Lisa J Strug

Lisa J Strug

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Lisa J Strug

Lisa J Strug

Publications by authors named "Lisa J Strug"

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Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1.

PLoS One 2020 13;15(1):e0227067. Epub 2020 Jan 13.

Department of Pediatrics, University of British Columbia and BC Children's Hospital, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227067PLOS
January 2020

VikNGS: A C ++ Variant Integration Kit for Next Generation Sequencing Association Analysis.

Bioinformatics 2019 Oct 3. Epub 2019 Oct 3.

Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, M5G0A4, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btz716DOI Listing
October 2019

Genetic modifiers of cystic fibrosis-related diabetes have extensive overlap with type 2 diabetes and related traits.

J Clin Endocrinol Metab 2019 Oct 19. Epub 2019 Oct 19.

McKusick-Nathans Institute of the Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1210/clinem/dgz102DOI Listing
October 2019

The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF.

J Cyst Fibros 2019 01 10;18(1):35-43. Epub 2018 Oct 10.

Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; Department of Biochemistry, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2018.03.013DOI Listing
January 2019

AGTR2 absence or antagonism prevents cystic fibrosis pulmonary manifestations.

J Cyst Fibros 2019 01 22;18(1):127-134. Epub 2018 Jun 22.

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.jcf.2018.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830504PMC
January 2019

Genetic association analysis with pedigrees: Direct inference using the composite likelihood ratio.

Genet Epidemiol 2018 12 17;42(8):826-837. Epub 2018 Sep 17.

Program in Genetics and Genome Biology and The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/gepi.22153DOI Listing
December 2018

The evidential statistical paradigm in genetics.

Authors:
Lisa J Strug

Genet Epidemiol 2018 Oct 18;42(7):590-607. Epub 2018 Aug 18.

Program in Genetics and Genome Biology, The Hospital for Sick Children, The Centre for Applied Genomics, The Hospital for Sick Children, Division of Biostatistics and Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/gepi.22151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284518PMC
October 2018

Recent advances in developing therapeutics for cystic fibrosis.

Hum Mol Genet 2018 08;27(R2):R173-R186

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

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https://academic.oup.com/hmg/article/27/R2/R173/5060051
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http://dx.doi.org/10.1093/hmg/ddy188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061831PMC
August 2018

Gene Is Associated With Lung Function Response to Ivacaftor in Patients With Cystic Fibrosis.

Front Pharmacol 2018 26;9:828. Epub 2018 Jul 26.

Centre de Recherche Saint-Antoine (CRSA), Sorbonne Université, UPMC Univ Paris 06, INSERM, Paris, France.

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https://www.frontiersin.org/article/10.3389/fphar.2018.00828
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http://dx.doi.org/10.3389/fphar.2018.00828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095007PMC
July 2018

Reference percentiles of FEV1 for the Canadian cystic fibrosis population: comparisons across time and countries.

Thorax 2018 05 6;73(5):446-450. Epub 2018 Feb 6.

Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1136/thoraxjnl-2017-210899DOI Listing
May 2018

Testing Calibration of Cox Survival Models at Extremes of Event Risk.

Front Genet 2018 22;9:177. Epub 2018 May 22.

Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fgene.2018.00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972303PMC
May 2018

Translational research to enable personalized treatment of cystic fibrosis.

J Cyst Fibros 2018 03 21;17(2S):S46-S51. Epub 2017 Dec 21.

Pediatric Pulmonology, Department of Pediatrics, Wilhelmina Children's hospital, Regenerative Medicine Center Utrecht, University Medical Center Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2017.10.017DOI Listing
March 2018

