Lisa Polin

Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, 48201, USA; Molecular Imaging Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI, 48201, USA. Electronic address:

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November 2018

A CARP-1 functional mimetic compound is synergistic with BRAF-targeting in non-small cell lung cancers.

Authors:

Vino T Cheriyan Hashem Alsaab Sreeja Sekhar Jaganathan Venkatesh Arindam Mondal Imran Vhora Samaresh Sau Magesh Muthu Lisa A Polin Edi Levi Gerold Bepler Arun K Iyer Mandip Singh Arun K Rishi

Oncotarget 2018 Jul 3;9(51):29680-29697. Epub 2018 Jul 3.

John D. Dingell VA Medical Center, Detroit, MI, 48201, USA.

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July 2018

Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

Authors:

Manasa Ravindra Mike R Wilson Nian Tong Carrie O'Connor Mohammad Karim Lisa Polin Adrianne Wallace-Povirk Kathryn White Juiwanna Kushner Zhanjun Hou Larry H Matherly Aleem Gangjee

J Med Chem 2018 05 27;61(9):4228-4248. Epub 2018 Apr 27.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences , Duquesne University , 600 Forbes Avenue , Pittsburgh , Pennsylvania 15282 , United States.

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May 2018

Using Radiolabeled 3'-Deoxy-3'-F-Fluorothymidine with PET to Monitor the Effect of Dexamethasone on Non-Small Cell Lung Cancer.

Authors:

Christopher I McHugh Monica R Thipparthi Jawana M Lawhorn-Crews Lisa Polin Shirish Gadgeel Janice Akoury Thomas J Mangner Kirk A Douglas Jing Li Manohar Ratnam Anthony F Shields

J Nucl Med 2018 10 19;59(10):1544-1550. Epub 2018 Apr 19.

Wayne State University School of Medicine, Detroit, Michigan

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October 2018

Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.

Authors:

Manasa Ravindra Adrianne Wallace-Povirk Mohammad A Karim Mike R Wilson Carrie O'Connor Kathryn White Juiwanna Kushner Lisa Polin Christina George Zhanjun Hou Larry H Matherly Aleem Gangjee

J Med Chem 2018 03 21;61(5):2027-2040. Epub 2018 Feb 21.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences , Duquesne University , 600 Forbes Avenue , Pittsburgh , Pennsylvania 15282 , United States.

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March 2018

A CARP-1 functional mimetic loaded vitamin E-TPGS micellar nano-formulation for inhibition of renal cell carcinoma.

Authors:

Vino T Cheriyan Hashem O Alsaab Sreeja Sekhar Caitlin Stieber Prashant Kesharwani Samaresh Sau Magesh Muthu Lisa A Polin Edi Levi Arun K Iyer Arun K Rishi

Oncotarget 2017 Dec 5;8(62):104928-104945. Epub 2017 Sep 5.

John D. Dingell VA Medical Center, Detroit, Michigan, 48201, USA.

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December 2017

Liposomal Cu-PET Imaging of Anti-VEGF Drug Effects on Liposomal Delivery to Colon Cancer Xenografts.

Authors:

Stephanie J Blocker Kirk A Douglas Lisa Anne Polin Helen Lee Bart S Hendriks Enxhi Lalo Wei Chen Anthony F Shields

Theranostics 2017 26;7(17):4229-4239. Epub 2017 Sep 26.

Department of Oncology, Wayne State University, Detroit, MI, USA.

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July 2018

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.

Authors:

Changwen Ning Min Liang Shuang Liu Guan Wang Holly Edwards Yang Xia Lisa Polin Gregory Dyson Jeffrey W Taub Ramzi M Mohammad Asfar S Azmi Lijing Zhao Yubin Ge

Oncotarget 2017 Jul;8(27):44295-44311

Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.

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July 2017

Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs.

Authors:

Matthew A Sanders Brittany Haynes Pratima Nangia-Makker Lisa A Polin Malathy P Shekhar

J Biol Chem 2017 06 10;292(25):10347-10363. Epub 2017 May 10.

From the Karmanos Cancer Institute and

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June 2017

Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-]pyrimidine Antifolates.

Authors:

Zhanjun Hou Leda Gattoc Carrie O'Connor Si Yang Adrianne Wallace-Povirk Christina George Steve Orr Lisa Polin Kathryn White Juiwanna Kushner Robert T Morris Aleem Gangjee Larry H Matherly

Mol Cancer Ther 2017 05 30;16(5):819-830. Epub 2017 Jan 30.

Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.

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May 2017

Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor.

Nat Med 2017 01 5;23(1):128-135. Epub 2016 Dec 5.

Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA.

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January 2017

Assessment of Tryptophan Uptake and Kinetics Using 1-(2-18F-Fluoroethyl)-l-Tryptophan and α-11C-Methyl-l-Tryptophan PET Imaging in Mice Implanted with Patient-Derived Brain Tumor Xenografts.

Authors:

Sharon K Michelhaugh Otto Muzik Anthony R Guastella Neil V Klinger Lisa A Polin Hancheng Cai Yangchun Xin Thomas J Mangner Shaohui Zhang Csaba Juhász Sandeep Mittal

J Nucl Med 2017 02 20;58(2):208-213. Epub 2016 Oct 20.

Department of Neurosurgery, Wayne State University, Detroit, Michigan

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February 2017

CARP-1 functional mimetics are novel inhibitors of drug-resistant triple negative breast cancers.

Authors:

Vino T Cheriyan Magesh Muthu Ketan Patel Sreeja Sekhar Walajapet Rajeswaran Scott D Larsen Lisa Polin Edi Levi Mandip Singh Arun K Rishi

Oncotarget 2016 Nov;7(45):73370-73388

John D. Dingell VA Medical Center, Wayne State University, Detroit, MI, 48201 USA.

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November 2016

Synthesis and Antileukemic Activities of Piperlongumine and HDAC Inhibitor Hybrids against Acute Myeloid Leukemia Cells.

Authors:

Yi Liao Xiaojia Niu Bailing Chen Holly Edwards Liping Xu Chengzhi Xie Hai Lin Lisa Polin Jeffrey W Taub Yubin Ge Zhihui Qin

J Med Chem 2016 09 24;59(17):7974-90. Epub 2016 Aug 24.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University , Detroit, Michigan 48201, United States.

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September 2016

Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

J Med Chem 2016 09 26;59(17):7856-76. Epub 2016 Aug 26.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University , 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.

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September 2016

Spectroscopic Characterization of the 3+ and 2+ Oxidation States of Europium in a Macrocyclic Tetraglycinate Complex.

Authors:

Levi A Ekanger Devin R Mills Meser M Ali Lisa A Polin Yimin Shen E Mark Haacke Matthew J Allen

Inorg Chem 2016 Oct 31;55(20):9981-9988. Epub 2016 May 31.

Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.

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October 2016

Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.

Authors:

Anthony R Guastella Sharon K Michelhaugh Neil V Klinger William J Kupsky Lisa A Polin Otto Muzik Csaba Juhász Sandeep Mittal

Mol Imaging 2016 5;15. Epub 2016 May 5.

Department of Neurosurgery, Wayne State University, Detroit, MI, USA Department of Oncology, Wayne State University, Detroit, MI, USA Karmanos Cancer Institute, Detroit, MI, USA

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December 2016

Evaluation of Eu(II) -based positive contrast enhancement after intravenous, intraperitoneal, and subcutaneous injections.

Authors:

Levi A Ekanger Lisa A Polin Yimin Shen E Mark Haacke Matthew J Allen

Contrast Media Mol Imaging 2016 07 30;11(4):299-303. Epub 2016 Mar 30.

Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.

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July 2016

Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates.

Authors:

Mike R Wilson Zhanjun Hou Si Yang Lisa Polin Juiwanna Kushner Kathryn White Jenny Huang Manohar Ratnam Aleem Gangjee Larry H Matherly

Mol Pharmacol 2016 Apr 2;89(4):425-34. Epub 2016 Feb 2.

Department of Oncology (M.R.W., Z.H., L.P., J.K., K.W., J.H., M.R., L.H.M.), and Department of Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (Z.H., L.P., M.R., L.H.M.); and Division of Medicinal Chemistry, Graduate School of Pharmaceutical Science, Duquesne University, Pittsburgh, Pennsylvania (S.Y., A.G.)

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April 2016

Identification and Testing of Novel CARP-1 Functional Mimetic Compounds as Inhibitors of Non-Small Cell Lung and Triple Negative Breast Cancers.

