Publications

Comprehensive genomic profiling of lung cancer using a validated panel to explore therapeutic targets in East Asian patients.
Cancer Sci 2017 Dec 20;108(12):2487-2494. Epub 2017 Oct 20.
State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou, China.

New insights into sorafenib resistance in hepatocellular carcinoma: Responsible mechanisms and promising strategies.
Biochim Biophys Acta 2017 Dec 17;1868(2):564-570. Epub 2017 Oct 17.
Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, Guangdong, China. Electronic address:

Mechanical thrombectomy and rescue therapy for intracranial large artery occlusion with underlying atherosclerosis.
J Neurointerv Surg 2017 Dec 4. Epub 2017 Dec 4.
Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.

Purification and characterization of a long-acting ciliary neurotrophic factor via genetically fused with an albumin-binding domain.
Protein Expr Purif 2017 Nov 12;139:14-20. Epub 2017 Jul 12.
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No.1 Beierjie Street, Zhongguancun, Haidian District, Beijing 100190, PR China.

A novel FBN1 mutation causes autosomal dominant Marfan syndrome.
Mol Med Rep 2017 Nov 20;16(5):7321-7328. Epub 2017 Sep 20.
Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China.

Pancreatic β-Cell Function and Prognosis of Nondiabetic Patients With Ischemic Stroke.
Stroke 2017 Nov 27;48(11):2999-3005. Epub 2017 Sep 27.
From the Department of Neurology, Beijing Tiantan Hospital (Y.P., W.C., J.J., H.Z., Q.J., H.L., X.Z., L.L., Yongjun Wang, Yilong Wang) and Department of Epidemiology and Health Statistics, School of Public Health (Y.P., Y.H.), Capital Medical University, China; China National Clinical Research Center for Neurological Diseases, Beijing (Y.P., W.C., J.J., H.Z., Q.J., H.L., X.Z., L.L., Yongjun Wang, Yilong Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (Y.P., W.C., J.J., H.Z., Q.J., H.L., X.Z., L.L., Yongjun Wang, Yilong Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Y.P., W.C., J.J., H.Z., Q.J., H.L., X.Z., L.L., Yongjun Wang, Yilong Wang); and Beijing Municipal Key Laboratory of Clinical Epidemiology, China (Y.P., Y.H.).

Stress Hyperglycemia and Prognosis of Minor Ischemic Stroke and Transient Ischemic Attack: The CHANCE Study (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events).
Stroke 2017 Nov;48(11):3006-3011
From the Department of Neurology, Beijing Tiantan Hospital (Y.P., J.J., X.M., H.L., Yongjun Wang, X.Z., L.L., Yilong Wang) and Department of Epidemiology and Health Statistics, School of Public Health (Y.P.), Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing (Y.P., J.J., X.M., H.L., Yongjun Wang, X.Z., L.L., Yilong Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (Y.P., J.J., X.M., H.L., Yongjun Wang, X.Z., L.L., Yilong Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Y.P., J.J., X.M., H.L., Yongjun Wang, X.Z., L.L., Yilong Wang); Beijing Municipal Key Laboratory of Clinical Epidemiology, China (Y.P.); Department of Neurology (X.C.) and Department of Cardiology (T.W.), Lishui Hospital of Zhejiang University (the Central Hospital of Lishui), China; INI Stroke Network, OSF Healthcare System, University of Illinois College of Medicine, Peoria (D.W.); and Dell Medical School, University of Texas at Austin (S.C.J.).

High On-Treatment Platelet Reactivity to Adenosine Diphosphate Predicts Ischemic Events of Minor Stroke and Transient Ischemic Attack.
J Stroke Cerebrovasc Dis 2017 Oct 20;26(10):2074-2081. Epub 2017 Jul 20.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. Electronic address:

Encapsulation of Hydrophilic and Hydrophobic Peptides into Hollow Mesoporous Silica Nanoparticles for Enhancement of Antitumor Immune Response.
Small 2017 Oct 1;13(40). Epub 2017 Sep 1.
Tongji School of Pharmacy and National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology (HUST), Wuhan, 430030, China.