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

CMAJ 2018 02;190(5):E126-E136

The Centre for Applied Genomics (Reuter, Walker, Thiruvahindrapuram, Whitney, Yuen, Trost, Paton, Pereira, Herbrick, Wintle, Merico, Howe, MacDonald, Lu, Nalpathamkalam, Sung, Wang, Patel, Pellecchia, J. Wei, Strug, Bell, Kellam, Mahtani, Hosseini, Fiume, Marshall, Buchanan, Scherer); Divisions of Clinical Pharmacology and Toxicology (I. Cohn), or Clinical, and Metabolic Genetics (Sondheimer, Weksberg, Shuman, Bowdin, Meyn, Monfared), The Hospital for Sick Children; Departments of Paediatrics (Sondheimer, R. Cohn) and Molecular Genetics (Yuen, Weksberg, Shuman, R. Cohn, Ellis, Meyn), University of Toronto; Deep Genomics Inc. (Merico); Department of Psychiatry (Bassett), University Health Network and Centre for Addiction and Mental Health, University of Toronto; Li Ka Shing Knowledge Institute (Bombard), St. Michael's Hospital; Institute of Health Policy, Management and Evaluation (Bombard), University of Toronto; Centre for Genetic Medicine (Stavropoulos, Bowdin, Ray, Monfared); Molecular Genetics Laboratory (Stavropoulos, Ray, Marshall), Division of Genome Diagnostics, Paediatric Laboratory Medicine; Developmental and Stem Cell Biology (Hildebrandt, W. Wei, Romm, Pasceri, Ellis); Ted Rogers Cardiac Genome Clinic (Hosseini); Cytogenetics Laboratory (Joseph-George), Division of Genome Diagnostics, Paediatric Laboratory Medicine, The Hospital for Sick Children; Departments of Biochemistry and Laboratory Medicine, and Pathobiology (Keeley), University of Toronto; DNAstack (Cook, Fiume); McLaughlin Centre (Lee, Scherer), University of Toronto; Medcan Health Management Inc. (Davies, Hazell); Dalla Lana School of Public Health (Szego), Department of Family and Community Medicine, and The Joint Centre for Bioethics, University of Toronto; Centre for Clinical Ethics (Szego), St. Joseph's Health Centre, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.171151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798982PMC
February 2018

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

Nat Neurosci 2017 Apr 6;20(4):602-611. Epub 2017 Mar 6.

The Centre for Applied Genomics, Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1038/nn.4524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501701PMC
April 2017

Reply to: Is a microRNA-328 binding site in PAX6 associated with Rolandic epilepsy?

Ann Clin Transl Neurol 2017 04 23;4(4):278-280. Epub 2017 Mar 23.

Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom; King's College Hospital London United Kingdom.

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http://dx.doi.org/10.1002/acn3.403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376750PMC
April 2017

Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation.

J Infect Dis 2017 01;215(2):293-302

Department of Microbiology & Immunology, University of British Columbia.

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http://dx.doi.org/10.1093/infdis/jiw516DOI Listing
January 2017

A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy.

Ann Clin Transl Neurol 2016 07 2;3(7):512-22. Epub 2016 Jun 2.

Program in Genetics and Genome Biology The Hospital for Sick Children Toronto Ontario M5G 0A4 Canada; Division of Biostatistics Dalla Lana School of Public Health University of Toronto Toronto Ontario M5T 3M7 Canada; The Centre for Applied Genomics The Hospital for Sick Children Toronto Ontario M5G 0A4 Canada.

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http://dx.doi.org/10.1002/acn3.320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931716PMC
July 2016

Novel variation at chr11p13 associated with cystic fibrosis lung disease severity.

Hum Genome Var 2016 7;3:16020. Epub 2016 Jul 7.

Marsico Lung Institute, CF/Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/hgv.2016.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935763PMC
July 2016

Prevalence of meconium ileus marks the severity of mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene.

Genet Med 2016 Apr 18;18(4):333-40. Epub 2015 Jun 18.

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/gim.2015.79DOI Listing
April 2016

Prioritizing rare variants with conditional likelihood ratios.

Hum Hered 2015 3;79(1):5-13. Epub 2015 Feb 3.

Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000371579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759929PMC
September 2015

A Joint Location-Scale Test Improves Power to Detect Associated SNPs, Gene Sets, and Pathways.

Am J Hum Genet 2015 Jul;97(1):125-38

Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada; Department of Statistical Sciences, University of Toronto, Toronto, ON M5S 3G3, Canada. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(15)00201-3.pdf
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S000292971500201
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http://dx.doi.org/10.1016/j.ajhg.2015.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572492PMC
July 2015

Variants in Solute Carrier SLC26A9 Modify Prenatal Exocrine Pancreatic Damage in Cystic Fibrosis.

J Pediatr 2015 May 11;166(5):1152-1157.e6. Epub 2015 Mar 11.

Program in Genetics and Genome Biology, the Hospital for Sick Children, Toronto, Ontario, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2015.01.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530786PMC
May 2015

The genetics of common epilepsies: common or distinct?

Lancet Neurol 2014 Sep 30;13(9):859-60. Epub 2014 Jul 30.

Program in Genetics and Genome Biology, The Hospital for Sick Children and Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5G 0A4, Canada.

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http://dx.doi.org/10.1016/S1474-4422(14)70124-3DOI Listing
September 2014

Association analysis using next-generation sequence data from publicly available control groups: the robust variance score statistic.

