Lionel Rouge

Lionel Rouge

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Lionel Rouge

Lionel Rouge

Publications by authors named "Lionel Rouge"

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Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation.

Structure 2018 01 14;26(1):72-84.e7. Epub 2017 Dec 14.

Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, CA 94080, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09692126173036
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http://dx.doi.org/10.1016/j.str.2017.11.010DOI Listing
January 2018

(1)H, (13)C and (15)N backbone resonance assignment for the 40.5 kDa catalytic domain of Ubiquitin Specific Protease 7 (USP7).

Biomol NMR Assign 2016 10 8;10(2):345-9. Epub 2016 Jul 8.

Departments of Structural Biology, Genentech, South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1007/s12104-016-9698-3DOI Listing
October 2016

Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation.

Structure 2016 08 21;24(8):1335-1345. Epub 2016 Jul 21.

Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.05.020DOI Listing
August 2016

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

J Med Chem 2015 Jun 12;58(12):5121-36. Epub 2015 Jun 12.

#Shanghai Chempartner Inc., 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, People's Republic of China.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00572DOI Listing
June 2015

Structural analysis of bacterial ABC transporter inhibition by an antibody fragment.

Structure 2015 Apr 5;23(4):713-23. Epub 2015 Mar 5.

Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.01.020DOI Listing
April 2015

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.

J Med Chem 2014 Feb 4;57(3):1033-45. Epub 2014 Feb 4.

Department of Discovery Chemistry, ‡Department of Translational Oncology, △Department of Pathology, §Department of Drug Metabolism and Pharmacokinetics, ∥Department of Biochemical and Cellular Pharmacology, and ⊥Department of Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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http://dx.doi.org/10.1021/jm401768tDOI Listing
February 2014

Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor.

J Mol Biol 2013 Jun 16;425(12):2247-59. Epub 2013 Mar 16.

Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00222836130016
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http://dx.doi.org/10.1016/j.jmb.2013.03.020DOI Listing
June 2013

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.

Nat Chem Biol 2013 Jan 25;9(1):51-8. Epub 2012 Nov 25.

Department of Early Discovery Biochemistry, Genentech Inc., San Francisco, California, USA.

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http://www.nature.com/articles/nchembio.1134
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http://dx.doi.org/10.1038/nchembio.1134DOI Listing
January 2013

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6.

Structure 2011 Oct 22;19(10):1433-42. Epub 2011 Sep 22.

Department of Early Discovery Biochemistry, Genentech Research and Early Development, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.str.2011.07.005DOI Listing
October 2011

Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation.

J Biol Chem 2009 Mar 30;284(10):6546-53. Epub 2008 Dec 30.

Department of Protein Chemistry, Genentech, Inc., South San Francisco, California 94080, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M806121200
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http://dx.doi.org/10.1074/jbc.M806121200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649088PMC
March 2009