Authors:

Magesh Muthu Jaganmohan Somagoni Vino T Cheriyan Sara Munie Edi Levi Abdelkader E Ashour Alaa Eldeen B Yassin Ahmed M Alafeefy Paula Sochacki Lisa A Polin Kaladhar B Reddy Scott D Larsen Mandip Singh Arun K Rishi

J Biomed Nanotechnol 2015 Sep;11(9):1608-27

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September 2015

A Eu(II)-Containing Cryptate as a Redox Sensor in Magnetic Resonance Imaging of Living Tissue.

Authors:

Levi A Ekanger Lisa A Polin Yimin Shen E Mark Haacke Philip D Martin Matthew J Allen

Angew Chem Int Ed Engl 2015 Nov 2;54(48):14398-401. Epub 2015 Oct 2.

Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202 (USA) http://chem.wayne.edu/allengroup.

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November 2015

6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.

Authors:

Lei Wang Adrianne Wallace Sudhir Raghavan Siobhan M Deis Mike R Wilson Si Yang Lisa Polin Kathryn White Juiwanna Kushner Steven Orr Christina George Carrie O'Connor Zhanjun Hou Shermaine Mitchell-Ryan Charles E Dann Larry H Matherly Aleem Gangjee

J Med Chem 2015 Sep 28;58(17):6938-59. Epub 2015 Aug 28.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University , 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.

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September 2015

Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1.

Authors:

Sharon K Michelhaugh Anthony R Guastella Kaushik Varadarajan Neil V Klinger Prahlad Parajuli Aamir Ahmad Seema Sethi Amro Aboukameel Sam Kiousis Ian M Zitron Salah A Ebrahim Lisa A Polin Fazlul H Sarkar Aliccia Bollig-Fischer Sandeep Mittal

J Transl Med 2015 Jul 15;13:227. Epub 2015 Jul 15.

Department of Neurosurgery, Wayne State University, 4160 John R Street, Suite 930, Detroit, MI, 48201, USA.

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July 2015

Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer.

Authors:

Julie L Boerner Nicole Nechiporchik Kelly L Mueller Lisa Polin Lance Heilbrun Scott A Boerner Gina L Zoratti Karri Stark Patricia M LoRusso Angelika Burger

PLoS One 2015 16;10(3):e0119614. Epub 2015 Mar 16.

Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America.

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February 2016

A novel ER-microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression.

Authors:

Xuebao Zhang Juan Cai Ze Zheng Lisa Polin Zhenghong Lin Aditya Dandekar Li Li Fei Sun Russell L Finley Deyu Fang Zeng-Quan Yang Kezhong Zhang

Cell Discov 2015 8;1:15024. Epub 2015 Sep 8.

Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA; Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI, USA.

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July 2016

Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis.

Authors:

Vino T Cheriyan Ying Wang Magesh Muthu Shazia Jamal Di Chen Huanjie Yang Lisa A Polin Adi L Tarca Harvey I Pass Q Ping Dou Sunita Sharma Anil Wali Arun K Rishi

PLoS One 2014 1;9(4):e93711. Epub 2014 Apr 1.

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America; Department of Oncology, Wayne State University, Detroit, Michigan, United States of America; John D. Dingell VA Medical Center, Detroit, Michigan, United States of America.

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June 2015

Reactivation of estrogen receptor α by vorinostat sensitizes mesenchymal-like triple-negative breast cancer to aminoflavone, a ligand of the aryl hydrocarbon receptor.

Authors:

Karri Stark Angelika Burger Jianmei Wu Phillip Shelton Lisa Polin Jing Li

PLoS One 2013 13;8(9):e74525. Epub 2013 Sep 13.

Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America.

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June 2014

CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth.

Authors:

Abdelkader E Ashour Shazia Jamal Vino T Cheryan Magesh Muthu Khairy M A Zoheir Ahmed M Alafeefy Adel R Abd-Allah Edi Levi Adi L Tarca Lisa A Polin Arun K Rishi

PLoS One 2013 24;8(6):e66733. Epub 2013 Jun 24.

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

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January 2014

Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.

Authors:

Christina Cherian Sita Kugel Desmoulin Lei Wang Lisa Polin Kathryn White Juiwanna Kushner Mark Stout Zhanjun Hou Aleem Gangjee Larry H Matherly

Cancer Chemother Pharmacol 2013 Apr 15;71(4):999-1011. Epub 2013 Feb 15.

Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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April 2013

Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo.

Authors:

Huanjie Yang Ying Wang Vino T Cheryan Wenjuan Wu Cindy Qiuzhi Cui Lisa A Polin Harvey I Pass Q Ping Dou Arun K Rishi Anil Wali

PLoS One 2012 17;7(8):e41214. Epub 2012 Aug 17.

Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America.

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April 2013

Cullin-3 protein expression levels correlate with breast cancer progression.

Authors:

Kelly K Haagenson Larry Tait Juan Wang Malathy P Shekhar Lisa Polin Wei Chen Gen Sheng Wu

Cancer Biol Ther 2012 Sep 24;13(11):1042-6. Epub 2012 Jul 24.

Karmanos Cancer Institute, Detroit, MI ,USA.

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September 2012

Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.

Authors:

Sita Kugel Desmoulin Lei Wang Lisa Polin Kathryn White Juiwanna Kushner Mark Stout Zhanjun Hou Christina Cherian Aleem Gangjee Larry H Matherly

Mol Pharmacol 2012 Oct 26;82(4):591-600. Epub 2012 Jun 26.

Graduate Program in Cancer Biology and Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA.

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October 2012

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

Authors:

Neesar Ahmed Minghui Zeng Indrajit Sinha Lisa Polin Wei-Zen Wei Chozhavendan Rathinam Richard Flavell Ramin Massoumi K Venuprasad

Nat Immunol 2011 Nov 6;12(12):1176-83. Epub 2011 Nov 6.

Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA.

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November 2011

Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter.

Authors:

Sita Kugel Desmoulin Lei Wang Eric Hales Lisa Polin Kathryn White Juiwanna Kushner Mark Stout Zhanjun Hou Christina Cherian Aleem Gangjee Larry H Matherly

Mol Pharmacol 2011 Dec 22;80(6):1096-107. Epub 2011 Sep 22.

Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, Michigan, USA.

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December 2011

Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.

Authors:

Vineshkumar Thidil Puliyappadamba Wenjuan Wu Debra Bevis Liyue Zhang Lisa Polin Robert Kilkuskie Russell L Finley Scott D Larsen Edi Levi Fred R Miller Anil Wali Arun K Rishi

J Biol Chem 2011 Nov 8;286(44):38000-17. Epub 2011 Sep 8.

John D. Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA.

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November 2011

Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.

Authors:

Lei Wang Sita Kugel Desmoulin Christina Cherian Lisa Polin Kathryn White Juiwanna Kushner Andreas Fulterer Min-Hwang Chang Shermaine Mitchell-Ryan Mark Stout Michael F Romero Zhanjun Hou Larry H Matherly Aleem Gangjee

J Med Chem 2011 Oct 22;54(20):7150-64. Epub 2011 Sep 22.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh 15219, Pennsylvania 15282, United States.

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October 2011

Identification and biological activities of new taccalonolide microtubule stabilizers.

Authors:

Jiangnan Peng April L Risinger Gary A Fest Evelyn M Jackson Gregory Helms Lisa A Polin Susan L Mooberry

J Med Chem 2011 Sep 11;54(17):6117-24. Epub 2011 Aug 11.

Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.

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September 2011

Curcumin suppresses growth of mesothelioma cells in vitro and in vivo, in part, by stimulating apoptosis.

Authors:

Ying Wang Arun K Rishi Wenjuan Wu Lisa Polin Sunita Sharma Edi Levi Steven Albelda Harvey I Pass Anil Wali

Mol Cell Biochem 2011 Nov 19;357(1-2):83-94. Epub 2011 May 19.

John D. Dingell VA Medical Center, Karmanos Cancer Institute, Wayne State University, VAMC, 4646 John R, Detroit, MI 48201, USA.

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November 2011

Cell cycle and apoptosis regulatory protein (CARP)-1 is a novel, adriamycin-inducible, diffuse large B-cell lymphoma (DLBL) growth suppressor.

Authors:

Edi Levi Liyue Zhang Amro Aboukameel Sunny Rishi Ramzi M Mohammad Lisa Polin James S Hatfield Arun K Rishi

Cancer Chemother Pharmacol 2011 Jun 31;67(6):1401-13. Epub 2010 Aug 31.

Room B4334, Veterans Affairs Medical Center, Wayne State University, 4646 John R, Detroit, MI 48201, USA.