Cortical Microinfarcts in Patients with Middle Cerebral Artery Stenosis.
J Stroke Cerebrovasc Dis 2017 Aug 15;26(8):1760-1765. Epub 2017 May 15.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics.
J Cereb Blood Flow Metab 2017 Jul 1;37(7):2567-2576. Epub 2016 Jan 1.
1 Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Association Analysis of Nonsyndromic Congenital Heart Disease and Tag Single Nucleotide Polymorphisms of TBX20 and Genes in the Ras-MAPK Pathway.
Genet Test Mol Biomarkers 2017 Jul 19;21(7):440-444. Epub 2017 May 19.
3 Department of Medical Genetics, The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College , Kunming, China .


Dacarbazine-Loaded Hollow Mesoporous Silica Nanoparticles Grafted with Folic Acid for Enhancing Antimetastatic Melanoma Response.
ACS Appl Mater Interfaces 2017 Jul 21;9(26):21673-21687. Epub 2017 Jun 21.
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan 430022, China.

High hydrostatic pressure encapsulation of doxorubicin in ferritin nanocages with enhanced efficiency.
J Biotechnol 2017 Jul 4;254:34-42. Epub 2017 Jun 4.
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No.1 Beierjie Street, Zhongguancun, Haidian District, Beijing 100190, PR China; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing 210023, PR China. Electronic address:

Prediction of Recurrent Stroke or Transient Ischemic Attack After Noncardiogenic Posterior Circulation Ischemic Stroke.
Stroke 2017 Jul 16;48(7):1835-1841. Epub 2017 Jun 16.
From the Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China (C.Z., Yilong Wang, X.Z., L.L., C.W., Y.P., X.Z., Y.P., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing (C.Z., Yilong Wang, X.Z., L.L., C.W., Y.P., X.Z., Y.P., Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Yongjun Wang); and Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, China (K.S.W.).

Comparison of Associations of Reduced Estimated Glomerular Filtration Rate With Stroke Outcomes Between Hypertension and No Hypertension.
Stroke 2017 Jun 24;48(6):1691-1694. Epub 2017 Apr 24.
From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.W., Yilong Wang, Z.L., H.L., C.W., X.Z., L.L., Yongjun Wang); Department of Neurology, Duke University Medical Center, Durham, NC (X.W., D.T.L.); and Department of Medicine (U.D.P.) and Department of Biostatistics and Bioinformatics (H.X.B.), Duke University, Durham, NC.

UGT1A1 polymorphisms with irinotecan-induced toxicities and treatment outcome in Asians with Lung Cancer: a meta-analysis.
Cancer Chemother Pharmacol 2017 Jun 13;79(6):1109-1117. Epub 2017 May 13.
Department of Thoracic Surgery, Guangzhou Institute of Respiratory Disease and State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, No 151, Yanjiang Rd, Guangzhou, 510120, Guangdong, People's Republic of China.

Risks and benefits of clopidogrel-aspirin in minor stroke or TIA: Time course analysis of CHANCE.
Neurology 2017 May 19;88(20):1906-1911. Epub 2017 Apr 19.
From the Department of Neurology (Y.P., J.J., W.C., X.M., H.L., X.Z., L.L., Yilong Wang, Yongjun Wang), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (Y.P., J.J., W.C., X.M., H.L., X.Z., L.L., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders (Y.P., J.J., W.C., X.M., H.L., X.Z., L.L., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.P., J.J., W.C., X.M., H.L., X.Z., L.L., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics (Y.P.), School of Public Health, Capital Medical University, Beijing, China; INI Stroke Network (D.W.), OSF Healthcare System, University of Illinois College of Medicine, Peoria; and Dell Medical School (S.C.J.), University of Texas at Austin.

Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke: The ACROSS-China Study (Abnormal Glucose Regulation in Patients With Acute Stroke Across China).
Stroke 2017 Apr 24;48(4):887-893. Epub 2017 Feb 24.
From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (J.J., Y.P., X.Z., H.Z., Q.J., D.M., W.C., H.L., L.L., C.W., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., X.Z., H.Z., Q.J., D.M., W.C., H.L., L.L., C.W., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (J.J., X.Z., H.Z., Q.J., D.M., W.C., H.L., L.L., C.W., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., X.Z., H.Z., Q.J., D.M., W.C., H.L., L.L., C.W., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, China (Y.P., Y.H.); and Illinois Neurological Institute Stroke Network, Sisters of the Third Order of St. Francis Healthcare System, University of Illinois College of Medicine, Peoria (D.W.).

