable nutrient management of bamboo ecosystems under increasing CO concentrations.
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http://dx.doi.org/10.1016/j.jenvman.2020.111600DOI Listing
February 2021

MXene-based ultra-thin film for terahertz radiation shielding.

Nanotechnology 2020 Dec;31(50):505710

Mathematics and Science College, Shanghai Normal University, Shanghai 200234 People's Republic of China.

We have successfully fabricated Ti-based MXenes flakes, TiCT, by chemical etching, then prepared it as an organic dispersion and finally spin-coated it on polyimide plastic substrate for terahertz wave shielding. The shielding effectivity of the 12 μm ultra-thin film can reach up to 17 dB measured by the terahertz time-domain spectra. We can attribute the excellent phenomenon to the intrinsic absorption of triple-layered TiC, due to the similar double-peak type refraction curves, which have been respectively observed from the experimental samples and the simulation ones. High conductivity and strong THz absorption indicate the TiCT MXene is the absorptive electromagnetic shielding material. Comparing with other kinds of THz shielding materials, the Ti-based MXenes might be a potential candidate for the next generation of ultra-thin and lightweight THz shielding.
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http://dx.doi.org/10.1088/1361-6528/abb6a7DOI Listing
December 2020

Anomalous Spin Behavior in FeGeTe Driven by Current Pulses.

ACS Nano 2020 Aug 17;14(8):9512-9520. Epub 2020 Jun 17.

Laboratory of Advanced Materials, Department of Materials Science, Collaborative Innovation Center of Chemistry for Energy Materials(iChEM), Fudan University, Shanghai 200433, China.

Recently, 2D ferromagnetic materials have aroused wide interest for their magnetic properties and potential applications in spintronic and topological devices. However, their actual applications have been severely hindered by intricate challenges such as the unclear spin arrangement. In particular, the evolution of spin texture driven by high-density electron current, which is an essential condition for fabricating devices, remains unclear. Herein, the current-pulse-driven spin textures in 2D ferromagnetic material FeGeTe have been thoroughly investigated by Lorentz transmission electron microscopy. The dynamic experiments reveal that the stripe domain structure in the and planes can be broken and rearranged by the high-density current. In particular, the density of domain walls can be modulated, which offers an avenue to achieve a high-density domain structure. This phenomenon is attributed to the weak interlayer exchange interaction in 2D metallic ferromagnetic materials and the strong disturbance from the high-density current. Therefore, a bubble domain structure and random magnetization in FeGeTe can be acquired by synchronous current pulses and magnetic fields. These achievements reveal domain structure transitions driven by the current in 2D metallic magnetic materials and provide references for the practical applications.
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http://dx.doi.org/10.1021/acsnano.0c03269DOI Listing
August 2020

Surface charge-controlled electron transfer and catalytic behavior of immobilized cytochrome P450 BM3 inside dendritic mesoporous silica nanoparticles.

Anal Bioanal Chem 2020 Jul 2;412(19):4703-4712. Epub 2020 Jun 2.

College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, 211816, Jiangsu, China.

Understanding the influencing factors on the reaction kinetics of P450 BM3 within confined spaces is essential for developing efficient P450 BM3 bioreactors. Herein, two dendritic mesoporous silica nanoparticles (OH-DMSNs and NH-DMSNs) with similar pore size but opposite surface charge have been prepared and served as the vehicle to immobilize P450 BM3. With the help of the film-forming material of chitosan, P450 BM3/OH-DMSN and P450 BM3/NH-DMSN composites were immobilized on GC electrode and characterized with electrochemical measurements. Compared with P450 BM3/OH-DMSNs/GCE, P450 BM3/NH-DMSNs/GCE showed higher electron transfer efficiency with higher current charge and lower k value. Besides, the generated catalytic current towards testosterone on P450 BM3/NH-DMSNs/GCE was 1.81 times larger than P450 BM3/OH-DMSNs/GCE. Furthermore, P450 BM3 inside NH-DMSNs displayed higher affinity towards testosterone with the lower K value of 244.82 μM. These results are attributed to the positively charged internal walls of NH-DMSNs so that P450 BM3 adapts to an orientation favorable for electron exchange with electrodes and substrate binding with the active sites. The present study provides fundamentals for regulating the surface charge to optimize redox process and catalytic behavior in CYP bioreactors through electrostatic interactions.
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http://dx.doi.org/10.1007/s00216-020-02727-0DOI Listing
July 2020

LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma.

Mol Oncol 2020 09 13;14(9):2251-2270. Epub 2020 Jun 13.

NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Long noncoding RNA (lncRNA) have emerged as crucial regulators for a myriad of biological processes, and perturbations in their cellular expression levels have often been associated with cancer pathogenesis. In this study, we identified AATBC (apoptosis-associated transcript in bladder cancer, LOC284837) as a novel lncRNA. AATBC was found to be highly expressed in nasopharyngeal carcinoma (NPC), and increased AATBC expression was associated with poor survival in patients with NPC. Furthermore, AATBC promoted migration and invasion of NPC cells in vitro, as well as metastasis in vivo. AATBC upregulated the expression of the desmosome-associated protein pinin (PNN) through miR-1237-3p sponging. In turn, PNN interacted with the epithelial-mesenchymal transition (EMT) activator ZEB1 and upregulated ZEB1 expression to promote EMT in NPC cells. Collectively, our results indicate that AATBC promotes NPC progression through the miR-1237-3p-PNN-ZEB1 axis. Our findings indicate AATBC as a potential prognostic biomarker or therapeutic target in NPC.
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http://dx.doi.org/10.1002/1878-0261.12703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463349PMC
September 2020

PdAgCu Alloy Nanoparticles Integrated on Three-Dimensional Nanoporous CuO for Efficient Electrocatalytic Nitrogen Reduction under Ambient Conditions.