Bioinformatics 2014 Aug 14;30(15):2179-88. Epub 2014 Apr 14.

Department of Statistical Science, University of Toronto, Toronto, ON, Canada, Program in Child Health Evaluative Sciences, the Hospital for Sick Children Research Institute, Toronto, ON, Canada, Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, Molecular and Population Genetics and NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK, Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, CanadaDepartment of Statistical Science, University of Toronto, Toronto, ON, Canada, Program in Child Health Evaluative Sciences, the Hospital for Sick Children Research Institute, Toronto, ON, Canada, Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, Molecular and Population Genetics and NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK, Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btu196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103600PMC
August 2014

Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a Mendelian randomization study.

Diabetes 2014 Jun 18;63(6):2114-9. Epub 2014 Feb 18.

Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, CanadaDivision of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/db13-1464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030111PMC
June 2014

Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities.

Hum Genet 2014 Feb 22;133(2):151-61. Epub 2013 Sep 22.

Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5T 3M7, Canada,

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http://dx.doi.org/10.1007/s00439-013-1363-7DOI Listing
February 2014

Using parametric multipoint lods and mods for linkage analysis requires a shift in statistical thinking.

Hum Hered 2011 23;72(4):264-75. Epub 2011 Dec 23.

Division of Epidemiology, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 722 W. 168th Street, New York, NY 10032, USA.

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https://www.karger.com/Article/FullText/331463
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http://dx.doi.org/10.1159/000331463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267993PMC
April 2012

A pure likelihood approach to the analysis of genetic association data: an alternative to Bayesian and frequentist analysis.

Eur J Hum Genet 2010 Aug 28;18(8):933-41. Epub 2010 Apr 28.

Child Health Evaluative Sciences, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.

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http://www.nature.com/articles/ejhg201047
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http://dx.doi.org/10.1038/ejhg.2010.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911506PMC
August 2010

Evidence of shared genetic risk factors for migraine and rolandic epilepsy.

Epilepsia 2009 Nov 8;50(11):2428-33. Epub 2009 Aug 8.

Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York City, New York, USA.

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http://dx.doi.org/10.1111/j.1528-1167.2009.02240.xDOI Listing
November 2009

Attention impairment in rolandic epilepsy: systematic review.

Epilepsia 2008 Sep 11;49(9):1570-80. Epub 2008 Apr 11.

Department of Epidemiology, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1528-1167.2008.01610.xDOI Listing
September 2008

Panic disorder, social anxiety disorder, and a possible medical syndrome previously linked to chromosome 13.

Biol Psychiatry 2008 Mar 24;63(6):594-601. Epub 2007 Oct 24.

Department of Psychiatry, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, New York 10032, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000632230700737
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http://dx.doi.org/10.1016/j.biopsych.2007.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000666PMC
March 2008

Evaluating candidate genes in common epilepsies and the nature of evidence.

Epilepsia 2008 Mar 19;49(3):386-92. Epub 2007 Nov 19.

Epidemiology Division, Department of Psychiatry, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1111/j.1528-1167.2007.01416.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2322852PMC
March 2008

Autosomal dominant inheritance of centrotemporal sharp waves in rolandic epilepsy families.

Epilepsia 2007 Dec 28;48(12):2266-72. Epub 2007 Jul 28.

Department of Epidemiology, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1111/j.1528-1167.2007.01221.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150739PMC
December 2007

An alternative foundation for the planning and evaluation of linkage analysis. II. Implications for multiple test adjustments.

Hum Hered 2006 27;61(4):200-9. Epub 2006 Jul 27.

Division of Statistical Genetics, Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, N.Y., USA.

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http://dx.doi.org/10.1159/000094775DOI Listing
December 2006

An alternative foundation for the planning and evaluation of linkage analysis. I. Decoupling "error probabilities" from "measures of evidence".

Hum Hered 2006 25;61(3):166-88. Epub 2006 Jul 25.

Division of Statistical Genetics, Department of Biostatistics, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1159/000094709DOI Listing
October 2006

Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease.

Thyroid 2006 Apr;16(4):351-5

Division of Clinical-Genetic Epidemiology, New York State Psychiatric Institute, New York, New York.

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http://dx.doi.org/10.1089/thy.2006.16.351DOI Listing
April 2006

Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.

BMC Genet 2005 Dec 30;6 Suppl 1:S3. Epub 2005 Dec 30.

Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866756PMC
December 2005

Disease severity in siblings with cystic fibrosis.

Pediatr Pulmonol 2004 May;37(5):407-12

Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ppul.20007DOI Listing
May 2004