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June 2011

Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.

Authors:

Lei Wang Christina Cherian Sita Kugel Desmoulin Lisa Polin Yijun Deng Jianmei Wu Zhanjun Hou Kathryn White Juiwanna Kushner Larry H Matherly Aleem Gangjee

J Med Chem 2010 Feb;53(3):1306-18

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, USA.

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February 2010

The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms.

Authors:

April L Risinger Evelyn M Jackson Lisa A Polin Gregory L Helms Desiree A LeBoeuf Patrick A Joe Elizabeth Hopper-Borge Richard F Ludueña Gary D Kruh Susan L Mooberry

Cancer Res 2008 Nov;68(21):8881-8

Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA.

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November 2008

The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80.

Authors:

David Kessel John J Reiners Stuart T Hazeldine Lisa Polin Jerome P Horwitz

Mol Cancer Ther 2007 Jan;6(1):370-9

Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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January 2007

Novel in vitro model barriers for evaluation of the permeability of antitumor compounds, thioxanthones.

Authors:

Venugopal Marasanapalle Xiaoling Li Lisa Polin Bhaskara R Jasti

Invest New Drugs 2006 Mar;24(2):111-6

Department of Pharmaceutics & Medicinal Chemistry, TJ Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA 95211, USA.

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March 2006

Synthesis and biological evaluation of conformationally constrained analogs of the antitumor agents XK469 and SH80. Part 5.

Authors:

Stuart T Hazeldine Lisa Polin Juiwanna Kushner Kathryn White Thomas H Corbett Jerome P Horwitz

Bioorg Med Chem 2006 Apr 5;14(7):2462-7. Epub 2005 Dec 5.

Department of Internal Medicine, Division of Hematology and Oncology, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.

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April 2006

Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides.

Authors:

Xinrong Qin Xinchao Chen Kun Wang Lisa Polin Earl R Kern John C Drach Elizabeth Gullen Yung-Chi Cheng Jiri Zemlicka

Bioorg Med Chem 2006 Feb 18;14(4):1247-54. Epub 2005 Oct 18.

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201-1379, USA.

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February 2006

Divalent cations influence colon cancer cell adhesion in a murine transplantable tumor model.

Authors:

Jochem van der Voort van Zyp William C Conway Vijayalakshmi Thamilselvan Lisa Polin Marc D Basson

Am J Surg 2005 Nov;190(5):701-7

Wayne State University, John D. Dingell VAMC, 4646 John R. Street, Detroit, MI 48201-1932, USA.

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November 2005

CB694, a novel antimitotic with antitumor activities.

Authors:

Kimberly N Weiderhold Deborah A Randall-Hlubek Lisa A Polin Ernest Hamel Susan L Mooberry

Int J Cancer 2006 Feb;118(4):1032-40

Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78425-0549, USA.

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February 2006

Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4.

Authors:

Stuart T Hazeldine Lisa Polin Juiwanna Kushner Kathryn White Thomas H Corbett Jerome P Horwitz

Bioorg Med Chem 2005 Jun;13(12):3910-20

Department of Internal Medicine, Division of Hematology and Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.

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June 2005

An in vivo evaluation of docetaxel delivered intratumorally in head and neck squamous cell carcinoma.

Authors:

George H Yoo Geetha Subramanian Ramesh R Boinpally Andrew Iskander Nasfat Shehadeh Jeffrey Oliver Waleed Ezzat Marie P Piechocki John F Ensley Ho-Sheng Lin Terry Y Shibuya Lisa Polin Ralph E Parchment

Arch Otolaryngol Head Neck Surg 2005 May;131(5):418-29

Department of Otolaryngology-Head and Neck Surgery, Division of Hematology/Oncology, Wayne State University, Detroit, MI 48201, USA.

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May 2005

Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors.

Invest New Drugs 2005 Jun;23(3):213-24

Department of Molecular Biosciences & Bioengineering, University of Hawaii at Manoa, Honolulu, HI 96822, USA.

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June 2005

Part 3: synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid.

Authors:

Stuart T Hazeldine Lisa Polin Juiwanna Kushner Kathryn White Thomas H Corbett Jason Biehl Jerome P Horwitz

Bioorg Med Chem 2005 Feb;13(4):1069-81

Department of Internal Medicine, Division of Hematology and Oncology, Wayne State University, School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.

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February 2005