Langmuir 2020 May 8;36(19):5112-5117. Epub 2020 May 8.

Tianjin Key Laboratory of Advanced Functional Porous Materials, Institute for New Energy Materials & Low-Carbon Technologies, Tianjin University of Technology, Tianjin 300384, China.

Exploration of catalysts is the primary focus of the electrochemical nitrogen reduction reaction (NRR). However, cost-effective materials are rarely reported. Herein, we report a composite consisting of a three-dimensional nanoporous CuO structure decorated with PdAgCu alloy nanoparticles (abbreviated as PdAgCu/CuO composites) as a highly effective catalyst. Compared with the nanoporous PdAgCu alloy and PdCu/CuO and Cu/CuO composites, PdAgCu/CuO composites exhibit much superior NRR catalytic activity with a high NH production rate of 40.4 μg h mg. In addition, PdAgCu/CuO composites show good catalytic stability for NRR. The superior NRR performance of PdAgCu/CuO composites can be ascribed to the synergistic effects of metals and metal oxides, which are highly significant for the exploration of efficient catalysts for NRR.
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http://dx.doi.org/10.1021/acs.langmuir.0c00228DOI Listing
May 2020

Engineering Phase Transformation of MoS/RGO by N-doping as an Excellent Microwave Absorber.

ACS Appl Mater Interfaces 2020 Apr 26;12(14):16831-16840. Epub 2020 Mar 26.

Laboratory of Advanced Materials, Department of Materials Science and Collaborative Innovation Center of Chemistry for Energy Materials (iChem), Fudan University, Shanghai 200438, P. R. China.

As a hot two-dimensional (2D) material, molybdenum disulfide has been attracting extensive attention for electromagnetic wave response applications because of its unique structure. However, the electronic conductivity of nanostructured MoS needs to be optimized urgently. Here, nitrogen-doped [email protected]/reduced graphene oxide (RGO) composites are effectively constructed by hydrothermal reaction and consecutive calcination under an NH atmosphere. The prepared composites possess great microwave absorption (MA) performance with an expected absorption bandwidth (4.00 GHz) at the Ku band and a maximum reflection loss value (-67.77 dB), which is much better than the performance of conventional 2H-MoS or 2H-MoS/RGO. The prominent absorption property is ascribed to the (i) unique self-assemble morphology of rose-like MoS supported on 2D RGO; (ii) controllable crystalline phase switch between 2H and 1T; and (iii) brilliant energy attenuation caused by the intense multipolarization. Furthermore, the dominant MA mechanism is described as the local polarization motivated by the interaction between RGO and MoS. Thus, our novel structure design provides a necessary reference to achieve optimized absorption performance based on 2D materials.
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http://dx.doi.org/10.1021/acsami.0c01998DOI Listing
April 2020

Preparation and Characterization of DOPO-Functionalized MWCNT and Its High Flame-Retardant Performance in Epoxy Nanocomposites.

Polymers (Basel) 2020 Mar 7;12(3). Epub 2020 Mar 7.

School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China.

In this work, functionalized multi-walled carbon nanotubes (MWCNT) were synthesized by the reaction between acylated MWCNT and 10-(2,5-dihydroxyphenyl)-9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (ODOPB). The obtained MWCNT-ODOPB was well dispersed into epoxy resins together with aluminum diethylphosphinate (AlPi) to form flame-retardant nanocomposites. The epoxy resin nanocomposite with phosphorus content of 1.00 wt % met UL 94 V-0 rating, exhibited LOI value of 39.5, and had a higher compared to neat epoxy resin, which indicates its excellent flame retardant performance. These experimental results indicated that MWCNT-ODOPB was a compatible and efficient flame retardant for epoxy resins. Moreover, cone calorimeter analysis showed that the peak heat release rate (pHRR), total heat release (THR) values, and CO production profiles of the composites decreased with an increase in the additional amount of phosphorus.
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http://dx.doi.org/10.3390/polym12030613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182840PMC
March 2020

A sensitive pH fluorescent probe based on triethylenetetramine bearing double dansyl groups in aqueous solutions and its application in cells.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Mar 2;229:117881. Epub 2019 Dec 2.

School of Chemistry, South China Normal University, Guangzhou 510006, PR China; School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, PR China; Key Laboratory of Theoretical Chemistry of Environment Ministry of Education, South China Normal University, Guangzhou 510631, PR China. Electronic address:

pH fluorescent probes possess many advantages, including intracellular detection, rapid response time and nondestructive testing. In this paper, a highly selective and sensitive fluorescent pH probe based on triethylenetetramine bearing double dansyl groups (1) was synthesized. This probe offers fluorescent measurement of pH value in the range of 5.81-7.21 in aqueous solution, with an 8.64-fold enhancement of fluorescent emission intensity over the unmodified probe. Probe 1 shows a fluorescent color change from a pale yellow to bright green when the pH is increased from 5.81 to 7.21. In addition, probe 1 shows good potential as a fluorescent visualizing sensor for pH values in living GS cells of epinepheluscoioides. The mechanism of the fluorescent response of probe 1 to solution pHs was further clarified by NMR, fluorescent spectra, and UV-vis absorption spectra. The results indicate that the fluorescent emission will shift with an increase in solution pHs, due to increasing deprotonation of the nitrogen atom on the sulfonamides. Deprotonation of the sulfonamide group will inhibits the intramolecular charge transfer process between the imino group and the naphthalene ring, resulting in the recognition phenomenon of blue shift and enhancement of fluorescent emission intensity.
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http://dx.doi.org/10.1016/j.saa.2019.117881DOI Listing
March 2020
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