Impact of Glycemic Control on Efficacy of Clopidogrel in Transient Ischemic Attack or Minor Stroke Patients With CYP2C19 Genetic Variants.
Stroke 2017 Apr 13;48(4):998-1004. Epub 2017 Mar 13.
From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (Y.L., A.W., J. Li, J. Lin, X.M., W.C., X.Z., L.L., Yilong Wang, Yongjun Wang); Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China (Y.L., L.O.); China National Clinical Research Center for Neurological Diseases, Beijing, China (Y.L., A.W., J. Li, J. Lin, X.M., W.C., X.Z., L.L., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (Y.L., A.W., J. Li, J. Lin, X.M., W.C., X.Z., L.L., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (A.W., J. Li, J. Lin, X.M., W.C., X.Z., L.L., Yilong Wang, Yongjun Wang); and Illinois Neurological Institute Stroke Network, OSF Healthcare Systems, University of Illinois College of Medicine at Peoria (D.W.).



Association of multiple infarctions and ICAS with outcomes of minor stroke and TIA.
Neurology 2017 Mar 15;88(11):1081-1088. Epub 2017 Feb 15.
From the Department of Neurology, Beijing Tiantan Hospital (Y.P., X.M., J.J., H.L., X.Z., L.L., Yilong Wang, Yongjun Wang), and Department of Epidemiology and Health Statistics, School of Public Health (Y.P.), Capital Medical University; China National Clinical Research Center for Neurological Diseases (Y.P., X.M., J.J., H.L., X.Z., L.L., Yilong Wang, Yongjun Wang); Center of Stroke (Y.P., X.M., J.J., H.L., X.Z., L.L., Yilong Wang, Yongjun Wang), Beijing Institute for Brain Disorders; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.P., X.M., J.J., H.L., X.Z., L.L., Yilong Wang, Yongjun Wang); Beijing Municipal Key Laboratory of Clinical Epidemiology (Y.P.), China; INI Stroke Network (D.W.), OSF Healthcare System, University of Illinois College of Medicine, Peoria; and Dell Medical School (S.C.J.), University of Texas at Austin.



Inhibition of glioblastoma dispersal by the MEK inhibitor PD0325901.
BMC Cancer 2017 Feb 10;17(1):121. Epub 2017 Feb 10.
Department of Surgery-Rutgers Robert Wood Johnson Medical School, Clinical Academic Building, 125 Paterson Street, New Brunswick, NJ, 08901, USA.

Genetic Polymorphisms and Clopidogrel Efficacy for Acute Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis.
Circulation 2017 Jan 2;135(1):21-33. Epub 2016 Nov 2.
From Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (Y.P., W.C., X.Z., L.L., Q.Z., G.W., Yongjun Wang, Yilong Wang); China National Clinical Research Center for Neurological Diseases, Beijing (Y.P., W.C., X.Z., L.L., Q.Z., G.W., Yongjun Wang, Yilong Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (Y.P., W.C., L.H., X.Z., L.L., Q.Z., G.W., Yongjun Wang, Yilong Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Y.P., W.C., L.H., X.Z., L.L., Q.Z., G.W., Yongjun Wang, Yilong Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P.); Beijing Municipal Key Laboratory of Clinical Epidemiology, China (Y.P.); Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, China (Y.X.); Department of Neurology, The People's Hospital of Deyang City, China (X.Y.); Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai, China (Y.H.); Department of Neurology, Xinqiao Hospital, the Third Military Medical University, Chongqing, China (Q.Y.); Department of Neurology, the Second Hospital of Tianjin Medical University, China (X.L.); The First Affiliated Hospital, Jinan University, Guangzhou, China (L.H.); and Dell Medical School, University of Texas at Austin, TX (S.C.J.).

Application of the analytic hierarchy approach to the risk assessment of Zika virus disease transmission in Guangdong Province, China.
BMC Infect Dis 2017 Jan 13;17(1):65. Epub 2017 Jan 13.
Guangdong Provincial Center for Disease Control and Prevention, No. 160 Qunxian Road, Panyu District, Guangzhou, 511430, China.

Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack: CHANCE Substudy (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events).
Stroke 2016 Nov 13;47(11):2791-2796. Epub 2016 Oct 13.
From the Department of Nephrology, Beijing Tiantan Hospital (Y.Z., Y.W.), Department of Neurology, Beijing Tiantan Hospital (Y.P., X.Z., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang), and Department of Epidemiology and Health Statistics, School of Public Health (Y.P.), Capital Medical University, China; China National Clinical Research Center for Neurological Diseases, Beijing, China (Y.P., X.Z., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (Y.P., X.Z., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Y.P., X.Z., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); INI Stroke Network, OSF Healthcare System, University of Illinois College of Medicine, Peoria (D.W.); and Dell Medical School, University of Texas at Austin (S.C.J.).

Socioeconomic Status and the Quality of Acute Stroke Care: The China National Stroke Registry.
Stroke 2016 Nov 6;47(11):2836-2842. Epub 2016 Oct 6.
From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (Y.P., Z.L., H.L., X.Z., L.L., C.W., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Y.P., Z.L., H.L., X.Z., L.L., C.W., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (Y.P., Z.L., H.L., X.Z., L.L., C.W., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Y.P., Z.L., H.L., X.Z., L.L., C.W., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P.); and Centre for Health and Social Care Improvement, Faculty of Education Health and Wellbeing, University of Wolverhampton, United Kingdom (R.C.).

Substantial Progress Yet Significant Opportunity for Improvement in Stroke Care in China.
Stroke 2016 Nov 6;47(11):2843-2849. Epub 2016 Oct 6.
From the Division of Vascular Neurology, Department of Neurology (Z.L., X.Z., C.Z., Yongjun Wang), Tiantan Clinical Trial and Research Center for Stroke, Department of Neurology (Z.L., Chunjuan Wang, H.L., A.W., Y.P., Y.J., X.Y., Yilong Wang), Neurointensive Care Unit, Department of Neurology (L.L.), and Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology (Chunxue Wang), Beijing TianTan Hospital, Capital Medical University, China; China National Clinical Research Center for Neurological Diseases, Beijing (Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (Z.L., X.Z.); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Chunjuan Wang); Department of Statistics and Operations Research, University of North Carolina at Chapel Hill (H.S.); Duke Clinical Research Institute (J.B., E.D.P., Y.X.) and Duke University School of Nursing (J.B., Q.Y.), Duke University, Durham, NC; INI Stroke Network, OSF Healthcare System, University of Illinois College of Medicine, Peoria (D.W.); Ahmanson-UCLA Cardiomyopathy Center, Ronald Reagan-UCLA Medical Center (G.C.F.); Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.H.S.); and Department of Quantitative Health Sciences, Cleveland Clinic, OH (B.H.).

External Validation of the Totaled Health Risks in Vascular Events Score to Predict Functional Outcome and Mortality in Patients Entered into the China National Stroke Registry.
J Stroke Cerebrovasc Dis 2016 Oct 17;25(10):2331-7. Epub 2016 Aug 17.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. Electronic address:

Herbivore teeth predict climatic limits in Kenyan ecosystems.
Proc Natl Acad Sci U S A 2016 Oct 24. Epub 2016 Oct 24.
Department of Geosciences and Geography, University of Helsinki, FI-00014 Helsinki, Finland; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, NO-0316 Oslo, Norway; Museum of Natural History, 10115 Berlin, Germany.

In-hospital medical complications associated with stroke recurrence after initial ischemic stroke: A prospective cohort study from the China National Stroke Registry.
Medicine (Baltimore) 2016 Sep;95(37):e4929
aDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University bCenter of Stroke, Beijing Institute for Brain Disorders cBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease dChina National Clinical Research Center for Neurological Diseases, Beijing, China.

Mesenchymal Stem Cells Reversed Morphine Tolerance and Opioid-induced Hyperalgesia.
Sci Rep 2016 Aug 24;6:32096. Epub 2016 Aug 24.
Departments of Pain Management and Neurosciences, Lerner Research Institute and Anaesthesiology Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.

Fractional Flow Assessment for the Evaluation of Intracranial Atherosclerosis: A Feasibility Study.
Interv Neurol 2016 Jun 1;5(1-2):65-75. Epub 2016 Apr 1.
Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China.

Development and Evaluation of Up-Converting Phosphor Technology-Based Lateral Flow Assay for Quantitative Detection of NT-proBNP in Blood.
PLoS One 2017 2;12(2):e0171376. Epub 2017 Feb 2.
Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P.R. China.


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